Compile Data Set for Download or QSAR

Found 36 hits Enz. Inhib. hit(s) with all data for entry = 50015347   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154997 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-7-20-11-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154987 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1C#N Show InChI InChI=1S/C19H11FN6/c20-15-9-14(17-6-2-1-5-13(17)12-21)10-16(11-15)26-24-19(23-25-26)18-7-3-4-8-22-18/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154988 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Nc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c19-13-9-12(15-5-1-2-6-16(15)20)10-14(11-13)25-23-18(22-24-25)17-7-3-4-8-21-17/h1-11H,20H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154985 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccc(c1)C#N Show InChI InChI=1S/C19H11FN6/c20-16-9-15(14-5-3-4-13(8-14)12-21)10-17(11-16)26-24-19(23-25-26)18-6-1-2-7-22-18/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50151910 (3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154990 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Nc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C17H12FN7/c18-12-7-11(14-10-20-6-4-15(14)19)8-13(9-12)25-23-17(22-24-25)16-3-1-2-5-21-16/h1-10H,(H2,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154993 (2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...) Show SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C19H14FN5/c1-13-6-2-3-7-17(13)14-10-15(20)12-16(11-14)25-23-19(22-24-25)18-8-4-5-9-21-18/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154991 (2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-4-8-21-17(12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)16-6-2-3-7-20-16/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154996 (2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Nc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C17H12FN7/c18-12-8-11(16-14(19)4-3-7-21-16)9-13(10-12)25-23-17(22-24-25)15-5-1-2-6-20-15/h1-10H,19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154986 (4-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cnccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-11-20-7-5-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	33	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154992 (5-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ccc(cn1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-6-13(11-21-12)14-8-15(19)10-16(9-14)25-23-18(22-24-25)17-4-2-3-7-20-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154981 (2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1 Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154984 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ncccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-16(5-4-8-20-12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)17-6-2-3-7-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	45	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154989 (2-[2-(5-Fluoro-biphenyl-3-yl)-2H-tetrazol-5-yl]-py...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1 Show InChI InChI=1S/C18H12FN5/c19-15-10-14(13-6-2-1-3-7-13)11-16(12-15)24-22-18(21-23-24)17-8-4-5-9-20-17/h1-12H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154983 (2-[2-(3-fluoro-5-pyridin-2-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccn1 Show InChI InChI=1S/C17H11FN6/c18-13-9-12(15-5-1-3-7-19-15)10-14(11-13)24-22-17(21-23-24)16-6-2-4-8-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	95	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154982 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cncc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-6-14(11-20-10-12)13-7-15(19)9-16(8-13)25-23-18(22-24-25)17-4-2-3-5-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	272	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154995 (2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1 Show InChI InChI=1S/C17H11FN6/c18-14-9-13(12-4-7-19-8-5-12)10-15(11-14)24-22-17(21-23-24)16-3-1-2-6-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	575	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity towards Metabotropic glutamate receptor was determined by displacing [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from rat cortica...				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50151910 (3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonit...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)C#N Show InChI InChI=1S/C13H7FN6/c14-10-5-9(8-15)6-11(7-10)20-18-13(17-19-20)12-3-1-2-4-16-12/h1-7H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154997 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-7-20-11-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154987 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1C#N Show InChI InChI=1S/C19H11FN6/c20-15-9-14(17-6-2-1-5-13(17)12-21)10-16(11-15)26-24-19(23-25-26)18-7-3-4-8-22-18/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154988 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Nc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c19-13-9-12(15-5-1-2-6-16(15)20)10-14(11-13)25-23-18(22-24-25)17-7-3-4-8-21-17/h1-11H,20H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154981 (2-[2-(3-fluoro-5-pyridin-3-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccnc1 Show InChI InChI=1S/C17H11FN6/c18-14-8-13(12-4-3-6-19-11-12)9-15(10-14)24-22-17(21-23-24)16-5-1-2-7-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154996 (2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Nc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C17H12FN7/c18-12-8-11(16-14(19)4-3-7-21-16)9-13(10-12)25-23-17(22-24-25)15-5-1-2-6-20-15/h1-10H,19H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154991 (2-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cccnc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-4-8-21-17(12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)16-6-2-3-7-20-16/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154983 (2-[2-(3-fluoro-5-pyridin-2-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccn1 Show InChI InChI=1S/C17H11FN6/c18-13-9-12(15-5-1-3-7-19-15)10-14(11-13)24-22-17(21-23-24)16-6-2-4-8-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154984 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ncccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-16(5-4-8-20-12)13-9-14(19)11-15(10-13)25-23-18(22-24-25)17-6-2-3-7-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154992 (5-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1ccc(cn1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-5-6-13(11-21-12)14-8-15(19)10-16(9-14)25-23-18(22-24-25)17-4-2-3-7-20-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154986 (4-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cnccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-11-20-7-5-16(12)13-8-14(19)10-15(9-13)25-23-18(22-24-25)17-4-2-3-6-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154990 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Nc1ccncc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C17H12FN7/c18-12-7-11(14-10-20-6-4-15(14)19)8-13(9-12)25-23-17(22-24-25)16-3-1-2-5-21-16/h1-10H,(H2,19,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154993 (2-[2-(5-Fluoro-2''-methyl-biphenyl-3-yl)-2H-tetraz...) Show SMILES Cc1ccccc1-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C19H14FN5/c1-13-6-2-3-7-17(13)14-10-15(20)12-16(11-14)25-23-19(22-24-25)18-8-4-5-9-21-18/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154989 (2-[2-(5-Fluoro-biphenyl-3-yl)-2H-tetrazol-5-yl]-py...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccccc1 Show InChI InChI=1S/C18H12FN5/c19-15-10-14(13-6-2-1-3-7-13)11-16(12-15)24-22-18(21-23-24)17-8-4-5-9-20-17/h1-12H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	247	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154985 (3''-Fluoro-5''-(5-pyridin-2-yl-tetrazol-2-yl)-biph...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1cccc(c1)C#N Show InChI InChI=1S/C19H11FN6/c20-16-9-15(14-5-3-4-13(8-14)12-21)10-17(11-16)26-24-19(23-25-26)18-6-1-2-7-22-18/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	253	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154982 (3-[3-Fluoro-5-(5-pyridin-2-yl-tetrazol-2-yl)-pheny...) Show SMILES Cc1cncc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C18H13FN6/c1-12-6-14(11-20-10-12)13-7-15(19)9-16(8-13)25-23-18(22-24-25)17-4-2-3-5-21-17/h2-11H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154995 (2-[2-(3-fluoro-5-pyridin-4-ylphenyl)-2H-tetrazol-5...) Show SMILES Fc1cc(cc(c1)-n1nnc(n1)-c1ccccn1)-c1ccncc1 Show InChI InChI=1S/C17H11FN6/c18-14-9-13(12-4-7-19-8-5-12)10-15(11-14)24-22-17(21-23-24)16-3-1-2-6-20-16/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	956	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154994 (2-[2-(5-Fluoro-3''-methyl-biphenyl-3-yl)-2H-tetraz...) Show SMILES Cc1cccc(c1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C19H14FN5/c1-13-5-4-6-14(9-13)15-10-16(20)12-17(11-15)25-23-19(22-24-25)18-7-2-3-8-21-18/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50154998 (2-[2-(5-Fluoro-4''-methyl-biphenyl-3-yl)-2H-tetraz...) Show SMILES Cc1ccc(cc1)-c1cc(F)cc(c1)-n1nnc(n1)-c1ccccn1 Show InChI InChI=1S/C19H14FN5/c1-13-5-7-14(8-6-13)15-10-16(20)12-17(11-15)25-23-19(22-24-25)18-4-2-3-9-21-18/h2-12H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Antagonistic activity of the compound against Metabotropic glutamate receptor 5 in [Ca2+] flux assay using glutamate (10 uM) as agonist				Bioorg Med Chem Lett 14: 5477-80 (2004) Article DOI: 10.1016/j.bmcl.2004.09.011 BindingDB Entry DOI: 10.7270/Q29C6WXB
					More data for this Ligand-Target Pair