Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Mer' and Ligand = 'BDBM396993'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...				J Med Chem 52: 3576-85 (2009) BindingDB Entry DOI: 10.7270/Q2FB5593
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10442810 (2019) BindingDB Entry DOI: 10.7270/Q2NG4T17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US10844069 (2020) BindingDB Entry DOI: 10.7270/Q2CZ3B73
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM396993 (US10442810, Example 55 | US10844069, Example 55 | ...) Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1 Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MW2N2P
					More data for this Ligand-Target Pair