Found 16 hits Enz. Inhib. hit(s) with Target = 'Macrophage migration inhibitory factor' and Ligand = 'BDBM50186426' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB US Patent
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
US Patent
| Assay Description Data obtained for the Example compounds, obtained using the methods described in Example B. |
US Patent US10968198 (2021)
BindingDB Entry DOI: 10.7270/Q2DJ5JR7 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB PCBioAssay
| 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SRMLSC
Curated by PubChem BioAssay
| Assay Description Inhibition of the tautomerase activity of MIF was measured using 4-hydroxyphenyl pyruvic acid (HPP) as substrate, largely following previously report... |
PubChem Bioassay (2007)
BindingDB Entry DOI: 10.7270/Q2RR1WNP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| 4.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128445 BindingDB Entry DOI: 10.7270/Q2Z03D5N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of C-terminal His-tagged recombinant human MIF expressed in Escherichia coli BL21 (DE3) using 4-HPP as substrate preincubated for 10 mins ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01160 BindingDB Entry DOI: 10.7270/Q2KW5KPR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of C-terminal His-tagged recombinant human MIF tautomerase activity expressed in Escherichia coli BL21 using 4-hydroxyphenyl pyruvic acid ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.111849 BindingDB Entry DOI: 10.7270/Q20C50GK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant MIF (unknown origin) tautomerase activity using dopachrome methyl ester as substrate measured for 2 to 20 secs by spectroph... |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Mus musculus (Mouse)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB US Patent
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | 7.2 | 25 |
The Feinstein Institute for Medical Research
US Patent
| Assay Description MIF tautomerase activity was measured by UV-Visible recording spectrophotometry (SHIMADZU, UV1600U). A fresh stock solution of L-dopachrome methyl es... |
US Patent US8618147 (2013)
BindingDB Entry DOI: 10.7270/Q23R0RHZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description Inhibition of MIF tautomerase activity |
Bioorg Med Chem Lett 16: 3376-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.038 BindingDB Entry DOI: 10.7270/Q27W6BSG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Yale University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human MIF (Pro2 to Ala115 residues) expressed in Escherichia coli using dopachrome methyl ester as substrate preincubated w... |
J Med Chem 61: 8104-8119 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00589 BindingDB Entry DOI: 10.7270/Q2KS6V5P |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISA |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of C-terminal His-tagged recombinant human MIF tautomerase activity expressed in Escherichia coli BL21 using 4-hydroxyphenyl pyruvic acid ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2019.111849 BindingDB Entry DOI: 10.7270/Q20C50GK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| n/a | n/a | 6.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128445 BindingDB Entry DOI: 10.7270/Q2Z03D5N |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of MIF in human THP1 cells |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| n/a | n/a | 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Groningen
Curated by ChEMBL
| Assay Description Inhibition of recombinant His-tagged MIF tautomerase activity (unknown origin) using 4-HPP as substrate |
Bioorg Med Chem 26: 999-1005 (2018)
Article DOI: 10.1016/j.bmc.2017.12.032 BindingDB Entry DOI: 10.7270/Q2G44SVK |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Piramal Life Sciences
Curated by ChEMBL
| Assay Description Inhibition of dopachrome tautomerase activity of human recombinant MIF |
Bioorg Med Chem Lett 19: 4773-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.06.052 BindingDB Entry DOI: 10.7270/Q2Z0387W |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Macrophage migration inhibitory factor
(Homo sapiens (Human)) | BDBM50186426
(CHEMBL210858 | US10336721, ISO-1 | US10968198, ISO...)Show InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,14H,6-7H2,1H3 | PDB MMDB
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| n/a | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Displacement of 4'-(7-Hydroxy-2-oxo-2H-chromen-3-yl)-[1,1'-biphenyl]-4-carboxylic acid from C-terminal His-tagged recombinant human MIF expressed in ... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01160 BindingDB Entry DOI: 10.7270/Q2KW5KPR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |