Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544867 (CHEMBL4642696) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544868 (CHEMBL4644765) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544865 (CHEMBL4638971 | US11292781, Compound T145) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544864 (CHEMBL4646395 | US11292781, Compound T169) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C285S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as inhibition of T cell to Th17 differentiation by flow cytometry | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at human full-length RORgammaT expressed in Jurkat cells co-transfected with 5 copies of ROR response element after 18 hrs b... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C345S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544862 (CHEMBL4645611 | US11292781, Compound T83) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544874 (CHEMBL4642370) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C320S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C455S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C345S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at wild type full-length human RORgammat co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C285S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at wild type full-length human RORgammat co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C366S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C278S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C320A mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544860 (CHEMBL4633864 | US11292781, Compound T56) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544863 (CHEMBL4638990 | US11292781, Compound T147) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C278S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544859 (CHEMBL4633131 | US11292781, Compound T51) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C393S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C366S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544868 (CHEMBL4644765) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C455S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C320S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544860 (CHEMBL4633864 | US11292781, Compound T56) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544859 (CHEMBL4633131 | US11292781, Compound T51) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C393S mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544861 (CHEMBL4634962 | US11292781, Compound T50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at human full-length RORgammaT expressed in Jurkat cells co-transfected with 5 copies of ROR response element after 18 hrs b... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at full-length human RORgammat C320A mutant co-transfected with ROR response element by luciferase based reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544855 (CHEMBL4633488 | US11292781, Compound T14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544871 (CHEMBL4647788 | US11292781, Compound T182) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544865 (CHEMBL4638971 | US11292781, Compound T145) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544862 (CHEMBL4645611 | US11292781, Compound T83) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544855 (CHEMBL4633488 | US11292781, Compound T14) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544871 (CHEMBL4647788 | US11292781, Compound T182) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544866 (CHEMBL4643904 | US11292781, Compound T146) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544856 (CHEMBL4640000 | US11292781, Compound T92) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544867 (CHEMBL4642696) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544873 (CHEMBL4639568 | US11292781, Compound T184) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 107 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544857 (CHEMBL4636596 | US11292781, Compound T139) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544870 (CHEMBL4642829 | US11292781, Compound T174) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544851 (CHEMBL4647611 | US11292781, Compound T29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544854 (CHEMBL4646412 | US11292781, Compound T36) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 132 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.126967 BindingDB Entry DOI: 10.7270/Q23X8B6Q | |||||||||||
More data for this Ligand-Target Pair |
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