Compile Data Set for Download or QSAR

Found 438 hits Enz. Inhib. hit(s) with all data for entry = 8747   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396975 (US10442810, Example 37 | US10844069, Example 37 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-15-12-20(13-16-37)26-17-25(27-28(33)34-18-35-39(26)27)19-4-8-22(9-5-19)36-29(40)24-3-2-14-38(30(24)41)23-10-6-21(32)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396976 (US10442810, Example 38 | US10844069, Example 38 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396977 (US10442810, Example 39 | US10844069, Example 39 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O4/c1-44-31(43)38-13-10-18(11-14-38)26-16-24(27-28(34)35-17-36-40(26)27)22-9-6-20(15-25(22)33)37-29(41)23-3-2-12-39(30(23)42)21-7-4-19(32)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396977 (US10442810, Example 39 | US10844069, Example 39 | ...) Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C31H27F2N7O4/c1-44-31(43)38-13-10-18(11-14-38)26-16-24(27-28(34)35-17-36-40(26)27)22-9-6-20(15-25(22)33)37-29(41)23-3-2-12-39(30(23)42)21-7-4-19(32)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396979 (US10442810, Example 41 | US10844069, Example 41 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396979 (US10442810, Example 41 | US10844069, Example 41 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396980 (US10442810, Example 42 | US10844069, Example 42 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396980 (US10442810, Example 42 | US10844069, Example 42 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396981 (US10442810, Example 43 | US10844069, Example 43 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396981 (US10442810, Example 43 | US10844069, Example 43 | ...) Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396982 (US10442810, Example 44 | US10844069, Example 44 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32N8O3/c1-37(2)32(43)38-17-14-22(15-18-38)27-19-26(28-29(33)34-20-35-40(27)28)21-10-12-23(13-11-21)36-30(41)25-9-6-16-39(31(25)42)24-7-4-3-5-8-24/h3-13,16,19-20,22H,14-15,17-18H2,1-2H3,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396982 (US10442810, Example 44 | US10844069, Example 44 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32N8O3/c1-37(2)32(43)38-17-14-22(15-18-38)27-19-26(28-29(33)34-20-35-40(27)28)21-10-12-23(13-11-21)36-30(41)25-9-6-16-39(31(25)42)24-7-4-3-5-8-24/h3-13,16,19-20,22H,14-15,17-18H2,1-2H3,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396983 (US10442810, Example 45 | US10844069, Example 45 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-16-13-21(14-17-39)27-18-26(28-29(34)35-19-36-41(27)28)20-5-9-23(10-6-20)37-30(42)25-4-3-15-40(31(25)43)24-11-7-22(33)8-12-24/h3-12,15,18-19,21H,13-14,16-17H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396983 (US10442810, Example 45 | US10844069, Example 45 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-16-13-21(14-17-39)27-18-26(28-29(34)35-19-36-41(27)28)20-5-9-23(10-6-20)37-30(42)25-4-3-15-40(31(25)43)24-11-7-22(33)8-12-24/h3-12,15,18-19,21H,13-14,16-17H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396984 (US10442810, Example 46 | US10844069, Example 46 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-15-12-20(13-16-39)27-18-25(28-29(34)35-19-36-41(27)28)23-11-10-21(17-26(23)33)37-30(42)24-9-6-14-40(31(24)43)22-7-4-3-5-8-22/h3-11,14,17-20H,12-13,15-16H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396984 (US10442810, Example 46 | US10844069, Example 46 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-15-12-20(13-16-39)27-18-25(28-29(34)35-19-36-41(27)28)23-11-10-21(17-26(23)33)37-30(42)24-9-6-14-40(31(24)43)22-7-4-3-5-8-22/h3-11,14,17-20H,12-13,15-16H2,1-2H3,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396985 (US10442810, Example 47 | US10844069, Example 47 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H30F2N8O3/c1-39(2)32(45)40-14-11-19(12-15-40)27-17-25(28-29(35)36-18-37-42(27)28)23-10-7-21(16-26(23)34)38-30(43)24-4-3-13-41(31(24)44)22-8-5-20(33)6-9-22/h3-10,13,16-19H,11-12,14-15H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396985 (US10442810, Example 47 | US10844069, Example 47 | ...) Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H30F2N8O3/c1-39(2)32(45)40-14-11-19(12-15-40)27-17-25(28-29(35)36-18-37-42(27)28)23-10-7-21(16-26(23)34)38-30(43)24-4-3-13-41(31(24)44)22-8-5-20(33)6-9-22/h3-10,13,16-19H,11-12,14-15H2,1-2H3,(H,38,43)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396987 (US10442810, Example 49 | US10844069, Example 49 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-18-17-38-15-12-22(13-16-38)28-19-27(29-30(34)35-20-36-40(28)29)21-4-8-24(9-5-21)37-31(41)26-3-2-14-39(32(26)42)25-10-6-23(33)7-11-25/h2-11,14,19-20,22H,12-13,15-18H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396988 (US10442810, Example 50 | US10844069, Example 50 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-17-16-38-14-11-21(12-15-38)28-19-26(29-30(34)35-20-36-40(28)29)24-10-9-22(18-27(24)33)37-31(41)25-8-5-13-39(32(25)42)23-6-3-2-4-7-23/h2-10,13,18-21H,11-12,14-17H2,1H3,(H,37,41)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396988 (US10442810, Example 50 | US10844069, Example 50 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H32FN7O3/c1-43-17-16-38-14-11-21(12-15-38)28-19-26(29-30(34)35-20-36-40(28)29)24-10-9-22(18-27(24)33)37-31(41)25-8-5-13-39(32(25)42)23-6-3-2-4-7-23/h2-10,13,18-21H,11-12,14-17H2,1H3,(H,37,41)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396989 (US10442810, Example 51 | US10844069, Example 51 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H31F2N7O3/c1-44-16-15-39-13-10-20(11-14-39)28-18-26(29-30(35)36-19-37-41(28)29)24-9-6-22(17-27(24)34)38-31(42)25-3-2-12-40(32(25)43)23-7-4-21(33)5-8-23/h2-9,12,17-20H,10-11,13-16H2,1H3,(H,38,42)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396989 (US10442810, Example 51 | US10844069, Example 51 | ...) Show SMILES COCCN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C32H31F2N7O3/c1-44-16-15-39-13-10-20(11-14-39)28-18-26(29-30(35)36-19-37-41(28)29)24-9-6-22(17-27(24)34)38-31(42)25-3-2-12-40(32(25)43)23-7-4-21(33)5-8-23/h2-9,12,17-20H,10-11,13-16H2,1H3,(H,38,42)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396990 (US10442810, Example 52 | US10844069, Example 52 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H31N7O3/c32-29-28-26(19-27(38(28)34-20-33-29)22-12-15-36(16-13-22)17-18-39)21-8-10-23(11-9-21)35-30(40)25-7-4-14-37(31(25)41)24-5-2-1-3-6-24/h1-11,14,19-20,22,39H,12-13,15-18H2,(H,35,40)(H2,32,33,34)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396990 (US10442810, Example 52 | US10844069, Example 52 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H31N7O3/c32-29-28-26(19-27(38(28)34-20-33-29)22-12-15-36(16-13-22)17-18-39)21-8-10-23(11-9-21)35-30(40)25-7-4-14-37(31(25)41)24-5-2-1-3-6-24/h1-11,14,19-20,22,39H,12-13,15-18H2,(H,35,40)(H2,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396991 (US10442810, Example 53 | US10844069, Example 53 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-22-5-9-24(10-6-22)38-13-1-2-25(31(38)42)30(41)36-23-7-3-20(4-8-23)26-18-27(39-28(26)29(33)34-19-35-39)21-11-14-37(15-12-21)16-17-40/h1-10,13,18-19,21,40H,11-12,14-17H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396992 (US10442810, Example 54 | US10844069, Example 54 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-26-17-21(36-30(41)24-7-4-12-38(31(24)42)22-5-2-1-3-6-22)8-9-23(26)25-18-27(39-28(25)29(33)34-19-35-39)20-10-13-37(14-11-20)15-16-40/h1-9,12,17-20,40H,10-11,13-16H2,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396992 (US10442810, Example 54 | US10844069, Example 54 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H30FN7O3/c32-26-17-21(36-30(41)24-7-4-12-38(31(24)42)22-5-2-1-3-6-22)8-9-23(26)25-18-27(39-28(25)29(33)34-19-35-39)20-10-13-37(14-11-20)15-16-40/h1-9,12,17-20,40H,10-11,13-16H2,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396995 (US10442810, Example 57 | US10844069, Example 57 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C37H37FN8O4/c1-3-43(2)37(50)44-17-15-23(16-18-44)31-20-27(33-34(39)40-21-41-46(31)33)22-7-11-25(12-8-22)42-35(48)29-19-28-30(5-4-6-32(28)47)45(36(29)49)26-13-9-24(38)10-14-26/h7-14,19-21,23H,3-6,15-18H2,1-2H3,(H,42,48)(H2,39,40,41)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396996 (US10442810, Example 58 | US10844069, Example 58 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CCCc4n(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12 Show InChI InChI=1S/C37H36F2N8O4/c1-3-44(2)37(51)45-15-13-21(14-16-45)31-19-26(33-34(40)41-20-42-47(31)33)25-12-9-23(17-29(25)39)43-35(49)28-18-27-30(5-4-6-32(27)48)46(36(28)50)24-10-7-22(38)8-11-24/h7-12,17-21H,3-6,13-16H2,1-2H3,(H,43,49)(H2,40,41,42)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396997 (US10442810, Example 59 | US10844069, Example 59 