Found 21 hits Enz. Inhib. hit(s) with all data for entry = 50035432 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143456
((S)-2-((S)-2-{3-Benzyl-3-[(2R,3S)-3-((S)-2-tert-bu...)Show SMILES COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C40H61N5O8/c1-25(2)21-31(35(47)43-34(27(5)6)37(49)52-10)42-38(50)45(23-29-19-15-12-16-20-29)24-32(46)30(22-28-17-13-11-14-18-28)41-36(48)33(26(3)4)44-39(51)53-40(7,8)9/h11-20,25-27,30-34,46H,21-24H2,1-10H3,(H,41,48)(H,42,50)(H,43,47)(H,44,51)/t30-,31-,32+,33-,34-/m0/s1 | PDB
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UniProtKB/SwissProt
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GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143445
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C36H46N4O7/c1-25(32(42)38-30(33(43)46-5)22-27-17-11-7-12-18-27)37-34(44)40(23-28-19-13-8-14-20-28)24-31(41)29(21-26-15-9-6-10-16-26)39-35(45)47-36(2,3)4/h6-20,25,29-31,41H,21-24H2,1-5H3,(H,37,44)(H,38,42)(H,39,45)/t25-,29-,30-,31+/m0/s1 | PDB
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UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143449
((S)-2-((S)-2-{3-Benzyl-3-[(2R,3S)-3-(2-tert-butoxy...)Show SMILES COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C38H57N5O8/c1-24(2)20-30(34(46)42-32(25(3)4)35(47)50-9)41-36(48)43(22-28-18-14-11-15-19-28)23-31(44)29(21-27-16-12-10-13-17-27)40-33(45)26(5)39-37(49)51-38(6,7)8/h10-19,24-26,29-32,44H,20-23H2,1-9H3,(H,39,49)(H,40,45)(H,41,48)(H,42,46)/t26-,29-,30-,31+,32-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143457
((R)-methyl 2-((R)-2-(3-benzyl-3-((2S,3R)-3-(tert-b...)Show SMILES COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C35H52N4O7/c1-23(2)19-28(31(41)38-30(24(3)4)32(42)45-8)36-33(43)39(21-26-17-13-10-14-18-26)22-29(40)27(20-25-15-11-9-12-16-25)37-34(44)46-35(5,6)7/h9-18,23-24,27-30,40H,19-22H2,1-8H3,(H,36,43)(H,37,44)(H,38,41)/t27-,28-,29+,30-/m0/s1 | PDB
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| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143442
((S)-2-((S)-2-{3-Benzyl-3-[(2R,3S)-3-((S)-2-tert-bu...)Show SMILES COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C41H63N5O8/c1-26(2)21-32(37(49)45-35(28(5)6)38(50)53-10)43-39(51)46(24-30-19-15-12-16-20-30)25-34(47)31(23-29-17-13-11-14-18-29)42-36(48)33(22-27(3)4)44-40(52)54-41(7,8)9/h11-20,26-28,31-35,47H,21-25H2,1-10H3,(H,42,48)(H,43,51)(H,44,52)(H,45,49)/t31-,32-,33-,34+,35-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143450
(2-((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxy...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C44H61N5O8/c1-29(2)24-35(39(51)48-38(30(3)4)40(52)45-36(41(53)56-8)26-32-20-14-10-15-21-32)46-42(54)49(27-33-22-16-11-17-23-33)28-37(50)34(25-31-18-12-9-13-19-31)47-43(55)57-44(5,6)7/h9-23,29-30,34-38,50H,24-28H2,1-8H3,(H,45,52)(H,46,54)(H,47,55)(H,48,51)/t34-,35-,36-,37+,38-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50366945
(CHEMBL1791282)Show SMILES CC[C@@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C)C(=O)OC Show InChI InChI=1S/C41H63N5O8/c1-11-28(6)35(38(50)53-10)45-37(49)34(27(4)5)44-36(48)32(22-26(2)3)42-39(51)46(24-30-20-16-13-17-21-30)25-33(47)31(23-29-18-14-12-15-19-29)43-40(52)54-41(7,8)9/h12-21,26-28,31-35,47H,11,22-25H2,1-10H3,(H,42,51)(H,43,52)(H,44,48)(H,45,49)/t28-,31+,32+,33-,34+,35+/m1/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143446
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C39H52N4O7/c1-27(2)22-32(35(45)40-33(36(46)49-6)24-29-18-12-8-13-19-29)41-37(47)43(25-30-20-14-9-15-21-30)26-34(44)31(23-28-16-10-7-11-17-28)42-38(48)50-39(3,4)5/h7-21,27,31-34,44H,22-26H2,1-6H3,(H,40,45)(H,41,47)(H,42,48)/t31-,32-,33-,34+/m0/s1 | PDB
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143438
((S)-2-{(S)-2-[3-((2R,3S)-3-tert-Butoxycarbonylamin...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C Show InChI InChI=1S/C36H54N4O7/c1-24(2)19-29(32(42)37-30(33(43)46-8)21-27-17-13-10-14-18-27)38-34(44)40(22-25(3)4)23-31(41)28(20-26-15-11-9-12-16-26)39-35(45)47-36(5,6)7/h9-18,24-25,28-31,41H,19-23H2,1-8H3,(H,37,42)(H,38,44)(H,39,45)/t28-,29-,30-,31+/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143439
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C38H50N4O7/c1-26(2)33(34(44)39-31(35(45)48-6)23-28-18-12-8-13-19-28)41-36(46)42(24-29-20-14-9-15-21-29)25-32(43)30(22-27-16-10-7-11-17-27)40-37(47)49-38(3,4)5/h7-21,26,30-33,43H,22-25H2,1-6H3,(H,39,44)(H,40,47)(H,41,46)/t30-,31-,32+,33-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143446
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C39H52N4O7/c1-27(2)22-32(35(45)40-33(36(46)49-6)24-29-18-12-8-13-19-29)41-37(47)43(25-30-20-14-9-15-21-30)26-34(44)31(23-28-16-10-7-11-17-28)42-38(48)50-39(3,4)5/h7-21,27,31-34,44H,22-26H2,1-6H3,(H,40,45)(H,41,47)(H,42,48)/t31-,32-,33-,34+/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143455
((S)-2-((S)-2-{3-Benzyl-3-[(2R,3S)-3-((S)-2-tert-bu...)Show SMILES COC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C44H61N5O8/c1-29(2)24-35(40(52)48-38(30(3)4)41(53)56-8)46-42(54)49(27-33-22-16-11-17-23-33)28-37(50)34(25-31-18-12-9-13-19-31)45-39(51)36(26-32-20-14-10-15-21-32)47-43(55)57-44(5,6)7/h9-23,29-30,34-38,50H,24-28H2,1-8H3,(H,45,51)(H,46,54)(H,47,55)(H,48,52)/t34-,35-,36-,37+,38-/m0/s1 | PDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143451
(2-((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxy...)Show SMILES COC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C)C(C)C Show InChI InChI=1S/C40H61N5O8/c1-25(2)21-31(35(47)43-33(26(3)4)36(48)44-34(27(5)6)37(49)52-10)41-38(50)45(23-29-19-15-12-16-20-29)24-32(46)30(22-28-17-13-11-14-18-28)42-39(51)53-40(7,8)9/h11-20,25-27,30-34,46H,21-24H2,1-10H3,(H,41,50)(H,42,51)(H,43,47)(H,44,48)/t30-,31-,32+,33-,34-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143447
(2-((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxy...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C41H63N5O8/c1-26(2)21-32(36(48)45-35(28(5)6)37(49)42-33(22-27(3)4)38(50)53-10)43-39(51)46(24-30-19-15-12-16-20-30)25-34(47)31(23-29-17-13-11-14-18-29)44-40(52)54-41(7,8)9/h11-20,26-28,31-35,47H,21-25H2,1-10H3,(H,42,49)(H,43,51)(H,44,52)(H,45,48)/t31-,32-,33-,34+,35-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143453
((R)-methyl 2-((R)-2-(3-benzyl-3-((2S,3R)-3-(tert-b...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C36H54N4O7/c1-24(2)19-29(32(42)37-30(20-25(3)4)33(43)46-8)38-34(44)40(22-27-17-13-10-14-18-27)23-31(41)28(21-26-15-11-9-12-16-26)39-35(45)47-36(5,6)7/h9-18,24-25,28-31,41H,19-23H2,1-8H3,(H,37,42)(H,38,44)(H,39,45)/t28-,29-,30-,31+/m0/s1 | PDB
