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Compile Data Set for Download or QSAR

Found 83 hits Enz. Inhib. hit(s) with all data for entry = 50009407   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528533
PNG
(CHEMBL4558430)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528542
PNG
(CHEMBL4472004)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528538
PNG
(CHEMBL4541139)
Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528539
PNG
(CHEMBL4553037)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528541
PNG
(CHEMBL4437631)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528528
PNG
(CHEMBL4441609)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528533
PNG
(CHEMBL4558430)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528539
PNG
(CHEMBL4553037)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528539
PNG
(CHEMBL4553037)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528535
PNG
(CHEMBL4472914)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528535
PNG
(CHEMBL4472914)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528539
PNG
(CHEMBL4553037)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528536
PNG
(CHEMBL4560079)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)-n1cnc(C)c1)C1CCCCC1)c1cncnc1 |r|
Show InChI InChI=1S/C31H34N6O/c1-21-18-37(20-34-21)29-14-26(22-6-4-3-5-7-22)11-27(15-29)35-31(38)24-9-8-23-12-28(13-25(23)10-24)36(2)30-16-32-19-33-17-30/h8-11,14-20,22,28H,3-7,12-13H2,1-2H3,(H,35,38)/t28-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528542
PNG
(CHEMBL4472004)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528528
PNG
(CHEMBL4441609)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528537
PNG
(CHEMBL4570381)
Show SMILES CCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C27H25F3N6O/c1-3-36(25-12-31-15-32-13-25)24-7-18-4-5-19(6-20(18)8-24)26(37)34-22-9-21(27(28,29)30)10-23(11-22)35-14-17(2)33-16-35/h4-6,9-16,24H,3,7-8H2,1-2H3,(H,34,37)/t24-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528542
PNG
(CHEMBL4472004)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528542
PNG
(CHEMBL4472004)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1
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n/an/a 174n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528528
PNG
(CHEMBL4441609)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1
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n/an/a 207n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528528
PNG
(CHEMBL4441609)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1
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n/an/a 215n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528542
PNG
(CHEMBL4472004)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C29H32N6O/c1-19-16-35(18-32-19)26-12-23(29(2,3)4)11-24(13-26)33-28(36)21-7-6-20-9-25(10-22(20)8-21)34(5)27-14-30-17-31-15-27/h6-8,11-18,25H,9-10H2,1-5H3,(H,33,36)/t25-/m1/s1
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n/an/a 271n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528537
PNG
(CHEMBL4570381)
Show SMILES CCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C27H25F3N6O/c1-3-36(25-12-31-15-32-13-25)24-7-18-4-5-19(6-20(18)8-24)26(37)34-22-9-21(27(28,29)30)10-23(11-22)35-14-17(2)33-16-35/h4-6,9-16,24H,3,7-8H2,1-2H3,(H,34,37)/t24-/m1/s1
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n/an/a 278n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528528
PNG
(CHEMBL4441609)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C28H30N6O/c1-18(2)22-8-24(12-26(10-22)34-15-19(3)31-17-34)32-28(35)21-6-5-20-9-25(11-23(20)7-21)33(4)27-13-29-16-30-14-27/h5-8,10,12-18,25H,9,11H2,1-4H3,(H,32,35)/t25-/m1/s1
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n/an/a 326n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528539
PNG
(CHEMBL4553037)
Show SMILES C[C@H]1CN(Cc2cc(ccc12)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-11-34(23-9-30-14-31-10-23)13-19-5-18(3-4-24(16)19)25(36)33-21-6-20(26(27,28)29)7-22(8-21)35-12-17(2)32-15-35/h3-10,12,14-16H,11,13H2,1-2H3,(H,33,36)/t16-/m0/s1
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n/an/a 341n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528535
PNG
(CHEMBL4472914)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1
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n/an/a 344n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528538
PNG
(CHEMBL4541139)
Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1
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n/an/a 364n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528535
PNG
(CHEMBL4472914)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1
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n/an/a 366n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528537
PNG
(CHEMBL4570381)
Show SMILES CCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C27H25F3N6O/c1-3-36(25-12-31-15-32-13-25)24-7-18-4-5-19(6-20(18)8-24)26(37)34-22-9-21(27(28,29)30)10-23(11-22)35-14-17(2)33-16-35/h4-6,9-16,24H,3,7-8H2,1-2H3,(H,34,37)/t24-/m1/s1
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n/an/a 398n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528538
PNG
(CHEMBL4541139)
Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528538
PNG
(CHEMBL4541139)
Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1
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n/an/a 467n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528537
PNG
(CHEMBL4570381)
Show SMILES CCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C27H25F3N6O/c1-3-36(25-12-31-15-32-13-25)24-7-18-4-5-19(6-20(18)8-24)26(37)34-22-9-21(27(28,29)30)10-23(11-22)35-14-17(2)33-16-35/h4-6,9-16,24H,3,7-8H2,1-2H3,(H,34,37)/t24-/m1/s1
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n/an/a 569n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528535
PNG
(CHEMBL4472914)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m0/s1
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n/an/a 634n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528534
PNG
(CHEMBL4585974)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(C)cc(c1)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H26N6O/c1-17-6-22(11-24(7-17)32-14-18(2)29-16-32)30-26(33)20-5-4-19-9-23(10-21(19)8-20)31(3)25-12-27-15-28-13-25/h4-8,11-16,23H,9-10H2,1-3H3,(H,30,33)/t23-/m1/s1
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n/an/a 639n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1


(Homo sapiens (Human))		BDBM50528529
PNG
(CHEMBL4443543)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3CC(C)(Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-7-20(26(27,28)29)6-21(8-23)33-24(36)17-3-4-18-9-25(2,10-19(18)5-17)34-22-11-30-14-31-12-22/h3-8,11-15,34H,9-10H2,1-2H3,(H,33,36)
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n/an/a 723n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528541
PNG
(CHEMBL4437631)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1
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n/an/a 790n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of human TrkC

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528541
PNG
(CHEMBL4437631)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1
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n/an/a 790n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528541
PNG
(CHEMBL4437631)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1
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n/an/a 933n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
Discoidin domain-containing receptor 2


(Homo sapiens (Human))		BDBM50528541
PNG
(CHEMBL4437631)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-9-20(26(27,28)29)8-21(10-23)33-25(36)18-4-3-17-6-22(7-19(17)5-18)34(2)24-11-30-14-31-12-24/h3-5,8-15,22H,6-7H2,1-2H3,(H,33,36)/t22-/m1/s1
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n/an/a 933n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of human DDR2

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528536
PNG
(CHEMBL4560079)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)-n1cnc(C)c1)C1CCCCC1)c1cncnc1 |r|
Show InChI InChI=1S/C31H34N6O/c1-21-18-37(20-34-21)29-14-26(22-6-4-3-5-7-22)11-27(15-29)35-31(38)24-9-8-23-12-28(13-25(23)10-24)36(2)30-16-32-19-33-17-30/h8-11,14-20,22,28H,3-7,12-13H2,1-2H3,(H,35,38)/t28-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50528532
PNG
(CHEMBL4574620)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C12CC3CC(CC(C3)C1)C2)-n1cnc(C)c1)c1cncnc1 |r,TLB:18:20:23:27.25.26,THB:25:24:21:27.26.28,25:26:23.24.29:21,28:26:23:29.20.21,28:20:23:27.25.26|
Show InChI InChI=1S/C35H38N6O/c1-22-19-41(21-38-22)32-12-29(35-14-23-5-24(15-35)7-25(6-23)16-35)11-30(13-32)39-34(42)27-4-3-26-9-31(10-28(26)8-27)40(2)33-17-36-20-37-18-33/h3-4,8,11-13,17-21,23-25,31H,5-7,9-10,14-16H2,1-2H3,(H,39,42)/t23?,24?,25?,31-,35?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528540
PNG
(CHEMBL4482862)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3CN(Cc3c2)c2cncnc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19F3N6O/c1-15-10-33(14-30-15)21-6-19(24(25,26)27)5-20(7-21)31-23(34)16-2-3-17-11-32(12-18(17)4-16)22-8-28-13-29-9-22/h2-10,13-14H,11-12H2,1H3,(H,31,34)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528529
PNG
(CHEMBL4443543)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3CC(C)(Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N6O/c1-16-13-35(15-32-16)23-7-20(26(27,28)29)6-21(8-23)33-24(36)17-3-4-18-9-25(2,10-19(18)5-17)34-22-11-30-14-31-12-22/h3-8,11-15,34H,9-10H2,1-2H3,(H,33,36)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528530
PNG
(CHEMBL4470262)
Show SMILES CCCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C28H27F3N6O/c1-3-6-37(26-13-32-16-33-14-26)25-8-19-4-5-20(7-21(19)9-25)27(38)35-23-10-22(28(29,30)31)11-24(12-23)36-15-18(2)34-17-36/h4-5,7,10-17,25H,3,6,8-9H2,1-2H3,(H,35,38)/t25-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528538
PNG
(CHEMBL4541139)
Show SMILES CCc1cc(NC(=O)c2ccc3C[C@H](Cc3c2)N(C)c2cncnc2)cc(c1)-n1cnc(C)c1 |r|
Show InChI InChI=1S/C27H28N6O/c1-4-19-7-23(12-25(8-19)33-15-18(2)30-17-33)31-27(34)21-6-5-20-10-24(11-22(20)9-21)32(3)26-13-28-16-29-14-26/h5-9,12-17,24H,4,10-11H2,1-3H3,(H,31,34)/t24-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528536
PNG
(CHEMBL4560079)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)-n1cnc(C)c1)C1CCCCC1)c1cncnc1 |r|
Show InChI InChI=1S/C31H34N6O/c1-21-18-37(20-34-21)29-14-26(22-6-4-3-5-7-22)11-27(15-29)35-31(38)24-9-8-23-12-28(13-25(23)10-24)36(2)30-16-32-19-33-17-30/h8-11,14-20,22,28H,3-7,12-13H2,1-2H3,(H,35,38)/t28-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM50528532
PNG
(CHEMBL4574620)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C12CC3CC(CC(C3)C1)C2)-n1cnc(C)c1)c1cncnc1 |r,TLB:18:20:23:27.25.26,THB:25:24:21:27.26.28,25:26:23.24.29:21,28:26:23:29.20.21,28:20:23:27.25.26|
Show InChI InChI=1S/C35H38N6O/c1-22-19-41(21-38-22)32-12-29(35-14-23-5-24(15-35)7-25(6-23)16-35)11-30(13-32)39-34(42)27-4-3-26-9-31(10-28(26)8-27)40(2)33-17-36-20-37-18-33/h3-4,8,11-13,17-21,23-25,31H,5-7,9-10,14-16H2,1-2H3,(H,39,42)/t23?,24?,25?,31-,35?/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528531
PNG
(CHEMBL4568103)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3CN(Cc4cncnc4)Cc3c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C25H21F3N6O/c1-16-10-34(15-31-16)23-6-21(25(26,27)28)5-22(7-23)32-24(35)18-2-3-19-12-33(13-20(19)4-18)11-17-8-29-14-30-9-17/h2-10,14-15H,11-13H2,1H3,(H,32,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528533
PNG
(CHEMBL4558430)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc3C[C@H](Cc3c2)Nc2cncnc2)cc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N6O/c1-15-12-34(14-31-15)23-8-19(25(26,27)28)7-21(9-23)33-24(35)17-3-2-16-5-20(6-18(16)4-17)32-22-10-29-13-30-11-22/h2-4,7-14,20,32H,5-6H2,1H3,(H,33,35)/t20-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528530
PNG
(CHEMBL4470262)
Show SMILES CCCN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(F)(F)F)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C28H27F3N6O/c1-3-6-37(26-13-32-16-33-14-26)25-8-19-4-5-20(7-21(19)9-25)27(38)35-23-10-22(28(29,30)31)11-24(12-23)36-15-18(2)34-17-36/h4-5,7,10-17,25H,3,6,8-9H2,1-2H3,(H,35,38)/t25-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
NT-3 growth factor receptor


(Homo sapiens (Human))		BDBM50528534
PNG
(CHEMBL4585974)
Show SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(C)cc(c1)-n1cnc(C)c1)c1cncnc1 |r|
Show InChI InChI=1S/C26H26N6O/c1-17-6-22(11-24(7-17)32-14-18(2)29-16-32)30-26(33)20-5-4-19-9-23(10-21(19)8-20)31(3)25-12-27-15-28-13-25/h4-8,11-16,23H,9-10H2,1-3H3,(H,30,33)/t23-/m1/s1
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Jinan University

Curated by ChEMBL


Assay Description
Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...

J Med Chem 62: 7431-7444 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00365
BindingDB Entry DOI: 10.7270/Q2DZ0CSV
More data for this
Ligand-Target Pair
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