Compile Data Set for Download or QSAR

Found 70 hits Enz. Inhib. hit(s) with all data for entry = 50011296   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50131550 ((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...) Show SMILES NC(=O)[C@H](Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)Cc1ccc(cc1)C(F)(F)P(O)(O)=O |r| Show InChI InChI=1S/C23H25F4N3O11P2/c24-22(25,42(36,37)38)14-5-1-12(2-6-14)9-16(20(28)34)30-21(35)17(11-19(32)33)29-18(31)10-13-3-7-15(8-4-13)23(26,27)43(39,40)41/h1-8,16-17H,9-11H2,(H2,28,34)(H,29,31)(H,30,35)(H,32,33)(H2,36,37,38)(H2,39,40,41)/t16-,17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli using p-nitrophenyl phosphate as substrate by spec...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair				3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM484440 (US10934285, Example 24) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)c(N)n1 |r| Show InChI InChI=1S/C28H33ClN8O3S/c29-22-16(33-24(38)21-25(39)35-19-8-1-2-12-37(19)27(21)40)5-3-6-17(22)41-26-23(31)34-20(15-32-26)36-13-10-28(11-14-36)9-4-7-18(28)30/h3,5-6,15,18,39H,1-2,4,7-14,30H2,(H2,31,34)(H,33,38)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546219 (CHEMBL4752026 | US11596633, Compound B | US1170239...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [H2N-LN(pY)AQLWHA(PEG8)LTI(pY)ATIRRF-amide]-activated N-terminal His6-fused human full length SHP2 (Met 1 to Arg 593 residue...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546222 (CHEMBL4752599) Show SMILES N[C@@H]1c2ccncc2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546217 (CHEMBL4798989) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)n(-c3ccc(Oc4ccn(C)n4)c(Cl)c3Cl)c(=O)c2C)[C@@H]1N |r,wD:34.39,1.0,(46.21,-15.08,;44.72,-15.48,;44.17,-16.91,;42.63,-16.83,;42.24,-15.35,;40.9,-16.1,;39.58,-15.33,;39.58,-13.79,;40.91,-13.02,;42.25,-13.8,;38.25,-13.02,;36.92,-13.78,;35.59,-13.02,;34.26,-13.79,;35.59,-11.48,;34.26,-10.72,;32.94,-11.49,;31.6,-10.73,;31.59,-9.18,;30.25,-8.42,;30.25,-6.88,;28.99,-5.99,;29.46,-4.52,;31,-4.51,;31.9,-3.26,;31.49,-5.98,;32.92,-8.41,;32.92,-6.87,;34.26,-9.18,;35.59,-8.4,;36.92,-10.7,;36.92,-9.16,;38.25,-11.48,;39.59,-10.71,;43.53,-14.51,;43.61,-12.97,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SHP2 E76K mutant expressed in Escherichia coli using DiFMUP as substrate preincubated for 30 mins followed by substrate addition ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546218 (CHEMBL4741490 | US11466016, Example 114) Show SMILES [H][C@]12CC[C@]([H])([C@@H](F)[C@@H](N)C1)N2c1nc2[nH]nc(-c3ccc4ncsc4c3Cl)c2nc1CO |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 mins in presence of activating peptide [IRSl_pY1172(dPEG...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM484836 (US10934302, Example 87) Show SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 |r| Show InChI InChI=1S/C22H24ClN7S/c23-17-15(5-8-27-19(17)25)31-21-20(26)29-16(12-28-21)30-9-6-22(7-10-30)11-13-3-1-2-4-14(13)18(22)24/h1-5,8,12,18H,6-7,9-11,24H2,(H2,25,27)(H2,26,29)/t18-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Protein phosphatase 1D (Homo sapiens (Human))	BDBM50118478 (CHEMBL3613749) Show SMILES Cc1ncc(Cl)cc1NCc1ccc(s1)C(=O)N[C@@H](CC1CCCC1)C(=O)NC1CC1 |r| Show InChI InChI=1S/C23H29ClN4O2S/c1-14-19(11-16(24)12-25-14)26-13-18-8-9-21(31-18)23(30)28-20(10-15-4-2-3-5-15)22(29)27-17-6-7-17/h8-9,11-12,15,17,20,26H,2-7,10,13H2,1H3,(H,27,29)(H,28,30)/t20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of human Wip1 (2 to 420 residues) expressed in baculovirus infected sf9 cells using FDP as substrate by fluorescence method				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546221 (CHEMBL4752704) Show SMILES N[C@@H]1c2cnccc2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546220 (CHEMBL4761760) Show SMILES N[C@@H]1Cc2ccccc2C11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM474104 (1'-(6-amino-5-((2-amino-3-chloropyridin- 4-yl)thio...) Show SMILES NC1C2CC2CC11CCN(CC1)c1cnc(Sc2ccnc(N)c2Cl)c(N)n1 Show InChI InChI=1S/C19H24ClN7S/c20-14-12(1-4-24-16(14)22)28-18-17(23)26-13(9-25-18)27-5-2-19(3-6-27)8-10-7-11(10)15(19)21/h1,4,9-11,15H,2-3,5-8,21H2,(H2,22,24)(H2,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of dPEG8 peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 followed by substrate addition a...