Found 54 hits Enz. Inhib. hit(s) with all data for entry = 50030556 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298023
![PNG](/data/jpeg/tenK5029/BindingDB_50298023.png) (2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C19H15FN2O4/c20-15-9-11(5-6-17(15)23)16-10-12(26-21-16)7-8-22-18(24)13-3-1-2-4-14(13)19(22)25/h1-6,9,12,23H,7-8,10H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298023
![PNG](/data/jpeg/tenK5029/BindingDB_50298023.png) (2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C19H15FN2O4/c20-15-9-11(5-6-17(15)23)16-10-12(26-21-16)7-8-22-18(24)13-3-1-2-4-14(13)19(22)25/h1-6,9,12,23H,7-8,10H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298023
![PNG](/data/jpeg/tenK5029/BindingDB_50298023.png) (2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C19H15FN2O4/c20-15-9-11(5-6-17(15)23)16-10-12(26-21-16)7-8-22-18(24)13-3-1-2-4-14(13)19(22)25/h1-6,9,12,23H,7-8,10H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298024
![PNG](/data/jpeg/tenK5029/BindingDB_50298024.png) (2-(3-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCCN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C20H17FN2O4/c21-16-10-12(7-8-18(16)24)17-11-13(27-22-17)4-3-9-23-19(25)14-5-1-2-6-15(14)20(23)26/h1-2,5-8,10,13,24H,3-4,9,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298024
![PNG](/data/jpeg/tenK5029/BindingDB_50298024.png) (2-(3-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCCN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C20H17FN2O4/c21-16-10-12(7-8-18(16)24)17-11-13(27-22-17)4-3-9-23-19(25)14-5-1-2-6-15(14)20(23)26/h1-2,5-8,10,13,24H,3-4,9,11H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298009
![PNG](/data/jpeg/tenK5029/BindingDB_50298009.png) (CHEMBL559125 | N-cyclohexyl-3(3-(3-(3-fluoro-4-met...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(=O)NC2CCCCC2)n1 |t:10| Show InChI InChI=1S/C21H25FN4O4/c1-28-17-8-7-13(11-15(17)22)16-12-18(29-25-16)21-24-20(30-26-21)10-9-19(27)23-14-5-3-2-4-6-14/h7-8,11,14,18H,2-6,9-10,12H2,1H3,(H,23,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298021
![PNG](/data/jpeg/tenK5029/BindingDB_50298021.png) (4-fluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-di...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCNC(=O)c2ccc(F)cc2)C1 |t:9| Show InChI InChI=1S/C18H16F2N2O3/c19-13-4-1-11(2-5-13)18(24)21-8-7-14-10-16(22-25-14)12-3-6-17(23)15(20)9-12/h1-6,9,14,23H,7-8,10H2,(H,21,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298008
![PNG](/data/jpeg/tenK5029/BindingDB_50298008.png) (3-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisox...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(O)=O)n1 |t:10| Show InChI InChI=1S/C15H14FN3O5/c1-22-11-3-2-8(6-9(11)16)10-7-12(23-18-10)15-17-13(24-19-15)4-5-14(20)21/h2-3,6,12H,4-5,7H2,1H3,(H,20,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298018
![PNG](/data/jpeg/tenK5029/BindingDB_50298018.png) (CHEMBL549864 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)(C)C(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-16(2,3)15(21)18-7-6-11-9-13(19-22-11)10-4-5-14(20)12(17)8-10/h4-5,8,11,20H,6-7,9H2,1-3H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298020
![PNG](/data/jpeg/tenK5029/BindingDB_50298020.png) (2,2,2-trifluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCNC(=O)C(F)(F)F)C1 |t:9| Show InChI InChI=1S/C13H12F4N2O3/c14-9-5-7(1-2-11(9)20)10-6-8(22-19-10)3-4-18-12(21)13(15,16)17/h1-2,5,8,20H,3-4,6H2,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298027
