Compile Data Set for Download or QSAR

Found 65 hits Enz. Inhib. hit(s) with all data for entry = 50005148   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033553 (6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...) Show SMILES COc1cc(cc(OC)c1OC)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C19H27N5O3/c1-24(12-8-15(25-2)17(27-4)16(9-12)26-3)10-11-5-6-14-13(7-11)18(20)23-19(21)22-14/h8-9,11H,5-7,10H2,1-4H3,(H4,20,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033547 (6-[(2,6-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3c(Cl)cccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-10-2-1-3-11(17)13(10)20-7-8-4-5-12-9(6-8)14(18)22-15(19)21-12/h1-3,8,20H,4-7H2,(H4,18,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033555 (6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...) Show SMILES COc1cc(cc(OC)c1OC)N(CC#C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C21H27N5O3/c1-5-8-26(14-10-17(27-2)19(29-4)18(11-14)28-3)12-13-6-7-16-15(9-13)20(22)25-21(23)24-16/h1,10-11,13H,6-9,12H2,2-4H3,(H4,22,23,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033557 (6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-5...) Show SMILES COc1ccc(OC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C18H25N5O2/c1-23(15-9-12(24-2)5-7-16(15)25-3)10-11-4-6-14-13(8-11)17(19)22-18(20)21-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H4,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033550 (6-{[(2,5-Diethoxy-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CCOc1ccc(OCC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C20H29N5O2/c1-4-26-14-7-9-18(27-5-2)17(11-14)25(3)12-13-6-8-16-15(10-13)19(21)24-20(22)23-16/h7,9,11,13H,4-6,8,10,12H2,1-3H3,(H4,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033556 (6-{[(2,5-Dimethoxy-phenyl)-ethyl-amino]-methyl}-5,...) Show SMILES CCN(CC1CCc2nc(N)nc(N)c2C1)c1cc(OC)ccc1OC Show InChI InChI=1S/C19H27N5O2/c1-4-24(16-10-13(25-2)6-8-17(16)26-3)11-12-5-7-15-14(9-12)18(20)23-19(21)22-15/h6,8,10,12H,4-5,7,9,11H2,1-3H3,(H4,20,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033546 (6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H19Cl2N5/c1-23(10-3-4-12(17)13(18)7-10)8-9-2-5-14-11(6-9)15(19)22-16(20)21-14/h3-4,7,9H,2,5-6,8H2,1H3,(H4,19,20,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033543 (6-{[(4-Chloro-phenyl)-methyl-amino]-methyl}-5,6,7,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C16H20ClN5/c1-22(12-5-3-11(17)4-6-12)9-10-2-7-14-13(8-10)15(18)21-16(19)20-14/h3-6,10H,2,7-9H2,1H3,(H4,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033544 (6-[(Methyl-naphthalen-1-yl-amino)-methyl]-5,6,7,8-...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1cccc2ccccc12 Show InChI InChI=1S/C20H23N5/c1-25(18-8-4-6-14-5-2-3-7-15(14)18)12-13-9-10-17-16(11-13)19(21)24-20(22)23-17/h2-8,13H,9-12H2,1H3,(H4,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033552 (6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CN3CCc4ccccc34)CCc2n1 Show InChI InChI=1S/C17H21N5/c18-16-13-9-11(5-6-14(13)20-17(19)21-16)10-22-8-7-12-3-1-2-4-15(12)22/h1-4,11H,5-10H2,(H4,18,19,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033540 (6-[(3-Bromo-phenylamino)-methyl]-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CNc3cccc(Br)c3)CCc2n1 Show InChI InChI=1S/C15H18BrN5/c16-10-2-1-3-11(7-10)19-8-9-4-5-13-12(6-9)14(17)21-15(18)20-13/h1-3,7,9,19H,4-6,8H2,(H4,17,18,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033546 (6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H19Cl2N5/c1-23(10-3-4-12(17)13(18)7-10)8-9-2-5-14-11(6-9)15(19)22-16(20)21-14/h3-4,7,9H,2,5-6,8H2,1H3,(H4,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033542 (6-(Naphthalen-1-ylaminomethyl)-5,6,7,8-tetrahydro-...) Show SMILES Nc1nc(N)c2CC(CNc3cccc4ccccc34)CCc2n1 Show InChI