Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM50182801 ((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18428 (Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18438 (4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM50396168 (CHEMBL1361379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM50068039 (1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18447 (2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM50068039 (1-{3-[(5-Bromo-pyridin-2-yl)-(3,4-dichloro-benzyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18428 (Aminoquinoline compound, 1 | N-[4-methyl-2-(morpho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18438 (4-benzenesulfonamido-N-(5-ethyl-1,3,4-thiadiazol-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM18447 (2-({4-[(5-chloro-2-methoxyphenyl)amino]-6-(pyrroli...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase in human spleen homogenate using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to subs... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysosomal acid glucosylceramidase (Homo sapiens (Human)) | BDBM50396168 (CHEMBL1361379) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translation Sciences Curated by ChEMBL | Assay Description Inhibition of wild type glucocerebrosidase using 4-methylumbellifereno-Glc as substrate incubated for 5 mins prior to substrate addition measured aft... | J Med Chem 55: 5734-48 (2012) Article DOI: 10.1021/jm300063b BindingDB Entry DOI: 10.7270/Q2H70GZ1 | |||||||||||
More data for this Ligand-Target Pair |