Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50179663'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) Curated by ChEMBL					Assay Description Negative allosteric modulation of human mGlu5a receptor expressed in HEK293 cells co-expressing EAAC1 assessed as inhibition of quisqualate-induced i...				Eur J Med Chem 127: 567-576 (2017) Article DOI: 10.1016/j.ejmech.2017.01.013 BindingDB Entry DOI: 10.7270/Q2736T4T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) Curated by ChEMBL					Assay Description Negative allosteric modulation of rat N-terminal HA-tagged mGlu5 receptor expressed in HEK293 cells co-expressing N-terminal HA-tagged EAAC1 assessed...				Eur J Med Chem 127: 567-576 (2017) Article DOI: 10.1016/j.ejmech.2017.01.013 BindingDB Entry DOI: 10.7270/Q2736T4T
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50179663 (1-(3-chlorophenyl)-3-(1-methyl-5-oxoimidazolidin-2...) Show SMILES Cn1c(O)cnc1NC(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C11H11ClN4O2/c1-16-9(17)6-13-10(16)15-11(18)14-8-4-2-3-7(12)5-8/h2-6,17H,1H3,(H2,13,14,15,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Displacement of [3H]MPEP from mGluR5d in rat brain membrane				Bioorg Med Chem Lett 16: 1142-5 (2006) Article DOI: 10.1016/j.bmcl.2005.11.092 BindingDB Entry DOI: 10.7270/Q2697348
					More data for this Ligand-Target Pair