![PNG](/data/jpeg/tenK5029/BindingDB_50298027.png) (2-fluoro-4-(5((5-(trifluoromethyl)-1,2,4-oxadiazol...)Show SMILES Oc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:9| Show InChI InChI=1S/C13H9F4N3O3/c14-8-3-6(1-2-10(8)21)9-4-7(22-19-9)5-11-18-12(23-20-11)13(15,16)17/h1-3,7,21H,4-5H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298021
![PNG](/data/jpeg/tenK5029/BindingDB_50298021.png) (4-fluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-di...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCNC(=O)c2ccc(F)cc2)C1 |t:9| Show InChI InChI=1S/C18H16F2N2O3/c19-13-4-1-11(2-5-13)18(24)21-8-7-14-10-16(22-25-14)12-3-6-17(23)15(20)9-12/h1-6,9,14,23H,7-8,10H2,(H,21,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298025
![PNG](/data/jpeg/tenK5029/BindingDB_50298025.png) (1-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)CCC2=O)C1 |t:9| Show InChI InChI=1S/C15H15FN2O4/c16-11-7-9(1-2-13(11)19)12-8-10(22-17-12)5-6-18-14(20)3-4-15(18)21/h1-2,7,10,19H,3-6,8H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298014
![PNG](/data/jpeg/tenK5029/BindingDB_50298014.png) (3-(3-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(C1)c1noc(n1)-c1cccc(O)c1O |t:9| Show InChI InChI=1S/C17H12FN3O5/c18-10-6-8(4-5-12(10)22)11-7-14(25-20-11)16-19-17(26-21-16)9-2-1-3-13(23)15(9)24/h1-6,14,22-24H,7H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298013
![PNG](/data/jpeg/tenK5029/BindingDB_50298013.png) (5-(2,3-dimethoxyphenyl)-3-(3-(3-fluoro-4-methoxyph...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(n1)-c1cccc(OC)c1OC |t:10| Show InChI InChI=1S/C20H18FN3O5/c1-25-15-8-7-11(9-13(15)21)14-10-17(28-23-14)19-22-20(29-24-19)12-5-4-6-16(26-2)18(12)27-3/h4-9,17H,10H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298021
![PNG](/data/jpeg/tenK5029/BindingDB_50298021.png) (4-fluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-di...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCNC(=O)c2ccc(F)cc2)C1 |t:9| Show InChI InChI=1S/C18H16F2N2O3/c19-13-4-1-11(2-5-13)18(24)21-8-7-14-10-16(22-25-14)12-3-6-17(23)15(20)9-12/h1-6,9,14,23H,7-8,10H2,(H,21,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298025
![PNG](/data/jpeg/tenK5029/BindingDB_50298025.png) (1-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)CCC2=O)C1 |t:9| Show InChI InChI=1S/C15H15FN2O4/c16-11-7-9(1-2-13(11)19)12-8-10(22-17-12)5-6-18-14(20)3-4-15(18)21/h1-2,7,10,19H,3-6,8H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298019
![PNG](/data/jpeg/tenK5029/BindingDB_50298019.png) (CHEMBL556445 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)CC(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-10(2)7-16(21)18-6-5-12-9-14(19-22-12)11-3-4-15(20)13(17)8-11/h3-4,8,10,12,20H,5-7,9H2,1-2H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298018
![PNG](/data/jpeg/tenK5029/BindingDB_50298018.png) (CHEMBL549864 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)(C)C(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-16(2,3)15(21)18-7-6-11-9-13(19-22-11)10-4-5-14(20)12(17)8-10/h4-5,8,11,20H,6-7,9H2,1-3H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298019