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM408034 (US10336774, Example 3) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1 |r| Show InChI InChI=1S/C19H23Cl2N5S/c20-12-3-1-4-13(16(12)21)27-18-17(23)25-15(11-24-18)26-9-7-19(8-10-26)6-2-5-14(19)22/h1,3-4,11,14H,2,5-10,22H2,(H2,23,25)/t14-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546214 (CHEMBL4762331) Show SMILES CC1(N)CCN(CC1)c1cnc2c(n[nH]c2c1)-c1cccc(Cl)c1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of full length N-terminal His6-tagged human SHP2 (2 to 593 residues) expressed in Escherichia coli using DiFMUP as substrate in...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546215 (CHEMBL4757856) Show SMILES CC1(N)CCN(CC1)c1nc2sc(nn2c1CO)-c1cccc(Cl)c1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of full length N-terminal His6-tagged human SHP2 (2 to 593 residues) expressed in Escherichia coli using DiFMUP as substrate in...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546219 (CHEMBL4752026 | US11596633, Compound B | US1170239...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of SHP2 in human PC9 cells assessed as reduction in oncogenic EGFR exon19del-driven ERK1/ERK2 phosphorylation at Thr202/Tyr204 ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546224 (CHEMBL4746963 | US11739093, Compound 2) Show SMILES Cc1nc(N2CCC3(CCC[C@H]3N)CC2)c2cncn2c1-c1cccc(Cl)c1Cl |r,wD:11.12,(9.5,-35.4,;9.5,-36.94,;10.84,-37.71,;10.84,-39.26,;12.18,-40.03,;12.17,-41.57,;13.5,-42.34,;14.84,-41.58,;15.24,-43.06,;16.78,-43.14,;17.33,-41.71,;16.13,-40.74,;16.22,-39.2,;14.84,-40.03,;13.51,-39.25,;9.51,-40.03,;9.19,-41.55,;7.65,-41.71,;7.02,-40.3,;8.16,-39.26,;8.17,-37.71,;6.84,-36.94,;5.51,-37.71,;4.18,-36.95,;4.17,-35.4,;5.51,-34.63,;5.51,-33.09,;6.84,-35.4,;8.18,-34.63,)| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins followed by substrate addition by f...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546223 (CHEMBL4740286 | US20240092795, Example 2) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cc(O)c(Sc2cccc(Cl)c2Cl)nc1CO |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins followed by substrate addition by f...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM433290 (3-(4-(aminomethyl)-4- methylpiperidin-1-yl)-6- ((2...) Show SMILES CC1(CN)CCN(CC1)c1ncc(Sc2cccc(Cl)c2Cl)[nH]c1=O Show InChI InChI=1S/C17H20Cl2N4OS/c1-17(10-20)5-7-23(8-6-17)15-16(24)22-13(9-21-15)25-12-4-2-3-11(18)14(12)19/h2-4,9H,5-8,10,20H2,1H3,(H,22,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of SHP2 (unknown origin) using DiFMUP as substrate preincubated for 60 mins in presence of activating peptide IRS-1 followed by...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546232 (CHEMBL4762771) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(cc2)[N+]([O-])=O)cc1 |c:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM392330 (US10301278, Example 2) Show SMILES CC1(N)CCN(CC1)c1cnc(Sc2ccccc2Cl)c(N)n1 Show InChI InChI=1S/C16H20ClN5S/c1-16(19)6-8-22(9-7-16)13-10-20-15(14(18)21-13)23-12-5-3-2-4-11(12)17/h2-5,10H,6-9,19H2,1H3,(H2,18,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546225 (CHEMBL4752507) Show SMILES N[C@@H]1CCCC11CCN(CC1)c1cnc(c(N)n1)-c1cccc(Cl)c1Cl |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546216 (CHEMBL4745519) Show SMILES C[C@@H]1OCC2(CCC(CC2)c2cnc3nc(Sc4ccnc(N5CCCC5)c4Cl)ccc3n2)[C@@H]1N |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of full-length His6-tagged human SHP2 (2 to 527 residues) expressed in Escherichia coli using DiFMUP as substrate in presence o...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50087879 (CHEMBL472004 | NSC-87877) Show SMILES Oc1c(cc(c2cccnc12)S(O)(=O)=O)\N=N\c1ccc2cc(ccc2c1)S(O)(=O)=O Show InChI InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29)/b22-21+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SHP2 catalytic domain (205 to 593 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50087879 (CHEMBL472004 | NSC-87877) Show SMILES Oc1c(cc(c2cccnc12)S(O)(=O)=O)\N=N\c1ccc2cc(ccc2c1)S(O)(=O)=O Show InChI InChI=1S/C19H13N3O7S2/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13/h1-10,23H,(H,24,25,26)(H,27,28,29)/b22-21+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SHP1 catalytic domain (205 to 597 residues) expressed in Escherichia coli DH5alpha using 6,8-difluoro-4-methylumbelliferyl phosph...