Compile Data Set for Download or QSAR

Found 209 hits Enz. Inhib. hit(s) with all data for entry = 8987   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362476 (US10562916, Compound 36 | US9834564, Compound 36) Show SMILES C(Cc1cc2ccccc2cn1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C20H17N3/c1-2-6-15(7-3-1)19-14-22-20(23-19)11-10-18-12-16-8-4-5-9-17(16)13-21-18/h1-9,12-14H,10-11H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362480 (US10562916, Compound 40 | US9834564, Compound 40) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccsc1 Show InChI InChI=1S/C19H17N3S/c1-22-12-18(15-10-11-23-13-15)21-19(22)9-8-16-7-6-14-4-2-3-5-17(14)20-16/h2-7,10-13H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362517 (US10562916, Compound 77 | US9834564, Compound 77) Show SMILES Fc1cccc(-c2c[nH]c(CCc3cnc4ccccc4n3)n2)c1F Show InChI InChI=1S/C19H14F2N4/c20-14-5-3-4-13(19(14)21)17-11-23-18(25-17)9-8-12-10-22-15-6-1-2-7-16(15)24-12/h1-7,10-11H,8-9H2,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362529 (US10562916, Compound 89 | US9834564, Compound 89) Show SMILES Cc1ccc(C)c2nc(CCc3nc4ccc5ncccc5c4n3C)cnc12 Show InChI InChI=1S/C23H21N5/c1-14-6-7-15(2)22-21(14)25-13-16(26-22)8-11-20-27-19-10-9-18-17(5-4-12-24-18)23(19)28(20)3/h4-7,9-10,12-13H,8,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362576 (US10562916, Compound 136 | US9834564, Compound 136) Show SMILES Cc1ccc2nc(CCc3nc4c(C)ncc(C)n4n3)cnc2c1C Show InChI InChI=1S/C19H20N6/c1-11-5-7-16-18(13(11)3)21-10-15(22-16)6-8-17-23-19-14(4)20-9-12(2)25(19)24-17/h5,7,9-10H,6,8H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362580 (US10562916, Compound 140 | US9834564, Compound 140) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ncccc4n3)nc12 Show InChI InChI=1S/C17H16N6/c1-11-10-19-12(2)17-21-16(22-23(11)17)8-6-13-5-7-14-15(20-13)4-3-9-18-14/h3-5,7,9-10H,6,8H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362584 (US10562916, Compound 144 | US9834564, Compound 144) Show SMILES COc1nc2ccccc2nc1CCc1nc2c(ccc3ncccc23)n1C Show InChI InChI=1S/C22H19N5O/c1-27-19-11-9-15-14(6-5-13-23-15)21(19)26-20(27)12-10-18-22(28-2)25-17-8-4-3-7-16(17)24-18/h3-9,11,13H,10,12H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50004053 (CHEMBL2180006 | US10562916, Compound 1 | US9834564...) Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)18-13-21-19(23-18)11-10-15-12-20-16-8-4-5-9-17(16)22-15/h1-9,12-13H,10-11H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Patents	PDB US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362429 (US10562916, Compound 2 | US9834564, Compound 2) Show SMILES O=c1[nH]c2ccccc2nc1CCc1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C19H16N4O/c24-19-16(21-14-8-4-5-9-15(14)23-19)10-11-18-20-12-17(22-18)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362430 (US10562916, Compound 14 | US9834564, Compound 3) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccccc12 Show InChI InChI=1S/C19H16N4O/c24-19-14-8-4-5-9-15(14)21-18(23-19)11-10-17-20-12-16(22-17)13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H,20,22)(H,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362431 (US10562916, Compound 4 | US9834564, Compound 4) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2cnccc12 Show InChI InChI=1S/C18H15N5O/c24-18-13-8-9-19-10-15(13)22-17(23-18)7-6-16-20-11-14(21-16)12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H,20,21)(H,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362432 (US10562916, Compound 5 | US9834564, Compound 5) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)nc2ccncc12 Show InChI InChI=1S/C18H15N5O/c24-18-13-10-19-9-8-14(13)21-17(23-18)7-6-16-20-11-15(22-16)12-4-2-1-3-5-12/h1-5,8-11H,6-7H2,(H,20,22)(H,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362444 (US10562916, Compound 11 | US9834564, Compound 11) Show SMILES C(Cc1ccc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C20H17N3/c1-2-6-15(7-3-1)19-14-21-20(23-19)13-12-17-11-10-16-8-4-5-9-18(16)22-17/h1-11,14H,12-13H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362446 (US10562916, Compound 13 | US9834564, Compound 13) Show SMILES C(Cc1ncc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)17-13-21-19(23-17)11-10-18-20-12-15-8-4-5-9-16(15)22-18/h1-9,12-13H,10-11H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362446 (US10562916, Compound 13 | US9834564, Compound 13) Show SMILES C(Cc1ncc2ccccc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C19H16N4/c1-2-6-14(7-3-1)17-13-21-19(23-17)11-10-18-20-12-15-8-4-5-9-16(15)22-18/h1-9,12-13H,10-11H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362456 (US10562916, Compound 16 | US9834564, Compound 16) Show SMILES C(Cc1cnc2cccnc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C18H15N5/c1-2-5-13(6-3-1)16-12-21-17(23-16)9-8-14-11-20-15-7-4-10-19-18(15)22-14/h1-7,10-12H,8-9H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362457 (US10562916, Compound 17 | US9834564, Compound 17) Show SMILES C(Cc1cnc2ccncc2n1)c1nc(c[nH]1)-c1ccccc1 Show InChI InChI=1S/C18H15N5/c1-2-4-13(5-3-1)16-12-21-18(23-16)7-6-14-10-20-15-8-9-19-11-17(15)22-14/h1-5,8-12H,6-7H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362458 (US10562916, Compound 18 | US9834564, Compound 18) Show SMILES Cn1cc(nc1CCc1ncc2ccccc2n1)-c1ccccc1 Show InChI InChI=1S/C20H18N4/c1-24-14-18(15-7-3-2-4-8-15)23-20(24)12-11-19-21-13-16-9-5-6-10-17(16)22-19/h2-10,13-14H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362459 (US10562916, Compound 19 | US9834564, Compound 19) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccccc1 Show InChI InChI=1S/C21H19N3/c1-24-15-20(16-7-3-2-4-8-16)23-21(24)14-13-18-12-11-17-9-5-6-10-19(17)22-18/h2-12,15H,13-14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362460 (Roche-Dataset for PDE10A, Compound 215 | US1056291...) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1 Show InChI InChI=1S/C20H18N4/c1-24-14-19(15-7-3-2-4-8-15)23-20(24)12-11-16-13-21-17-9-5-6-10-18(17)22-16/h2-10,13-14H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362474 (US10562916, Compound 34 | US9834564, Compound 34) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccccc2)cc2ccccc12 Show InChI InChI=1S/C20H17N3O/c24-20-17-9-5-4-8-15(17)12-16(22-20)10-11-19-21-13-18(23-19)14-6-2-1-3-7-14/h1-9,12-13H,10-11H2,(H,21,23)(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362479 (US10562916, Compound 39 | US9834564, Compound 39) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccco1 Show InChI InChI=1S/C19H17N3O/c1-22-13-17(18-7-4-12-23-18)21-19(22)11-10-15-9-8-14-5-2-3-6-16(14)20-15/h2-9,12-13H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362482 (US10562916, Compound 42 | US9834564, Compound 42) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1ccccc1F Show InChI InChI=1S/C21H18FN3/c1-25-14-20(17-7-3-4-8-18(17)22)24-21(25)13-12-16-11-10-15-6-2-5-9-19(15)23-16/h2-11,14H,12-13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362483 (US10562916, Compound 43 | US9834564, Compound 43) Show SMILES Cn1cc(nc1CCc1ccc2ccccc2n1)-c1cccc(F)c1 Show InChI InChI=1S/C21H18FN3/c1-25-14-20(16-6-4-7-17(22)13-16)24-21(25)12-11-18-10-9-15-5-2-3-8-19(15)23-18/h2-10,13-14H,11-12H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362485 (US10562916, Compound 45 | US9834564, Compound 45) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccco1 Show InChI InChI=1S/C18H16N4O/c1-22-12-16(17-7-4-10-23-17)21-18(22)9-8-13-11-19-14-5-2-3-6-15(14)20-13/h2-7,10-12H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362486 (US10562916, Compound 46 | US9834564, Compound 46) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccsc1 Show InChI InChI=1S/C18H16N4S/c1-22-11-17(13-8-9-23-12-13)21-18(22)7-6-14-10-19-15-4-2-3-5-16(15)20-14/h2-5,8-12H,6-7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362488 (US10562916, Compound 48 | US9834564, Compound 48) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1ccccc1F Show InChI InChI=1S/C20H17FN4/c1-25-13-19(15-6-2-3-7-16(15)21)24-20(25)11-10-14-12-22-17-8-4-5-9-18(17)23-14/h2-9,12-13H,10-11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362489 (US10562916, Compound 49 | US9834564, Compound 49) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1cccc(F)c1 Show InChI InChI=1S/C20H17FN4/c1-25-13-19(14-5-4-6-15(21)11-14)24-20(25)10-9-16-12-22-17-7-2-3-8-18(17)23-16/h2-8,11-13H,9-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362490 (US10562916, Compound 50 | US9834564, Compound 50) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1cccc(F)c1F Show InChI InChI=1S/C20H16F2N4/c1-26-12-18(14-5-4-6-15(21)20(14)22)25-19(26)10-9-13-11-23-16-7-2-3-8-17(16)24-13/h2-8,11-12H,9-10H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362491 (US10562916, Compound 51 | US9834564, Compound 51) Show SMILES Cn1cc(nc1CCc1cnc2ccccc2n1)-c1cccnc1 Show InChI InChI=1S/C19H17N5/c1-24-13-18(14-5-4-10-20-11-14)23-19(24)9-8-15-12-21-16-6-2-3-7-17(16)22-15/h2-7,10-13H,8-9H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362492 (US10562916, Compound 52 | US9834564, Compound 52) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccco2)nc2ccccc12 Show InChI InChI=1S/C17H14N4O2/c22-17-11-4-1-2-5-12(11)19-16(21-17)8-7-15-18-10-13(20-15)14-6-3-9-23-14/h1-6,9-10H,7-8H2,(H,18,20)(H,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362496 (US10562916, Compound 56 | US9834564, Compound 56) Show SMILES Cc1cccc(c1)-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1 Show InChI InChI=1S/C20H18N4O/c1-13-5-4-6-14(11-13)17-12-21-18(23-17)9-10-19-22-16-8-3-2-7-15(16)20(25)24-19/h2-8,11-12H,9-10H2,1H3,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362499 (US10562916, Compound 59 | US9834564, Compound 59) Show SMILES Fc1ccccc1-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1 Show InChI InChI=1S/C19H15FN4O/c20-14-7-3-1-5-12(14)16-11-21-17(23-16)9-10-18-22-15-8-4-2-6-13(15)19(25)24-18/h1-8,11H,9-10H2,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362501 (US10562916, Compound 61 | US9834564, Compound 61) Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2nc3ccccc3c(=O)[nH]2)n1 Show InChI InChI=1S/C19H15FN4O/c20-13-5-3-4-12(10-13)16-11-21-17(23-16)8-9-18-22-15-7-2-1-6-14(15)19(25)24-18/h1-7,10-11H,8-9H2,(H,21,23)(H,22,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50003989 (CHEMBL2180007 | US10562916, Compound 64 | US983456...) Show SMILES O=c1[nH]c(CCc2nc(c[nH]2)-c2ccsc2)nc2ccccc12 Show InChI InChI=1S/C17H14N4OS/c22-17-12-3-1-2-4-13(12)19-16(21-17)6-5-15-18-9-14(20-15)11-7-8-23-10-11/h1-4,7-10H,5-6H2,(H,18,20)(H,19,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362507 (US10562916, Compound 67 | US9834564, Compound 67) Show SMILES C(Cc1ccc2ccccc2n1)c1nc(c[nH]1)-c1ccsc1 Show InChI InChI=1S/C18H15N3S/c1-2-4-16-13(3-1)5-6-15(20-16)7-8-18-19-11-17(21-18)14-9-10-22-12-14/h1-6,9-12H,7-8H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362509 (US10562916, Compound 69 | US9834564, Compound 69) Show SMILES Fc1ccccc1-c1c[nH]c(CCc2ccc3ccccc3n2)n1 Show InChI InChI=1S/C20H16FN3/c21-17-7-3-2-6-16(17)19-13-22-20(24-19)12-11-15-10-9-14-5-1-4-8-18(14)23-15/h1-10,13H,11-12H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362510 (US10562916, Compound 70 | US9834564, Compound 70) Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2ccc3ccccc3n2)n1 Show