InChI=1S/C19H21N5/c20-18-15-10-12(8-9-17(15)23-19(21)24-18)11-22-16-7-3-5-13-4-1-2-6-14(13)16/h1-7,12,22H,8-11H2,(H4,20,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033553 (6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...) Show SMILES COc1cc(cc(OC)c1OC)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C19H27N5O3/c1-24(12-8-15(25-2)17(27-4)16(9-12)26-3)10-11-5-6-14-13(7-11)18(20)23-19(21)22-14/h8-9,11H,5-7,10H2,1-4H3,(H4,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM18268 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) Show SMILES COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC Show InChI InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033544 (6-[(Methyl-naphthalen-1-yl-amino)-methyl]-5,6,7,8-...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1cccc2ccccc12 Show InChI InChI=1S/C20H23N5/c1-25(18-8-4-6-14-5-2-3-7-15(14)18)12-13-9-10-17-16(11-13)19(21)24-20(22)23-17/h2-8,13H,9-12H2,1H3,(H4,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033539 (6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-5,6,7,8-...) Show SMILES COc1cc(NCC2CCc3nc(N)nc(N)c3C2)cc(OC)c1OC Show InChI InChI=1S/C18H25N5O3/c1-24-14-7-11(8-15(25-2)16(14)26-3)21-9-10-4-5-13-12(6-10)17(19)23-18(20)22-13/h7-8,10,21H,4-6,9H2,1-3H3,(H4,19,20,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033543 (6-{[(4-Chloro-phenyl)-methyl-amino]-methyl}-5,6,7,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C16H20ClN5/c1-22(12-5-3-11(17)4-6-12)9-10-2-7-14-13(8-10)15(18)21-16(19)20-14/h3-6,10H,2,7-9H2,1H3,(H4,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033556 (6-{[(2,5-Dimethoxy-phenyl)-ethyl-amino]-methyl}-5,...) Show SMILES CCN(CC1CCc2nc(N)nc(N)c2C1)c1cc(OC)ccc1OC Show InChI InChI=1S/C19H27N5O2/c1-4-24(16-10-13(25-2)6-8-17(16)26-3)11-12-5-7-15-14(9-12)18(20)23-19(21)22-15/h6,8,10,12H,4-5,7,9,11H2,1-3H3,(H4,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033555 (6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...) Show SMILES COc1cc(cc(OC)c1OC)N(CC#C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C21H27N5O3/c1-5-8-26(14-10-17(27-2)19(29-4)18(11-14)28-3)12-13-6-7-16-15(9-13)20(22)25-21(23)24-16/h1,10-11,13H,6-9,12H2,2-4H3,(H4,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033545 (6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahyd...) Show SMILES Nc1nc(N)c2CC(CNc3ccc(Cl)cc3)CCc2n1 Show InChI InChI=1S/C15H18ClN5/c16-10-2-4-11(5-3-10)19-8-9-1-6-13-12(7-9)14(17)21-15(18)20-13/h2-5,9,19H,1,6-8H2,(H4,17,18,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033553 (6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl...) Show SMILES COc1cc(cc(OC)c1OC)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C19H27N5O3/c1-24(12-8-15(25-2)17(27-4)16(9-12)26-3)10-11-5-6-14-13(7-11)18(20)23-19(21)22-14/h8-9,11H,5-7,10H2,1-4H3,(H4,20,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033554 (6-[(2,5-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3cc(Cl)ccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-9-2-3-11(17)13(6-9)20-7-8-1-4-12-10(5-8)14(18)22-15(19)21-12/h2-3,6,8,20H,1,4-5,7H2,(H4,18,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033544 (6-[(Methyl-naphthalen-1-yl-amino)-methyl]-5,6,7,8-...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1cccc2ccccc12 Show InChI InChI=1S/C20H23N5/c1-25(18-8-4-6-14-5-2-3-7-15(14)18)12-13-9-10-17-16(11-13)19(21)24-20(22)23-17/h2-8,13H,9-12H2,1H3,(H4,21,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033547 (6-[(2,6-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3c(Cl)cccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-10-2-1-3-11(17)13(10)20-7-8-4-5-12-9(6-8)14(18)22-15(19)21-12/h1-3,8,20H,4-7H2,(H4,18,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033541 (6-[(3,4-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3ccc(Cl)c(Cl)c3)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-11-3-2-9(6-12(11)17)20-7-8-1-4-13-10(5-8)14(18)22-15(19)21-13/h2-3,6,8,20H,1,4-5,7H2,(H4,18,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033556 (6-{[(2,5-Dimethoxy-phenyl)-ethyl-amino]-methyl}-5,...) Show SMILES CCN(CC1CCc2nc(N)nc(N)c2C1)c1cc(OC)ccc1OC Show InChI InChI=1S/C19H27N5O2/c1-4-24(16-10-13(25-2)6-8-17(16)26-3)11-12-5-7-15-14(9-12)18(20)23-19(21)22-15/h6,8,10,12H,4-5,7,9,11H2,1-3H3,(H4,20,21,22,23)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033550 (6-{[(2,5-Diethoxy-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CCOc1ccc(OCC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C20H29N5O2/c1-4-26-14-7-9-18(27-5-2)17(11-14)25(3)12-13-6-8-16-15(10-13)19(21)24-20(22)23-16/h7,9,11,13H,4-6,8,10,12H2,1-3H3,(H4,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	116	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033555 (6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...) Show SMILES COc1cc(cc(OC)c1OC)N(CC#C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C21H27N5O3/c1-5-8-26(14-10-17(27-2)19(29-4)18(11-14)28-3)12-13-6-7-16-15(9-13)20(22)25-21(23)24-16/h1,10-11,13H,6-9,12H2,2-4H3,(H4,22,23,24,25)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	119	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033545 (6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahyd...) Show SMILES Nc1nc(N)c2CC(CNc3ccc(Cl)cc3)CCc2n1 Show InChI InChI=1S/C15H18ClN5/c16-10-2-4-11(5-3-10)19-8-9-1-6-13-12(7-9)14(17)21-15(18)20-13/h2-5,9,19H,1,6-8H2,(H4,17,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	128	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033542 (6-(Naphthalen-1-ylaminomethyl)-5,6,7,8-tetrahydro-...) Show SMILES Nc1nc(N)c2CC(CNc3cccc4ccccc34)CCc2n1 Show InChI InChI=1S/C19H21N5/c20-18-15-10-12(8-9-17(15)23-19(21)24-18)11-22-16-7-3-5-13-4-1-2-6-14(13)16/h1-7,12,22H,8-11H2,(H4,20,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033548 (6-[(2,5-Diethoxy-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES CCOc1ccc(OCC)c(NCC2CCc3nc(N)nc(N)c3C2)c1 Show InChI InChI=1S/C19H27N5O2/c1-3-25-13-6-8-17(26-4-2)16(10-13)22-11-12-5-7-15-14(9-12)18(20)24-19(21)23-15/h6,8,10,12,22H,3-5,7,9,11H2,1-2H3,(H4,20,21,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033541 (6-[(3,4-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3ccc(Cl)c(Cl)c3)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-11-3-2-9(6-12(11)17)20-7-8-1-4-13-10(5-8)14(18)22-15(19)21-13/h2-3,6,8,20H,1,4-5,7H2,(H4,18,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033552 (6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CN3CCc4ccccc34)CCc2n1 Show InChI InChI=1S/C17H21N5/c18-16-13-9-11(5-6-14(13)20-17(19)21-16)10-22-8-7-12-3-1-2-4-15(12)22/h1-4,11H,5-10H2,(H4,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033543 (6-{[(4-Chloro-phenyl)-methyl-amino]-methyl}-5,6,7,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)cc1 Show InChI InChI=1S/C16H20ClN5/c1-22(12-5-3-11(17)4-6-12)9-10-2-7-14-13(8-10)15(18)21-16(19)20-14/h3-6,10H,2,7-9H2,1H3,(H4,18,19,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	171	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033549 (6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...) Show SMILES COc1ccc(OC)c(NCC2CCc3nc(N)nc(N)c3C2)c1 Show InChI InChI=1S/C17H23N5O2/c1-23-11-4-6-15(24-2)14(8-11)20-9-10-3-5-13-12(7-10)16(18)22-17(19)21-13/h4,6,8,10,20H,3,5,7,9H2,1-2H3,(H4,18,19,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033552 (6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CN3CCc4ccccc34)CCc2n1 Show InChI InChI=1S/C17H21N5/c18-16-13-9-11(5-6-14(13)20-17(19)21-16)10-22-8-7-12-3-1-2-4-15(12)22/h1-4,11H,5-10H2,(H4,18,19,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033540 (6-[(3-Bromo-phenylamino)-methyl]-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CNc3cccc(Br)c3)CCc2n1 