Found 19 hits Enz. Inhib. hit(s) with all data for entry = 50005918 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495409
(CHEMBL3110313)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSC1CC(=O)N(CCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C180H245N41O54S/c1-16-91(10)146(174(268)197-94(13)153(247)205-121(72-101-76-189-109-42-28-25-39-105(101)109)163(257)207-117(68-88(4)5)164(258)217-144(89(6)7)172(266)204-111(43-31-32-64-181)156(250)191-79-132(230)199-110(151(184)245)44-34-65-188-180(185)186)219-165(259)119(69-97-35-20-17-21-36-97)208-160(254)115(59-63-139(239)240)203-171(265)126(85-276-129-75-136(234)221(177(129)271)66-33-19-24-47-131(229)198-102-52-50-100(51-53-102)141(142-149(243)106-40-26-29-45-127(106)274-178(142)272)143-150(244)107-41-27-30-46-128(107)275-179(143)273)215-154(248)93(12)195-152(246)92(11)196-159(253)114(56-60-130(183)228)201-134(232)80-192-158(252)113(58-62-138(237)238)202-161(255)116(67-87(2)3)206-162(256)118(71-99-48-54-104(227)55-49-99)209-168(262)123(82-222)212-170(264)125(84-224)213-173(267)145(90(8)9)218-167(261)122(74-140(241)242)210-169(263)124(83-223)214-176(270)148(96(15)226)220-166(260)120(70-98-37-22-18-23-38-98)211-175(269)147(95(14)225)216-135(233)81-193-157(251)112(57-61-137(235)236)200-133(231)78-190-155(249)108(182)73-103-77-187-86-194-103/h17-18,20-23,25-30,35-42,45-46,48-55,76-77,86-96,108,110-126,129,141,144-148,189,222-227,243-244H,16,19,24,31-34,43-44,47,56-75,78-85,181-182H2,1-15H3,(H2,183,228)(H2,184,245)(H,187,194)(H,190,249)(H,191,250)(H,192,252)(H,193,251)(H,195,246)(H,196,253)(H,197,268)(H,198,229)(H,199,230)(H,200,231)(H,201,232)(H,202,255)(H,203,265)(H,204,266)(H,205,247)(H,206,256)(H,207,257)(H,208,254)(H,209,262)(H,210,263)(H,211,269)(H,212,264)(H,213,267)(H,214,270)(H,215,248)(H,216,233)(H,217,258)(H,218,261)(H,219,259)(H,220,260)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H4,185,186,188)/t91-,92-,93-,94-,95+,96+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,129?,144-,145-,146-,147-,148-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495424
(CHEMBL3110316)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSC1CC(=O)N(CCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C180H245N41O54S/c1-16-91(10)146(174(268)197-94(13)154(248)205-121(72-101-76-189-109-42-28-25-39-105(101)109)164(258)207-117(68-88(4)5)165(259)217-145(90(8)9)173(267)215-126(158(252)193-79-132(230)199-110(151(184)245)44-34-65-188-180(185)186)85-276-129-75-136(234)221(177(129)271)66-33-19-24-47-131(229)198-102-52-50-100(51-53-102)141(142-149(243)106-40-26-29-45-127(106)274-178(142)272)143-150(244)107-41-27-30-46-128(107)275-179(143)273)219-166(260)119(69-97-35-20-17-21-36-97)208-161(255)115(59-63-139(239)240)204-160(254)111(43-31-32-64-181)202-153(247)93(12)195-152(246)92(11)196-159(253)114(56-60-130(183)228)201-134(232)80-191-157(251)113(58-62-138(237)238)203-162(256)116(67-87(2)3)206-163(257)118(71-99-48-54-104(227)55-49-99)209-169(263)123(82-222)212-171(265)125(84-224)213-172(266)144(89(6)7)218-168(262)122(74-140(241)242)210-170(264)124(83-223)214-176(270)148(96(15)226)220-167(261)120(70-98-37-22-18-23-38-98)211-175(269)147(95(14)225)216-135(233)81-192-156(250)112(57-61-137(235)236)200-133(231)78-190-155(249)108(182)73-103-77-187-86-194-103/h17-18,20-23,25-30,35-42,45-46,48-55,76-77,86-96,108,110-126,129,141,144-148,189,222-227,243-244H,16,19,24,31-34,43-44,47,56-75,78-85,181-182H2,1-15H3,(H2,183,228)(H2,184,245)(H,187,194)(H,190,249)(H,191,251)(H,192,250)(H,193,252)(H,195,246)(H,196,253)(H,197,268)(H,198,229)(H,199,230)(H,200,231)(H,201,232)(H,202,247)(H,203,256)(H,204,254)(H,205,248)(H,206,257)(H,207,258)(H,208,255)(H,209,263)(H,210,264)(H,211,269)(H,212,265)(H,213,266)(H,214,270)(H,215,267)(H,216,233)(H,217,259)(H,218,262)(H,219,260)(H,220,261)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H4,185,186,188)/t91-,92-,93-,94-,95+,96+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,129?,144-,145-,146-,147-,148-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00700 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495410
