Compile Data Set for Download or QSAR

Found 80 hits Enz. Inhib. hit(s) with all data for entry = 50004210   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480105 (CHEMBL496201) Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O3S/c1-34-16-9-11(33-15-6-7-26-18-17(15)29-20(32)30-18)3-5-14(16)28-19(31)27-10-2-4-13(22)12(8-10)21(23,24)25/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480108 (CHEMBL496009) Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F3N5O3S/c1-33-16-10-13(32-15-7-8-25-18-17(15)28-20(31)29-18)5-6-14(16)27-19(30)26-12-4-2-3-11(9-12)21(22,23)24/h2-10H,1H3,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480091 (CHEMBL523753) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C24H16F3N5O3/c25-24(26,27)13-4-3-5-14(12-13)29-22(33)30-17-8-9-18(16-7-2-1-6-15(16)17)35-19-10-11-28-21-20(19)31-23(34)32-21/h1-12H,(H2,29,30,33)(H2,28,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480123 (CHEMBL496612) Show SMILES Fc1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2F)cc(c1)C(F)(F)F Show InChI InChI=1S/C20H12F5N5O3/c21-10-5-9(20(23,24)25)6-11(7-10)27-18(31)28-14-2-1-12(8-13(14)22)33-15-3-4-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480092 (CHEMBL522072) Show SMILES Fc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cccc(SC(F)(F)F)c1 Show InChI InChI=1S/C20H13F4N5O3S/c21-13-9-11(32-15-6-7-25-17-16(15)28-19(31)29-17)4-5-14(13)27-18(30)26-10-2-1-3-12(8-10)33-20(22,23)24/h1-9H,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480112 (CHEMBL496020) Show SMILES Fc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C20H12ClF4N5O3/c21-12-3-1-9(7-11(12)20(23,24)25)27-18(31)28-14-4-2-10(8-13(14)22)33-15-5-6-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480093 (CHEMBL487717) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H18F3N5O3/c1-33-21-20(11-12-29-22(21)32-24(33)35)36-19-10-9-18(16-7-2-3-8-17(16)19)31-23(34)30-15-6-4-5-14(13-15)25(26,27)28/h2-13H,1H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480124 (CHEMBL496202) Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C21H15F4N5O3S/c1-34-16-9-11(33-15-6-7-26-18-17(15)29-20(32)30-18)3-5-13(16)27-19(31)28-14-8-10(21(23,24)25)2-4-12(14)22/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480094 (CHEMBL496414) Show SMILES Fc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C20H13F4N5O3/c21-13-9-12(32-15-6-7-25-17-16(15)28-19(31)29-17)4-5-14(13)27-18(30)26-11-3-1-2-10(8-11)20(22,23)24/h1-9H,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480095 (CHEMBL501686) Show SMILES FC(F)(F)c1ccc(N2CCOCC2)c(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C28H23F3N6O4/c29-28(30,31)16-5-7-21(37-11-13-40-14-12-37)20(15-16)34-26(38)33-19-6-8-22(18-4-2-1-3-17(18)19)41-23-9-10-32-25-24(23)35-27(39)36-25/h1-10,15H,11-14H2,(H2,33,34,38)(H2,32,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480127 (CHEMBL496203) Show SMILES COc1cc(NC(=O)Nc2cccc(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]c(=O)[nH]c12 Show InChI InChI=1S/C21H16F3N5O4/c1-32-16-10-13(27-19(30)26-12-4-2-3-11(9-12)21(22,23)24)5-6-14(16)33-15-7-8-25-18-17(15)28-20(31)29-18/h2-10H,1H3,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480096 (CHEMBL524068) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H17F4N5O3/c1-34-21-20(10-11-30-22(21)33-24(34)36)37-19-9-8-17(14-4-2-3-5-15(14)19)31-23(35)32-18-12-13(25(27,28)29)6-7-16(18)26/h2-12H,1H3,(H,30,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480097 (CHEMBL498025) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2Cl)ccc1Cl Show InChI InChI=1S/C20H12Cl2F3N5O3/c21-12-3-1-9(7-11(12)20(23,24)25)27-18(31)28-14-4-2-10(8-13(14)22)33-15-5-6-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480098 (CHEMBL496185) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2C(F)(F)F)ccc1Cl Show InChI InChI=1S/C21H12ClF6N5O3/c22-13-3-1-9(7-11(13)20(23,24)25)30-18(34)31-14-4-2-10(8-12(14)21(26,27)28)36-15-5-6-29-17-16(15)32-19(35)33-17/h1-8H,(H2,30,31,34)(H2,29,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480099 (CHEMBL498459) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H17ClF3N5O3/c1-34-21-20(10-11-30-22(21)33-24(34)36)37-19-9-8-18(14-4-2-3-5-15(14)19)32-23(35)31-13-6-7-17(26)16(12-13)25(27,28)29/h2-12H,1H3,(H,30,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM29701 (Pyridoimidazolone, 5a) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2)ccc1Cl Show InChI InChI=1S/C20H13ClF3N5O3/c21-14-6-3-11(9-13(14)20(22,23)24)27-18(30)26-10-1-4-12(5-2-10)32-15-7-8-25-17-16(15)28-19(31)29-17/h1-9H,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480116 (CHEMBL522724) Show SMILES Cc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]c(=O)[nH]c12 Show InChI InChI=1S/C21H15ClF3N5O3/c1-10-8-11(27-19(31)28-12-2-4-14(22)13(9-12)21(23,24)25)3-5-15(10)33-16-6-7-26-18-17(16)29-20(32)30-18/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480100 (CHEMBL487718) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(SC(F)(F)F)c4)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H18F3N5O3S/c1-33-21-20(11-12-29-22(21)32-24(33)35)36-19-10-9-18(16-7-2-3-8-17(16)19)31-23(34)30-14-5-4-6-15(13-14)37-25(26,27)28/h2-13H,1H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480115 (CHEMBL496019) Show SMILES COc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]c(=O)[nH]c12 Show InChI InChI=1S/C21H15ClF3N5O4/c1-33-16-9-11(28-19(31)27-10-2-4-13(22)12(8-10)21(23,24)25)3-5-14(16)34-15-6-7-26-18-17(15)29-20(32)30-18/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480101 (CHEMBL521725) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)ccc1Cl Show InChI InChI=1S/C24H15ClF3N5O3/c25-16-6-5-12(11-15(16)24(26,27)28)30-22(34)31-17-7-8-18(14-4-2-1-3-13(14)17)36-19-9-10-29-21-20(19)32-23(35)33-21/h1-11H,(H2,30,31,34)(H2,29,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480103 (CHEMBL498112) Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(F)(F)F Show InChI InChI=1S/C24H15F4N5O3/c25-15-6-5-12(24(26,27)28)11-17(15)31-22(34)30-16-7-8-18(14-4-2-1-3-13(14)16)36-19-9-10-29-21-20(19)32-23(35)33-21/h1-11H,(H2,30,31,34)(H2,29,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480102 (CHEMBL524801) Show SMILES Cc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O3/c1-10-8-12(33-16-6-7-26-18-17(16)29-20(32)30-18)3-5-15(10)28-19(31)27-11-2-4-14(22)13(9-11)21(23,24)25/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480121 (CHEMBL526838) Show SMILES Fc1cccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C23H16FN5O3/c24-13-4-3-5-14(12-13)26-22(30)27-17-8-9-18(16-7-2-1-6-15(16)17)32-19-10-11-25-21-20(19)28-23(31)29-21/h1-12H,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480107 (CHEMBL496081) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(c4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C28H27N5O3/c1-28(2,3)17-8-7-9-18(16-17)30-26(34)31-21-12-13-22(20-11-6-5-10-19(20)21)36-23-14-15-29-25-24(23)33(4)27(35)32-25/h5-16H,1-4H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480104 (CHEMBL498024) Show SMILES Fc1cc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)ccc1Oc1ccnc2[nH]c(=O)[nH]c12 Show InChI InChI=1S/C20H12ClF4N5O3/c21-12-3-1-9(7-11(12)20(23,24)25)27-18(31)28-10-2-4-14(13(22)8-10)33-15-5-6-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480125 (CHEMBL523905) Show SMILES Cc1c(C)c(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C22H17ClF3N5O3/c1-10-11(2)16(34-17-7-8-27-19-18(17)30-21(33)31-19)6-5-15(10)29-20(32)28-12-3-4-14(23)13(9-12)22(24,25)26/h3-9H,1-2H3,(H2,28,29,32)(H2,27,30,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480110 (CHEMBL496073) Show SMILES CC(C)(C)c1cccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C27H25N5O3/c1-27(2,3)16-7-6-8-17(15-16)29-25(33)30-20-11-12-21(19-10-5-4-9-18(19)20)35-22-13-14-28-24-23(22)31-26(34)32-24/h4-15H,1-3H3,(H2,29,30,33)(H2,28,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480109 (CHEMBL495801) Show SMILES CS(=O)(=O)c1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O5S/c1-36(33,34)16-9-11(35-15-6-7-26-18-17(15)29-20(32)30-18)3-5-14(16)28-19(31)27-10-2-4-13(22)12(8-10)21(23,24)25/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480119 (CHEMBL523229) Show SMILES COc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O4/c1-33-16-9-11(34-15-6-7-26-18-17(15)29-20(32)30-18)3-5-14(16)28-19(31)27-10-2-4-13(22)12(8-10)21(23,24)25/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	106	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480126 (CHEMBL487719) Show SMILES Cn1c2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c4ccccc34)c2[nH]c1=O Show InChI InChI=1S/C25H17ClF3N5O3/c1-34-22-21(33-24(34)36)20(10-11-30-22)37-19-9-8-18(14-4-2-3-5-15(14)19)32-23(35)31-13-6-7-17(26)16(12-13)25(27,28)29/h2-12H,1H3,(H,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480111 (CHEMBL489856) Show SMILES Cn1c2nccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)c2[nH]c1=O Show InChI InChI=1S/C25H17F4N5O3/c1-34-22-21(33-24(34)36)20(10-11-30-22)37-19-9-8-17(14-4-2-3-5-15(14)19)31-23(35)32-18-12-13(25(27,28)29)6-7-16(18)26/h2-12H,1H3,(H,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	167	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480121 (CHEMBL526838) Show SMILES Fc1cccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C23H16FN5O3/c24-13-4-3-5-14(12-13)26-22(30)27-17-8-9-18(16-7-2-1-6-15(16)17)32-19-10-11-25-21-20(19)28-23(31)29-21/h1-12H,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480103 (CHEMBL498112) Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(F)(F)F Show InChI InChI=1S/C24H15F4N5O3/c25-15-6-5-12(24(26,27)28)11-17(15)31-22(34)30-16-7-8-18(14-4-2-1-3-13(14)16)36-19-9-10-29-21-20(19)32-23(35)33-21/h1-11H,(H2,30,31,34)(H2,29,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	214	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480120 (CHEMBL498113) Show SMILES Fc1ccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)cc1F Show InChI InChI=1S/C23H15F2N5O3/c24-15-6-5-12(11-16(15)25)27-22(31)28-17-7-8-18(14-4-2-1-3-13(14)17)33-19-9-10-26-21-20(19)29-23(32)30-21/h1-11H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480095 (CHEMBL501686) Show SMILES FC(F)(F)c1ccc(N2CCOCC2)c(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C28H23F3N6O4/c29-28(30,31)16-5-7-21(37-11-13-40-14-12-37)20(15-16)34-26(38)33-19-6-8-22(18-4-2-1-3-17(18)19)41-23-9-10-32-25-24(23)35-27(39)36-25/h1-10,15H,11-14H2,(H2,33,34,38)(H2,32,35,36,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	346	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480129 (CHEMBL523907) Show SMILES Cn1c2nccc(Oc3ccc(NC(=O)Nc4cccc(c4)C(C)(C)C)c4ccccc34)c2[nH]c1=O Show InChI InChI=1S/C28H27N5O3/c1-28(2,3)17-8-7-9-18(16-17)30-26(34)31-21-12-13-22(20-11-6-5-10-19(20)21)36-23-14-15-29-25-24(23)32-27(35)33(25)4/h5-16H,1-4H3,(H,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480101 (CHEMBL521725) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)ccc1Cl Show InChI InChI=1S/C24H15ClF3N5O3/c25-16-6-5-12(11-15(16)24(26,27)28)30-22(34)31-17-7-8-18(14-4-2-1-3-13(14)17)36-19-9-10-29-21-20(19)32-23(35)33-21/h1-11H,(H2,30,31,34)(H2,29,32,33,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	559	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480093 (CHEMBL487717) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(c4)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H18F3N5O3/c1-33-21-20(11-12-29-22(21)32-24(33)35)36-19-10-9-18(16-7-2-3-8-17(16)19)31-23(34)30-15-6-4-5-14(13-15)25(26,27)28/h2-13H,1H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480105 (CHEMBL496201) Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H15ClF3N5O3S/c1-34-16-9-11(33-15-6-7-26-18-17(15)29-20(32)30-18)3-5-14(16)28-19(31)27-10-2-4-13(22)12(8-10)21(23,24)25/h2-9H,1H3,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480106 (CHEMBL498458) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c(F)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C21H14ClF4N5O3/c1-31-17-16(6-7-27-18(17)30-20(31)33)34-11-3-5-15(14(23)9-11)29-19(32)28-10-2-4-13(22)12(8-10)21(24,25)26/h2-9H,1H3,(H,27,30,33)(H2,28,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	638	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480099 (CHEMBL498459) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H17ClF3N5O3/c1-34-21-20(10-11-30-22(21)33-24(34)36)37-19-9-8-18(14-4-2-3-5-15(14)19)32-23(35)31-13-6-7-17(26)16(12-13)25(27,28)29/h2-12H,1H3,(H,30,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480096 (CHEMBL524068) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H17F4N5O3/c1-34-21-20(10-11-30-22(21)33-24(34)36)37-19-9-8-17(14-4-2-3-5-15(14)19)31-23(35)32-18-12-13(25(27,28)29)6-7-16(18)26/h2-12H,1H3,(H,30,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	810	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480107 (CHEMBL496081) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(c4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C28H27N5O3/c1-28(2,3)17-8-7-9-18(16-17)30-26(34)31-21-12-13-22(20-11-6-5-10-19(20)21)36-23-14-15-29-25-24(23)33(4)27(35)32-25/h5-16H,1-4H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480123 (CHEMBL496612) Show SMILES Fc1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2F)cc(c1)C(F)(F)F Show InChI InChI=1S/C20H12F5N5O3/c21-10-5-9(20(23,24)25)6-11(7-10)27-18(31)28-14-2-1-12(8-13(14)22)33-15-3-4-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480108 (CHEMBL496009) Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)[nH]c23)ccc1NC(=O)Nc1cccc(c1)C(F)(F)F Show InChI InChI=1S/C21H16F3N5O3S/c1-33-16-10-13(32-15-7-8-25-18-17(15)28-20(31)29-18)5-6-14(16)27-19(30)26-12-4-2-3-11(9-12)21(22,23)24/h2-10H,1H3,(H2,26,27,30)(H2,25,28,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480097 (CHEMBL498025) Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)cc2Cl)ccc1Cl Show InChI InChI=1S/C20H12Cl2F3N5O3/c21-12-3-1-9(7-11(12)20(23,24)25)27-18(31)28-14-4-2-10(8-13(14)22)33-15-5-6-26-17-16(15)29-19(32)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480100 (CHEMBL487718) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cccc(SC(F)(F)F)c4)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H18F3N5O3S/c1-33-21-20(11-12-29-22(21)32-24(33)35)36-19-10-9-18(16-7-2-3-8-17(16)19)31-23(34)30-14-5-4-6-15(13-14)37-25(26,27)28/h2-13H,1H3,(H,29,32,35)(H2,30,31,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480106 (CHEMBL498458) Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c(F)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C21H14ClF4N5O3/c1-31-17-16(6-7-27-18(17)30-20(31)33)34-11-3-5-15(14(23)9-11)29-19(32)28-10-2-4-13(22)12(8-10)21(24,25)26/h2-9H,1H3,(H,27,30,33)(H2,28,29,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.57E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480091 (CHEMBL523753) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)c1 Show InChI InChI=1S/C24H16F3N5O3/c25-24(26,27)13-4-3-5-14(12-13)29-22(33)30-17-8-9-18(16-7-2-1-6-15(16)17)35-19-10-11-28-21-20(19)31-23(34)32-21/h1-12H,(H2,29,30,33)(H2,28,31,32,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50480111 (CHEMBL489856) Show SMILES Cn1c2nccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)c2[nH]c1=O Show InChI InChI=1S/C25H17F4N5O3/c1-34-22-21(33-24(34)36)20(10-11-30-22)37-19-9-8-17(14-4-2-3-5-15(14)19)31-23(35)32-18-12-13(25(27,28)29)6-7-16(18)26/h2-12H,1H3,(H,33,36)(H2,31,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells				J Med Chem 52: 3881-91 (2009) Article DOI: 10.1021/jm900242c BindingDB Entry DOI: 10.7270/Q2Z03BZ4
					More data for this Ligand-Target Pair

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