Compile Data Set for Download or QSAR

Found 42 hits Enz. Inhib. hit(s) with all data for entry = 50017251   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179654 (1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...) Show SMILES CCn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C12H13ClN4O2/c1-2-17-7-10(18)15-11(17)16-12(19)14-9-5-3-4-8(13)6-9/h3-7,18H,2H2,1H3,(H2,14,15,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179654 (1-(3-chlorophenyl)-3-(1-ethyl-4-oxoimidazolidin-2-...) Show SMILES CCn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C12H13ClN4O2/c1-2-17-7-10(18)15-11(17)16-12(19)14-9-5-3-4-8(13)6-9/h3-7,18H,2H2,1H3,(H2,14,15,16,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179643 (1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...) Show SMILES CN1CCSC1=NC(=O)Nc1cccc(Cl)c1 |w:6.7| Show InChI InChI=1S/C11H12ClN3OS/c1-15-5-6-17-11(15)14-10(16)13-9-4-2-3-8(12)7-9/h2-4,7H,5-6H2,1H3,(H,13,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179642 (1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...) Show SMILES CCn1c(C)c(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C13H15ClN4O2/c1-3-18-8(2)11(19)16-12(18)17-13(20)15-10-6-4-5-9(14)7-10/h4-7,19H,3H2,1-2H3,(H2,15,16,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM86716 (CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179667 (1-(3-bromophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccc(Br)c1 Show InChI InChI=1S/C11H11BrN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179642 (1-(3-chlorophenyl)-3-(1-ethyl-5-methyl-4-oxoimidaz...) Show SMILES CCn1c(C)c(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C13H15ClN4O2/c1-3-18-8(2)11(19)16-12(18)17-13(20)15-10-6-4-5-9(14)7-10/h4-7,19H,3H2,1-2H3,(H2,15,16,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM86716 (CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179645 (1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...) Show SMILES Cc1c(O)nc(NC(=O)Nc2cccc(Cl)c2)n1C Show InChI InChI=1S/C12H13ClN4O2/c1-7-10(18)15-11(17(7)2)16-12(19)14-9-5-3-4-8(13)6-9/h3-6,18H,1-2H3,(H2,14,15,16,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179669 (1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-m-tolyl...) Show SMILES Cc1cccc(NC(=O)Nc2nc(O)cn2C)c1 Show InChI InChI=1S/C12H14N4O2/c1-8-4-3-5-9(6-8)13-12(18)15-11-14-10(17)7-16(11)2/h3-7,17H,1-2H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179641 (1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...) Show SMILES CN1CCCC1=NC(=O)Nc1cccc(Cl)c1 |w:6.7| Show InChI InChI=1S/C12H14ClN3O/c1-16-7-3-6-11(16)15-12(17)14-10-5-2-4-9(13)8-10/h2,4-5,8H,3,6-7H2,1H3,(H,14,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179646 (1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...) Show SMILES CCCCn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H17ClN4O2/c1-2-3-7-19-9-12(20)17-13(19)18-14(21)16-11-6-4-5-10(15)8-11/h4-6,8-9,20H,2-3,7H2,1H3,(H2,16,17,18,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179640 (1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...) Show SMILES Oc1nc(NC(=O)Nc2cccc(Cl)c2)n2CCCc12 Show InChI InChI=1S/C13H13ClN4O2/c14-8-3-1-4-9(7-8)15-13(20)17-12-16-11(19)10-5-2-6-18(10)12/h1,3-4,7,19H,2,5-6H2,(H2,15,16,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179643 (1-(3-chlorophenyl)-3-(3-methylthiazolidin-2-yliden...) Show SMILES CN1CCSC1=NC(=O)Nc1cccc(Cl)c1 |w:6.7| Show InChI InChI=1S/C11H12ClN3OS/c1-15-5-6-17-11(15)14-10(16)13-9-4-2-3-8(12)7-9/h2-4,7H,5-6H2,1H3,(H,13,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179646 (1-(1-butyl-4-oxoimidazolidin-2-ylidene)-3-(3-chlor...) Show SMILES