(CHEMBL3110311)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CSC1CC(=O)N(CCCCCCCCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C189H264N42O53S/c1-16-100(10)155(183(277)207-103(13)163(257)216-131(82-110-86-199-118-50-34-31-47-114(110)118)173(267)218-127(78-97(4)5)174(268)227-153(98(6)7)181(275)215-120(51-37-39-73-190)165(259)201-89-141(239)209-119(160(194)254)53-42-75-198-189(195)196)229-175(269)129(79-106-43-26-24-27-44-106)219-170(264)125(68-72-148(248)249)214-169(263)121(52-38-40-74-191)212-162(256)102(12)205-161(255)101(11)206-168(262)124(65-69-139(193)237)211-143(241)90-202-167(261)123(67-71-147(246)247)213-171(265)126(77-96(2)3)217-172(266)128(81-108-57-63-113(236)64-58-108)220-178(272)133(92-232)223-180(274)135(94-285-138-85-145(243)231(186(138)280)76-41-23-21-19-17-18-20-22-30-56-140(238)208-111-61-59-109(60-62-111)150(151-158(252)115-48-32-35-54-136(115)283-187(151)281)152-159(253)116-49-33-36-55-137(116)284-188(152)282)225-182(276)154(99(8)9)228-177(271)132(84-149(250)251)221-179(273)134(93-233)224-185(279)157(105(15)235)230-176(270)130(80-107-45-28-25-29-46-107)222-184(278)156(104(14)234)226-144(242)91-203-166(260)122(66-70-146(244)245)210-142(240)88-200-164(258)117(192)83-112-87-197-95-204-112/h24-29,31-36,43-50,54-55,57-64,86-87,95-105,117,119-135,138,150,153-157,199,232-236,252-253H,16-23,30,37-42,51-53,56,65-85,88-94,190-192H2,1-15H3,(H2,193,237)(H2,194,254)(H,197,204)(H,200,258)(H,201,259)(H,202,261)(H,203,260)(H,205,255)(H,206,262)(H,207,277)(H,208,238)(H,209,239)(H,210,240)(H,211,241)(H,212,256)(H,213,265)(H,214,263)(H,215,275)(H,216,257)(H,217,266)(H,218,267)(H,219,264)(H,220,272)(H,221,273)(H,222,278)(H,223,274)(H,224,279)(H,225,276)(H,226,242)(H,227,268)(H,228,271)(H,229,269)(H,230,270)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,195,196,198)/t100-,101-,102-,103-,104+,105+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,138?,153-,154-,155-,156-,157-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0370 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50461653
(CHEMBL509016)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C148H224N40O45/c1-16-76(10)119(145(231)166-79(13)125(211)174-103(59-85-62-158-90-35-24-23-34-88(85)90)135(221)176-99(55-73(4)5)136(222)185-117(74(6)7)143(229)173-92(36-25-27-51-149)127(213)160-65-109(196)167-91(122(153)208)38-29-53-157-148(154)155)187-137(223)101(56-82-30-19-17-20-31-82)177-132(218)97(46-50-115(204)205)172-131(217)93(37-26-28-52-150)170-124(210)78(12)164-123(209)77(11)165-130(216)96(43-47-108(152)195)169-111(198)66-161-129(215)95(45-49-114(202)203)171-133(219)98(54-72(2)3)175-134(220)100(58-84-39-41-87(194)42-40-84)178-140(226)105(68-189)181-142(228)107(70-191)182-144(230)118(75(8)9)186-139(225)104(61-116(206)207)179-141(227)106(69-190)183-147(233)121(81(15)193)188-138(224)102(57-83-32-21-18-22-33-83)180-146(232)120(80(14)192)184-112(199)67-162-128(214)94(44-48-113(200)201)168-110(197)64-159-126(212)89(151)60-86-63-156-71-163-86/h17-24,30-35,39-42,62-63,71-81,89,91-107,117-121,158,189-194H,16,25-29,36-38,43-61,64-70,149-151H2,1-15H3,(H2,152,195)(H2,153,208)(H,156,163)(H,159,212)(H,160,213)(H,161,215)(H,162,214)(H,164,209)(H,165,216)(H,166,231)(H,167,196)(H,168,197)(H,169,198)(H,170,210)(H,171,219)(H,172,217)(H,173,229)(H,174,211)(H,175,220)(H,176,221)(H,177,218)(H,178,226)(H,179,227)(H,180,232)(H,181,228)(H,182,230)(H,183,233)(H,184,199)(H,185,222)(H,186,225)(H,187,223)(H,188,224)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,154,155,157)/t76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-,121-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00800 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495411
(CHEMBL3110317)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSC1CC(=O)N(CCCCCCCCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C186H257N41O54S/c1-16-97(10)152(180(274)203-100(13)160(254)211-127(78-107-82-195-115-48-34-31-45-111(107)115)170(264)213-123(74-94(4)5)171(265)223-151(96(8)9)179(273)221-132(164(258)199-85-138(236)205-116(157(190)251)50-40-71-194-186(191)192)91-282-135-81-142(240)227(183(135)277)72-39-23-21-19-17-18-20-22-30-53-137(235)204-108-58-56-106(57-59-108)147(148-155(249)112-46-32-35-51-133(112)280-184(148)278)149-156(250)113-47-33-36-52-134(113)281-185(149)279)225-172(266)125(75-103-41-26-24-27-42-103)214-167(261)121(65-69-145(245)246)210-166(260)117(49-37-38-70-187)208-159(253)99(12)201-158(252)98(11)202-165(259)120(62-66-136(189)234)207-140(238)86-197-163(257)119(64-68-144(243)244)209-168(262)122(73-93(2)3)212-169(263)124(77-105-54-60-110(233)61-55-105)215-175(269)129(88-228)218-177(271)131(90-230)219-178(272)150(95(6)7)224-174(268)128(80-146(247)248)216-176(270)130(89-229)220-182(276)154(102(15)232)226-173(267)126(76-104-43-28-25-29-44-104)217-181(275)153(101(14)231)222-141(239)87-198-162(256)118(63-67-143(241)242)206-139(237)84-196-161(255)114(188)79-109-83-193-92-200-109/h24-29,31-36,41-48,51-52,54-61,82-83,92-102,114,116-132,135,147,150-154,195,228-233,249-250H,16-23,30,37-40,49-50,53,62-81,84-91,187-188H2,1-15H3,(H2,189,234)(H2,190,251)(H,193,200)(H,196,255)(H,197,257)(H,198,256)(H,199,258)(H,201,252)(H,202,259)(H,203,274)(H,204,235)(H,205,236)(H,206,237)(H,207,238)(H,208,253)(H,209,262)(H,210,260)(H,211,254)(H,212,263)(H,213,264)(H,214,261)(H,215,269)(H,216,270)(H,217,275)(H,218,271)(H,219,272)(H,220,276)(H,221,273)(H,222,239)(H,223,265)(H,224,268)(H,225,266)(H,226,267)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,191,192,194)/t97-,98-,99-,100-,101+,102+,114-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,135?,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495412
(CHEMBL3110310)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CSC1CC(=O)N(CCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C183H252N42O53S/c1-16-94(10)149(177(271)201-97(13)157(251)210-125(76-104-80-193-112-44-28-25-41-108(104)112)167(261)212-121(72-91(4)5)168(262)221-147(92(6)7)175(269)209-114(45-31-33-67-184)159(253)195-83-135(233)203-113(154(188)248)47-36-69-192-183(189)190)223-169(263)123(73-100-37-20-17-21-38-100)213-164(258)119(62-66-142(242)243)208-163(257)115(46-32-34-68-185)206-156(250)96(12)199-155(249)95(11)200-162(256)118(59-63-133(187)231)205-137(235)84-196-161(255)117(61-65-141(240)241)207-165(259)120(71-90(2)3)211-166(260)122(75-102-51-57-107(230)58-52-102)214-172(266)127(86-226)217-174(268)129(88-279-132-79-139(237)225(180(132)274)70-35-19-24-50-134(232)202-105-55-53-103(54-56-105)144(145-152(246)109-42-26-29-48-130(109)277-181(145)275)146-153(247)110-43-27-30-49-131(110)278-182(146)276)219-176(270)148(93(8)9)222-171(265)126(78-143(244)245)215-173(267)128(87-227)218-179(273)151(99(15)229)224-170(264)124(74-101-39-22-18-23-40-101)216-178(272)150(98(14)228)220-138(236)85-197-160(254)116(60-64-140(238)239)204-136(234)82-194-158(252)111(186)77-106-81-191-89-198-106/h17-18,20-23,25-30,37-44,48-49,51-58,80-81,89-99,111,113-129,132,144,147-151,193,226-230,246-247H,16,19,24,31-36,45-47,50,59-79,82-88,184-186H2,1-15H3,(H2,187,231)(H2,188,248)(H,191,198)(H,194,252)(H,195,253)(H,196,255)(H,197,254)(H,199,249)(H,200,256)(H,201,271)(H,202,232)(H,203,233)(H,204,234)(H,205,235)(H,206,250)(H,207,259)(H,208,257)(H,209,269)(H,210,251)(H,211,260)(H,212,261)(H,213,258)(H,214,266)(H,215,267)(H,216,272)(H,217,268)(H,218,273)(H,219,270)(H,220,236)(H,221,262)(H,222,265)(H,223,263)(H,224,264)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H4,189,190,192)/t94-,95-,96-,97-,98+,99+,111-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,132?,147-,148-,149-,150-,151-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0340 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495413