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H34FN7O4/c36-23-6-10-25(11-7-23)42-29-2-1-3-31(45)27(29)18-28(35(42)47)34(46)40-24-8-4-21(5-9-24)26-19-30(43-32(26)33(37)38-20-39-43)22-12-14-41(15-13-22)16-17-44/h4-11,18-20,22,44H,1-3,12-17H2,(H,40,46)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396998 (US10442810, Example 60 | US10844069, Example 60 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cc5C(=O)CCCc5n(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C35H33F2N7O4/c36-21-4-7-23(8-5-21)43-29-2-1-3-31(46)26(29)17-27(35(43)48)34(47)41-22-6-9-24(28(37)16-22)25-18-30(44-32(25)33(38)39-19-40-44)20-10-12-42(13-11-20)14-15-45/h4-9,16-20,45H,1-3,10-15H2,(H,41,47)(H2,38,39,40)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM396999 (US10442810, Example 61 | US10844069, Example 61 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C34H37N9O4/c1-21(2)41-19-27(32(45)42(34(41)47)25-8-6-5-7-9-25)31(44)38-24-12-10-22(11-13-24)26-18-28(43-29(26)30(35)36-20-37-43)23-14-16-40(17-15-23)33(46)39(3)4/h5-13,18-21,23H,14-17H2,1-4H3,(H,38,44)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396999 (US10442810, Example 61 | US10844069, Example 61 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C34H37N9O4/c1-21(2)41-19-27(32(45)42(34(41)47)25-8-6-5-7-9-25)31(44)38-24-12-10-22(11-13-24)26-18-28(43-29(26)30(35)36-20-37-43)23-14-16-40(17-15-23)33(46)39(3)4/h5-13,18-21,23H,14-17H2,1-4H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397000 (US10442810, Example 62 | US10844069, Example 62 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397001 (US10442810, Example 63 | US10844069, Example 63 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H38N8O4/c1-21(2)33(45)40-16-14-24(15-17-40)29-18-27(30-31(36)37-20-38-43(29)30)23-10-12-25(13-11-23)39-32(44)28-19-41(22(3)4)35(47)42(34(28)46)26-8-6-5-7-9-26/h5-13,18-22,24H,14-17H2,1-4H3,(H,39,44)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397001 (US10442810, Example 63 | US10844069, Example 63 | ...) Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H38N8O4/c1-21(2)33(45)40-16-14-24(15-17-40)29-18-27(30-31(36)37-20-38-43(29)30)23-10-12-25(13-11-23)39-32(44)28-19-41(22(3)4)35(47)42(34(28)46)26-8-6-5-7-9-26/h5-13,18-22,24H,14-17H2,1-4H3,(H,39,44)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397002 (US10442810, Example 64 | US10844069, Example 64 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(C)CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C32H34N8O3/c1-20(2)38-18-26(31(42)39(32(38)43)24-7-5-4-6-8-24)30(41)36-23-11-9-21(10-12-23)25-17-27(22-13-15-37(3)16-14-22)40-28(25)29(33)34-19-35-40/h4-12,17-20,22H,13-16H2,1-3H3,(H,36,41)(H2,33,34,35)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397002 (US10442810, Example 64 | US10844069, Example 64 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(C)CC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C32H34N8O3/c1-20(2)38-18-26(31(42)39(32(38)43)24-7-5-4-6-8-24)30(41)36-23-11-9-21(10-12-23)25-17-27(22-13-15-37(3)16-14-22)40-28(25)29(33)34-19-35-40/h4-12,17-20,22H,13-16H2,1-3H3,(H,36,41)(H2,33,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397003 (US10442810, Example 65 | US10844069, Example 65 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-11-7-23(35)8-12-25)31(45)39-24-9-5-21(6-10-24)26-17-28(44-29(26)30(36)37-19-38-44)22-13-15-41(16-14-22)33(47)40(3)4/h5-12,17-20,22H,13-16H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397003 (US10442810, Example 65 | US10844069, Example 65 | ...) Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-11-7-23(35)8-12-25)31(45)39-24-9-5-21(6-10-24)26-17-28(44-29(26)30(36)37-19-38-44)22-13-15-41(16-14-22)33(47)40(3)4/h5-12,17-20,22H,13-16H2,1-4H3,(H,39,45)(H2,36,37,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397004 (US10442810, Example 66 | US10844069, Example 66 | ...) Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12 Show InChI InChI=1S/C35H38FN9O4/c1-5-41(4)34(48)42-16-14-23(15-17-42)29-18-27(30-31(37)38-20-39-45(29)30)22-6-10-25(11-7-22)40-32(46)28-19-43(21(2)3)35(49)44(33(28)47)26-12-8-24(36)9-13-26/h6-13,18-21,23H,5,14-17H2,1-4H3,(H,40,46)(H2,37,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM397005 (US10442810, Example 67 | US10844069, Example 67 | ...) Show SMILES CCn1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2ccc(F)cc2)c1=O Show InChI InChI=1S/C33H34FN9O4/c1-4-40-18-26(31(45)42(33(40)47)24-11-7-22(34)8-12-24)30(44)38-23-9-5-20(6-10-23)25-17-27(43-28(25)29(35)36-19-37-43)21-13-15-41(16-14-21)32(46)39(2)3/h5-12,17-19,21H,4,13-16H2,1-3H3,(H,38,44)(H2,35,36,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair

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