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546228 (CHEMBL4784105) Show SMILES Cc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:9| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546229 (CHEMBL4780471) Show SMILES COc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:10| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546209 (CHEMBL4776707) Show SMILES [H][C@@]1(CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@@]4([H])C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)NCCCNCCCCNCCCN)[C@H](C)CCC(OS(O)(=O)=O)C(C)C |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of PTP1B (1 to 405 residues) (unknown origin) expressed in Escherichia coli BL21 cells using DiFMUP as substrate by dixon plot ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546233 (CHEMBL4757579) Show SMILES CCOC(=O)c1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:13| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 (225 to 541 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546230 (CHEMBL4750975) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(cc2)C(F)(F)F)cc1 |c:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	940	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546231 (CHEMBL4746515) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(Cl)cc2)cc1 |c:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 catalytic domain (248 to 527 residues) expressed in Escherichia coli Rosetta(...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546233 (CHEMBL4757579) Show SMILES CCOC(=O)c1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:13| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP1 (222 to 535 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546232 (CHEMBL4762771) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(cc2)[N+]([O-])=O)cc1 |c:14| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546233 (CHEMBL4757579) Show SMILES CCOC(=O)c1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:13| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human PTP1B (2 to 297 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL21...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50342004 (4-(2-(3-(4-nitrophenyl)-5-oxo-1-phenyl-1H-pyrazol-...) Show SMILES OS(=O)(=O)c1ccc(cc1)N=Nc1c([nH]n(-c2ccccc2)c1=O)-c1ccc(cc1)[N+]([O-])=O |w:10.10| Show InChI InChI=1S/C21H15N5O6S/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16/h1-13,24H,(H,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of N-terminal His6-tagged TEV cleavage site-fused human SHP2 (225 to 541 residues) expressed in Escherichia coli BL21(DE3)RILcodon+ or BL2...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546229 (CHEMBL4780471) Show SMILES COc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:10| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50342002 ((2S,3aR,6S,6aR)-N-(cyclohexylmethyl)-6-(5-((R)-3-(...) Show SMILES C(N[C@@H]1C[C@H]2OC[C@@H]([C@H]2O1)n1nnnc1-c1cccc(CN2CCCC2)c1)C1CCCCC1 |r| Show InChI InChI=1S/C25H36N6O2/c1-2-7-18(8-3-1)15-26-23-14-22-24(33-23)21(17-32-22)31-25(27-28-29-31)20-10-6-9-19(13-20)16-30-11-4-5-12-30/h6,9-10,13,18,21-24,26H,1-5,7-8,11-12,14-17H2/t21-,22+,23-,24+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP2 catalytic domain (unknown origin) using p-nitrophenyl phosphate as substrate incubated for 10 to 15 mins				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546227 (CHEMBL4797568) Show SMILES Cc1cc(C)c2[nH]c3nc(SCC(=O)Nc4cccc5ccccc45)nnc3c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP2 E76K mutant in splenocytes derived from JMML patient assessed as reduction in cell proliferation in presence of GM-CSF				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546232 (CHEMBL4762771) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(cc2)[N+]([O-])=O)cc1 |c:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fl...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546226 (CHEMBL4778434) Show SMILES CC[C@@H](C)C[C@@H](C)\C=C(/C)\C=C\C=C\C=C(/C)C(=O)c1c(O)c(cn(O)c1=O)-c1ccc(O)cc1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His-tagged human SHP2 PTP domain expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate preincubated for 30 mins...