Found 54 hits Enz. Inhib. hit(s) with all data for entry = 50002873 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50264998
(CHEMBL4103458)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C51H90N14O8/c1-28(2)23-38(59-33(11)66)46(69)62-40(25-30(5)6)48(71)64-41(26-31(7)8)49(72)63-39(24-29(3)4)47(70)60-37(16-14-22-57-51(55)56)45(68)65-42(32(9)10)50(73)61-36(15-12-13-21-52)44(67)58-27-34-17-19-35(20-18-34)43(53)54/h17-20,28-32,36-42H,12-16,21-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,72)(H,64,71)(H,65,68)(H4,55,56,57)/t36-,37-,38+,39-,40-,41-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50264998
(CHEMBL4103458)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C51H90N14O8/c1-28(2)23-38(59-33(11)66)46(69)62-40(25-30(5)6)48(71)64-41(26-31(7)8)49(72)63-39(24-29(3)4)47(70)60-37(16-14-22-57-51(55)56)45(68)65-42(32(9)10)50(73)61-36(15-12-13-21-52)44(67)58-27-34-17-19-35(20-18-34)43(53)54/h17-20,28-32,36-42H,12-16,21-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,70)(H,61,73)(H,62,69)(H,63,72)(H,64,71)(H,65,68)(H4,55,56,57)/t36-,37-,38+,39-,40-,41-,42-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464000
(CHEMBL4243204)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(NC(N)=N)cc1)C(N)=O |r| Show InChI InChI=1S/C59H106N20O10/c1-31(2)26-43(70-36(11)80)52(85)76-45(28-33(5)6)54(87)78-46(29-34(7)8)55(88)77-44(27-32(3)4)53(86)73-41(18-15-25-69-58(64)65)51(84)79-47(35(9)10)56(89)74-39(16-12-13-23-60)49(82)72-40(17-14-24-68-57(62)63)50(83)75-42(48(61)81)30-37-19-21-38(22-20-37)71-59(66)67/h19-22,31-35,39-47H,12-18,23-30,60H2,1-11H3,(H2,61,81)(H,70,80)(H,72,82)(H,73,86)(H,74,89)(H,75,83)(H,76,85)(H,77,88)(H,78,87)(H,79,84)(H4,62,63,68)(H4,64,65,69)(H4,66,67,71)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464002
(CHEMBL4242301)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C58H103N17O10/c1-32(2)27-43(67-37(11)76)52(81)72-45(29-34(5)6)54(83)74-46(30-35(7)8)55(84)73-44(28-33(3)4)53(82)69-41(23-18-26-66-58(63)64)51(80)75-47(36(9)10)56(85)70-39(21-15-16-24-59)49(78)68-40(22-17-25-65-57(61)62)50(79)71-42(48(60)77)31-38-19-13-12-14-20-38/h12-14,19-20,32-36,39-47H,15-18,21-31,59H2,1-11H3,(H2,60,77)(H,67,76)(H,68,78)(H,69,82)(H,70,85)(H,71,79)(H,72,81)(H,73,84)(H,74,83)(H,75,80)(H4,61,62,65)(H4,63,64,66)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50399746
(CHEMBL2179435)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#7])=O |r| Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464004
(CHEMBL4238095)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C53H101N17O11/c1-27(2)23-37(62-33(12)72)47(77)66-39(25-29(5)6)49(79)68-40(26-30(7)8)50(80)67-38(24-28(3)4)48(78)64-35(18-15-21-60-52(56)57)45(75)69-41(31(9)10)51(81)65-34(17-13-14-20-54)44(74)63-36(19-16-22-61-53(58)59)46(76)70-42(32(11)71)43(55)73/h27-32,34-42,71H,13-26,54H2,1-12H3,(H2,55,73)(H,62,72)(H,63,74)(H,64,78)(H,65,81)(H,66,77)(H,67,80)(H,68,79)(H,69,75)(H,70,76)(H4,56,57,60)(H4,58,59,61)/t32-,34+,35+,36+,37+,38+,39+,40+,41+,42+/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463992
(CHEMBL4239833)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C53H100N18O11/c1-27(2)22-37(63-32(11)72)47(78)68-39(24-29(5)6)49(80)70-40(25-30(7)8)50(81)69-38(23-28(3)4)48(79)65-35(18-15-21-62-53(59)60)46(77)71-42(31(9)10)51(82)66-33(16-12-13-19-54)44(75)64-34(17-14-20-61-52(57)58)45(76)67-36(43(56)74)26-41(55)73/h27-31,33-40,42H,12-26,54H2,1-11H3,(H2,55,73)(H2,56,74)(H,63,72)(H,64,75)(H,65,79)(H,66,82)(H,67,76)(H,68,78)(H,69,81)(H,70,80)(H,71,77)(H4,57,58,61)(H4,59,60,62)/t33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463999
(CHEMBL4241012)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r| Show InChI InChI=1S/C60H104N18O10/c1-32(2)26-45(70-37(11)79)54(84)75-47(28-34(5)6)56(86)77-48(29-35(7)8)57(87)76-46(27-33(3)4)55(85)72-43(22-17-25-68-60(65)66)53(83)78-49(36(9)10)58(88)73-41(20-14-15-23-61)51(81)71-42(21-16-24-67-59(63)64)52(82)74-44(50(62)80)30-38-31-69-40-19-13-12-18-39(38)40/h12-13,18-19,31-36,41-49,69H,14-17,20-30,61H2,1-11H3,(H2,62,80)(H,70,79)(H,71,81)(H,72,85)(H,73,88)(H,74,82)(H,75,84)(H,76,87)(H,77,86)(H,78,83)(H4,63,64,67)(H4,65,66,68)/t41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464012