Show InChI InChI=1S/C15H18BrN5/c16-10-2-1-3-11(7-10)19-8-9-4-5-13-12(6-9)14(17)21-15(18)20-13/h1-3,7,9,19H,4-6,8H2,(H4,17,18,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033554 (6-[(2,5-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3cc(Cl)ccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-9-2-3-11(17)13(6-9)20-7-8-1-4-12-10(5-8)14(18)22-15(19)21-12/h2-3,6,8,20H,1,4-5,7H2,(H4,18,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033546 (6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CN(CC1CCc2nc(N)nc(N)c2C1)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H19Cl2N5/c1-23(10-3-4-12(17)13(18)7-10)8-9-2-5-14-11(6-9)15(19)22-16(20)21-14/h3-4,7,9H,2,5-6,8H2,1H3,(H4,19,20,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	246	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033557 (6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-5...) Show SMILES COc1ccc(OC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C18H25N5O2/c1-23(15-9-12(24-2)5-7-16(15)25-3)10-11-4-6-14-13(8-11)17(19)22-18(20)21-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H4,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50033539 (6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-5,6,7,8-...) Show SMILES COc1cc(NCC2CCc3nc(N)nc(N)c3C2)cc(OC)c1OC Show InChI InChI=1S/C18H25N5O3/c1-24-14-7-11(8-15(25-2)16(14)26-3)21-9-10-4-5-13-12(6-10)17(19)23-18(20)22-13/h7-8,10,21H,4-6,9H2,1-3H3,(H4,19,20,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from rat				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033557 (6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-5...) Show SMILES COc1ccc(OC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C18H25N5O2/c1-23(15-9-12(24-2)5-7-16(15)25-3)10-11-4-6-14-13(8-11)17(19)22-18(20)21-14/h5,7,9,11H,4,6,8,10H2,1-3H3,(H4,19,20,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033550 (6-{[(2,5-Diethoxy-phenyl)-methyl-amino]-methyl}-5,...) Show SMILES CCOc1ccc(OCC)c(c1)N(C)CC1CCc2nc(N)nc(N)c2C1 Show InChI InChI=1S/C20H29N5O2/c1-4-26-14-7-9-18(27-5-2)17(11-14)25(3)12-13-6-8-16-15(10-13)19(21)24-20(22)23-16/h7,9,11,13H,4-6,8,10,12H2,1-3H3,(H4,21,22,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	319	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033540 (6-[(3-Bromo-phenylamino)-methyl]-5,6,7,8-tetrahydr...) Show SMILES Nc1nc(N)c2CC(CNc3cccc(Br)c3)CCc2n1 Show InChI InChI=1S/C15H18BrN5/c16-10-2-1-3-11(7-10)19-8-9-4-5-13-12(6-9)14(17)21-15(18)20-13/h1-3,7,9,19H,4-6,8H2,(H4,17,18,20,21)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Bifunctional dihydrofolate reductase-thymidylate synthase (Toxoplasma gondii)	BDBM50033538 (6-{[Methyl-(3,4,5-trimethoxy-benzyl)-amino]-methyl...) Show SMILES COc1cc(CN(C)CC2CCc3nc(N)nc(N)c3C2)cc(OC)c1OC Show InChI InChI=1S/C20H29N5O3/c1-25(11-13-8-16(26-2)18(28-4)17(9-13)27-3)10-12-5-6-15-14(7-12)19(21)24-20(22)23-15/h8-9,12H,5-7,10-11H2,1-4H3,(H4,21,22,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033554 (6-[(2,5-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3cc(Cl)ccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-9-2-3-11(17)13(6-9)20-7-8-1-4-12-10(5-8)14(18)22-15(19)21-12/h2-3,6,8,20H,1,4-5,7H2,(H4,18,19,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair
Dihydrofolate reductase (Pneumocystis carinii)	BDBM50033547 (6-[(2,6-Dichloro-phenylamino)-methyl]-5,6,7,8-tetr...) Show SMILES Nc1nc(N)c2CC(CNc3c(Cl)cccc3Cl)CCc2n1 Show InChI InChI=1S/C15H17Cl2N5/c16-10-2-1-3-11(17)13(10)20-7-8-4-5-12-9(6-8)14(18)22-15(19)21-12/h1-3,8,20H,4-7H2,(H4,18,19,21,22)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	502	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.				J Med Chem 38: 3660-8 (1995) BindingDB Entry DOI: 10.7270/Q27080FN
					More data for this Ligand-Target Pair

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