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Similars
| Article
PubMed
| n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143444
(2-((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxy...)Show SMILES COC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(C)C Show InChI InChI=1S/C38H57N5O8/c1-24(2)20-30(33(45)42-32(25(3)4)34(46)39-26(5)35(47)50-9)40-36(48)43(22-28-18-14-11-15-19-28)23-31(44)29(21-27-16-12-10-13-17-27)41-37(49)51-38(6,7)8/h10-19,24-26,29-32,44H,20-23H2,1-9H3,(H,39,46)(H,40,48)(H,41,49)(H,42,45)/t26-,29-,30-,31+,32-/m0/s1 | PDB
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Similars
| Article
PubMed
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143452
((S)-2-{(S)-2-[3-((2R,3S)-3-tert-Butoxycarbonylamin...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C Show InChI InChI=1S/C33H48N4O7/c1-22(2)18-26(29(39)34-27(30(40)43-7)20-24-16-12-9-13-17-24)35-31(41)37(6)21-28(38)25(19-23-14-10-8-11-15-23)36-32(42)44-33(3,4)5/h8-17,22,25-28,38H,18-21H2,1-7H3,(H,34,39)(H,35,41)(H,36,42)/t25-,26-,27-,28+/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143454
((S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycarbonylam...)Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C30H43N3O6/c1-21(2)17-25(27(35)38-6)31-28(36)33(19-23-15-11-8-12-16-23)20-26(34)24(18-22-13-9-7-10-14-22)32-29(37)39-30(3,4)5/h7-16,21,24-26,34H,17-20H2,1-6H3,(H,31,36)(H,32,37)/t24-,25-,26+/m0/s1 | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143441
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C42H50N4O7/c1-42(2,3)53-41(51)45-34(25-30-17-9-5-10-18-30)37(47)29-46(28-33-23-15-8-16-24-33)40(50)44-35(26-31-19-11-6-12-20-31)38(48)43-36(39(49)52-4)27-32-21-13-7-14-22-32/h5-24,34-37,47H,25-29H2,1-4H3,(H,43,48)(H,44,50)(H,45,51)/t34-,35-,36-,37+/m0/s1 | PDB
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143443
((S)-2-{(S)-2-[3-Benzyl-3-((2R,3S)-3-tert-butoxycar...)Show SMILES COC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1 Show InChI InChI=1S/C33H48N4O7/c1-22(2)18-27(29(39)34-23(3)30(40)43-7)35-31(41)37(20-25-16-12-9-13-17-25)21-28(38)26(19-24-14-10-8-11-15-24)36-32(42)44-33(4,5)6/h8-17,22-23,26-28,38H,18-21H2,1-7H3,(H,34,39)(H,35,41)(H,36,42)/t23-,26-,27-,28+/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2
(Homo sapiens (Human)) | BDBM50143448
((S)-2-{(S)-2-[3-((2R,3S)-3-tert-Butoxycarbonylamin...)Show SMILES COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)N(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C Show InChI InChI=1S/C35H52N4O7/c1-23(2)19-28(31(41)36-29(32(42)45-8)21-26-17-13-10-14-18-26)37-33(43)39(24(3)4)22-30(40)27(20-25-15-11-9-12-16-25)38-34(44)46-35(5,6)7/h9-18,23-24,27-30,40H,19-22H2,1-8H3,(H,36,41)(H,37,43)(H,38,44)/t27-,28-,29-,30+/m0/s1 | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School
Curated by ChEMBL
| Assay Description
Inhibition of amyloid-beta production in Chinese hamster ovary (CHO) cells expressing human amyloid precursor protein (APP) |
Bioorg Med Chem Lett 14: 1935-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.077
BindingDB Entry DOI: 10.7270/Q2F19080 |
More data for this
Ligand-Target Pair | |
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