(CHEMBL4251139)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C58H103N17O11/c1-31(2)26-43(67-36(11)76)52(82)72-45(28-33(5)6)54(84)74-46(29-34(7)8)55(85)73-44(27-32(3)4)53(83)69-41(18-15-25-66-58(63)64)51(81)75-47(35(9)10)56(86)70-39(16-12-13-23-59)49(79)68-40(17-14-24-65-57(61)62)50(80)71-42(48(60)78)30-37-19-21-38(77)22-20-37/h19-22,31-35,39-47,77H,12-18,23-30,59H2,1-11H3,(H2,60,78)(H,67,76)(H,68,79)(H,69,83)(H,70,86)(H,71,80)(H,72,82)(H,73,85)(H,74,84)(H,75,81)(H4,61,62,65)(H4,63,64,66)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464007
(CHEMBL4244211)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(N)=O |r| Show InChI InChI=1S/C53H99N17O12/c1-27(2)22-37(62-32(11)71)47(78)67-39(24-29(5)6)49(80)69-40(25-30(7)8)50(81)68-38(23-28(3)4)48(79)64-35(18-15-21-61-53(58)59)46(77)70-42(31(9)10)51(82)65-33(16-12-13-19-54)44(75)63-34(17-14-20-60-52(56)57)45(76)66-36(43(55)74)26-41(72)73/h27-31,33-40,42H,12-26,54H2,1-11H3,(H2,55,74)(H,62,71)(H,63,75)(H,64,79)(H,65,82)(H,66,76)(H,67,78)(H,68,81)(H,69,80)(H,70,77)(H,72,73)(H4,56,57,60)(H4,58,59,61)/t33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463993
(CHEMBL4246646)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(N)cc1)C(N)=O |r| Show InChI InChI=1S/C58H104N18O10/c1-31(2)26-43(68-36(11)77)52(82)73-45(28-33(5)6)54(84)75-46(29-34(7)8)55(85)74-44(27-32(3)4)53(83)70-41(18-15-25-67-58(64)65)51(81)76-47(35(9)10)56(86)71-39(16-12-13-23-59)49(79)69-40(17-14-24-66-57(62)63)50(80)72-42(48(61)78)30-37-19-21-38(60)22-20-37/h19-22,31-35,39-47H,12-18,23-30,59-60H2,1-11H3,(H2,61,78)(H,68,77)(H,69,79)(H,70,83)(H,71,86)(H,72,80)(H,73,82)(H,74,85)(H,75,84)(H,76,81)(H4,62,63,66)(H4,64,65,67)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | Reactome pathway
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| PC cid
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UniChem
| Article
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| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464003
(CHEMBL4245293)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C54H103N17O10S/c1-29(2)25-39(63-34(11)72)48(77)68-41(27-31(5)6)50(79)70-42(28-32(7)8)51(80)69-40(26-30(3)4)49(78)66-38(19-16-23-62-54(59)60)47(76)71-43(33(9)10)52(81)67-36(17-13-14-21-55)46(75)65-37(18-15-22-61-53(57)58)45(74)64-35(44(56)73)20-24-82-12/h29-33,35-43H,13-28,55H2,1-12H3,(H2,56,73)(H,63,72)(H,64,74)(H,65,75)(H,66,78)(H,67,81)(H,68,77)(H,69,80)(H,70,79)(H,71,76)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464008
(CHEMBL4245488)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r| Show InChI InChI=1S/C55H101N19O10/c1-29(2)22-40(66-34(11)75)49(80)71-42(24-31(5)6)51(82)73-43(25-32(7)8)52(83)72-41(23-30(3)4)50(81)68-38(18-15-21-64-55(60)61)48(79)74-44(33(9)10)53(84)69-36(16-12-13-19-56)46(77)67-37(17-14-20-63-54(58)59)47(78)70-39(45(57)76)26-35-27-62-28-65-35/h27-33,36-44H,12-26,56H2,1-11H3,(H2,57,76)(H,62,65)(H,66,75)(H,67,77)(H,68,81)(H,69,84)(H,70,78)(H,71,80)(H,72,83)(H,73,82)(H,74,79)(H4,58,59,63)(H4,60,61,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | Reactome pathway
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| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464001
(CHEMBL4244893)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C52H99N17O10/c1-27(2)23-37(62-33(12)70)46(75)66-39(25-29(5)6)48(77)68-40(26-30(7)8)49(78)67-38(24-28(3)4)47(76)64-36(19-16-22-60-52(57)58)45(74)69-41(31(9)10)50(79)65-34(17-13-14-20-53)44(73)63-35(18-15-21-59-51(55)56)43(72)61-32(11)42(54)71/h27-32,34-41H,13-26,53H2,1-12H3,(H2,54,71)(H,61,72)(H,62,70)(H,63,73)(H,64,76)(H,65,79)(H,66,75)(H,67,78)(H,68,77)(H,69,74)(H4,55,56,59)(H4,57,58,60)/t32-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1 | Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463995
(CHEMBL4245651)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C54H103N17O10/c1-28(2)24-38(63-34(13)72)48(77)67-40(26-30(5)6)50(79)69-41(27-31(7)8)51(80)68-39(25-29(3)4)49(78)65-37(20-17-23-62-54(59)60)47(76)71-43(33(11)12)52(81)66-35(18-14-15-21-55)45(74)64-36(19-16-22-61-53(57)58)46(75)70-42(32(9)10)44(56)73/h28-33,35-43H,14-27,55H2,1-13H3,(H2,56,73)(H,63,72)(H,64,74)(H,65,78)(H,66,81)(H,67,77)(H,68,80)(H,69,79)(H,70,75)(H,71,76)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | Reactome pathway
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| PC cid
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UniChem
| Article
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464014
(CHEMBL4242118)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(cc1)C(N)=N)C(=O)NCCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C72H119N21O11/c1-39(2)33-54(85-45(12)94)66(100)90-56(35-41(5)6)68(102)92-57(36-42(7)8)69(103)91-55(34-40(3)4)67(101)87-53(23-18-31-82-72(78)79)65(99)93-59(43(9)10)70(104)88-51(21-15-16-29-73)64(98)86-52(22-17-30-81-71(76)77)63(97)84-44(11)61(95)89-58(37-46-24-26-47(27-25-46)60(74)75)62(96)80-32-28-48-38-83-50-20-14-13-19-49(48)50/h13-14,19-20,24-27,38-44,51-59,83H,15-18,21-23,28-37,73H2,1-12H3,(H3,74,75)(H,80,96)(H,84,97)(H,85,94)(H,86,98)(H,87,101)(H,88,104)(H,89,95)(H,90,100)(H,91,103)(H,92,102)(H,93,99)(H4,76,77,81)(H4,78,79,82)/t44-,51-,52-,53-,54+,55-,56-,57-,58-,59-/m0/s1 | Reactome pathway
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UniProtKB/SwissProt
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| PC cid
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| Article
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| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463998
(CHEMBL4247378)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(N)=O |r| Show InChI InChI=1S/C54H102N18O11/c1-28(2)24-38(64-33(11)73)48(79)69-40(26-30(5)6)50(81)71-41(27-31(7)8)51(82)70-39(25-29(3)4)49(80)67-37(18-15-23-63-54(60)61)47(78)72-43(32(9)10)52(83)68-35(16-12-13-21-55)46(77)66-36(17-14-22-62-53(58)59)45(76)65-34(44(57)75)19-20-42(56)74/h28-32,34-41,43H,12-27,55H2,1-11H3,(H2,56,74)(H2,57,75)(H,64,73)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,79)(H,70,82)(H,71,81)(H,72,78)(H4,58,59,62)(H4,60,61,63)/t34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | Reactome pathway
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| PC cid
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UniChem
| Article
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| 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464016
(CHEMBL4250694)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C51H97N17O10/c1-27(2)22-36(61-32(11)69)45(74)65-38(24-29(5)6)47(76)67-39(25-30(7)8)48(77)66-37(23-28(3)4)46(75)63-35(18-15-21-59-51(56)57)44(73)68-41(31(9)10)49(78)64-34(16-12-13-19-52)43(72)62-33(17-14-20-58-50(54)55)42(71)60-26-40(53)70/h27-31,33-39,41H,12-26,52H2,1-11H3,(H2,53,70)(H,60,71)(H,61,69)(H,62,72)(H,63,75)(H,64,78)(H,65,74)(H,66,77)(H,67,76)(H,68,73)(H4,54,55,58)(H4,56,57,59)/t33-,34-,35-,36-,37-,38-,39-,41-/m0/s1 | Reactome pathway
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UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463996
(CHEMBL4239986)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C54H101N17O12/c1-28(2)24-38(63-33(11)72)48(79)68-40(26-30(5)6)50(81)70-41(27-31(7)8)51(82)69-39(25-29(3)4)49(80)66-37(18-15-23-62-54(59)60)47(78)71-43(32(9)10)52(83)67-35(16-12-13-21-55)46(77)65-36(17-14-22-61-53(57)58)45(76)64-34(44(56)75)19-20-42(73)74/h28-32,34-41,43H,12-27,55H2,1-11H3,(H2,56,75)(H,63,72)(H,64,76)(H,65,77)(H,66,80)(H,67,83)(H,68,79)(H,69,82)(H,70,81)(H,71,78)(H,73,74)(H4,57,58,61)(H4,59,60,62)/t34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464011
(CHEMBL4237338)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C52H99N17O11/c1-27(2)22-36(61-32(11)71)46(76)65-38(24-29(5)6)48(78)67-39(25-30(7)8)49(79)66-37(23-28(3)4)47(77)63-35(18-15-21-60-52(57)58)45(75)69-41(31(9)10)50(80)64-33(16-12-13-19-53)43(73)62-34(17-14-20-59-51(55)56)44(74)68-40(26-70)42(54)72/h27-31,33-41,70H,12-26,53H2,1-11H3,(H2,54,72)(H,61,71)(H,62,73)(H,63,77)(H,64,80)(H,65,76)(H,66,79)(H,67,78)(H,68,74)(H,69,75)(H4,55,56,59)(H4,57,58,60)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464009
(CHEMBL4242768)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C55H105N17O10/c1-14-34(12)44(45(57)74)72-48(77)38(21-18-24-63-55(60)61)65-46(75)36(19-15-16-22-56)67-53(82)43(33(10)11)71-47(76)37(20-17-23-62-54(58)59)66-50(79)40(26-30(4)5)69-52(81)42(28-32(8)9)70-51(80)41(27-31(6)7)68-49(78)39(25-29(2)3)64-35(13)73/h29-34,36-44H,14-28,56H2,1-13H3,(H2,57,74)(H,64,73)(H,65,75)(H,66,79)(H,67,82)(H,68,78)(H,69,81)(H,70,80)(H,71,76)(H,72,77)(H4,58,59,62)(H4,60,61,63)/t34-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | Reactome pathway
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UniChem
| Article
PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464012
(CHEMBL4251139)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C58H103N17O11/c1-31(2)26-43(67-36(11)76)52(82)72-45(28-33(5)6)54(84)74-46(29-34(7)8)55(85)73-44(27-32(3)4)53(83)69-41(18-15-25-66-58(63)64)51(81)75-47(35(9)10)56(86)70-39(16-12-13-23-59)49(79)68-40(17-14-24-65-57(61)62)50(80)71-42(48(60)78)30-37-19-21-38(77)22-20-37/h19-22,31-35,39-47,77H,12-18,23-30,59H2,1-11H3,(H2,60,78)(H,67,76)(H,68,79)(H,69,83)(H,70,86)(H,71,80)(H,72,82)(H,73,85)(H,74,84)(H,75,81)(H4,61,62,65)(H4,63,64,66)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464013
(CHEMBL4249395)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCc1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C58H104N18O9/c1-32(2)28-43(69-37(11)77)52(81)73-45(30-34(5)6)54(83)75-46(31-35(7)8)55(84)74-44(29-33(3)4)53(82)71-42(18-15-26-68-58(64)65)51(80)76-47(36(9)10)56(85)72-41(16-12-13-24-59)50(79)70-40(17-14-25-67-57(62)63)49(78)66-27-23-38-19-21-39(22-20-38)48(60)61/h19-22,32-36,40-47H,12-18,23-31,59H2,1-11H3,(H3,60,61)(H,66,78)(H,69,77)(H,70,79)(H,71,82)(H,72,85)(H,73,81)(H,74,84)(H,75,83)(H,76,80)(H4,62,63,67)(H4,64,65,68)/t40-,41-,42-,43+,44-,45-,46-,47-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
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UniChem
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464005
(CHEMBL4245151)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C59H103N17O9/c1-33(2)28-45(69-38(11)77)53(81)73-47(30-35(5)6)55(83)75-48(31-36(7)8)56(84)74-46(29-34(3)4)54(82)71-44(22-17-26-67-59(63)64)52(80)76-49(37(9)10)57(85)72-43(20-14-15-24-60)51(79)70-42(21-16-25-66-58(61)62)50(78)65-27-23-39-32-68-41-19-13-12-18-40(39)41/h12-13,18-19,32-37,42-49,68H,14-17,20-31,60H2,1-11H3,(H,65,78)(H,69,77)(H,70,79)(H,71,82)(H,72,85)(H,73,81)(H,74,84)(H,75,83)(H,76,80)(H4,61,62,66)(H4,63,64,67)/t42-,43-,44-,45+,46-,47-,48-,49-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464002
(CHEMBL4242301)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| Show InChI InChI=1S/C58H103N17O10/c1-32(2)27-43(67-37(11)76)52(81)72-45(29-34(5)6)54(83)74-46(30-35(7)8)55(84)73-44(28-33(3)4)53(82)69-41(23-18-26-66-58(63)64)51(80)75-47(36(9)10)56(85)70-39(21-15-16-24-59)49(78)68-40(22-17-25-65-57(61)62)50(79)71-42(48(60)77)31-38-19-13-12-14-20-38/h12-14,19-20,32-36,39-47H,15-18,21-31,59H2,1-11H3,(H2,60,77)(H,67,76)(H,68,78)(H,69,82)(H,70,85)(H,71,79)(H,72,81)(H,73,84)(H,74,83)(H,75,80)(H4,61,62,65)(H4,63,64,66)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464007
(CHEMBL4244211)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(N)=O |r| Show InChI InChI=1S/C53H99N17O12/c1-27(2)22-37(62-32(11)71)47(78)67-39(24-29(5)6)49(80)69-40(25-30(7)8)50(81)68-38(23-28(3)4)48(79)64-35(18-15-21-61-53(58)59)46(77)70-42(31(9)10)51(82)65-33(16-12-13-19-54)44(75)63-34(17-14-20-60-52(56)57)45(76)66-36(43(55)74)26-41(72)73/h27-31,33-40,42H,12-26,54H2,1-11H3,(H2,55,74)(H,62,71)(H,63,75)(H,64,79)(H,65,82)(H,66,76)(H,67,78)(H,68,81)(H,69,80)(H,70,77)(H,72,73)(H4,56,57,60)(H4,58,59,61)/t33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464014
(CHEMBL4242118)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(cc1)C(N)=N)C(=O)NCCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C72H119N21O11/c1-39(2)33-54(85-45(12)94)66(100)90-56(35-41(5)6)68(102)92-57(36-42(7)8)69(103)91-55(34-40(3)4)67(101)87-53(23-18-31-82-72(78)79)65(99)93-59(43(9)10)70(104)88-51(21-15-16-29-73)64(98)86-52(22-17-30-81-71(76)77)63(97)84-44(11)61(95)89-58(37-46-24-26-47(27-25-46)60(74)75)62(96)80-32-28-48-38-83-50-20-14-13-19-49(48)50/h13-14,19-20,24-27,38-44,51-59,83H,15-18,21-23,28-37,73H2,1-12H3,(H3,74,75)(H,80,96)(H,84,97)(H,85,94)(H,86,98)(H,87,101)(H,88,104)(H,89,95)(H,90,100)(H,91,103)(H,92,102)(H,93,99)(H4,76,77,81)(H4,78,79,82)/t44-,51-,52-,53-,54+,55-,56-,57-,58-,59-/m0/s1 | PDB
KEGG
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antibodypedia
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| PC cid
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UniChem
| Article
PubMed
| 80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464004
(CHEMBL4238095)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r| Show InChI InChI=1S/C53H101N17O11/c1-27(2)23-37(62-33(12)72)47(77)66-39(25-29(5)6)49(79)68-40(26-30(7)8)50(80)67-38(24-28(3)4)48(78)64-35(18-15-21-60-52(56)57)45(75)69-41(31(9)10)51(81)65-34(17-13-14-20-54)44(74)63-36(19-16-22-61-53(58)59)46(76)70-42(32(11)71)43(55)73/h27-32,34-42,71H,13-26,54H2,1-12H3,(H2,55,73)(H,62,72)(H,63,74)(H,64,78)(H,65,81)(H,66,77)(H,67,80)(H,68,79)(H,69,75)(H,70,76)(H4,56,57,60)(H4,58,59,61)/t32-,34+,35+,36+,37+,38+,39+,40+,41+,42+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463999
(CHEMBL4241012)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O |r| Show InChI InChI=1S/C60H104N18O10/c1-32(2)26-45(70-37(11)79)54(84)75-47(28-34(5)6)56(86)77-48(29-35(7)8)57(87)76-46(27-33(3)4)55(85)72-43(22-17-25-68-60(65)66)53(83)78-49(36(9)10)58(88)73-41(20-14-15-23-61)51(81)71-42(21-16-24-67-59(63)64)52(82)74-44(50(62)80)30-38-31-69-40-19-13-12-18-39(38)40/h12-13,18-19,31-36,41-49,69H,14-17,20-30,61H2,1-11H3,(H2,62,80)(H,70,79)(H,71,81)(H,72,85)(H,73,88)(H,74,82)(H,75,84)(H,76,87)(H,77,86)(H,78,83)(H4,63,64,67)(H4,65,66,68)/t41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463993
(CHEMBL4246646)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(N)cc1)C(N)=O |r| Show InChI InChI=1S/C58H104N18O10/c1-31(2)26-43(68-36(11)77)52(82)73-45(28-33(5)6)54(84)75-46(29-34(7)8)55(85)74-44(27-32(3)4)53(83)70-41(18-15-25-67-58(64)65)51(81)76-47(35(9)10)56(86)71-39(16-12-13-23-59)49(79)69-40(17-14-24-66-57(62)63)50(80)72-42(48(61)78)30-37-19-21-38(60)22-20-37/h19-22,31-35,39-47H,12-18,23-30,59-60H2,1-11H3,(H2,61,78)(H,68,77)(H,69,79)(H,70,83)(H,71,86)(H,72,80)(H,73,82)(H,74,85)(H,75,84)(H,76,81)(H4,62,63,66)(H4,64,65,67)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463992
(CHEMBL4239833)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| Show InChI InChI=1S/C53H100N18O11/c1-27(2)22-37(63-32(11)72)47(78)68-39(24-29(5)6)49(80)70-40(25-30(7)8)50(81)69-38(23-28(3)4)48(79)65-35(18-15-21-62-53(59)60)46(77)71-42(31(9)10)51(82)66-33(16-12-13-19-54)44(75)64-34(17-14-20-61-52(57)58)45(76)67-36(43(56)74)26-41(55)73/h27-31,33-40,42H,12-26,54H2,1-11H3,(H2,55,73)(H2,56,74)(H,63,72)(H,64,75)(H,65,79)(H,66,82)(H,67,76)(H,68,78)(H,69,81)(H,70,80)(H,71,77)(H4,57,58,61)(H4,59,60,62)/t33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464000
(CHEMBL4243204)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(NC(N)=N)cc1)C(N)=O |r| Show InChI InChI=1S/C59H106N20O10/c1-31(2)26-43(70-36(11)80)52(85)76-45(28-33(5)6)54(87)78-46(29-34(7)8)55(88)77-44(27-32(3)4)53(86)73-41(18-15-25-69-58(64)65)51(84)79-47(35(9)10)56(89)74-39(16-12-13-23-60)49(82)72-40(17-14-24-68-57(62)63)50(83)75-42(48(61)81)30-37-19-21-38(22-20-37)71-59(66)67/h19-22,31-35,39-47H,12-18,23-30,60H2,1-11H3,(H2,61,81)(H,70,80)(H,72,82)(H,73,86)(H,74,89)(H,75,83)(H,76,85)(H,77,88)(H,78,87)(H,79,84)(H4,62,63,68)(H4,64,65,69)(H4,66,67,71)/t39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1 | PDB