CCCCn1cc(O)nc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C14H17ClN4O2/c1-2-3-7-19-9-12(20)17-13(19)18-14(21)16-11-6-4-5-10(15)8-11/h4-6,8-9,20H,2-3,7H2,1H3,(H2,16,17,18,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179645 (1-(3-chlorophenyl)-3-(1,5-dimethyl-4-oxoimidazolid...) Show SMILES Cc1c(O)nc(NC(=O)Nc2cccc(Cl)c2)n1C Show InChI InChI=1S/C12H13ClN4O2/c1-7-10(18)15-11(17(7)2)16-12(19)14-9-5-3-4-8(13)6-9/h3-6,18H,1-2H3,(H2,14,15,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179644 (1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...) Show SMILES Cc1cccc(NC(=O)Nc2nc(O)c(-c3ccccc3)n2C)c1 Show InChI InChI=1S/C18H18N4O2/c1-12-7-6-10-14(11-12)19-18(24)21-17-20-16(23)15(22(17)2)13-8-4-3-5-9-13/h3-11,23H,1-2H3,(H2,19,20,21,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179640 (1-(3-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...) Show SMILES Oc1nc(NC(=O)Nc2cccc(Cl)c2)n2CCCc12 Show InChI InChI=1S/C13H13ClN4O2/c14-8-3-1-4-9(7-8)15-13(20)17-12-16-11(19)10-5-2-6-18(10)12/h1,3-4,7,19H,2,5-6H2,(H2,15,16,17,20)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179657 ((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(6-...) Show SMILES Cc1cccnc1NC(=O)Nc1nc(O)cn1C Show InChI InChI=1S/C11H13N5O2/c1-7-4-3-5-12-9(7)14-11(18)15-10-13-8(17)6-16(10)2/h3-6,17H,1-2H3,(H2,12,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179641 (1-(3-chlorophenyl)-3-(1-methylpyrrolidin-2-ylidene...) Show SMILES CN1CCCC1=NC(=O)Nc1cccc(Cl)c1 |w:6.7| Show InChI InChI=1S/C12H14ClN3O/c1-16-7-3-6-11(16)15-12(17)14-10-5-2-4-9(13)8-10/h2,4-5,8H,3,6-7H2,1H3,(H,14,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179666 (3-chloro-N-(1-methyl-4-oxoimidazolidin-2-ylidene)b...) Show SMILES Cn1cc(O)nc1NC(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C11H10ClN3O2/c1-15-6-9(16)13-11(15)14-10(17)7-3-2-4-8(12)5-7/h2-6,16H,1H3,(H,13,14,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179662 (1-(3-methoxyphenyl)-3-(1-methyl-4-oxoimidazolidin-...) Show SMILES COc1cccc(NC(=O)Nc2nc(O)cn2C)c1 Show InChI InChI=1S/C12H14N4O3/c1-16-7-10(17)14-11(16)15-12(18)13-8-4-3-5-9(6-8)19-2/h3-7,17H,1-2H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179665 (1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(5-meth...) Show SMILES Cc1ccc(NC(=O)Nc2nc(O)cn2C)nc1 Show InChI InChI=1S/C11H13N5O2/c1-7-3-4-8(12-5-7)13-11(18)15-10-14-9(17)6-16(10)2/h3-6,17H,1-2H3,(H2,12,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179652 (1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccc(c1)C#N Show InChI InChI=1S/C12H11N5O2/c1-17-7-10(18)15-11(17)16-12(19)14-9-4-2-3-8(5-9)6-13/h2-5,7,18H,1H3,(H2,14,15,16,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179652 (1-(3-cyanophenyl)-3-(1-methyl-4-oxoimidazolidin-2-...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccc(c1)C#N Show InChI InChI=1S/C12H11N5O2/c1-17-7-10(18)15-11(17)16-12(19)14-9-4-2-3-8(5-9)6-13/h2-5,7,18H,1H3,(H2,14,15,16,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179660 (1-(1-oxo-hexahydropyrrolo[1,2-e]imidazol-3-ylidene...) Show SMILES Oc1nc(NC(=O)Nc2ccccc2)n2CCCc12 Show InChI InChI=1S/C13H14N4O2/c18-11-10-7-4-8-17(10)12(15-11)16-13(19)14-9-5-2-1-3-6-9/h1-3,5-6,18H,4,7-8H2,(H2,14,15,16,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50201659 ((E)-1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-phe...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1ccccc1 Show InChI InChI=1S/C11H12N4O2/c1-15-7-9(16)13-10(15)14-11(17)12-8-5-3-2-4-6-8/h2-7,16H,1H3,(H2,12,13,14,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179668 (1-(1-methyl-4-oxoimidazolidin-2-ylidene)-3-(thioph...