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Compile Data Set for Download or QSAR

Found 62 hits Enz. Inhib. hit(s) with all data for entry = 50013218   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 3


(Homo sapiens)
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR3 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of poly...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 4


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR4 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of LPS-...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 5


(Homo sapiens)
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR5 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of flag...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR7 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of imid...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 9


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR9 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as assessed as inhibition of ODN2...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 2


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human TLR2 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as inhibition of Pam2CS-induced N...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit beta


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK2beta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric ho...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK1alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1B


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK1beta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric ho...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1D


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK1delta using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type 1G


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK1gamma using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit alpha


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK2alpha using KKALRRQETVDAL peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit delta


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK2delta using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type II subunit gamma


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK2gamma using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric h...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Calcium/calmodulin-dependent protein kinase type IV


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wild-type human CAMK4 using KKLNRTLSFAEPG peptide as substrate in presence of Ca2+ calmodulin and [gamma-33P]-ATP by radiometric hotspo...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.72E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TLR8 in human CD14-positive monocytes cells in presence of TLR7 stimulus


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.46E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of TLR8 in human CD14-positive monocytes cells in presence of TLR4 stimulus


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL12 p40 production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IFNgamma production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL-8 production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced MCP1 production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced TNFalpha production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563780
PNG
(CHEMBL4795714)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OCc1ccccc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.06E+3n/an/an/an/an/an/a


TBA

Assay Description
Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of compound 1f-induced IL-6 production incubated for 16 hrs by immunoassay


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563765
PNG
(CHEMBL4776983)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(OC)cc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.94E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563766
PNG
(CHEMBL4784621)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(OC)cc1C
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563767
PNG
(CHEMBL4783001)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(C)c1OC
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.50E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563768
PNG
(CHEMBL4784841)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(OC)c1OC
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.50E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563769
PNG
(CHEMBL4781234)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cc(OC)c(OC)c(OC)c1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 3.08E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563770
PNG
(CHEMBL4786081)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1Cl
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.36E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563771
PNG
(CHEMBL4800009)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(Cl)c1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.93E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563772
PNG
(CHEMBL4784330)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(Cl)cc1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 6.83E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563773
PNG
(CHEMBL4791268)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1F
PDB

UniProtKB/SwissProt

antibodypedia
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AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.35E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563774
PNG
(CHEMBL4780573)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(F)c1
PDB

UniProtKB/SwissProt

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n/an/an/an/a 2.57E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563775
PNG
(CHEMBL4789165)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(F)cc1
PDB

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n/an/an/an/a 1.96E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563776
PNG
(CHEMBL4781072)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(F)cc1C
PDB

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n/an/an/an/a 2.01E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563777
PNG
(CHEMBL4786035)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1C(F)(F)F
PDB

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n/an/an/an/a 1.64E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563778
PNG
(CHEMBL4795355)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(c1)C(F)(F)F
PDB

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n/an/an/an/a 1.98E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563779
PNG
(CHEMBL4787815)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(cc1)C(F)(F)F
PDB

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n/an/an/an/a 2.48E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563764
PNG
(CHEMBL4792768)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc(OC)c1
PDB

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n/an/an/an/a 2.20E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563763
PNG
(CHEMBL4784184)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1OC
PDB

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n/an/an/an/a 1.60E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563762
PNG
(CHEMBL4796992)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1C(=O)OC
PDB

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n/an/an/an/a 1.11E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563761
PNG
(CHEMBL4787810)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(cc1)C(=O)OC
PDB

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n/an/an/an/a 4.04E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563760
PNG
(CHEMBL4780875)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(cc1)C(N)=O
PDB

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n/an/an/an/a 2.02E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563759
PNG
(CHEMBL4777656)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccc(N)cc1
PDB

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n/an/an/an/a 8.00E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563758
PNG
(CHEMBL4780289)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1CO
PDB

UniProtKB/SwissProt

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n/an/an/an/a 8.05E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563757
PNG
(CHEMBL4794560)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1ccccc1O
PDB

UniProtKB/SwissProt

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n/an/an/an/a 5.10E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563756
PNG
(CHEMBL4783445)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1c(C)noc1C
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.88E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563755
PNG
(CHEMBL4796864)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccnc1
PDB

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n/an/an/an/a 2.13E+4n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563754
PNG
(CHEMBL4779978)
Show SMILES Cl.CCCCCn1cc(nc1N)-c1cccc2ccccc12
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.50E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50563753
PNG
(CHEMBL4785005)
Show SMILES Cl.CCCCCn1cc(CCc2ccccc2)nc1N
PDB

UniProtKB/SwissProt

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n/an/an/an/a 1.80E+3n/an/an/an/a


TBA

Assay Description
Agonist activity at human TLR8 stably expressed in HEK293 cells cotransfected with secreted alkaline phosphatase assessed as induction of NFkappaB ac...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.6b00023
BindingDB Entry DOI: 10.7270/Q2CR5Z3F
More data for this
Ligand-Target Pair
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