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| Article
PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464008
(CHEMBL4245488)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O |r| Show InChI InChI=1S/C55H101N19O10/c1-29(2)22-40(66-34(11)75)49(80)71-42(24-31(5)6)51(82)73-43(25-32(7)8)52(83)72-41(23-30(3)4)50(81)68-38(18-15-21-64-55(60)61)48(79)74-44(33(9)10)53(84)69-36(16-12-13-19-56)46(77)67-37(17-14-20-63-54(58)59)47(78)70-39(45(57)76)26-35-27-62-28-65-35/h27-33,36-44H,12-26,56H2,1-11H3,(H2,57,76)(H,62,65)(H,66,75)(H,67,77)(H,68,81)(H,69,84)(H,70,78)(H,71,80)(H,72,83)(H,73,82)(H,74,79)(H4,58,59,63)(H4,60,61,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | PDB
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| PC cid
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| Article
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463997
(CHEMBL4242223)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O |r| Show InChI InChI=1S/C55H106N18O10/c1-30(2)26-40(65-35(11)74)49(79)70-42(28-32(5)6)51(81)72-43(29-33(7)8)52(82)71-41(27-31(3)4)50(80)68-39(21-17-25-64-55(61)62)48(78)73-44(34(9)10)53(83)69-37(19-13-15-23-57)47(77)67-38(20-16-24-63-54(59)60)46(76)66-36(45(58)75)18-12-14-22-56/h30-34,36-44H,12-29,56-57H2,1-11H3,(H2,58,75)(H,65,74)(H,66,76)(H,67,77)(H,68,80)(H,69,83)(H,70,79)(H,71,82)(H,72,81)(H,73,78)(H4,59,60,63)(H4,61,62,64)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | Reactome pathway
KEGG
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| PC cid
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| Article
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464010
(CHEMBL4248565)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C55H106N20O10/c1-29(2)25-39(67-34(11)76)48(81)72-41(27-31(5)6)50(83)74-42(28-32(7)8)51(84)73-40(26-30(3)4)49(82)70-38(20-16-24-66-55(62)63)47(80)75-43(33(9)10)52(85)71-36(17-12-13-21-56)46(79)69-37(19-15-23-65-54(60)61)45(78)68-35(44(57)77)18-14-22-64-53(58)59/h29-33,35-43H,12-28,56H2,1-11H3,(H2,57,77)(H,67,76)(H,68,78)(H,69,79)(H,70,82)(H,71,85)(H,72,81)(H,73,84)(H,74,83)(H,75,80)(H4,58,59,64)(H4,60,61,65)(H4,62,63,66)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | Reactome pathway
KEGG
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| PC cid
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| Article
PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50463994
(CHEMBL4239018)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C55H105N17O10/c1-29(2)24-39(45(57)74)68-47(76)37(19-16-22-62-54(58)59)65-46(75)36(18-14-15-21-56)67-53(82)44(34(11)12)72-48(77)38(20-17-23-63-55(60)61)66-50(79)41(26-31(5)6)70-52(81)43(28-33(9)10)71-51(80)42(27-32(7)8)69-49(78)40(25-30(3)4)64-35(13)73/h29-34,36-44H,14-28,56H2,1-13H3,(H2,57,74)(H,64,73)(H,65,75)(H,66,79)(H,67,82)(H,68,76)(H,69,78)(H,70,81)(H,71,80)(H,72,77)(H4,58,59,62)(H4,60,61,63)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464003
(CHEMBL4245293)Show SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C54H103N17O10S/c1-29(2)25-39(63-34(11)72)48(77)68-41(27-31(5)6)50(79)70-42(28-32(7)8)51(80)69-40(26-30(3)4)49(78)66-38(19-16-23-62-54(59)60)47(76)71-43(33(9)10)52(81)67-36(17-13-14-21-55)46(75)65-37(18-15-22-61-53(57)58)45(74)64-35(44(56)73)20-24-82-12/h29-33,35-43H,13-28,55H2,1-12H3,(H2,56,73)(H,63,72)(H,64,74)(H,65,75)(H,66,78)(H,67,81)(H,68,77)(H,69,80)(H,70,79)(H,71,76)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463998
(CHEMBL4247378)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(N)=O |r| Show InChI InChI=1S/C54H102N18O11/c1-28(2)24-38(64-33(11)73)48(79)69-40(26-30(5)6)50(81)71-41(27-31(7)8)51(82)70-39(25-29(3)4)49(80)67-37(18-15-23-63-54(60)61)47(78)72-43(32(9)10)52(83)68-35(16-12-13-21-55)46(77)66-36(17-14-22-62-53(58)59)45(76)65-34(44(57)75)19-20-42(56)74/h28-32,34-41,43H,12-27,55H2,1-11H3,(H2,56,74)(H2,57,75)(H,64,73)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,79)(H,70,82)(H,71,81)(H,72,78)(H4,58,59,62)(H4,60,61,63)/t34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463995