InChI InChI=1S/C20H16FN3/c21-16-6-3-5-15(12-16)19-13-22-20(24-19)11-10-17-9-8-14-4-1-2-7-18(14)23-17/h1-9,12-13H,10-11H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362512 (US10562916, Compound 72 | US9834564, Compound 72) Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccco1 Show InChI InChI=1S/C17H14N4O/c1-2-5-14-13(4-1)18-10-12(20-14)7-8-17-19-11-15(21-17)16-6-3-9-22-16/h1-6,9-11H,7-8H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362513 (US10562916, Compound 73 | US9834564, Compound 73) Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1ccsc1 Show InChI InChI=1S/C17H14N4S/c1-2-4-15-14(3-1)18-9-13(20-15)5-6-17-19-10-16(21-17)12-7-8-22-11-12/h1-4,7-11H,5-6H2,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362515 (US10562916, Compound 75 | US9834564, Compound 75) Show SMILES Fc1ccccc1-c1c[nH]c(CCc2cnc3ccccc3n2)n1 Show InChI InChI=1S/C19H15FN4/c20-15-6-2-1-5-14(15)18-12-22-19(24-18)10-9-13-11-21-16-7-3-4-8-17(16)23-13/h1-8,11-12H,9-10H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362516 (US10562916, Compound 76 | US9834564, Compound 76) Show SMILES Fc1cccc(c1)-c1c[nH]c(CCc2cnc3ccccc3n2)n1 Show InChI InChI=1S/C19H15FN4/c20-14-5-3-4-13(10-14)18-12-22-19(24-18)9-8-15-11-21-16-6-1-2-7-17(16)23-15/h1-7,10-12H,8-9H2,(H,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362518 (US10562916, Compound 78 | US9834564, Compound 78) Show SMILES C(Cc1cnc2ccccc2n1)c1nc(c[nH]1)-c1cccnc1 Show InChI InChI=1S/C18H15N5/c1-2-6-16-15(5-1)20-11-14(22-16)7-8-18-21-12-17(23-18)13-4-3-9-19-10-13/h1-6,9-12H,7-8H2,(H,21,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362524 (US10562916, Compound 84 | US9834564, Compound 84) Show SMILES Cn1c(CCc2cnc3ccccc3n2)nc2c1ccc1ncccc21 Show InChI InChI=1S/C21H17N5/c1-26-19-10-9-16-15(5-4-12-22-16)21(19)25-20(26)11-8-14-13-23-17-6-2-3-7-18(17)24-14/h2-7,9-10,12-13H,8,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362525 (US10562916, Compound 85 | US9834564, Compound 85) Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ncccc21 Show InChI InChI=1S/C22H18N4/c1-26-20-12-11-19-17(6-4-14-23-19)22(20)25-21(26)13-10-16-9-8-15-5-2-3-7-18(15)24-16/h2-9,11-12,14H,10,13H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362527 (US10562916, Compound 87 | US9834564, Compound 87) Show SMILES Cc1ccc(C)c2nc(CCc3nc4c(ccc5ncccc45)[nH]3)cnc12 Show InChI InChI=1S/C22H19N5/c1-13-5-6-14(2)21-20(13)24-12-15(25-21)7-10-19-26-18-9-8-17-16(22(18)27-19)4-3-11-23-17/h3-6,8-9,11-12H,7,10H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362528 (US10562916, Compound 88 | US9834564, Compound 88) Show SMILES Cc1ccc(C)c2nc(CCc3nc4c(ccc5ncccc45)n3C)cnc12 Show InChI InChI=1S/C23H21N5/c1-14-6-7-15(2)22-21(14)25-13-16(26-22)8-11-20-27-23-17-5-4-12-24-18(17)9-10-19(23)28(20)3/h4-7,9-10,12-13H,8,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362530 (US10562916, Compound 90 | US9834564, Compound 90) Show SMILES Cn1c(CCc2ccc3ccccc3n2)nc2c1ccc1ccccc21 Show InChI InChI=1S/C23H19N3/c1-26-21-14-11-16-6-2-4-8-19(16)23(21)25-22(26)15-13-18-12-10-17-7-3-5-9-20(17)24-18/h2-12,14H,13,15H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362532 (US10562916, Compound 92 | US9834564, Compound 92) Show SMILES C(Cc1cnc2ccccc2n1)c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H14N4/c1-2-6-14-13(5-1)18-11-12(19-14)9-10-17-20-15-7-3-4-8-16(15)21-17/h1-8,11H,9-10H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362534 (US10562916, Compound 94 | US9834564, Compound 94) Show SMILES C(Cc1cnc2ccccc2n1)c1nc2cc3ccccc3cc2[nH]1 Show InChI InChI=1S/C21H16N4/c1-2-6-15-12-20-19(11-14(15)5-1)24-21(25-20)10-9-16-13-22-17-7-3-4-8-18(17)23-16/h1-8,11-13H,9-10H2,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair

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