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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with all data for entry = 50048815   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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n/an/a 0.600n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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n/an/a 9.10n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM31046
PNG
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10|
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
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n/an/a 10n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM31046
PNG
(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1 |t:10|
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
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n/an/a 10n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228240
PNG
(CHEMBL284056)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN2CCC(CC2)n2c(O)nc3ccccc23)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:33,t:30|
Show InChI InChI=1S/C30H33N5O7/c1-18-25(28(36)41-3)27(20-7-6-8-22(17-20)35(39)40)26(19(2)31-18)29(37)42-16-15-33-13-11-21(12-14-33)34-24-10-5-4-9-23(24)32-30(34)38/h4-10,17,21,27,36H,11-16H2,1-3H3,(H,32,38)/b28-25+
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n/an/a 41n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM29568
PNG
(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
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n/an/a 140n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2 adrenergic receptor activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 210n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228238
PNG
(CHEMBL30911)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8/c1-17-24(27(32)36-4)26(20-9-5-6-10-21(20)31(34)35)25(18(2)29-17)28(33)37-14-13-30(3)15-19-16-38-22-11-7-8-12-23(22)39-19/h5-12,19,26,32H,13-16H2,1-4H3/b27-24+
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n/an/a 270n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228238
PNG
(CHEMBL30911)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8/c1-17-24(27(32)36-4)26(20-9-5-6-10-21(20)31(34)35)25(18(2)29-17)28(33)37-14-13-30(3)15-19-16-38-22-11-7-8-12-23(22)39-19/h5-12,19,26,32H,13-16H2,1-4H3/b27-24+
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n/an/a 300n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228242
PNG
(CHEMBL542812)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C)COc2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:27,t:24|
Show InChI InChI=1S/C28H33N3O7.ClH/c1-18(17-38-23-12-7-6-8-13-23)30(4)14-15-37-28(33)25-20(3)29-19(2)24(27(32)36-5)26(25)21-10-9-11-22(16-21)31(34)35;/h6-13,16,18,26,32H,14-15,17H2,1-5H3;1H/b27-24+;
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n/an/a 380n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228244
PNG
(CHEMBL553942)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OC(C)CN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:30,t:27|
Show InChI InChI=1S/C29H33N3O8.ClH/c1-17(14-31(4)15-22-16-38-23-11-6-7-12-24(23)40-22)39-29(34)26-19(3)30-18(2)25(28(33)37-5)27(26)20-9-8-10-21(13-20)32(35)36;/h6-13,17,22,27,33H,14-16H2,1-5H3;1H/b28-25+;
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n/an/a 470n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228237
PNG
(CHEMBL554455)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;
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n/an/a 480n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228242
PNG
(CHEMBL542812)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C)COc2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:27,t:24|
Show InChI InChI=1S/C28H33N3O7.ClH/c1-18(17-38-23-12-7-6-8-13-23)30(4)14-15-37-28(33)25-20(3)29-19(2)24(27(32)36-5)26(25)21-10-9-11-22(16-21)31(34)35;/h6-13,16,18,26,32H,14-15,17H2,1-5H3;1H/b27-24+;
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n/an/a 480n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228237
PNG
(CHEMBL554455)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;
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n/an/a 500n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228241
PNG
(CHEMBL540511)
Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C30H35N3O8.ClH/c1-18(2)40-30(35)27-20(4)31-19(3)26(28(27)21-9-8-10-22(15-21)33(36)37)29(34)38-14-13-32(5)16-23-17-39-24-11-6-7-12-25(24)41-23;/h6-12,15,18,23,28,35H,13-14,16-17H2,1-5H3;1H/b30-27+;
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n/an/a 830n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228238
PNG
(CHEMBL30911)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8/c1-17-24(27(32)36-4)26(20-9-5-6-10-21(20)31(34)35)25(18(2)29-17)28(33)37-14-13-30(3)15-19-16-38-22-11-7-8-12-23(22)39-19/h5-12,19,26,32H,13-16H2,1-4H3/b27-24+
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n/an/a>1.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50013515
PNG
((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Show SMILES COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 |r|
Show InChI InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228237
PNG
(CHEMBL554455)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;
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n/an/a>1.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228241
PNG
(CHEMBL540511)
Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C30H35N3O8.ClH/c1-18(2)40-30(35)27-20(4)31-19(3)26(28(27)21-9-8-10-22(15-21)33(36)37)29(34)38-14-13-32(5)16-23-17-39-24-11-6-7-12-25(24)41-23;/h6-12,15,18,23,28,35H,13-14,16-17H2,1-5H3;1H/b30-27+;
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n/an/a>1.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228244
PNG
(CHEMBL553942)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OC(C)CN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:30,t:27|
Show InChI InChI=1S/C29H33N3O8.ClH/c1-17(14-31(4)15-22-16-38-23-11-6-7-12-24(23)40-22)39-29(34)26-19(3)30-18(2)25(28(33)37-5)27(26)20-9-8-10-21(13-20)32(35)36;/h6-13,17,22,27,33H,14-16H2,1-5H3;1H/b28-25+;
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n/an/a 1.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50101815
PNG
(CHEBI:7550 | Nicardipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9|
Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228240
PNG
(CHEMBL284056)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN2CCC(CC2)n2c(O)nc3ccccc23)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:33,t:30|
Show InChI InChI=1S/C30H33N5O7/c1-18-25(28(36)41-3)27(20-7-6-8-22(17-20)35(39)40)26(19(2)31-18)29(37)42-16-15-33-13-11-21(12-14-33)34-24-10-5-4-9-23(24)32-30(34)38/h4-10,17,21,27,36H,11-16H2,1-3H3,(H,32,38)/b28-25+
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n/an/a 1.60E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228243
PNG
(CHEMBL542814)
Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OC(C)CN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:32,t:29|
Show InChI InChI=1S/C31H37N3O8.ClH/c1-18(2)40-30(35)27-20(4)32-21(5)28(29(27)22-10-9-11-23(14-22)34(37)38)31(36)41-19(3)15-33(6)16-24-17-39-25-12-7-8-13-26(25)42-24;/h7-14,18-19,24,29,35H,15-17H2,1-6H3;1H/b30-27+;
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228239
PNG
(CHEMBL2093965)
Show SMILES Cl.CO\C(O)=C1\[C@@H](C(C(=O)OCCN(C)C[C@@H]2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |r,c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;/t21-,26+;/m1./s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228241
PNG
(CHEMBL540511)
Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C30H35N3O8.ClH/c1-18(2)40-30(35)27-20(4)31-19(3)26(28(27)21-9-8-10-22(15-21)33(36)37)29(34)38-14-13-32(5)16-23-17-39-24-11-6-7-12-25(24)41-23;/h6-12,15,18,23,28,35H,13-14,16-17H2,1-5H3;1H/b30-27+;
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n/an/a 3.50E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50101815
PNG
(CHEBI:7550 | Nicardipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9|
Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
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n/an/a 3.60E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228243
PNG
(CHEMBL542814)
Show SMILES Cl.CC(C)O\C(O)=C1\C(C(C(=O)OC(C)CN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:32,t:29|
Show InChI InChI=1S/C31H37N3O8.ClH/c1-18(2)40-30(35)27-20(4)32-21(5)28(29(27)22-10-9-11-23(14-22)34(37)38)31(36)41-19(3)15-33(6)16-24-17-39-25-12-7-8-13-26(25)42-24;/h7-14,18-19,24,29,35H,15-17H2,1-6H3;1H/b30-27+;
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n/an/a 3.90E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 4.00E+3n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228240
PNG
(CHEMBL284056)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN2CCC(CC2)n2c(O)nc3ccccc23)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:33,t:30|
Show InChI InChI=1S/C30H33N5O7/c1-18-25(28(36)41-3)27(20-7-6-8-22(17-20)35(39)40)26(19(2)31-18)29(37)42-16-15-33-13-11-21(12-14-33)34-24-10-5-4-9-23(24)32-30(34)38/h4-10,17,21,27,36H,11-16H2,1-3H3,(H,32,38)/b28-25+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50101815
PNG
(CHEBI:7550 | Nicardipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9|
Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228238
PNG
(CHEMBL30911)
Show SMILES CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1ccccc1[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8/c1-17-24(27(32)36-4)26(20-9-5-6-10-21(20)31(34)35)25(18(2)29-17)28(33)37-14-13-30(3)15-19-16-38-22-11-7-8-12-23(22)39-19/h5-12,19,26,32H,13-16H2,1-4H3/b27-24+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50101815
PNG
(CHEBI:7550 | Nicardipine)
Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9|
Show InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228239
PNG
(CHEMBL2093965)
Show SMILES Cl.CO\C(O)=C1\[C@@H](C(C(=O)OCCN(C)C[C@@H]2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |r,c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;/t21-,26+;/m1./s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed in vitro from the ability to inhibit norepinephrine binding to guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228235
PNG
(CHEMBL554235)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C2CCCCC2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C32H39N3O6.ClH/c1-21-27(31(36)40-4)29(25-16-11-17-26(20-25)35(38)39)28(22(2)33-21)32(37)41-19-18-34(3)30(23-12-7-5-8-13-23)24-14-9-6-10-15-24;/h5,7-8,11-13,16-17,20,24,29-30,36H,6,9-10,14-15,18-19H2,1-4H3;1H/b31-27+;
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n/an/a 1.60E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Ability to inhibit [3H]yohimbine binding to alpha-2 adrenergic receptor of rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor


(RAT-NEONATAL RAT-Rattus norvegicus (rat))		BDBM50228239
PNG
(CHEMBL2093965)
Show SMILES Cl.CO\C(O)=C1\[C@@H](C(C(=O)OCCN(C)C[C@@H]2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |r,c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;/t21-,26+;/m1./s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-2-adrenolytic activity was assessed from the ability to inhibit [3H]yohimbine binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228237
PNG
(CHEMBL554455)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)CC2COc3ccccc3O2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:29,t:26|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,32H,12-13,15-16H2,1-4H3;1H/b27-24+;
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n/an/a 4.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228242
PNG
(CHEMBL542812)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C)COc2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:27,t:24|
Show InChI InChI=1S/C28H33N3O7.ClH/c1-18(17-38-23-12-7-6-8-13-23)30(4)14-15-37-28(33)25-20(3)29-19(2)24(27(32)36-5)26(25)21-10-9-11-22(16-21)31(34)35;/h6-13,16,18,26,32H,14-15,17H2,1-5H3;1H/b27-24+;
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n/an/a 7.00E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228235
PNG
(CHEMBL554235)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C2CCCCC2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C32H39N3O6.ClH/c1-21-27(31(36)40-4)29(25-16-11-17-26(20-25)35(38)39)28(22(2)33-21)32(37)41-19-18-34(3)30(23-12-7-5-8-13-23)24-14-9-6-10-15-24;/h5,7-8,11-13,16-17,20,24,29-30,36H,6,9-10,14-15,18-19H2,1-4H3;1H/b31-27+;
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n/an/a 7.50E+4n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed from the ability to inhibit [3H]prazosin binding to rat cerebral cortex preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228236
PNG
(CHEMBL3350238)
Show SMILES Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)C[C@H]1COc2ccccc2O1 |r,c:4,9|
Show InChI InChI=1S/C28H31N3O8.ClH/c1-17-24(27(32)36-4)26(19-8-7-9-20(14-19)31(34)35)25(18(2)29-17)28(33)37-13-12-30(3)15-21-16-38-22-10-5-6-11-23(22)39-21;/h5-11,14,21,26,29H,12-13,15-16H2,1-4H3;1H/t21-,26+;/m0./s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor


(Homo sapiens (Human))		BDBM50228235
PNG
(CHEMBL554235)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C2CCCCC2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C32H39N3O6.ClH/c1-21-27(31(36)40-4)29(25-16-11-17-26(20-25)35(38)39)28(22(2)33-21)32(37)41-19-18-34(3)30(23-12-7-5-8-13-23)24-14-9-6-10-15-24;/h5,7-8,11-13,16-17,20,24,29-30,36H,6,9-10,14-15,18-19H2,1-4H3;1H/b31-27+;
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n/an/a>1.00E+5n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
In vitro ability to inhibit norepinephrine binding to alpha-2 adrenergic receptor of guinea pig vas deferens

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))		BDBM50228235
PNG
(CHEMBL554235)
Show SMILES Cl.CO\C(O)=C1\C(C(C(=O)OCCN(C)C(C2CCCCC2)c2ccccc2)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O |c:31,t:28|
Show InChI InChI=1S/C32H39N3O6.ClH/c1-21-27(31(36)40-4)29(25-16-11-17-26(20-25)35(38)39)28(22(2)33-21)32(37)41-19-18-34(3)30(23-12-7-5-8-13-23)24-14-9-6-10-15-24;/h5,7-8,11-13,16-17,20,24,29-30,36H,6,9-10,14-15,18-19H2,1-4H3;1H/b31-27+;
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n/an/a>1.00E+5n/an/an/an/an/an/a



Institut de Pharmacologie (UA 589 CNRS)

Curated by ChEMBL


Assay Description
Alpha-1-adrenolytic activity was assessed in vitro from the ability to inhibit clonidine binding to rat aorta preparation

J Med Chem 32: 1402-7 (1989)


BindingDB Entry DOI: 10.7270/Q2SQ92M9
More data for this
Ligand-Target Pair