(CHEMBL4245651)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(N)=O |r| Show InChI InChI=1S/C54H103N17O10/c1-28(2)24-38(63-34(13)72)48(77)67-40(26-30(5)6)50(79)69-41(27-31(7)8)51(80)68-39(25-29(3)4)49(78)65-37(20-17-23-62-54(59)60)47(76)71-43(33(11)12)52(81)66-35(18-14-15-21-55)45(74)64-36(19-16-22-61-53(57)58)46(75)70-42(32(9)10)44(56)73/h28-33,35-43H,14-27,55H2,1-13H3,(H2,56,73)(H,63,72)(H,64,74)(H,65,78)(H,66,81)(H,67,77)(H,68,80)(H,69,79)(H,70,75)(H,71,76)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464001
(CHEMBL4244893)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(N)=O |r| Show InChI InChI=1S/C52H99N17O10/c1-27(2)23-37(62-33(12)70)46(75)66-39(25-29(5)6)48(77)68-40(26-30(7)8)49(78)67-38(24-28(3)4)47(76)64-36(19-16-22-60-52(57)58)45(74)69-41(31(9)10)50(79)65-34(17-13-14-20-53)44(73)63-35(18-15-21-59-51(55)56)43(72)61-32(11)42(54)71/h27-32,34-41H,13-26,53H2,1-12H3,(H2,54,71)(H,61,72)(H,62,70)(H,63,73)(H,64,76)(H,65,79)(H,66,75)(H,67,78)(H,68,77)(H,69,74)(H4,55,56,59)(H4,57,58,60)/t32-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464015
(CHEMBL4237970)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCCc1c[nH]c2ccccc12)c1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C71H117N21O11/c1-38(2)33-53(84-44(12)93)64(98)88-55(35-40(5)6)66(100)90-56(36-41(7)8)67(101)89-54(34-39(3)4)65(99)86-52(23-18-31-81-71(77)78)63(97)91-57(42(9)10)69(103)87-50(21-15-16-29-72)62(96)85-51(22-17-30-80-70(75)76)61(95)83-43(11)60(94)92-58(45-24-26-46(27-25-45)59(73)74)68(102)79-32-28-47-37-82-49-20-14-13-19-48(47)49/h13-14,19-20,24-27,37-43,50-58,82H,15-18,21-23,28-36,72H2,1-12H3,(H3,73,74)(H,79,102)(H,83,95)(H,84,93)(H,85,96)(H,86,99)(H,87,103)(H,88,98)(H,89,101)(H,90,100)(H,91,97)(H,92,94)(H4,75,76,80)(H4,77,78,81)/t43-,50-,51-,52-,53+,54-,55-,56-,57-,58-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 248 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Proprotein convertase subtilisin/kexin type 6
(Homo sapiens (Human)) | BDBM50464006
(CHEMBL4243136)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(N)=O |r| Show InChI InChI=1S/C54H101N17O10/c1-29(2)25-38(63-34(11)72)47(76)67-40(27-31(5)6)49(78)69-41(28-32(7)8)50(79)68-39(26-30(3)4)48(77)64-36(18-14-22-61-53(57)58)46(75)70-43(33(9)10)51(80)65-35(17-12-13-21-55)45(74)66-37(19-15-23-62-54(59)60)52(81)71-24-16-20-42(71)44(56)73/h29-33,35-43H,12-28,55H2,1-11H3,(H2,56,73)(H,63,72)(H,64,77)(H,65,80)(H,66,74)(H,67,76)(H,68,79)(H,69,78)(H,70,75)(H4,57,58,61)(H4,59,60,62)/t35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1 | Reactome pathway
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| Article
PubMed
| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human PACE4 expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463996
(CHEMBL4239986)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(N)=O |r| Show InChI InChI=1S/C54H101N17O12/c1-28(2)24-38(63-33(11)72)48(79)68-40(26-30(5)6)50(81)70-41(27-31(7)8)51(82)69-39(25-29(3)4)49(80)66-37(18-15-23-62-54(59)60)47(78)71-43(32(9)10)52(83)67-35(16-12-13-21-55)46(77)65-36(17-14-22-61-53(57)58)45(76)64-34(44(56)75)19-20-42(73)74/h28-32,34-41,43H,12-27,55H2,1-11H3,(H2,56,75)(H,63,72)(H,64,76)(H,65,77)(H,66,80)(H,67,83)(H,68,79)(H,69,82)(H,70,81)(H,71,78)(H,73,74)(H4,57,58,61)(H4,59,60,62)/t34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464005
(CHEMBL4245151)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCc1c[nH]c2ccccc12 |r| Show InChI InChI=1S/C59H103N17O9/c1-33(2)28-45(69-38(11)77)53(81)73-47(30-35(5)6)55(83)75-48(31-36(7)8)56(84)74-46(29-34(3)4)54(82)71-44(22-17-26-67-59(63)64)52(80)76-49(37(9)10)57(85)72-43(20-14-15-24-60)51(79)70-42(21-16-25-66-58(61)62)50(78)65-27-23-39-32-68-41-19-13-12-18-40(39)41/h12-13,18-19,32-37,42-49,68H,14-17,20-31,60H2,1-11H3,(H,65,78)(H,69,77)(H,70,79)(H,71,82)(H,72,85)(H,73,81)(H,74,84)(H,75,83)(H,76,80)(H4,61,62,66)(H4,63,64,67)/t42-,43-,44-,45+,46-,47-,48-,49-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464009
(CHEMBL4242768)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C55H105N17O10/c1-14-34(12)44(45(57)74)72-48(77)38(21-18-24-63-55(60)61)65-46(75)36(19-15-16-22-56)67-53(82)43(33(10)11)71-47(76)37(20-17-23-62-54(58)59)66-50(79)40(26-30(4)5)69-52(81)42(28-32(8)9)70-51(80)41(27-31(6)7)68-49(78)39(25-29(2)3)64-35(13)73/h29-34,36-44H,14-28,56H2,1-13H3,(H2,57,74)(H,64,73)(H,65,75)(H,66,79)(H,67,82)(H,68,78)(H,69,81)(H,70,80)(H,71,76)(H,72,77)(H4,58,59,62)(H4,60,61,63)/t34-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464011
(CHEMBL4237338)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C52H99N17O11/c1-27(2)22-36(61-32(11)71)46(76)65-38(24-29(5)6)48(78)67-39(25-30(7)8)49(79)66-37(23-28(3)4)47(77)63-35(18-15-21-60-52(57)58)45(75)69-41(31(9)10)50(80)64-33(16-12-13-19-53)43(73)62-34(17-14-20-59-51(55)56)44(74)68-40(26-70)42(54)72/h27-31,33-41,70H,12-26,53H2,1-11H3,(H2,54,72)(H,61,71)(H,62,73)(H,63,77)(H,64,80)(H,65,76)(H,66,79)(H,67,78)(H,68,74)(H,69,75)(H4,55,56,59)(H4,57,58,60)/t33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| 330 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50399746
(CHEMBL2179435)Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](-[#6])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#7])=O |r| Show InChI InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1 | PDB
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Similars
| Article
PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464016
(CHEMBL4250694)Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C51H97N17O10/c1-27(2)22-36(61-32(11)69)45(74)65-38(24-29(5)6)47(76)67-39(25-30(7)8)48(77)66-37(23-28(3)4)46(75)63-35(18-15-21-59-51(56)57)44(73)68-41(31(9)10)49(78)64-34(16-12-13-19-52)43(72)62-33(17-14-20-58-50(54)55)42(71)60-26-40(53)70/h27-31,33-39,41H,12-26,52H2,1-11H3,(H2,53,70)(H,60,71)(H,61,69)(H,62,72)(H,63,75)(H,64,78)(H,65,74)(H,66,77)(H,67,76)(H,68,73)(H4,54,55,58)(H4,56,57,59)/t33-,34-,35-,36-,37-,38-,39-,41-/m0/s1 | PDB
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| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50464013
(CHEMBL4249395)Show SMILES CC(C)C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCCc1ccc(cc1)C(N)=N |r| Show InChI InChI=1S/C58H104N18O9/c1-32(2)28-43(69-37(11)77)52(81)73-45(30-34(5)6)54(83)75-46(31-35(7)8)55(84)74-44(29-33(3)4)53(82)71-42(18-15-26-68-58(64)65)51(80)76-47(36(9)10)56(85)72-41(16-12-13-24-59)50(79)70-40(17-14-25-67-57(62)63)49(78)66-27-23-38-19-21-39(22-20-38)48(60)61/h19-22,32-36,40-47H,12-18,23-31,59H2,1-11H3,(H3,60,61)(H,66,78)(H,69,77)(H,70,79)(H,71,82)(H,72,85)(H,73,81)(H,74,84)(H,75,83)(H,76,80)(H4,62,63,67)(H4,64,65,68)/t40-,41-,42-,43+,44-,45-,46-,47-/m0/s1 | PDB
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UniChem
| Article
PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
Furin
(Homo sapiens (Human)) | BDBM50463994
(CHEMBL4239018)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C(C)C)C(N)=O |r| Show InChI InChI=1S/C55H105N17O10/c1-29(2)24-39(45(57)74)68-47(76)37(19-16-22-62-54(58)59)65-46(75)36(18-14-15-21-56)67-53(82)44(34(11)12)72-48(77)38(20-17-23-63-55(60)61)66-50(79)41(26-31(5)6)70-52(81)43(28-33(9)10)71-51(80)42(27-32(7)8)69-49(78)40(25-30(3)4)64-35(13)73/h29-34,36-44H,14-28,56H2,1-13H3,(H2,57,74)(H,64,73)(H,65,75)(H,66,79)(H,67,82)(H,68,76)(H,69,78)(H,70,81)(H,71,80)(H,72,77)(H4,58,59,62)(H4,60,61,63)/t36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1 | PDB
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UniChem
| Article
PubMed
| 990 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human furin expressed in S2 insect cells using pyroGlu-Arg-Thr-Lys-Arg-AMC peptide as substrate after 1 hr by spectrofluoro... |
J Med Chem 61: 8457-8467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01144
BindingDB Entry DOI: 10.7270/Q2SJ1P8H |
More data for this
Ligand-Target Pair | |
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