![PNG](/data/jpeg/tenK5029/BindingDB_50298019.png) (CHEMBL556445 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)CC(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-10(2)7-16(21)18-6-5-12-9-14(19-22-12)11-3-4-15(20)13(17)8-11/h3-4,8,10,12,20H,5-7,9H2,1-2H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
![PNG](/data/jpeg/tenK5018/BindingDB_50186426.png) (CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298010
![PNG](/data/jpeg/tenK5029/BindingDB_50298010.png) (CHEMBL559258 | N-cyclohexyl-3-(3-(3-(3-fluoro-4-hy...)Show SMILES Oc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(=O)NC2CCCCC2)n1 |t:9| Show InChI InChI=1S/C20H23FN4O4/c21-14-10-12(6-7-16(14)26)15-11-17(28-24-15)20-23-19(29-25-20)9-8-18(27)22-13-4-2-1-3-5-13/h6-7,10,13,17,26H,1-5,8-9,11H2,(H,22,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298018
![PNG](/data/jpeg/tenK5029/BindingDB_50298018.png) (CHEMBL549864 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)(C)C(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-16(2,3)15(21)18-7-6-11-9-13(19-22-11)10-4-5-14(20)12(17)8-10/h4-5,8,11,20H,6-7,9H2,1-3H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298022
![PNG](/data/jpeg/tenK5029/BindingDB_50298022.png) (2-((3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxaz...)Show SMILES Oc1ccc(cc1F)C1=NOC(CN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C18H13FN2O4/c19-14-7-10(5-6-16(14)22)15-8-11(25-20-15)9-21-17(23)12-3-1-2-4-13(12)18(21)24/h1-7,11,22H,8-9H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298019
![PNG](/data/jpeg/tenK5029/BindingDB_50298019.png) (CHEMBL556445 | N-(2-(3-(3-fluoro-4-hydroxyphenyl)-...)Show SMILES CC(C)CC(=O)NCCC1CC(=NO1)c1ccc(O)c(F)c1 |c:11| Show InChI InChI=1S/C16H21FN2O3/c1-10(2)7-16(21)18-6-5-12-9-14(19-22-12)11-3-4-15(20)13(17)8-11/h3-4,8,10,12,20H,5-7,9H2,1-2H3,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298009
![PNG](/data/jpeg/tenK5029/BindingDB_50298009.png) (CHEMBL559125 | N-cyclohexyl-3(3-(3-(3-fluoro-4-met...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(=O)NC2CCCCC2)n1 |t:10| Show InChI InChI=1S/C21H25FN4O4/c1-28-17-8-7-13(11-15(17)22)16-12-18(29-25-16)21-24-20(30-26-21)10-9-19(27)23-14-5-3-2-4-6-14/h7-8,11,14,18H,2-6,9-10,12H2,1H3,(H,23,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298013
![PNG](/data/jpeg/tenK5029/BindingDB_50298013.png) (5-(2,3-dimethoxyphenyl)-3-(3-(3-fluoro-4-methoxyph...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(n1)-c1cccc(OC)c1OC |t:10| Show InChI InChI=1S/C20H18FN3O5/c1-25-15-8-7-11(9-13(15)21)14-10-17(28-23-14)19-22-20(29-24-19)12-5-4-6-16(26-2)18(12)27-3/h4-9,17H,10H2,1-3H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298022
![PNG](/data/jpeg/tenK5029/BindingDB_50298022.png) (2-((3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxaz...)Show SMILES Oc1ccc(cc1F)C1=NOC(CN2C(=O)c3ccccc3C2=O)C1 |t:9| Show InChI InChI=1S/C18H13FN2O4/c19-14-7-10(5-6-16(14)22)15-8-11(25-20-15)9-21-17(23)12-3-1-2-4-13(12)18(21)24/h1-7,11,22H,8-9H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298027
![PNG](/data/jpeg/tenK5029/BindingDB_50298027.png) (2-fluoro-4-(5((5-(trifluoromethyl)-1,2,4-oxadiazol...)Show SMILES Oc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:9| Show InChI InChI=1S/C13H9F4N3O3/c14-8-3-6(1-2-10(8)21)9-4-7(22-19-9)5-11-18-12(23-20-11)13(15,16)17/h1-3,7,21H,4-5H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298020