(CHEMBL3110307)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C145H217N39O45S/c1-16-73(10)116(142(227)162-76(13)122(207)169-99(55-82-58-154-87-33-24-23-32-85(82)87)132(217)171-95(51-70(4)5)133(218)181-115(72(8)9)141(226)179-104(67-230)126(211)158-61-106(192)163-88(119(149)204)35-27-49-153-145(150)151)183-134(219)97(52-79-28-19-17-20-29-79)172-129(214)93(43-47-112(200)201)168-128(213)89(34-25-26-48-146)166-121(206)75(12)160-120(205)74(11)161-127(212)92(40-44-105(148)191)165-108(194)62-156-125(210)91(42-46-111(198)199)167-130(215)94(50-69(2)3)170-131(216)96(54-81-36-38-84(190)39-37-81)173-137(222)101(64-185)176-139(224)103(66-187)177-140(225)114(71(6)7)182-136(221)100(57-113(202)203)174-138(223)102(65-186)178-144(229)118(78(15)189)184-135(220)98(53-80-30-21-18-22-31-80)175-143(228)117(77(14)188)180-109(195)63-157-124(209)90(41-45-110(196)197)164-107(193)60-155-123(208)86(147)56-83-59-152-68-159-83/h17-24,28-33,36-39,58-59,68-78,86,88-104,114-118,154,185-190,230H,16,25-27,34-35,40-57,60-67,146-147H2,1-15H3,(H2,148,191)(H2,149,204)(H,152,159)(H,155,208)(H,156,210)(H,157,209)(H,158,211)(H,160,205)(H,161,212)(H,162,227)(H,163,192)(H,164,193)(H,165,194)(H,166,206)(H,167,215)(H,168,213)(H,169,207)(H,170,216)(H,171,217)(H,172,214)(H,173,222)(H,174,223)(H,175,228)(H,176,224)(H,177,225)(H,178,229)(H,179,226)(H,180,195)(H,181,218)(H,182,221)(H,183,219)(H,184,220)(H,196,197)(H,198,199)(H,200,201)(H,202,203)(H4,150,151,153)/t73-,74-,75-,76-,77+,78+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,114-,115-,116-,117-,118-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00500 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495414
(CHEMBL3110314)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSC1CC(=O)N(CCCCCCCCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C186H257N41O54S/c1-16-97(10)152(180(274)203-100(13)159(253)211-127(78-107-82-195-115-48-34-31-45-111(107)115)169(263)213-123(74-94(4)5)170(264)223-150(95(6)7)178(272)210-117(49-37-38-70-187)162(256)197-85-138(236)205-116(157(190)251)50-40-71-194-186(191)192)225-171(265)125(75-103-41-26-24-27-42-103)214-166(260)121(65-69-145(245)246)209-177(271)132(91-282-135-81-142(240)227(183(135)277)72-39-23-21-19-17-18-20-22-30-53-137(235)204-108-58-56-106(57-59-108)147(148-155(249)112-46-32-35-51-133(112)280-184(148)278)149-156(250)113-47-33-36-52-134(113)281-185(149)279)221-160(254)99(12)201-158(252)98(11)202-165(259)120(62-66-136(189)234)207-140(238)86-198-164(258)119(64-68-144(243)244)208-167(261)122(73-93(2)3)212-168(262)124(77-105-54-60-110(233)61-55-105)215-174(268)129(88-228)218-176(270)131(90-230)219-179(273)151(96(8)9)224-173(267)128(80-146(247)248)216-175(269)130(89-229)220-182(276)154(102(15)232)226-172(266)126(76-104-43-28-25-29-44-104)217-181(275)153(101(14)231)222-141(239)87-199-163(257)118(63-67-143(241)242)206-139(237)84-196-161(255)114(188)79-109-83-193-92-200-109/h24-29,31-36,41-48,51-52,54-61,82-83,92-102,114,116-132,135,147,150-154,195,228-233,249-250H,16-23,30,37-40,49-50,53,62-81,84-91,187-188H2,1-15H3,(H2,189,234)(H2,190,251)(H,193,200)(H,196,255)(H,197,256)(H,198,258)(H,199,257)(H,201,252)(H,202,259)(H,203,274)(H,204,235)(H,205,236)(H,206,237)(H,207,238)(H,208,261)(H,209,271)(H,210,272)(H,211,253)(H,212,262)(H,213,263)(H,214,260)(H,215,268)(H,216,269)(H,217,275)(H,218,270)(H,219,273)(H,220,276)(H,221,254)(H,222,239)(H,223,264)(H,224,267)(H,225,265)(H,226,266)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H4,191,192,194)/t97-,98-,99-,100-,101+,102+,114-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,135?,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495415
(CHEMBL3110320)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CSC1CC(=O)N(CCCCCCCCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(N)=O |r| Show InChI InChI=1S/C192H269N43O55S/c1-16-101(10)157(186(283)210-104(13)165(262)219-132(82-111-86-202-119-50-34-31-47-115(111)119)176(273)221-128(78-98(4)5)177(274)231-155(99(6)7)184(281)218-120(51-37-39-73-193)167(264)204-89-144(245)212-121(53-42-75-201-192(198)199)171(268)229-137(162(197)259)95-291-140-85-147(248)235(189(140)286)76-41-23-21-19-17-18-20-22-30-56-142(243)211-112-61-59-110(60-62-112)152(153-160(257)116-48-32-35-54-138(116)289-190(153)287)154-161(258)117-49-33-36-55-139(117)290-191(154)288)233-178(275)130(79-107-43-26-24-27-44-107)222-173(270)126(68-72-150(253)254)217-172(269)122(52-38-40-74-194)215-164(261)103(12)208-163(260)102(11)209-170(267)125(65-69-141(196)242)214-145(246)90-205-169(266)124(67-71-149(251)252)216-174(271)127(77-97(2)3)220-175(272)129(81-109-57-63-114(241)64-58-109)223-181(278)134(92-236)226-183(280)136(94-238)227-185(282)156(100(8)9)232-180(277)133(84-151(255)256)224-182(279)135(93-237)228-188(285)159(106(15)240)234-179(276)131(80-108-45-28-25-29-46-108)225-187(284)158(105(14)239)230-146(247)91-206-168(265)123(66-70-148(249)250)213-143(244)88-203-166(263)118(195)83-113-87-200-96-207-113/h24-29,31-36,43-50,54-55,57-64,86-87,96-106,118,120-137,140,152,155-159,202,236-241,257-258H,16-23,30,37-42,51-53,56,65-85,88-95,193-195H2,1-15H3,(H2,196,242)(H2,197,259)(H,200,207)(H,203,263)(H,204,264)(H,205,266)(H,206,265)(H,208,260)(H,209,267)(H,210,283)(H,211,243)(H,212,245)(H,213,244)(H,214,246)(H,215,261)(H,216,271)(H,217,269)(H,218,281)(H,219,262)(H,220,272)(H,221,273)(H,222,270)(H,223,278)(H,224,279)(H,225,284)(H,226,280)(H,227,282)(H,228,285)(H,229,268)(H,230,247)(H,231,274)(H,232,277)(H,233,275)(H,234,276)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,198,199,201)/t101-,102-,103-,104-,105+,106+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,140?,155-,156-,157-,158-,159-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495416
(CHEMBL3110319)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CSC1CC(=O)N(CCCCCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(N)=O |r| Show InChI InChI=1S/C186H257N43O55S/c1-16-95(10)151(180(277)204-98(13)159(256)213-126(76-105-80-196-113-44-28-25-41-109(105)113)170(267)215-122(72-92(4)5)171(268)225-149(93(6)7)178(275)212-114(45-31-33-67-187)161(258)198-83-138(239)206-115(47-36-69-195-186(192)193)165(262)223-131(156(191)253)89-285-134-79-141(242)229(183(134)280)70-35-19-24-50-136(237)205-106-55-53-104(54-56-106)146(147-154(251)110-42-26-29-48-132(110)283-184(147)281)148-155(252)111-43-27-30-49-133(111)284-185(148)282)227-172(269)124(73-101-37-20-17-21-38-101)216-167(264)120(62-66-144(247)248)211-166(263)116(46-32-34-68-188)209-158(255)97(12)202-157(254)96(11)203-164(261)119(59-63-135(190)236)208-139(240)84-199-163(260)118(61-65-143(245)246)210-168(265)121(71-91(2)3)214-169(266)123(75-103-51-57-108(235)58-52-103)217-175(272)128(86-230)220-177(274)130(88-232)221-179(276)150(94(8)9)226-174(271)127(78-145(249)250)218-176(273)129(87-231)222-182(279)153(100(15)234)228-173(270)125(74-102-39-22-18-23-40-102)219-181(278)152(99(14)233)224-140(241)85-200-162(259)117(60-64-142(243)244)207-137(238)82-197-160(257)112(189)77-107-81-194-90-201-107/h17-18,20-23,25-30,37-44,48-49,51-58,80-81,90-100,112,114-131,134,146,149-153,196,230-235,251-252H,16,19,24,31-36,45-47,50,59-79,82-89,187-189H2,1-15H3,(H2,190,236)(H2,191,253)(H,194,201)(H,197,257)(H,198,258)(H,199,260)(H,200,259)(H,202,254)(H,203,261)(H,204,277)(H,205,237)(H,206,239)(H,207,238)(H,208,240)(H,209,255)(H,210,265)(H,211,263)(H,212,275)(H,213,256)(H,214,266)(H,215,267)(H,216,264)(H,217,272)(H,218,273)(H,219,278)(H,220,274)(H,221,276)(H,222,279)(H,223,262)(H,224,241)(H,225,268)(H,226,271)(H,227,269)(H,228,270)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,192,193,195)/t95-,96-,97-,98-,99+,100+,112-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,134?,149-,150-,151-,152-,153-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495417
(CHEMBL3110318)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CSC1CC(=O)N(CCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(N)=O |r| Show InChI InChI=1S/C183H251N43O55S/c1-16-92(10)148(177(274)201-95(13)156(253)210-123(73-102-77-193-110-41-26-23-38-106(102)110)167(264)212-119(69-89(4)5)168(265)222-146(90(6)7)175(272)209-111(42-29-31-64-184)158(255)195-80-135(236)203-112(44-33-66-192-183(189)190)162(259)220-128(153(188)250)86-282-131-76-138(239)226(180(131)277)67-63-133(234)202-103-51-49-101(50-52-103)143(144-151(248)107-39-24-27-45-129(107)280-181(144)278)145-152(249)108-40-25-28-46-130(108)281-182(145)279)224-169(266)121(70-98-34-19-17-20-35-98)213-164(261)117(58-62-141(244)245)208-163(260)113(43-30-32-65-185)206-155(252)94(12)199-154(251)93(11)200-161(258)116(55-59-132(187)233)205-136(237)81-196-160(257)115(57-61-140(242)243)207-165(262)118(68-88(2)3)211-166(263)120(72-100-47-53-105(232)54-48-100)214-172(269)125(83-227)217-174(271)127(85-229)218-176(273)147(91(8)9)223-171(268)124(75-142(246)247)215-173(270)126(84-228)219-179(276)150(97(15)231)225-170(267)122(71-99-36-21-18-22-37-99)216-178(275)149(96(14)230)221-137(238)82-197-159(256)114(56-60-139(240)241)204-134(235)79-194-157(254)109(186)74-104-78-191-87-198-104/h17-28,34-41,45-54,77-78,87-97,109,111-128,131,143,146-150,193,227-232,248-249H,16,29-33,42-44,55-76,79-86,184-186H2,1-15H3,(H2,187,233)(H2,188,250)(H,191,198)(H,194,254)(H,195,255)(H,196,257)(H,197,256)(H,199,251)(H,200,258)(H,201,274)(H,202,234)(H,203,236)(H,204,235)(H,205,237)(H,206,252)(H,207,262)(H,208,260)(H,209,272)(H,210,253)(H,211,263)(H,212,264)(H,213,261)(H,214,269)(H,215,270)(H,216,275)(H,217,271)(H,218,273)(H,219,276)(H,220,259)(H,221,238)(H,222,265)(H,223,268)(H,224,266)(H,225,267)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,189,190,192)/t92-,93-,94-,95-,96+,97+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,131?,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495418
(CHEMBL3110315)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSC1CC(=O)N(CCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C177H239N41O54S/c1-16-88(10)143(171(265)194-91(13)151(245)202-118(69-98-73-186-106-39-26-23-36-102(98)106)161(255)204-114(65-85(4)5)162(256)214-142(87(8)9)170(264)212-123(155(249)190-76-129(227)196-107(148(181)242)41-31-62-185-177(182)183)82-273-126-72-133(231)218(174(126)268)63-60-128(226)195-99-48-46-97(47-49-99)138(139-146(240)103-37-24-27-42-124(103)271-175(139)269)140-147(241)104-38-25-28-43-125(104)272-176(140)270)216-163(257)116(66-94-32-19-17-20-33-94)205-158(252)112(55-59-136(236)237)201-157(251)108(40-29-30-61-178)199-150(244)90(12)192-149(243)89(11)193-156(250)111(52-56-127(180)225)198-131(229)77-188-154(248)110(54-58-135(234)235)200-159(253)113(64-84(2)3)203-160(254)115(68-96-44-50-101(224)51-45-96)206-166(260)120(79-219)209-168(262)122(81-221)210-169(263)141(86(6)7)215-165(259)119(71-137(238)239)207-167(261)121(80-220)211-173(267)145(93(15)223)217-164(258)117(67-95-34-21-18-22-35-95)208-172(266)144(92(14)222)213-132(230)78-189-153(247)109(53-57-134(232)233)197-130(228)75-187-152(246)105(179)70-100-74-184-83-191-100/h17-28,32-39,42-51,73-74,83-93,105,107-123,126,138,141-145,186,219-224,240-241H,16,29-31,40-41,52-72,75-82,178-179H2,1-15H3,(H2,180,225)(H2,181,242)(H,184,191)(H,187,246)(H,188,248)(H,189,247)(H,190,249)(H,192,243)(H,193,250)(H,194,265)(H,195,226)(H,196,227)(H,197,228)(H,198,229)(H,199,244)(H,200,253)(H,201,251)(H,202,245)(H,203,254)(H,204,255)(H,205,252)(H,206,260)(H,207,261)(H,208,266)(H,209,262)(H,210,263)(H,211,267)(H,212,264)(H,213,230)(H,214,256)(H,215,259)(H,216,257)(H,217,258)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H4,182,183,185)/t88-,89-,90-,91-,92+,93+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,126?,141-,142-,143-,144-,145-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00700 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495419
(CHEMBL3110312)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CSC1CC(=O)N(CCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C177H239N41O54S/c1-16-88(10)143(171(265)194-91(13)150(244)202-118(69-98-73-186-106-39-26-23-36-102(98)106)160(254)204-114(65-85(4)5)161(255)214-141(86(6)7)169(263)201-108(40-29-30-61-178)153(247)188-76-129(227)196-107(148(181)242)41-31-62-185-177(182)183)216-162(256)116(66-94-32-19-17-20-33-94)205-157(251)112(55-59-136(236)237)200-168(262)123(82-273-126-72-133(231)218(174(126)268)63-60-128(226)195-99-48-46-97(47-49-99)138(139-146(240)103-37-24-27-42-124(103)271-175(139)269)140-147(241)104-38-25-28-43-125(104)272-176(140)270)212-151(245)90(12)192-149(243)89(11)193-156(250)111(52-56-127(180)225)198-131(229)77-189-155(249)110(54-58-135(234)235)199-158(252)113(64-84(2)3)203-159(253)115(68-96-44-50-101(224)51-45-96)206-165(259)120(79-219)209-167(261)122(81-221)210-170(264)142(87(8)9)215-164(258)119(71-137(238)239)207-166(260)121(80-220)211-173(267)145(93(15)223)217-163(257)117(67-95-34-21-18-22-35-95)208-172(266)