Found 13 hits Enz. Inhib. hit(s) with all data for entry = 50045662 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073221
(CHEMBL3408420)Show SMILES COc1ccc(cc1OC)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:11| Show InChI InChI=1S/C25H22N4O3/c1-31-19-12-11-17(15-20(19)32-2)24-26-18(14-16-8-4-3-5-9-16)23(30)22-25(28-24)27-21-10-6-7-13-29(21)22/h3-13,15,18H,14H2,1-2H3,(H,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysis |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073222
(CHEMBL3125572)Show SMILES Cc1ccccc1C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:8| Show InChI InChI=1S/C24H20N4O/c1-16-9-5-6-12-18(16)23-25-19(15-17-10-3-2-4-11-17)22(29)21-24(27-23)26-20-13-7-8-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Competitive inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate by Lineweaver-Burk plot analysis |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073221
(CHEMBL3408420)Show SMILES COc1ccc(cc1OC)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:11| Show InChI InChI=1S/C25H22N4O3/c1-31-19-12-11-17(15-20(19)32-2)24-26-18(14-16-8-4-3-5-9-16)23(30)22-25(28-24)27-21-10-6-7-13-29(21)22/h3-13,15,18H,14H2,1-2H3,(H,26,28)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073228
(CHEMBL3408421)Show SMILES COc1cc(cc(OC)c1OC)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:13| Show InChI InChI=1S/C26H24N4O4/c1-32-19-14-17(15-20(33-2)24(19)34-3)25-27-18(13-16-9-5-4-6-10-16)23(31)22-26(29-25)28-21-11-7-8-12-30(21)22/h4-12,14-15,18H,13H2,1-3H3,(H,27,29)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073222
(CHEMBL3125572)Show SMILES Cc1ccccc1C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:8| Show InChI InChI=1S/C24H20N4O/c1-16-9-5-6-12-18(16)23-25-19(15-17-10-3-2-4-11-17)22(29)21-24(27-23)26-20-13-7-8-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073230
(CHEMBL3125570)Show SMILES Cc1ccc(cc1)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:8| Show InChI InChI=1S/C24H20N4O/c1-16-10-12-18(13-11-16)23-25-19(15-17-7-3-2-4-8-17)22(29)21-24(27-23)26-20-9-5-6-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073231
(CHEMBL3125571)Show SMILES COc1ccc(cc1)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:9| Show InChI InChI=1S/C24H20N4O2/c1-30-18-12-10-17(11-13-18)23-25-19(15-16-7-3-2-4-8-16)22(29)21-24(27-23)26-20-9-5-6-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073229
(CHEMBL3408419)Show SMILES COc1ccc(OC)c(c1)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:11| Show InChI InChI=1S/C25H22N4O3/c1-31-17-11-12-20(32-2)18(15-17)24-26-19(14-16-8-4-3-5-9-16)23(30)22-25(28-24)27-21-10-6-7-13-29(21)22/h3-13,15,19H,14H2,1-2H3,(H,26,28)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.09E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073233
(CHEMBL3408416)Show SMILES Cc1ccc(c(C)c1)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:9| Show InChI InChI=1S/C25H22N4O/c1-16-11-12-19(17(2)14-16)24-26-20(15-18-8-4-3-5-9-18)23(30)22-25(28-24)27-21-10-6-7-13-29(21)22/h3-14,20H,15H2,1-2H3,(H,26,28)/t20-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073232
(CHEMBL3408410)Show SMILES Cc1ccccc1C1=Nc2nc3ccccn3c2C(=O)[C@@H](Cc2ccccc2)N1 |r,t:8| Show InChI InChI=1S/C24H20N4O/c1-16-9-5-6-12-18(16)23-25-19(15-17-10-3-2-4-11-17)22(29)21-24(27-23)26-20-13-7-8-14-28(20)21/h2-14,19H,15H2,1H3,(H,25,27)/t19-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073227
(CHEMBL3408430)Show SMILES Oc1cccc(c1)C1=Nc2nc3ccccn3c2C(=O)[C@H](Cc2ccccc2)N1 |r,t:8| Show InChI InChI=1S/C23H18N4O2/c28-17-10-6-9-16(14-17)22-24-18(13-15-7-2-1-3-8-15)21(29)20-23(26-22)25-19-11-4-5-12-27(19)20/h1-12,14,18,28H,13H2,(H,24,26)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073226
(CHEMBL3408439)Show SMILES Cc1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(=O)c1c(N)nc2ccccn12 |r| Show InChI InChI=1S/C24H22N4O2/c1-16-9-5-6-12-18(16)24(30)26-19(15-17-10-3-2-4-11-17)22(29)21-23(25)27-20-13-7-8-14-28(20)21/h2-14,19H,15,25H2,1H3,(H,26,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
Kallikrein-7
(Homo sapiens (Human)) | BDBM50073224
(CHEMBL3408441)Show SMILES Nc1nc2ccccn2c1C(=O)[C@H](Cc1ccccc1)NC(=O)Cc1ccccc1 |r| Show InChI InChI=1S/C24H22N4O2/c25-24-22(28-14-8-7-13-20(28)27-24)23(30)19(15-17-9-3-1-4-10-17)26-21(29)16-18-11-5-2-6-12-18/h1-14,19H,15-16,25H2,(H,26,29)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.49E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Montpellier
Curated by ChEMBL
| Assay Description
Inhibition of human KLK7 using Suc-Leu-Leu-Val-Tyr-AMC as substrate after 15 mins by fluorescence assay |
Eur J Med Chem 93: 202-13 (2015)
Article DOI: 10.1016/j.ejmech.2015.02.008
BindingDB Entry DOI: 10.7270/Q27P913V |
More data for this
Ligand-Target Pair | |
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