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546228 (CHEMBL4784105) Show SMILES Cc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:9| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fl...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546229 (CHEMBL4780471) Show SMILES COc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:10| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fl...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50546227 (CHEMBL4797568) Show SMILES Cc1cc(C)c2[nH]c3nc(SCC(=O)Nc4cccc5ccccc45)nnc3c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP2 E76K mutant in splenocytes derived from JMML patient assessed as reduction in GM-CSF induced colony formation of myeloid blast cel...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50341989 (3-(3,5-DIBROMO-4-HYDROXY-BENZOYL)-2-ETHYL-BENZOFUR...) Show SMILES CCc1oc2cc(ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1)S(=O)(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1 Show InChI InChI=1S/C26H19Br2N3O7S3/c1-2-21-23(24(32)14-11-19(27)25(33)20(28)12-14)18-8-7-17(13-22(18)38-21)41(36,37)30-15-3-5-16(6-4-15)40(34,35)31-26-29-9-10-39-26/h3-13,30,33H,2H2,1H3,(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of PTP1B (unknown origin) using pNPP as substrate				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546231 (CHEMBL4746515) Show SMILES OS(=O)(=O)c1ccc(N\N=C2/C(=O)N(N=C2c2ccc(cc2)[N+]([O-])=O)c2ccc(Cl)cc2)cc1 |c:14| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of PTP1B (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by fl...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546228 (CHEMBL4784105) Show SMILES Cc1ccc(cc1)N1N=C(\C(=N\Nc2ccc(cc2)S(O)(=O)=O)C1=O)c1ccc(cc1)[N+]([O-])=O |c:9| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of SHP1 (unknown origin) using 6,8-difluoro-4-methylum-belliferylphosphate as substrate preincubated for 1 hr followed by substrate by flu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546219 (CHEMBL4752026 | US11596633, Compound B | US1170239...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His6-fused human full length SHP1 expressed in Escherichia coli cells using DiFMUP as substrate preincubated for 30 mins followed by su...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 6 (Homo sapiens (Human))	BDBM50546219 (CHEMBL4752026 | US11596633, Compound B | US1170239...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His6-fused human SHP1 catalytic domain expressed in Escherichia coli cells using DiFMUP as substrate preincubated for 30 followed by su...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50546219 (CHEMBL4752026 | US11596633, Compound B | US1170239...) Show SMILES C[C@@H]1OCC2(CCN(CC2)c2nc(C)c(nc2CO)-c2cccc(Cl)c2Cl)[C@@H]1N |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His6-fused human PTP1B expressed in Escherichia coli cells using DiFMUP as substrate preincubated for 30 followed by substrate addition...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM384140 (1-(3-(3-chloro-2- fluorophenyl)-1H- pyrazolo[3,4-b...) Show SMILES CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1F Show InChI InChI=1S/C17H18ClFN6/c1-17(20)5-7-25(8-6-17)12-9-21-15-14(23-24-16(15)22-12)10-3-2-4-11(18)13(10)19/h2-4,9H,5-8,20H2,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Allosteric inhibition of [IRSl_pY1172(dPEG8)pY1222] peptide-activated SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 to 60 mins ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human))	BDBM50131550 ((3S)-3-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...) Show SMILES NC(=O)[C@H](Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)Cc1ccc(cc1)C(F)(F)P(O)(O)=O |r| Show InChI InChI=1S/C23H25F4N3O11P2/c24-22(25,42(36,37)38)14-5-1-12(2-6-14)9-16(20(28)34)30-21(35)17(11-19(32)33)29-18(31)10-13-3-7-15(8-4-13)23(26,27)43(39,40)41/h1-8,16-17H,9-11H2,(H2,28,34)(H,29,31)(H,30,35)(H,32,33)(H2,36,37,38)(H2,39,40,41)/t16-,17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant His6-fused SHP2 catalytic domain (unknown origin) using p-nitrophenyl phosphate as substrate by spectrophotometric analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00249 BindingDB Entry DOI: 10.7270/Q2736VH5
					More data for this Ligand-Target Pair

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