Found 15 hits Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM32020' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
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Similars
| PDB PubMed
| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Canada Inc.
Curated by ChEMBL
| Assay Description Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound |
J Med Chem 32: 1190-7 (1989)
BindingDB Entry DOI: 10.7270/Q2ST7NVR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | 97 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112090 BindingDB Entry DOI: 10.7270/Q2P272WN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Consejo Superior de Investigaciones Cient�ficas (IQM-CSIC)
Curated by ChEMBL
| Assay Description Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured aft... |
Eur J Med Chem 156: 534-553 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.026 BindingDB Entry DOI: 10.7270/Q2N300PH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokushima Bunri University
Curated by ChEMBL
| Assay Description In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined |
J Med Chem 36: 3904-9 (1994)
BindingDB Entry DOI: 10.7270/Q2MS3RT4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst-Roussel Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant |
J Med Chem 39: 246-52 (1996)
Article DOI: 10.1021/jm950563z BindingDB Entry DOI: 10.7270/Q22806PF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Tahitian Noni International
Curated by ChEMBL
| Assay Description Inhibition of 5LOX in human PBMC by EIA assay |
J Nat Prod 70: 859-62 (2007)
Article DOI: 10.1021/np0605539 BindingDB Entry DOI: 10.7270/Q2J38S79 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Rorer Central Research
Curated by ChEMBL
| Assay Description Inhibition against 5-lipoxygenase from guinea pig polymorphonuclear lymphocytes |
J Med Chem 33: 1186-94 (1990)
BindingDB Entry DOI: 10.7270/Q2TB15WM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Vitry
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay) |
J Med Chem 33: 2744-9 (1990)
BindingDB Entry DOI: 10.7270/Q2MK6BVP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Advanced Industrial Science and Technology (AIST)
Curated by ChEMBL
| Assay Description Inhibition of 5LOX |
Bioorg Med Chem 16: 10332-7 (2008)
Article DOI: 10.1016/j.bmc.2008.10.038 BindingDB Entry DOI: 10.7270/Q24M94C2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells |
J Med Chem 34: 2158-65 (1991)
BindingDB Entry DOI: 10.7270/Q2NS0SWM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Lille 2
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cells |
Bioorg Med Chem Lett 11: 845-8 (2001)
BindingDB Entry DOI: 10.7270/Q2K35SXF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Heinrich-Heine-Universität Düsseldorf
Curated by ChEMBL
| Assay Description Inhibition of 5-lipoxygenase |
J Nat Prod 61: 347-50 (1998)
Article DOI: 10.1021/np970430b BindingDB Entry DOI: 10.7270/Q2PN95D7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches de Vitry
Curated by ChEMBL
| Assay Description Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation) |
J Med Chem 33: 2744-9 (1990)
BindingDB Entry DOI: 10.7270/Q2MK6BVP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB
| n/a | n/a | 1.25E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM32020
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay |
Bioorg Med Chem Lett 18: 4195-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.071 BindingDB Entry DOI: 10.7270/Q2SF2VZW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |