Compile Data Set for Download or QSAR

Found 105 hits Enz. Inhib. hit(s) with all data for entry = 50008374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50240552 (CHEMBL195) Show SMILES [H][C@@]12CC[C@]([H])(CC(C1)OC(=O)C(CO)c1ccccc1)N2C |r,@@:7,TLB:9:7:21:2.3| Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14-,16?/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50240552 (CHEMBL195) Show SMILES [H][C@@]12CC[C@]([H])(CC(C1)OC(=O)C(CO)c1ccccc1)N2C |r,@@:7,TLB:9:7:21:2.3| Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14-,16?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50240552 (CHEMBL195) Show SMILES [H][C@@]12CC[C@]([H])(CC(C1)OC(=O)C(CO)c1ccccc1)N2C |r,@@:7,TLB:9:7:21:2.3| Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14-,16?/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50240552 (CHEMBL195) Show SMILES [H][C@@]12CC[C@]([H])(CC(C1)OC(=O)C(CO)c1ccccc1)N2C |r,@@:7,TLB:9:7:21:2.3| Show InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14-,16?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518557 (CHEMBL4519301) Show SMILES Fc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:10:11:14.15:17.18,(18.31,-36.25,;16.97,-35.49,;15.64,-36.26,;14.31,-35.49,;14.31,-33.95,;12.98,-33.18,;11.65,-33.95,;10.31,-33.18,;8.98,-33.95,;8.98,-35.49,;7.65,-33.18,;6.31,-33.95,;5.96,-35.38,;4.48,-34.87,;4.47,-32.84,;5.07,-31.58,;5.1,-33.5,;3.39,-33.95,;2.99,-35.39,;10.31,-31.64,;8.98,-30.87,;8.98,-29.32,;10.31,-28.55,;11.65,-29.32,;11.65,-30.87,;15.64,-33.17,;16.97,-33.94,)| Show InChI InChI=1S/C22H25FN2O2/c23-19-8-6-17(7-9-19)10-15-25(20-4-2-1-3-5-20)22(26)27-21-16-24-13-11-18(21)12-14-24/h1-9,18,21H,10-16H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518557 (CHEMBL4519301) Show SMILES Fc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:10:11:14.15:17.18,(18.31,-36.25,;16.97,-35.49,;15.64,-36.26,;14.31,-35.49,;14.31,-33.95,;12.98,-33.18,;11.65,-33.95,;10.31,-33.18,;8.98,-33.95,;8.98,-35.49,;7.65,-33.18,;6.31,-33.95,;5.96,-35.38,;4.48,-34.87,;4.47,-32.84,;5.07,-31.58,;5.1,-33.5,;3.39,-33.95,;2.99,-35.39,;10.31,-31.64,;8.98,-30.87,;8.98,-29.32,;10.31,-28.55,;11.65,-29.32,;11.65,-30.87,;15.64,-33.17,;16.97,-33.94,)| Show InChI InChI=1S/C22H25FN2O2/c23-19-8-6-17(7-9-19)10-15-25(20-4-2-1-3-5-20)22(26)27-21-16-24-13-11-18(21)12-14-24/h1-9,18,21H,10-16H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50518557 (CHEMBL4519301) Show SMILES Fc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:10:11:14.15:17.18,(18.31,-36.25,;16.97,-35.49,;15.64,-36.26,;14.31,-35.49,;14.31,-33.95,;12.98,-33.18,;11.65,-33.95,;10.31,-33.18,;8.98,-33.95,;8.98,-35.49,;7.65,-33.18,;6.31,-33.95,;5.96,-35.38,;4.48,-34.87,;4.47,-32.84,;5.07,-31.58,;5.1,-33.5,;3.39,-33.95,;2.99,-35.39,;10.31,-31.64,;8.98,-30.87,;8.98,-29.32,;10.31,-28.55,;11.65,-29.32,;11.65,-30.87,;15.64,-33.17,;16.97,-33.94,)| Show InChI InChI=1S/C22H25FN2O2/c23-19-8-6-17(7-9-19)10-15-25(20-4-2-1-3-5-20)22(26)27-21-16-24-13-11-18(21)12-14-24/h1-9,18,21H,10-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M4 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518557 (CHEMBL4519301) Show SMILES Fc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:10:11:14.15:17.18,(18.31,-36.25,;16.97,-35.49,;15.64,-36.26,;14.31,-35.49,;14.31,-33.95,;12.98,-33.18,;11.65,-33.95,;10.31,-33.18,;8.98,-33.95,;8.98,-35.49,;7.65,-33.18,;6.31,-33.95,;5.96,-35.38,;4.48,-34.87,;4.47,-32.84,;5.07,-31.58,;5.1,-33.5,;3.39,-33.95,;2.99,-35.39,;10.31,-31.64,;8.98,-30.87,;8.98,-29.32,;10.31,-28.55,;11.65,-29.32,;11.65,-30.87,;15.64,-33.17,;16.97,-33.94,)| Show InChI InChI=1S/C22H25FN2O2/c23-19-8-6-17(7-9-19)10-15-25(20-4-2-1-3-5-20)22(26)27-21-16-24-13-11-18(21)12-14-24/h1-9,18,21H,10-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518559 (CHEMBL4585326) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:11:12:15.16:18.19,(19.07,-20.84,;17.73,-21.62,;16.4,-20.85,;15.06,-21.62,;13.73,-20.85,;13.74,-19.31,;12.4,-18.54,;11.07,-19.31,;9.74,-18.54,;8.4,-19.31,;8.4,-20.85,;7.07,-18.54,;5.74,-19.31,;5.39,-20.74,;3.9,-20.23,;3.89,-18.2,;4.49,-16.94,;4.52,-18.86,;2.82,-19.32,;2.41,-20.75,;9.74,-17,;8.4,-16.23,;8.41,-14.68,;9.73,-13.91,;11.07,-14.68,;11.07,-16.23,;15.06,-18.54,;16.39,-19.3,)| Show InChI InChI=1S/C23H28N2O3/c1-27-21-9-7-18(8-10-21)11-16-25(20-5-3-2-4-6-20)23(26)28-22-17-24-14-12-19(22)13-15-24/h2-10,19,22H,11-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518559 (CHEMBL4585326) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:11:12:15.16:18.19,(19.07,-20.84,;17.73,-21.62,;16.4,-20.85,;15.06,-21.62,;13.73,-20.85,;13.74,-19.31,;12.4,-18.54,;11.07,-19.31,;9.74,-18.54,;8.4,-19.31,;8.4,-20.85,;7.07,-18.54,;5.74,-19.31,;5.39,-20.74,;3.9,-20.23,;3.89,-18.2,;4.49,-16.94,;4.52,-18.86,;2.82,-19.32,;2.41,-20.75,;9.74,-17,;8.4,-16.23,;8.41,-14.68,;9.73,-13.91,;11.07,-14.68,;11.07,-16.23,;15.06,-18.54,;16.39,-19.3,)| Show InChI InChI=1S/C23H28N2O3/c1-27-21-9-7-18(8-10-21)11-16-25(20-5-3-2-4-6-20)23(26)28-22-17-24-14-12-19(22)13-15-24/h2-10,19,22H,11-17H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518559 (CHEMBL4585326) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:11:12:15.16:18.19,(19.07,-20.84,;17.73,-21.62,;16.4,-20.85,;15.06,-21.62,;13.73,-20.85,;13.74,-19.31,;12.4,-18.54,;11.07,-19.31,;9.74,-18.54,;8.4,-19.31,;8.4,-20.85,;7.07,-18.54,;5.74,-19.31,;5.39,-20.74,;3.9,-20.23,;3.89,-18.2,;4.49,-16.94,;4.52,-18.86,;2.82,-19.32,;2.41,-20.75,;9.74,-17,;8.4,-16.23,;8.41,-14.68,;9.73,-13.91,;11.07,-14.68,;11.07,-16.23,;15.06,-18.54,;16.39,-19.3,)| Show InChI InChI=1S/C23H28N2O3/c1-27-21-9-7-18(8-10-21)11-16-25(20-5-3-2-4-6-20)23(26)28-22-17-24-14-12-19(22)13-15-24/h2-10,19,22H,11-17H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518557 (CHEMBL4519301) Show SMILES Fc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:10:11:14.15:17.18,(18.31,-36.25,;16.97,-35.49,;15.64,-36.26,;14.31,-35.49,;14.31,-33.95,;12.98,-33.18,;11.65,-33.95,;10.31,-33.18,;8.98,-33.95,;8.98,-35.49,;7.65,-33.18,;6.31,-33.95,;5.96,-35.38,;4.48,-34.87,;4.47,-32.84,;5.07,-31.58,;5.1,-33.5,;3.39,-33.95,;2.99,-35.39,;10.31,-31.64,;8.98,-30.87,;8.98,-29.32,;10.31,-28.55,;11.65,-29.32,;11.65,-30.87,;15.64,-33.17,;16.97,-33.94,)| Show InChI InChI=1S/C22H25FN2O2/c23-19-8-6-17(7-9-19)10-15-25(20-4-2-1-3-5-20)22(26)27-21-16-24-13-11-18(21)12-14-24/h1-9,18,21H,10-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518567 (CHEMBL4576768) Show SMILES O=C(OCc1ccc2OCOc2c1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:13:14:17.18:20.21,(54.21,-33.97,;54.27,-32.43,;55.63,-31.71,;56.93,-32.53,;58.29,-31.81,;58.34,-30.28,;59.7,-29.55,;61.01,-30.37,;62.49,-29.95,;63.35,-31.22,;62.41,-32.43,;60.96,-31.91,;59.6,-32.63,;52.96,-31.61,;51.6,-32.34,;51.25,-33.77,;49.76,-33.26,;49.75,-31.23,;50.35,-29.97,;50.38,-31.89,;48.68,-32.34,;48.28,-33.78,;53.02,-30.07,;54.38,-29.36,;54.44,-27.82,;53.13,-27,;51.76,-27.73,;51.71,-29.27,)| Show InChI InChI=1S/C22H24N2O4/c25-22(26-14-16-6-7-20-21(12-16)28-15-27-20)24(18-4-2-1-3-5-18)19-13-23-10-8-17(19)9-11-23/h1-7,12,17,19H,8-11,13-15H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518570 (CHEMBL4462631) Show SMILES Cc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:9:10:13.14:16.17,(39.78,-53.75,;38.42,-54.48,;38.36,-56.02,;37,-56.74,;35.7,-55.91,;34.34,-56.63,;33.03,-55.81,;31.67,-56.54,;31.62,-58.07,;30.37,-55.72,;29.01,-56.44,;28.66,-57.87,;27.17,-57.37,;27.16,-55.34,;27.76,-54.07,;27.79,-55.99,;26.09,-56.45,;25.68,-57.88,;30.42,-54.18,;31.78,-53.46,;31.84,-51.93,;30.53,-51.11,;29.17,-51.84,;29.12,-53.37,;35.75,-54.38,;37.1,-53.66,;37.15,-52.12,)| Show InChI InChI=1S/C22H25FN2O2/c1-16-7-8-17(13-20(16)23)15-27-22(26)25(19-5-3-2-4-6-19)21-14-24-11-9-18(21)10-12-24/h2-8,13,18,21H,9-12,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50518559 (CHEMBL4585326) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:11:12:15.16:18.19,(19.07,-20.84,;17.73,-21.62,;16.4,-20.85,;15.06,-21.62,;13.73,-20.85,;13.74,-19.31,;12.4,-18.54,;11.07,-19.31,;9.74,-18.54,;8.4,-19.31,;8.4,-20.85,;7.07,-18.54,;5.74,-19.31,;5.39,-20.74,;3.9,-20.23,;3.89,-18.2,;4.49,-16.94,;4.52,-18.86,;2.82,-19.32,;2.41,-20.75,;9.74,-17,;8.4,-16.23,;8.41,-14.68,;9.73,-13.91,;11.07,-14.68,;11.07,-16.23,;15.06,-18.54,;16.39,-19.3,)| Show InChI InChI=1S/C23H28N2O3/c1-27-21-9-7-18(8-10-21)11-16-25(20-5-3-2-4-6-20)23(26)28-22-17-24-14-12-19(22)13-15-24/h2-10,19,22H,11-17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M4 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518567 (CHEMBL4576768) Show SMILES O=C(OCc1ccc2OCOc2c1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:13:14:17.18:20.21,(54.21,-33.97,;54.27,-32.43,;55.63,-31.71,;56.93,-32.53,;58.29,-31.81,;58.34,-30.28,;59.7,-29.55,;61.01,-30.37,;62.49,-29.95,;63.35,-31.22,;62.41,-32.43,;60.96,-31.91,;59.6,-32.63,;52.96,-31.61,;51.6,-32.34,;51.25,-33.77,;49.76,-33.26,;49.75,-31.23,;50.35,-29.97,;50.38,-31.89,;48.68,-32.34,;48.28,-33.78,;53.02,-30.07,;54.38,-29.36,;54.44,-27.82,;53.13,-27,;51.76,-27.73,;51.71,-29.27,)| Show InChI InChI=1S/C22H24N2O4/c25-22(26-14-16-6-7-20-21(12-16)28-15-27-20)24(18-4-2-1-3-5-18)19-13-23-10-8-17(19)9-11-23/h1-7,12,17,19H,8-11,13-15H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518567 (CHEMBL4576768) Show SMILES O=C(OCc1ccc2OCOc2c1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:13:14:17.18:20.21,(54.21,-33.97,;54.27,-32.43,;55.63,-31.71,;56.93,-32.53,;58.29,-31.81,;58.34,-30.28,;59.7,-29.55,;61.01,-30.37,;62.49,-29.95,;63.35,-31.22,;62.41,-32.43,;60.96,-31.91,;59.6,-32.63,;52.96,-31.61,;51.6,-32.34,;51.25,-33.77,;49.76,-33.26,;49.75,-31.23,;50.35,-29.97,;50.38,-31.89,;48.68,-32.34,;48.28,-33.78,;53.02,-30.07,;54.38,-29.36,;54.44,-27.82,;53.13,-27,;51.76,-27.73,;51.71,-29.27,)| Show InChI InChI=1S/C22H24N2O4/c25-22(26-14-16-6-7-20-21(12-16)28-15-27-20)24(18-4-2-1-3-5-18)19-13-23-10-8-17(19)9-11-23/h1-7,12,17,19H,8-11,13-15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518570 (CHEMBL4462631) Show SMILES Cc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:9:10:13.14:16.17,(39.78,-53.75,;38.42,-54.48,;38.36,-56.02,;37,-56.74,;35.7,-55.91,;34.34,-56.63,;33.03,-55.81,;31.67,-56.54,;31.62,-58.07,;30.37,-55.72,;29.01,-56.44,;28.66,-57.87,;27.17,-57.37,;27.16,-55.34,;27.76,-54.07,;27.79,-55.99,;26.09,-56.45,;25.68,-57.88,;30.42,-54.18,;31.78,-53.46,;31.84,-51.93,;30.53,-51.11,;29.17,-51.84,;29.12,-53.37,;35.75,-54.38,;37.1,-53.66,;37.15,-52.12,)| Show InChI InChI=1S/C22H25FN2O2/c1-16-7-8-17(13-20(16)23)15-27-22(26)25(19-5-3-2-4-6-19)21-14-24-11-9-18(21)10-12-24/h2-8,13,18,21H,9-12,14-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518570 (CHEMBL4462631) Show SMILES Cc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:9:10:13.14:16.17,(39.78,-53.75,;38.42,-54.48,;38.36,-56.02,;37,-56.74,;35.7,-55.91,;34.34,-56.63,;33.03,-55.81,;31.67,-56.54,;31.62,-58.07,;30.37,-55.72,;29.01,-56.44,;28.66,-57.87,;27.17,-57.37,;27.16,-55.34,;27.76,-54.07,;27.79,-55.99,;26.09,-56.45,;25.68,-57.88,;30.42,-54.18,;31.78,-53.46,;31.84,-51.93,;30.53,-51.11,;29.17,-51.84,;29.12,-53.37,;35.75,-54.38,;37.1,-53.66,;37.15,-52.12,)| Show InChI InChI=1S/C22H25FN2O2/c1-16-7-8-17(13-20(16)23)15-27-22(26)25(19-5-3-2-4-6-19)21-14-24-11-9-18(21)10-12-24/h2-8,13,18,21H,9-12,14-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518567 (CHEMBL4576768) Show SMILES O=C(OCc1ccc2OCOc2c1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:13:14:17.18:20.21,(54.21,-33.97,;54.27,-32.43,;55.63,-31.71,;56.93,-32.53,;58.29,-31.81,;58.34,-30.28,;59.7,-29.55,;61.01,-30.37,;62.49,-29.95,;63.35,-31.22,;62.41,-32.43,;60.96,-31.91,;59.6,-32.63,;52.96,-31.61,;51.6,-32.34,;51.25,-33.77,;49.76,-33.26,;49.75,-31.23,;50.35,-29.97,;50.38,-31.89,;48.68,-32.34,;48.28,-33.78,;53.02,-30.07,;54.38,-29.36,;54.44,-27.82,;53.13,-27,;51.76,-27.73,;51.71,-29.27,)| Show InChI InChI=1S/C22H24N2O4/c25-22(26-14-16-6-7-20-21(12-16)28-15-27-20)24(18-4-2-1-3-5-18)19-13-23-10-8-17(19)9-11-23/h1-7,12,17,19H,8-11,13-15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518564 (CHEMBL4473985) Show SMILES COc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:10:11:14.15:17.18,(75.72,-42.28,;74.41,-41.47,;73.05,-42.19,;72.99,-43.73,;71.63,-44.45,;70.33,-43.63,;68.97,-44.35,;67.66,-43.53,;66.3,-44.25,;66.25,-45.79,;65,-43.43,;63.64,-44.15,;63.29,-45.59,;61.8,-45.08,;61.79,-43.05,;62.39,-41.79,;62.42,-43.7,;60.72,-44.16,;60.31,-45.59,;65.05,-41.89,;66.42,-41.18,;66.47,-39.64,;65.17,-38.82,;63.8,-39.55,;63.75,-41.08,;70.38,-42.1,;71.73,-41.37,;71.79,-39.83,)| Show InChI InChI=1S/C22H25FN2O3/c1-27-21-8-7-16(13-19(21)23)15-28-22(26)25(18-5-3-2-4-6-18)20-14-24-11-9-17(20)10-12-24/h2-8,13,17,20H,9-12,14-15H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518570 (CHEMBL4462631) Show SMILES Cc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:9:10:13.14:16.17,(39.78,-53.75,;38.42,-54.48,;38.36,-56.02,;37,-56.74,;35.7,-55.91,;34.34,-56.63,;33.03,-55.81,;31.67,-56.54,;31.62,-58.07,;30.37,-55.72,;29.01,-56.44,;28.66,-57.87,;27.17,-57.37,;27.16,-55.34,;27.76,-54.07,;27.79,-55.99,;26.09,-56.45,;25.68,-57.88,;30.42,-54.18,;31.78,-53.46,;31.84,-51.93,;30.53,-51.11,;29.17,-51.84,;29.12,-53.37,;35.75,-54.38,;37.1,-53.66,;37.15,-52.12,)| Show InChI InChI=1S/C22H25FN2O2/c1-16-7-8-17(13-20(16)23)15-27-22(26)25(19-5-3-2-4-6-19)21-14-24-11-9-18(21)10-12-24/h2-8,13,18,21H,9-12,14-15H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518564 (CHEMBL4473985) Show SMILES COc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:10:11:14.15:17.18,(75.72,-42.28,;74.41,-41.47,;73.05,-42.19,;72.99,-43.73,;71.63,-44.45,;70.33,-43.63,;68.97,-44.35,;67.66,-43.53,;66.3,-44.25,;66.25,-45.79,;65,-43.43,;63.64,-44.15,;63.29,-45.59,;61.8,-45.08,;61.79,-43.05,;62.39,-41.79,;62.42,-43.7,;60.72,-44.16,;60.31,-45.59,;65.05,-41.89,;66.42,-41.18,;66.47,-39.64,;65.17,-38.82,;63.8,-39.55,;63.75,-41.08,;70.38,-42.1,;71.73,-41.37,;71.79,-39.83,)| Show InChI InChI=1S/C22H25FN2O3/c1-27-21-8-7-16(13-19(21)23)15-28-22(26)25(18-5-3-2-4-6-18)20-14-24-11-9-17(20)10-12-24/h2-8,13,17,20H,9-12,14-15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518578 (CHEMBL4580590) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC |TLB:11:12:15.16:18.19,(18.3,-9.26,;16.97,-10.03,;15.64,-9.27,;14.3,-10.04,;12.97,-9.27,;12.98,-7.73,;11.64,-6.96,;10.31,-7.73,;8.98,-6.96,;7.64,-7.73,;7.64,-9.27,;6.31,-6.96,;4.97,-7.73,;4.62,-9.16,;3.14,-8.65,;3.13,-6.62,;3.73,-5.36,;3.76,-7.28,;2.06,-7.74,;1.65,-9.17,;8.98,-5.42,;7.64,-4.65,;7.64,-3.1,;8.97,-2.33,;10.31,-3.1,;10.31,-4.65,;14.3,-6.96,;15.63,-7.72,;16.96,-6.94,;18.3,-7.71,)| Show InChI InChI=1S/C24H30N2O4/c1-28-21-9-8-18(16-22(21)29-2)10-15-26(20-6-4-3-5-7-20)24(27)30-23-17-25-13-11-19(23)12-14-25/h3-9,16,19,23H,10-15,17H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518581 (CHEMBL4446039) Show SMILES Clc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:9:10:13.14:16.17,(17.52,-43.11,;16.16,-43.84,;16.11,-45.38,;14.75,-46.1,;13.44,-45.27,;12.08,-45.99,;10.78,-45.18,;9.41,-45.9,;9.36,-47.44,;8.11,-45.08,;6.75,-45.8,;6.4,-47.23,;4.91,-46.73,;4.9,-44.7,;5.5,-43.43,;5.53,-45.35,;3.83,-45.81,;3.42,-47.24,;8.16,-43.54,;9.53,-42.82,;9.58,-41.28,;8.28,-40.46,;6.91,-41.19,;6.86,-42.73,;13.49,-43.74,;14.85,-43.02,;14.9,-41.48,)| Show InChI InChI=1S/C21H22Cl2N2O2/c22-18-7-6-15(12-19(18)23)14-27-21(26)25(17-4-2-1-3-5-17)20-13-24-10-8-16(20)9-11-24/h1-7,12,16,20H,8-11,13-14H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518569 (CHEMBL4435641) Show SMILES Clc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:11:12:15.16:18.19,(58.17,-41.63,;56.81,-42.36,;56.76,-43.9,;55.4,-44.62,;54.09,-43.79,;52.73,-44.51,;51.43,-43.7,;50.07,-44.42,;48.76,-43.6,;47.4,-44.32,;47.35,-45.86,;46.1,-43.5,;44.74,-44.22,;44.39,-45.65,;42.9,-45.15,;42.89,-43.12,;43.49,-41.86,;43.52,-43.77,;41.82,-44.23,;41.42,-45.66,;46.15,-41.96,;47.52,-41.25,;47.57,-39.71,;46.27,-38.89,;44.9,-39.62,;44.85,-41.16,;54.14,-42.26,;55.5,-41.54,;55.55,-40,)| Show InChI InChI=1S/C23H26Cl2N2O2/c24-20-9-8-17(15-21(20)25)5-4-14-29-23(28)27(19-6-2-1-3-7-19)22-16-26-12-10-18(22)11-13-26/h1-3,6-9,15,18,22H,4-5,10-14,16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518581 (CHEMBL4446039) Show SMILES Clc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:9:10:13.14:16.17,(17.52,-43.11,;16.16,-43.84,;16.11,-45.38,;14.75,-46.1,;13.44,-45.27,;12.08,-45.99,;10.78,-45.18,;9.41,-45.9,;9.36,-47.44,;8.11,-45.08,;6.75,-45.8,;6.4,-47.23,;4.91,-46.73,;4.9,-44.7,;5.5,-43.43,;5.53,-45.35,;3.83,-45.81,;3.42,-47.24,;8.16,-43.54,;9.53,-42.82,;9.58,-41.28,;8.28,-40.46,;6.91,-41.19,;6.86,-42.73,;13.49,-43.74,;14.85,-43.02,;14.9,-41.48,)| Show InChI InChI=1S/C21H22Cl2N2O2/c22-18-7-6-15(12-19(18)23)14-27-21(26)25(17-4-2-1-3-5-17)20-13-24-10-8-16(20)9-11-24/h1-7,12,16,20H,8-11,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518576 (CHEMBL4472832) Show SMILES CN1CCC(CC1)OC(=O)N(CCc1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C21H25FN2O2/c1-23-14-12-20(13-15-23)26-21(25)24(19-5-3-2-4-6-19)16-11-17-7-9-18(22)10-8-17/h2-10,20H,11-16H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518578 (CHEMBL4580590) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC |TLB:11:12:15.16:18.19,(18.3,-9.26,;16.97,-10.03,;15.64,-9.27,;14.3,-10.04,;12.97,-9.27,;12.98,-7.73,;11.64,-6.96,;10.31,-7.73,;8.98,-6.96,;7.64,-7.73,;7.64,-9.27,;6.31,-6.96,;4.97,-7.73,;4.62,-9.16,;3.14,-8.65,;3.13,-6.62,;3.73,-5.36,;3.76,-7.28,;2.06,-7.74,;1.65,-9.17,;8.98,-5.42,;7.64,-4.65,;7.64,-3.1,;8.97,-2.33,;10.31,-3.1,;10.31,-4.65,;14.3,-6.96,;15.63,-7.72,;16.96,-6.94,;18.3,-7.71,)| Show InChI InChI=1S/C24H30N2O4/c1-28-21-9-8-18(16-22(21)29-2)10-15-26(20-6-4-3-5-7-20)24(27)30-23-17-25-13-11-19(23)12-14-25/h3-9,16,19,23H,10-15,17H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	65	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518581 (CHEMBL4446039) Show SMILES Clc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:9:10:13.14:16.17,(17.52,-43.11,;16.16,-43.84,;16.11,-45.38,;14.75,-46.1,;13.44,-45.27,;12.08,-45.99,;10.78,-45.18,;9.41,-45.9,;9.36,-47.44,;8.11,-45.08,;6.75,-45.8,;6.4,-47.23,;4.91,-46.73,;4.9,-44.7,;5.5,-43.43,;5.53,-45.35,;3.83,-45.81,;3.42,-47.24,;8.16,-43.54,;9.53,-42.82,;9.58,-41.28,;8.28,-40.46,;6.91,-41.19,;6.86,-42.73,;13.49,-43.74,;14.85,-43.02,;14.9,-41.48,)| Show InChI InChI=1S/C21H22Cl2N2O2/c22-18-7-6-15(12-19(18)23)14-27-21(26)25(17-4-2-1-3-5-17)20-13-24-10-8-16(20)9-11-24/h1-7,12,16,20H,8-11,13-14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518576 (CHEMBL4472832) Show SMILES CN1CCC(CC1)OC(=O)N(CCc1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C21H25FN2O2/c1-23-14-12-20(13-15-23)26-21(25)24(19-5-3-2-4-6-19)16-11-17-7-9-18(22)10-8-17/h2-10,20H,11-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518564 (CHEMBL4473985) Show SMILES COc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:10:11:14.15:17.18,(75.72,-42.28,;74.41,-41.47,;73.05,-42.19,;72.99,-43.73,;71.63,-44.45,;70.33,-43.63,;68.97,-44.35,;67.66,-43.53,;66.3,-44.25,;66.25,-45.79,;65,-43.43,;63.64,-44.15,;63.29,-45.59,;61.8,-45.08,;61.79,-43.05,;62.39,-41.79,;62.42,-43.7,;60.72,-44.16,;60.31,-45.59,;65.05,-41.89,;66.42,-41.18,;66.47,-39.64,;65.17,-38.82,;63.8,-39.55,;63.75,-41.08,;70.38,-42.1,;71.73,-41.37,;71.79,-39.83,)| Show