| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM50544866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1993919 (CHEMBL4627814) |
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| IC50 | 28±n/a nM |
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| Citation |  Jiang, X; Dulubova, I; Reisman, SA; Hotema, M; Lee, CI; Liu, L; McCauley, L; Trevino, I; Ferguson, DA; Eken, Y; Wilson, AK; Wigley, WC; Visnick, M A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor ROR?t. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM50544866 |
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| n/a |
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| Name | BDBM50544866 |
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| Synonyms: | CHEMBL4643904 | US11292781, Compound T146 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29FN4O |
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| Mol. Mass. | 492.5866 |
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| SMILES | [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2CCC)-c1ccnc(c1)C1CC1)-c1ccccc1F |r,t:14| |
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| Structure | 
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