![PNG](/data/jpeg/tenK5029/BindingDB_50298020.png) (2,2,2-trifluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCNC(=O)C(F)(F)F)C1 |t:9| Show InChI InChI=1S/C13H12F4N2O3/c14-9-5-7(1-2-11(9)20)10-6-8(22-19-10)3-4-18-12(21)13(15,16)17/h1-2,5,8,20H,3-4,6H2,(H,18,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298011
![PNG](/data/jpeg/tenK5029/BindingDB_50298011.png) (CHEMBL563301 | methyl 3-(3-(3(3-fluoro-4hydroxyphe...)Show SMILES COC(=O)CCc1nc(no1)C1CC(=NO1)c1ccc(O)c(F)c1 |c:14| Show InChI InChI=1S/C15H14FN3O5/c1-22-14(21)5-4-13-17-15(19-24-13)12-7-10(18-23-12)8-2-3-11(20)9(16)6-8/h2-3,6,12,20H,4-5,7H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298025
![PNG](/data/jpeg/tenK5029/BindingDB_50298025.png) (1-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)Show SMILES Oc1ccc(cc1F)C1=NOC(CCN2C(=O)CCC2=O)C1 |t:9| Show InChI InChI=1S/C15H15FN2O4/c16-11-7-9(1-2-13(11)19)12-8-10(22-17-12)5-6-18-14(20)3-4-15(18)21/h1-2,7,10,19H,3-6,8H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298026
![PNG](/data/jpeg/tenK5029/BindingDB_50298026.png) (3-((3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxaz...)Show SMILES COc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:10| Show InChI InChI=1S/C14H11F4N3O3/c1-22-11-3-2-7(4-9(11)15)10-5-8(23-20-10)6-12-19-13(24-21-12)14(16,17)18/h2-4,8H,5-6H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298027
![PNG](/data/jpeg/tenK5029/BindingDB_50298027.png) (2-fluoro-4-(5((5-(trifluoromethyl)-1,2,4-oxadiazol...)Show SMILES Oc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:9| Show InChI InChI=1S/C13H9F4N3O3/c14-8-3-6(1-2-10(8)21)9-4-7(22-19-9)5-11-18-12(23-20-11)13(15,16)17/h1-3,7,21H,4-5H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298007
![PNG](/data/jpeg/tenK5029/BindingDB_50298007.png) (2-fluoro-4-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol...)Show SMILES Oc1ccc(cc1F)C1=NOC(C1)c1noc(n1)C(F)(F)F |t:9| Show InChI InChI=1S/C12H7F4N3O3/c13-6-3-5(1-2-8(6)20)7-4-9(21-18-7)10-17-11(22-19-10)12(14,15)16/h1-3,9,20H,4H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298005
![PNG](/data/jpeg/tenK5029/BindingDB_50298005.png) (2-fluoro-4-(5-(5-methyl-1,2,4-oxadiazol-3-yl)-4,5-...)Show InChI InChI=1S/C12H10FN3O3/c1-6-14-12(16-18-6)11-5-9(15-19-11)7-2-3-10(17)8(13)4-7/h2-4,11,17H,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298008
![PNG](/data/jpeg/tenK5029/BindingDB_50298008.png) (3-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisox...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(O)=O)n1 |t:10| Show InChI InChI=1S/C15H14FN3O5/c1-22-11-3-2-8(6-9(11)16)10-7-12(23-18-10)15-17-13(24-19-15)4-5-14(20)21/h2-3,6,12H,4-5,7H2,1H3,(H,20,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
![PNG](/data/jpeg/tenK5018/BindingDB_50186426.png) (CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298006
![PNG](/data/jpeg/tenK5029/BindingDB_50298006.png) (3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazo...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(n1)C(F)(F)F |t:10| Show InChI InChI=1S/C13H9F4N3O3/c1-21-9-3-2-6(4-7(9)14)8-5-10(22-19-8)11-18-12(23-20-11)13(15,16)17/h2-4,10H,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298008