InChI InChI=1S/C22H25FN2O3/c1-27-21-8-7-16(13-19(21)23)15-28-22(26)25(18-5-3-2-4-6-18)20-14-24-11-9-17(20)10-12-24/h2-8,13,17,20H,9-12,14-15H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518568 (CHEMBL4451770) Show SMILES Clc1ccc(CCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:10:11:14.15:17.18,(36.39,-47.74,;35.08,-46.92,;33.72,-47.64,;32.41,-46.83,;32.48,-45.29,;31.17,-44.47,;29.81,-45.19,;28.5,-44.37,;27.14,-45.09,;27.09,-46.63,;25.84,-44.28,;24.48,-45,;24.13,-46.43,;22.64,-45.92,;22.63,-43.89,;23.23,-42.63,;23.26,-44.55,;21.56,-45,;21.16,-46.44,;25.89,-42.74,;27.26,-42.02,;27.31,-40.48,;26.01,-39.66,;24.64,-40.39,;24.59,-41.93,;33.83,-44.56,;35.13,-45.37,;36.49,-44.65,)| Show InChI InChI=1S/C22H24Cl2N2O2/c23-19-7-6-16(14-20(19)24)10-13-28-22(27)26(18-4-2-1-3-5-18)21-15-25-11-8-17(21)9-12-25/h1-7,14,17,21H,8-13,15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518582 (CHEMBL4441786) Show SMILES O=C(OCc1ccccc1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:10:11:14.15:17.18,(26.99,-23.41,;27.05,-21.87,;28.41,-21.15,;29.72,-21.97,;31.08,-21.25,;32.38,-22.07,;33.74,-21.35,;33.8,-19.81,;32.48,-18.99,;31.13,-19.72,;25.74,-21.05,;24.38,-21.78,;24.03,-23.21,;22.55,-22.7,;22.54,-20.67,;23.14,-19.41,;23.17,-21.32,;21.46,-21.78,;21.06,-23.22,;25.8,-19.51,;27.16,-18.8,;27.22,-17.26,;25.91,-16.44,;24.55,-17.17,;24.5,-18.71,)| Show InChI InChI=1S/C21H24N2O2/c24-21(25-16-17-7-3-1-4-8-17)23(19-9-5-2-6-10-19)20-15-22-13-11-18(20)12-14-22/h1-10,18,20H,11-16H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518578 (CHEMBL4580590) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1OC |TLB:11:12:15.16:18.19,(18.3,-9.26,;16.97,-10.03,;15.64,-9.27,;14.3,-10.04,;12.97,-9.27,;12.98,-7.73,;11.64,-6.96,;10.31,-7.73,;8.98,-6.96,;7.64,-7.73,;7.64,-9.27,;6.31,-6.96,;4.97,-7.73,;4.62,-9.16,;3.14,-8.65,;3.13,-6.62,;3.73,-5.36,;3.76,-7.28,;2.06,-7.74,;1.65,-9.17,;8.98,-5.42,;7.64,-4.65,;7.64,-3.1,;8.97,-2.33,;10.31,-3.1,;10.31,-4.65,;14.3,-6.96,;15.63,-7.72,;16.96,-6.94,;18.3,-7.71,)| Show InChI InChI=1S/C24H30N2O4/c1-28-21-9-8-18(16-22(21)29-2)10-15-26(20-6-4-3-5-7-20)24(27)30-23-17-25-13-11-19(23)12-14-25/h3-9,16,19,23H,10-15,17H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518556 (CHEMBL4577453) Show SMILES Fc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:11:12:15.16:18.19,(80.95,-52.51,;79.59,-53.23,;79.54,-54.77,;78.18,-55.49,;76.88,-54.66,;75.51,-55.39,;74.21,-54.57,;72.85,-55.29,;71.54,-54.47,;70.18,-55.19,;70.13,-56.73,;68.88,-54.38,;67.52,-55.1,;67.17,-56.53,;65.68,-56.02,;65.67,-53.99,;66.27,-52.73,;66.3,-54.65,;64.6,-55.1,;64.2,-56.54,;68.93,-52.84,;70.3,-52.12,;70.35,-50.58,;69.05,-49.76,;67.68,-50.49,;67.63,-52.03,;76.92,-53.14,;78.28,-52.41,;78.33,-50.87,)| Show InChI InChI=1S/C23H26F2N2O2/c24-20-9-8-17(15-21(20)25)5-4-14-29-23(28)27(19-6-2-1-3-7-19)22-16-26-12-10-18(22)11-13-26/h1-3,6-9,15,18,22H,4-5,10-14,16H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518564 (CHEMBL4473985) Show SMILES COc1ccc(COC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:10:11:14.15:17.18,(75.72,-42.28,;74.41,-41.47,;73.05,-42.19,;72.99,-43.73,;71.63,-44.45,;70.33,-43.63,;68.97,-44.35,;67.66,-43.53,;66.3,-44.25,;66.25,-45.79,;65,-43.43,;63.64,-44.15,;63.29,-45.59,;61.8,-45.08,;61.79,-43.05,;62.39,-41.79,;62.42,-43.7,;60.72,-44.16,;60.31,-45.59,;65.05,-41.89,;66.42,-41.18,;66.47,-39.64,;65.17,-38.82,;63.8,-39.55,;63.75,-41.08,;70.38,-42.1,;71.73,-41.37,;71.79,-39.83,)| Show InChI InChI=1S/C22H25FN2O3/c1-27-21-8-7-16(13-19(21)23)15-28-22(26)25(18-5-3-2-4-6-18)20-14-24-11-9-17(20)10-12-24/h2-8,13,17,20H,9-12,14-15H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518577 (CHEMBL4448667) Show SMILES CN1CCCC(C1)OC(=O)N(CCc1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C21H25FN2O2/c1-23-14-5-8-20(16-23)26-21(25)24(19-6-3-2-4-7-19)15-13-17-9-11-18(22)12-10-17/h2-4,6-7,9-12,20H,5,8,13-16H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518582 (CHEMBL4441786) Show SMILES O=C(OCc1ccccc1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:10:11:14.15:17.18,(26.99,-23.41,;27.05,-21.87,;28.41,-21.15,;29.72,-21.97,;31.08,-21.25,;32.38,-22.07,;33.74,-21.35,;33.8,-19.81,;32.48,-18.99,;31.13,-19.72,;25.74,-21.05,;24.38,-21.78,;24.03,-23.21,;22.55,-22.7,;22.54,-20.67,;23.14,-19.41,;23.17,-21.32,;21.46,-21.78,;21.06,-23.22,;25.8,-19.51,;27.16,-18.8,;27.22,-17.26,;25.91,-16.44,;24.55,-17.17,;24.5,-18.71,)| Show InChI InChI=1S/C21H24N2O2/c24-21(25-16-17-7-3-1-4-8-17)23(19-9-5-2-6-10-19)20-15-22-13-11-18(20)12-14-22/h1-10,18,20H,11-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518571 (CHEMBL4541518) Show SMILES Cc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:11:12:15.16:18.19,(59.84,-52.87,;58.48,-53.59,;58.42,-55.13,;57.06,-55.85,;55.76,-55.03,;54.4,-55.75,;53.1,-54.93,;51.74,-55.65,;50.43,-54.83,;49.07,-55.55,;49.01,-57.09,;47.76,-54.74,;46.4,-55.46,;46.05,-56.89,;44.57,-56.38,;44.56,-54.35,;45.16,-53.09,;45.19,-55.01,;43.49,-55.47,;43.08,-56.9,;47.82,-53.2,;49.18,-52.48,;49.24,-50.94,;47.93,-50.13,;46.57,-50.85,;46.52,-52.39,;55.81,-53.5,;57.17,-52.77,;57.22,-51.23,)| Show InChI InChI=1S/C24H29FN2O2/c1-18-9-10-19(16-22(18)25)6-5-15-29-24(28)27(21-7-3-2-4-8-21)23-17-26-13-11-20(23)12-14-26/h2-4,7-10,16,20,23H,5-6,11-15,17H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518571 (CHEMBL4541518) Show SMILES Cc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:11:12:15.16:18.19,(59.84,-52.87,;58.48,-53.59,;58.42,-55.13,;57.06,-55.85,;55.76,-55.03,;54.4,-55.75,;53.1,-54.93,;51.74,-55.65,;50.43,-54.83,;49.07,-55.55,;49.01,-57.09,;47.76,-54.74,;46.4,-55.46,;46.05,-56.89,;44.57,-56.38,;44.56,-54.35,;45.16,-53.09,;45.19,-55.01,;43.49,-55.47,;43.08,-56.9,;47.82,-53.2,;49.18,-52.48,;49.24,-50.94,;47.93,-50.13,;46.57,-50.85,;46.52,-52.39,;55.81,-53.5,;57.17,-52.77,;57.22,-51.23,)| Show InChI InChI=1S/C24H29FN2O2/c1-18-9-10-19(16-22(18)25)6-5-15-29-24(28)27(21-7-3-2-4-8-21)23-17-26-13-11-20(23)12-14-26/h2-4,7-10,16,20,23H,5-6,11-15,17H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518569 (CHEMBL4435641) Show SMILES Clc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:11:12:15.16:18.19,(58.17,-41.63,;56.81,-42.36,;56.76,-43.9,;55.4,-44.62,;54.09,-43.79,;52.73,-44.51,;51.43,-43.7,;50.07,-44.42,;48.76,-43.6,;47.4,-44.32,;47.35,-45.86,;46.1,-43.5,;44.74,-44.22,;44.39,-45.65,;42.9,-45.15,;42.89,-43.12,;43.49,-41.86,;43.52,-43.77,;41.82,-44.23,;41.42,-45.66,;46.15,-41.96,;47.52,-41.25,;47.57,-39.71,;46.27,-38.89,;44.9,-39.62,;44.85,-41.16,;54.14,-42.26,;55.5,-41.54,;55.55,-40,)| Show InChI InChI=1S/C23H26Cl2N2O2/c24-20-9-8-17(15-21(20)25)5-4-14-29-23(28)27(19-6-2-1-3-7-19)22-16-26-12-10-18(22)11-13-26/h1-3,6-9,15,18,22H,4-5,10-14,16H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50518559 (CHEMBL4585326) Show SMILES COc1ccc(CCN(C(=O)OC2CN3CCC2CC3)c2ccccc2)cc1 |TLB:11:12:15.16:18.19,(19.07,-20.84,;17.73,-21.62,;16.4,-20.85,;15.06,-21.62,;13.73,-20.85,;13.74,-19.31,;12.4,-18.54,;11.07,-19.31,;9.74,-18.54,;8.4,-19.31,;8.4,-20.85,;7.07,-18.54,;5.74,-19.31,;5.39,-20.74,;3.9,-20.23,;3.89,-18.2,;4.49,-16.94,;4.52,-18.86,;2.82,-19.32,;2.41,-20.75,;9.74,-17,;8.4,-16.23,;8.41,-14.68,;9.73,-13.91,;11.07,-14.68,;11.07,-16.23,;15.06,-18.54,;16.39,-19.3,)| Show InChI InChI=1S/C23H28N2O3/c1-27-21-9-7-18(8-10-21)11-16-25(20-5-3-2-4-6-20)23(26)28-22-17-24-14-12-19(22)13-15-24/h2-10,19,22H,11-17H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M2 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50518576 (CHEMBL4472832) Show SMILES CN1CCC(CC1)OC(=O)N(CCc1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C21H25FN2O2/c1-23-14-12-20(13-15-23)26-21(25)24(19-5-3-2-4-6-19)16-11-17-7-9-18(22)10-8-17/h2-10,20H,11-16H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M3 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518577 (CHEMBL4448667) Show SMILES CN1CCCC(C1)OC(=O)N(CCc1ccc(F)cc1)c1ccccc1 Show InChI InChI=1S/C21H25FN2O2/c1-23-14-5-8-20(16-23)26-21(25)24(19-6-3-2-4-7-19)15-13-17-9-11-18(22)12-10-17/h2-4,6-7,9-12,20H,5,8,13-16H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518582 (CHEMBL4441786) Show SMILES O=C(OCc1ccccc1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:10:11:14.15:17.18,(26.99,-23.41,;27.05,-21.87,;28.41,-21.15,;29.72,-21.97,;31.08,-21.25,;32.38,-22.07,;33.74,-21.35,;33.8,-19.81,;32.48,-18.99,;31.13,-19.72,;25.74,-21.05,;24.38,-21.78,;24.03,-23.21,;22.55,-22.7,;22.54,-20.67,;23.14,-19.41,;23.17,-21.32,;21.46,-21.78,;21.06,-23.22,;25.8,-19.51,;27.16,-18.8,;27.22,-17.26,;25.91,-16.44,;24.55,-17.17,;24.5,-18.71,)| Show InChI InChI=1S/C21H24N2O2/c24-21(25-16-17-7-3-1-4-8-17)23(19-9-5-2-6-10-19)20-15-22-13-11-18(20)12-14-22/h1-10,18,20H,11-16H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518569 (CHEMBL4435641) Show SMILES Clc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1Cl |TLB:11:12:15.16:18.19,(58.17,-41.63,;56.81,-42.36,;56.76,-43.9,;55.4,-44.62,;54.09,-43.79,;52.73,-44.51,;51.43,-43.7,;50.07,-44.42,;48.76,-43.6,;47.4,-44.32,;47.35,-45.86,;46.1,-43.5,;44.74,-44.22,;44.39,-45.65,;42.9,-45.15,;42.89,-43.12,;43.49,-41.86,;43.52,-43.77,;41.82,-44.23,;41.42,-45.66,;46.15,-41.96,;47.52,-41.25,;47.57,-39.71,;46.27,-38.89,;44.9,-39.62,;44.85,-41.16,;54.14,-42.26,;55.5,-41.54,;55.55,-40,)| Show InChI InChI=1S/C23H26Cl2N2O2/c24-20-9-8-17(15-21(20)25)5-4-14-29-23(28)27(19-6-2-1-3-7-19)22-16-26-12-10-18(22)11-13-26/h1-3,6-9,15,18,22H,4-5,10-14,16H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518582 (CHEMBL4441786) Show SMILES O=C(OCc1ccccc1)N(C1CN2CCC1CC2)c1ccccc1 |TLB:10:11:14.15:17.18,(26.99,-23.41,;27.05,-21.87,;28.41,-21.15,;29.72,-21.97,;31.08,-21.25,;32.38,-22.07,;33.74,-21.35,;33.8,-19.81,;32.48,-18.99,;31.13,-19.72,;25.74,-21.05,;24.38,-21.78,;24.03,-23.21,;22.55,-22.7,;22.54,-20.67,;23.14,-19.41,;23.17,-21.32,;21.46,-21.78,;21.06,-23.22,;25.8,-19.51,;27.16,-18.8,;27.22,-17.26,;25.91,-16.44,;24.55,-17.17,;24.5,-18.71,)| Show InChI InChI=1S/C21H24N2O2/c24-21(25-16-17-7-3-1-4-8-17)23(19-9-5-2-6-10-19)20-15-22-13-11-18(20)12-14-22/h1-10,18,20H,11-16H2	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human))	BDBM50518574 (CHEMBL4456775) Show SMILES COc1ccc(CCN(C(=O)OC2CCN(C)CC2)c2ccccc2)cc1 Show InChI InChI=1S/C22H28N2O3/c1-23-15-13-21(14-16-23)27-22(25)24(19-6-4-3-5-7-19)17-12-18-8-10-20(26-2)11-9-18/h3-11,21H,12-17H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M5 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50518571 (CHEMBL4541518) Show SMILES Cc1ccc(CCCOC(=O)N(C2CN3CCC2CC3)c2ccccc2)cc1F |TLB:11:12:15.16:18.19,(59.84,-52.87,;58.48,-53.59,;58.42,-55.13,;57.06,-55.85,;55.76,-55.03,;54.4,-55.75,;53.1,-54.93,;51.74,-55.65,;50.43,-54.83,;49.07,-55.55,;49.01,-57.09,;47.76,-54.74,;46.4,-55.46,;46.05,-56.89,;44.57,-56.38,;44.56,-54.35,;45.16,-53.09,;45.19,-55.01,;43.49,-55.47,;43.08,-56.9,;47.82,-53.2,;49.18,-52.48,;49.24,-50.94,;47.93,-50.13,;46.57,-50.85,;46.52,-52.39,;55.81,-53.5,;57.17,-52.77,;57.22,-51.23,)| Show InChI InChI=1S/C24H29FN2O2/c1-18-9-10-19(16-22(18)25)6-5-15-29-24(28)27(21-7-3-2-4-8-21)23-17-26-13-11-20(23)12-14-26/h2-4,7-10,16,20,23H,5-6,11-15,17H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kentucky Curated by ChEMBL					Assay Description Displacement of [3H]NMS from human M1 AChR expressed in CHO cell membranes after 1 to 2 hrs by liquid scintillation spectrometry method				Bioorg Med Chem Lett 29: 471-476 (2019) Article DOI: 10.1016/j.bmcl.2018.12.022 BindingDB Entry DOI: 10.7270/Q2NP27SC
					More data for this Ligand-Target Pair

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