144(92(14)222)213-132(230)78-190-154(248)109(53-57-134(232)233)197-130(228)75-187-152(246)105(179)70-100-74-184-83-191-100/h17-28,32-39,42-51,73-74,83-93,105,107-123,126,138,141-145,186,219-224,240-241H,16,29-31,40-41,52-72,75-82,178-179H2,1-15H3,(H2,180,225)(H2,181,242)(H,184,191)(H,187,246)(H,188,247)(H,189,249)(H,190,248)(H,192,243)(H,193,250)(H,194,265)(H,195,226)(H,196,227)(H,197,228)(H,198,229)(H,199,252)(H,200,262)(H,201,263)(H,202,244)(H,203,253)(H,204,254)(H,205,251)(H,206,259)(H,207,260)(H,208,266)(H,209,261)(H,210,264)(H,211,267)(H,212,245)(H,213,230)(H,214,255)(H,215,258)(H,216,256)(H,217,257)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H4,182,183,185)/t88-,89-,90-,91-,92+,93+,105-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,126?,141-,142-,143-,144-,145-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495420
(CHEMBL3110309)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CSC1CC(=O)N(CCC(=O)Nc2ccc(cc2)C(c2c(O)c3ccccc3oc2=O)c2c(O)c3ccccc3oc2=O)C1=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C180H246N42O53S/c1-16-91(10)146(174(268)198-94(13)154(248)207-122(73-101-77-190-109-41-26-23-38-105(101)109)164(258)209-118(69-88(4)5)165(259)218-144(89(6)7)172(266)206-111(42-29-31-64-181)156(250)192-80-132(230)200-110(151(185)245)44-33-66-189-180(186)187)220-166(260)120(70-97-34-19-17-20-35-97)210-161(255)116(58-62-139(239)240)205-160(254)112(43-30-32-65-182)203-153(247)93(12)196-152(246)92(11)197-159(253)115(55-59-130(184)228)202-134(232)81-193-158(252)114(57-61-138(237)238)204-162(256)117(68-87(2)3)208-163(257)119(72-99-47-53-104(227)54-48-99)211-169(263)124(83-223)214-171(265)126(85-276-129-76-136(234)222(177(129)271)67-63-131(229)199-102-51-49-100(50-52-102)141(142-149(243)106-39-24-27-45-127(106)274-178(142)272)143-150(244)107-40-25-28-46-128(107)275-179(143)273)216-173(267)145(90(8)9)219-168(262)123(75-140(241)242)212-170(264)125(84-224)215-176(270)148(96(15)226)221-167(261)121(71-98-36-21-18-22-37-98)213-175(269)147(95(14)225)217-135(233)82-194-157(251)113(56-60-137(235)236)201-133(231)79-191-155(249)108(183)74-103-78-188-86-195-103/h17-28,34-41,45-54,77-78,86-96,108,110-126,129,141,144-148,190,223-227,243-244H,16,29-33,42-44,55-76,79-85,181-183H2,1-15H3,(H2,184,228)(H2,185,245)(H,188,195)(H,191,249)(H,192,250)(H,193,252)(H,194,251)(H,196,246)(H,197,253)(H,198,268)(H,199,229)(H,200,230)(H,201,231)(H,202,232)(H,203,247)(H,204,256)(H,205,254)(H,206,266)(H,207,248)(H,208,257)(H,209,258)(H,210,255)(H,211,263)(H,212,264)(H,213,269)(H,214,265)(H,215,270)(H,216,267)(H,217,233)(H,218,259)(H,219,262)(H,220,260)(H,221,261)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H4,186,187,189)/t91-,92-,93-,94-,95+,96+,108-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,129?,144-,145-,146-,147-,148-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495421
(CHEMBL3110308)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(N)=O |r| Show InChI InChI=1S/C145H217N37O45S/c1-16-74(10)117(143(225)160-77(13)123(205)168-100(56-83-59-152-88-34-24-23-33-86(83)88)133(215)170-96(52-71(4)5)134(216)179-115(72(6)7)141(223)167-89(35-25-27-49-146)125(207)154-63-109(192)163-105(68-228)120(150)202)181-135(217)98(53-80-29-19-17-20-30-80)171-130(212)94(44-48-113(198)199)166-129(211)90(36-26-28-50-147)164-122(204)76(12)158-121(203)75(11)159-128(210)93(41-45-106(149)189)162-108(191)62-155-127(209)92(43-47-112(196)197)165-131(213)95(51-70(2)3)169-132(214)97(55-82-37-39-85(188)40-38-82)172-138(220)102(65-183)175-140(222)104(67-185)176-142(224)116(73(8)9)180-137(219)101(58-114(200)201)173-139(221)103(66-184)177-145(227)119(79(15)187)182-136(218)99(54-81-31-21-18-22-32-81)174-144(226)118(78(14)186)178-110(193)64-156-126(208)91(42-46-111(194)195)161-107(190)61-153-124(206)87(148)57-84-60-151-69-157-84/h17-24,29-34,37-40,59-60,69-79,87,89-105,115-119,152,183-188,228H,16,25-28,35-36,41-58,61-68,146-148H2,1-15H3,(H2,149,189)(H2,150,202)(H,151,157)(H,153,206)(H,154,207)(H,155,209)(H,156,208)(H,158,203)(H,159,210)(H,160,225)(H,161,190)(H,162,191)(H,163,192)(H,164,204)(H,165,213)(H,166,211)(H,167,223)(H,168,205)(H,169,214)(H,170,215)(H,171,212)(H,172,220)(H,173,221)(H,174,226)(H,175,222)(H,176,224)(H,177,227)(H,178,193)(H,179,216)(H,180,219)(H,181,217)(H,182,218)(H,194,195)(H,196,197)(H,198,199)(H,200,201)/t74-,75-,76-,77-,78+,79+,87-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,115-,116-,117-,118-,119-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495422
(CHEMBL3110306)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C145H217N39O45S/c1-16-73(10)116(142(227)162-76(13)121(206)169-99(55-82-58-154-87-33-24-23-32-85(82)87)131(216)171-95(51-70(4)5)132(217)181-114(71(6)7)140(225)168-89(34-25-26-48-146)124(209)156-61-106(192)163-88(119(149)204)35-27-49-153-145(150)151)183-133(218)97(52-79-28-19-17-20-29-79)172-128(213)93(43-47-112(200)201)167-139(224)104(67-230)179-122(207)75(12)160-120(205)74(11)161-127(212)92(40-44-105(148)191)165-108(194)62-157-126(211)91(42-46-111(198)199)166-129(214)94(50-69(2)3)170-130(215)96(54-81-36-38-84(190)39-37-81)173-136(221)101(64-185)176-138(223)103(66-187)177-141(226)115(72(8)9)182-135(220)100(57-113(202)203)174-137(222)102(65-186)178-144(229)118(78(15)189)184-134(219)98(53-80-30-21-18-22-31-80)175-143(228)117(77(14)188)180-109(195)63-158-125(210)90(41-45-110(196)197)164-107(193)60-155-123(208)86(147)56-83-59-152-68-159-83/h17-24,28-33,36-39,58-59,68-78,86,88-104,114-118,154,185-190,230H,16,25-27,34-35,40-57,60-67,146-147H2,1-15H3,(H2,148,191)(H2,149,204)(H,152,159)(H,155,208)(H,156,209)(H,157,211)(H,158,210)(H,160,205)(H,161,212)(H,162,227)(H,163,192)(H,164,193)(H,165,194)(H,166,214)(H,167,224)(H,168,225)(H,169,206)(H,170,215)(H,171,216)(H,172,213)(H,173,221)(H,174,222)(H,175,228)(H,176,223)(H,177,226)(H,178,229)(H,179,207)(H,180,195)(H,181,217)(H,182,220)(H,183,218)(H,184,219)(H,196,197)(H,198,199)(H,200,201)(H,202,203)(H4,150,151,153)/t73-,74-,75-,76-,77+,78+,86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,114-,115-,116-,117-,118-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50495423
(CHEMBL3110305)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r| Show InChI InChI=1S/C148H224N40O44S/c1-16-76(10)119(145(230)166-79(13)125(210)174-103(59-85-62-158-90-35-24-23-34-88(85)90)135(220)176-99(55-73(4)5)136(221)185-117(74(6)7)143(228)173-92(36-25-27-51-149)127(212)160-65-109(195)167-91(122(153)207)38-29-53-157-148(154)155)187-137(222)101(56-82-30-19-17-20-31-82)177-132(217)97(46-50-115(203)204)172-131(216)93(37-26-28-52-150)170-124(209)78(12)164-123(208)77(11)165-130(215)96(43-47-108(152)194)169-111(197)66-161-129(214)95(45-49-114(201)202)171-133(218)98(54-72(2)3)175-134(219)100(58-84-39-41-87(193)42-40-84)178-140(225)105(68-189)181-142(227)107(70-233)183-144(229)118(75(8)9)186-139(224)104(61-116(205)206)179-141(226)106(69-190)182-147(232)121(81(15)192)188-138(223)102(57-83-32-21-18-22-33-83)180-146(231)120(80(14)191)184-112(198)67-162-128(213)94(44-48-113(199)200)168-110(196)64-159-126(211)89(151)60-86-63-156-71-163-86/h17-24,30-35,39-42,62-63,71-81,89,91-107,117-121,158,189-193,233H,16,25-29,36-38,43-61,64-70,149-151H2,1-15H3,(H2,152,194)(H2,153,207)(H,156,163)(H,159,211)(H,160,212)(H,161,214)(H,162,213)(H,164,208)(H,165,215)(H,166,230)(H,167,195)(H,168,196)(H,169,197)(H,170,209)(H,171,218)(H,172,216)(H,173,228)(H,174,210)(H,175,219)(H,176,220)(H,177,217)(H,178,225)(H,179,226)(H,180,231)(H,181,227)(H,182,232)(H,183,229)(H,184,198)(H,185,221)(H,186,224)(H,187,222)(H,188,223)(H,199,200)(H,201,202)(H,203,204)(H,205,206)(H4,154,155,157)/t76-,77-,78-,79-,80+,81+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,117-,118-,119-,120-,121-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00600 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00200 | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description
Activation of human GLP-1 receptor overexpressed in HEK293 cells assessed as cAMP accumulation after 20 mins by HTRF assay |
J Med Chem 56: 9955-68 (2013)
Article DOI: 10.1021/jm4017448
BindingDB Entry DOI: 10.7270/Q2H41VDR |
More data for this
Ligand-Target Pair | |
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