Found 11 hits Enz. Inhib. hit(s) with all data for entry = 50007961 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Guanine nucleotide binding protein, alpha q polypeptide
(Cricetulus griseus) | BDBM50514449
(CHEMBL4171381)Show SMILES CCC(=O)N[C@@H]([C@H](O)C(C)C)C(=O)O[C@H](C(C)C)[C@@H]1NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@H](OC(=O)[C@H]([C@@H](C)OC)N(C)C1=O)C(C)C |r| Show InChI InChI=1S/C49H75N7O15/c1-17-34(58)52-35(39(59)24(2)3)47(65)70-40(25(4)5)36-46(64)56(15)38(30(11)68-16)49(67)71-41(26(6)7)37(51-31(12)57)48(66)69-33(23-32-21-19-18-20-22-32)45(63)55(14)28(9)42(60)50-27(8)44(62)54(13)29(10)43(61)53-36/h18-22,24-27,29-30,33,35-41,59H,9,17,23H2,1-8,10-16H3,(H,50,60)(H,51,57)(H,52,58)(H,53,61)/t27-,29-,30+,33+,35-,36-,37-,38-,39+,40+,41+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet 
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of Gq-mediated signalling in CHOK1 cells stably expressing M1 muscarinic receptor assessed as inhibition of carbachol-induced IP1 producti... |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide binding protein, alpha q polypeptide
(Cricetulus griseus) | BDBM50468902
(CHEMBL4288881)Show SMILES CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| Show InChI InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1 | PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
AffyNet
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of Gq-mediated signalling in CHOK1 cells stably expressing M1 muscarinic receptor assessed as inhibition of carbachol-induced IP1 producti... |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha/subunit alpha-11
(Homo sapiens) | BDBM50468902
(CHEMBL4288881)Show SMILES CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| Show InChI InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-alphaq/11 in human platelet rich plasma assessed as inhibition of ADP-mediated platelet aggregation |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(q) subunit alpha
(Homo sapiens) | BDBM50468902
(CHEMBL4288881)Show SMILES CO[C@H](C)[C@@H]1N(C)C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)[C@H](C)NC(=O)C(=C)N(C)C(=O)[C@@H](Cc2ccccc2)OC(=O)[C@@H](NC(C)=O)[C@@H](C)OC1=O)[C@H](OC(=O)[C@@H](NC(C)=O)[C@H](O)C(C)C)C(C)C |r| Show InChI InChI=1S/C46H69N7O15/c1-22(2)37(56)34(49-30(11)55)45(63)68-38(23(3)4)35-43(61)53(14)36(28(9)65-15)46(64)66-27(8)33(48-29(10)54)44(62)67-32(21-31-19-17-16-18-20-31)42(60)52(13)25(6)39(57)47-24(5)41(59)51(12)26(7)40(58)50-35/h16-20,22-24,26-28,32-38,56H,6,21H2,1-5,7-15H3,(H,47,57)(H,48,54)(H,49,55)(H,50,58)/t24-,26-,27+,28+,32+,33-,34-,35-,36-,37+,38+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
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MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-alphaq/11 in human platelet rich plasma assessed as inhibition of ADP-mediated calcium ion mobilization |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM114291
(8-(3,4,5-trihydroxy-6-keto-xanthen-9-yl)-1-naphtho...)Show SMILES OC(=O)c1cccc2cccc(-c3c4ccc(O)c(O)c4oc4c(O)c(=O)ccc34)c12 |(4.7,1.65,;6.16,1.41,;6.69,.02,;7.1,2.55,;6.56,3.99,;7.55,5.17,;9.07,4.89,;9.57,3.44,;11.03,3.18,;11.53,1.79,;10.58,.66,;9.13,.92,;8.18,-.22,;9.46,-.96,;10.78,-.17,;12.12,-.93,;12.12,-2.47,;13.4,-3.21,;10.78,-3.23,;10.76,-4.7,;9.46,-2.44,;8.18,-3.17,;6.9,-2.44,;5.57,-3.23,;5.59,-4.7,;4.23,-2.47,;2.96,-3.21,;4.23,-.93,;5.57,-.17,;6.9,-.96,;8.62,2.3,)| Show InChI InChI=1S/C24H14O7/c25-16-9-7-13-19(12-5-1-3-11-4-2-6-15(18(11)12)24(29)30)14-8-10-17(26)21(28)23(14)31-22(13)20(16)27/h1-10,25,27-28H,(H,29,30) | PDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM50246208
(2-(3,4,5-trihydroxy-6-oxo-6H-xanthen-9-yl)cyclohex...)Show SMILES OC(=O)C1CCCCC1c1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12 Show InChI InChI=1S/C20H18O7/c21-13-7-5-11-15(9-3-1-2-4-10(9)20(25)26)12-6-8-14(22)17(24)19(12)27-18(11)16(13)23/h5-10,21,23-24H,1-4H2,(H,25,26) | PDB
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UniProtKB/SwissProt
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM50514448
(CHEMBL4469620)Show SMILES Oc1ccc2c(Oc3c(O)c(O)ccc3C22OC(=O)c3ccccc23)c1O Show InChI InChI=1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H | PDB
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UniProtKB/SwissProt
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PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM50514450
(CHEMBL4443974)Show SMILES OC(=O)C1CC23C(Cl)C(Cl)=C(Cl)C(Cl)C2(CC1c1c2ccc(O)c(O)c2oc2c(O)c(=O)ccc12)C3(Cl)Cl |t:9| Show InChI InChI=1S/C25H16Cl6O7/c26-14-15(27)21(29)24-6-10(22(36)37)9(5-23(24,20(14)28)25(24,30)31)13-7-1-3-11(32)16(34)18(7)38-19-8(13)2-4-12(33)17(19)35/h1-4,9-10,20-21,32,34-35H,5-6H2,(H,36,37) | PDB
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UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2/G(I)/G(S)/G(T) subunit beta-1
(Homo sapiens) | BDBM50444748
(Aminoquinuride)Show SMILES Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1 Show InChI InChI=1S/C21H20N6O/c1-11-7-17(22)15-9-13(3-5-19(15)24-11)26-21(28)27-14-4-6-20-16(10-14)18(23)8-12(2)25-20/h3-10H,1-2H3,(H2,22,24)(H2,23,25)(H2,26,27,28) | PDB
UniProtKB/SwissProt
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PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM97335
(7-amino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo...)Show InChI InChI=1S/C20H23NO5/c1-23-16-8-6-12-13(10-15(16)22)14(21)7-5-11-9-17(24-2)19(25-3)20(26-4)18(11)12/h6,8-10,14H,5,7,21H2,1-4H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
(Homo sapiens) | BDBM50514451
(CHEMBL1967787)Show InChI InChI=1S/C20H18O5/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24/h5-10,13-14,21H,1-4H2,(H,23,24) | PDB
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| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sun Yat-sen University
Curated by ChEMBL
| Assay Description
Inhibition of G-protein beta1gamma2 (unknown origin) by flow cytometry |
J Med Chem 63: 5013-5030 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01452
BindingDB Entry DOI: 10.7270/Q28S4T82 |
More data for this
Ligand-Target Pair | |
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