![PNG](/data/jpeg/tenK5029/BindingDB_50298008.png) (3-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisox...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(CCC(O)=O)n1 |t:10| Show InChI InChI=1S/C15H14FN3O5/c1-22-11-3-2-8(6-9(11)16)10-7-12(23-18-10)15-17-13(24-19-15)4-5-14(20)21/h2-3,6,12H,4-5,7H2,1H3,(H,20,21) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298007
![PNG](/data/jpeg/tenK5029/BindingDB_50298007.png) (2-fluoro-4-(5-(5-(trifluoromethyl)-1,2,4-oxadiazol...)Show SMILES Oc1ccc(cc1F)C1=NOC(C1)c1noc(n1)C(F)(F)F |t:9| Show InChI InChI=1S/C12H7F4N3O3/c13-6-3-5(1-2-8(6)20)7-4-9(21-18-7)10-17-11(22-19-10)12(14,15)16/h1-3,9,20H,4H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298005
![PNG](/data/jpeg/tenK5029/BindingDB_50298005.png) (2-fluoro-4-(5-(5-methyl-1,2,4-oxadiazol-3-yl)-4,5-...)Show InChI InChI=1S/C12H10FN3O3/c1-6-14-12(16-18-6)11-5-9(15-19-11)7-2-3-10(17)8(13)4-7/h2-4,11,17H,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298004
![PNG](/data/jpeg/tenK5029/BindingDB_50298004.png) (3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazo...)Show InChI InChI=1S/C13H12FN3O3/c1-7-15-13(17-19-7)12-6-10(16-20-12)8-3-4-11(18-2)9(14)5-8/h3-5,12H,6H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
![PNG](/data/jpeg/tenK5018/BindingDB_50186426.png) (CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298017
![PNG](/data/jpeg/tenK5029/BindingDB_50298017.png) (3-((3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisoxaz...)Show InChI InChI=1S/C13H16FN3O3/c1-17(2)13(19)15-7-9-6-11(16-20-9)8-3-4-12(18)10(14)5-8/h3-5,9,18H,6-7H2,1-2H3,(H,15,19) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298016
![PNG](/data/jpeg/tenK5029/BindingDB_50298016.png) (CHEMBL557060 | N-((3-(3-fluoro-4-hydroxyphenyl)-4,...)Show SMILES CC(C)CC(=O)NCC1CC(=NO1)c1ccc(O)c(F)c1 |c:10| Show InChI InChI=1S/C15H19FN2O3/c1-9(2)5-15(20)17-8-11-7-13(18-21-11)10-3-4-14(19)12(16)6-10/h3-4,6,9,11,19H,5,7-8H2,1-2H3,(H,17,20) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298015
![PNG](/data/jpeg/tenK5029/BindingDB_50298015.png) (CHEMBL559497 | N-((3-(3-fluoro-4-hydroxyphenyl)-4,...)Show SMILES CC(C)(C)C(=O)NCC1CC(=NO1)c1ccc(O)c(F)c1 |c:10| Show InChI InChI=1S/C15H19FN2O3/c1-15(2,3)14(20)17-8-10-7-12(18-21-10)9-4-5-13(19)11(16)6-9/h4-6,10,19H,7-8H2,1-3H3,(H,17,20) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298012
![PNG](/data/jpeg/tenK5029/BindingDB_50298012.png) (2-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisox...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(n1)-c1ccccc1N(C)C(O)=O |t:10| Show InChI InChI=1S/C20H17FN4O5/c1-25(20(26)27)15-6-4-3-5-12(15)19-22-18(24-30-19)17-10-14(23-29-17)11-7-8-16(28-2)13(21)9-11/h3-9,17H,10H2,1-2H3,(H,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298006
![PNG](/data/jpeg/tenK5029/BindingDB_50298006.png) (3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxazo...)Show SMILES COc1ccc(cc1F)C1=NOC(C1)c1noc(n1)C(F)(F)F |t:10| Show InChI InChI=1S/C13H9F4N3O3/c1-21-9-3-2-6(4-7(9)14)8-5-10(22-19-8)11-18-12(23-20-11)13(15,16)17/h2-4,10H,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50298026
![PNG](/data/jpeg/tenK5029/BindingDB_50298026.png) (3-((3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisoxaz...)Show SMILES COc1ccc(cc1F)C1=NOC(Cc2noc(n2)C(F)(F)F)C1 |t:10| Show InChI InChI=1S/C14H11F4N3O3/c1-22-11-3-2-7(4-9(11)15)10-5-8(23-20-10)6-12-19-13(24-21-12)14(16,17)18/h2-4,8H,5-6H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | |