BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with all data for entry = 50026329
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50243848 (1-(2-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...) Show SMILES NS(=O)(=O)c1ccccc1C#Cc1ccc(=O)n(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay				Bioorg Med Chem Lett 18: 4195-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.071 BindingDB Entry DOI: 10.7270/Q2SF2VZW
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50243739 (1-(3-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...) Show SMILES NS(=O)(=O)c1cccc(c1)C#Cc1ccc(=O)n(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay				Bioorg Med Chem Lett 18: 4195-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.071 BindingDB Entry DOI: 10.7270/Q2SF2VZW
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM32020 (4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...) Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay				Bioorg Med Chem Lett 18: 4195-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.071 BindingDB Entry DOI: 10.7270/Q2SF2VZW
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Polyunsaturated fatty acid 5-lipoxygenase (Homo sapiens (Human))	BDBM50243740 (1-(4-Benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(...) Show SMILES NS(=O)(=O)c1ccc(cc1)C#Cc1ccc(=O)n(O)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Alberta Curated by ChEMBL					Assay Description Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay				Bioorg Med Chem Lett 18: 4195-8 (2008) Article DOI: 10.1016/j.bmcl.2008.05.071 BindingDB Entry DOI: 10.7270/Q2SF2VZW
University of Alberta Curated by ChEMBL					More data for this Ligand-Target Pair