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cccs1 Show InChI InChI=1S/C9H10N4O2S/c1-13-5-6(14)10-8(13)12-9(15)11-7-3-2-4-16-7/h2-5,14H,1H3,(H2,10,11,12,15)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	4.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179644 (1-(1-methyl-4-oxo-5-phenylimidazolidin-2-ylidene)-...) Show SMILES Cc1cccc(NC(=O)Nc2nc(O)c(-c3ccccc3)n2C)c1 Show InChI InChI=1S/C18H18N4O2/c1-12-7-6-10-14(11-12)19-18(24)21-17-20-16(23)15(22(17)2)13-8-4-3-5-9-13/h3-11,23H,1-2H3,(H2,19,20,21,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179664 (1-(2,6-dimethylphenyl)-3-(1-methylpyrrolidin-2-yli...) Show SMILES CN1CCCC1=NC(=O)Nc1c(C)cccc1C |w:6.7| Show InChI InChI=1S/C14H19N3O/c1-10-6-4-7-11(2)13(10)16-14(18)15-12-8-5-9-17(12)3/h4,6-7H,5,8-9H2,1-3H3,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179655 (1-(3-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)ur...) Show SMILES Cn1ccnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O/c1-16-6-5-13-10(16)15-11(17)14-9-4-2-3-8(12)7-9/h2-7H,1H3,(H2,13,14,15,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179648 (1-(3,5-dichlorophenyl)-3-(1-methyl-4-oxoimidazolid...) Show SMILES Cn1cc(O)nc1NC(=O)Nc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C11H10Cl2N4O2/c1-17-5-9(18)15-10(17)16-11(19)14-8-3-6(12)2-7(13)4-8/h2-5,18H,1H3,(H2,14,15,16,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179659 (1-(1-oxo-hexahydropyrrolo[1,2-e]imidazol-3-ylidene...) Show SMILES Cc1ccccc1NC(=O)Nc1nc(O)c2CCCn12 Show InChI InChI=1S/C14H16N4O2/c1-9-5-2-3-6-10(9)15-14(20)17-13-16-12(19)11-7-4-8-18(11)13/h2-3,5-6,19H,4,7-8H2,1H3,(H2,15,16,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179661 (1-(2,3-dimethylphenyl)-3-(1-oxo-hexahydropyrrolo[1...) Show SMILES Cc1cccc(NC(=O)Nc2nc(O)c3CCCn23)c1C Show InChI InChI=1S/C15H18N4O2/c1-9-5-3-6-11(10(9)2)16-15(21)18-14-17-13(20)12-7-4-8-19(12)14/h3,5-6,20H,4,7-8H2,1-2H3,(H2,16,17,18,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179658 (1-(2,5-dimethylphenyl)-3-(1-oxo-hexahydropyrrolo[1...) Show SMILES Cc1ccc(C)c(NC(=O)Nc2nc(O)c3CCCn23)c1 Show InChI InChI=1S/C15H18N4O2/c1-9-5-6-10(2)11(8-9)16-15(21)18-14-17-13(20)12-4-3-7-19(12)14/h5-6,8,20H,3-4,7H2,1-2H3,(H2,16,17,18,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179656 (1-(3-chloro-4-methylphenyl)-3-(1-oxo-hexahydropyrr...) Show SMILES Cc1ccc(NC(=O)Nc2nc(O)c3CCCn23)cc1Cl Show InChI InChI=1S/C14H15ClN4O2/c1-8-4-5-9(7-10(8)15)16-14(21)18-13-17-12(20)11-3-2-6-19(11)13/h4-5,7,20H,2-3,6H2,1H3,(H2,16,17,18,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179655 (1-(3-chlorophenyl)-3-(1-methyl-1H-imidazol-2-yl)ur...) Show SMILES Cn1ccnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O/c1-16-6-5-13-10(16)15-11(17)14-9-4-2-3-8(12)7-9/h2-7H,1H3,(H2,13,14,15,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179653 (1-(4-chlorophenyl)-3-(1-oxo-hexahydropyrrolo[1,2-e...) Show SMILES Oc1nc(NC(=O)Nc2ccc(Cl)cc2)n2CCCc12 Show InChI InChI=1S/C13H13ClN4O2/c14-8-3-5-9(6-4-8)15-13(20)17-12-16-11(19)10-2-1-7-18(10)12/h3-6,19H,1-2,7H2,(H2,15,16,17,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179649 (1-hexyl-3-(1-methyl-4-oxoimidazolidin-2-ylidene)ur...) Show SMILES CCCCCCNC(=O)Nc1nc(O)cn1C Show InChI InChI=1S/C11H20N4O2/c1-3-4-5-6-7-12-11(17)14-10-13-9(16)8-15(10)2/h8,16H,3-7H2,1-2H3,(H2,12,13,14,17)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179647 (CHEMBL424681 | methyl 3-(3-(1-methyl-4-oxoimidazol...) Show SMILES COC(=O)c1cccc(NC(=O)Nc2nc(O)cn2C)c1 Show InChI InChI=1S/C13H14N4O4/c1-17-7-10(18)15-12(17)16-13(20)14-9-5-3-4-8(6-9)11(19)21-2/h3-7,18H,1-2H3,(H2,14,15,16,20)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair