Found 24 hits Enz. Inhib. hit(s) with all data for entry = 9253 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453207
(1-(5-fluoro-2-methoxy-4-(4,4,4-trifluoro-3,3- dime...)Show SMILES COc1cc(C#CC(C)(C)C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.26,;1.18,-2.03,;2.52,-1.26,;2.52,.28,;3.85,1.05,;3.85,2.59,;3.85,4.13,;3.85,5.67,;3.08,7.01,;2.31,5.67,;5.19,6.44,;6.52,5.67,;5.19,7.98,;6.52,7.21,;5.19,.28,;6.52,1.05,;5.19,-1.26,;3.85,-2.03,;3.85,-3.57,;2.52,-4.34,;1.18,-3.57,;-.15,-4.34,;-.15,-5.88,;1.18,-6.65,;2.52,-5.88,;3.85,-6.65,;5.19,-5.88,;5.19,-4.34,;6.52,-3.57,;-1.48,-6.65,;-2.25,-5.31,;-.71,-7.98,;-2.82,-7.42,;-4.15,-6.65,;-5.61,-7.12,;-6.52,-5.88,;-5.61,-4.63,;-4.15,-5.11,)| Show InChI InChI=1S/C25H19F4N3O5S/c1-24(2,25(27,28)29)10-8-15-13-21(36-3)20(14-18(15)26)32-19-6-5-17(12-16(19)4-7-23(32)33)38(34,35)31-22-9-11-37-30-22/h4-7,9,11-14H,1-3H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453206
(1-(4-((4,4-difluorocyclohexyl)ethynyl)-5-fluoro-2-...)Show SMILES COc1cc(C#CC2CCC(F)(F)CC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-2.31,;1.18,-3.08,;2.52,-2.31,;2.52,-.77,;3.85,,;3.85,1.54,;3.85,3.08,;3.85,4.62,;5.19,5.39,;5.19,6.93,;3.85,7.7,;4.62,9.03,;3.08,9.03,;2.52,6.93,;2.52,5.39,;5.19,-.77,;6.52,,;5.19,-2.31,;3.85,-3.08,;3.85,-4.62,;2.52,-5.39,;1.18,-4.62,;-.15,-5.39,;-.15,-6.93,;1.18,-7.7,;2.52,-6.93,;3.85,-7.7,;5.19,-6.93,;5.19,-5.39,;6.52,-4.62,;-1.48,-7.7,;-2.25,-6.37,;-.71,-9.03,;-2.82,-8.47,;-4.15,-7.7,;-5.61,-8.18,;-6.52,-6.93,;-5.61,-5.68,;-4.15,-6.16,)| Show InChI InChI=1S/C27H22F3N3O5S/c1-37-24-15-18(3-2-17-8-11-27(29,30)12-9-17)21(28)16-23(24)33-22-6-5-20(14-19(22)4-7-26(33)34)39(35,36)32-25-10-13-38-31-25/h4-7,10,13-17H,8-9,11-12H2,1H3,(H,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217959
(US10729684, Example 10 | US9212182, 643)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,)| Show InChI InChI=1S/C26H22FN3O5S/c1-34-24-15-18(7-6-17-4-2-3-5-17)21(27)16-23(24)30-22-10-9-20(14-19(22)8-11-26(30)31)36(32,33)29-25-12-13-35-28-25/h8-17H,2-5H2,1H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4.53 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453211
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)Show SMILES COc1cc(C#C[C@@H]2C[C@@H]2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:7.6,9.10,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;4.62,6.34,;3.08,6.34,;1.75,7.11,;.41,6.34,;1.75,8.65,;.41,7.88,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31)/t14-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453210
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)Show SMILES COc1cc(C#C[C@H]2C[C@@H]2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:9.10,wD:7.6,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;4.62,6.34,;3.08,6.34,;1.75,7.11,;.41,6.34,;1.75,8.65,;.41,7.88,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31)/t14-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453209
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2-(trifluorometh...)Show SMILES COc1cc(C#CC2CC2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-1.92,-14.18,;-1.92,-12.64,;-.58,-11.87,;.75,-12.64,;2.09,-11.87,;3.42,-12.64,;4.75,-13.41,;6.09,-14.18,;6.86,-15.51,;5.32,-15.58,;4.01,-16.4,;2.71,-17.21,;3.2,-15.09,;4.83,-17.7,;2.09,-10.33,;3.42,-9.56,;.75,-9.56,;-.58,-10.33,;-1.92,-9.56,;-1.92,-8.02,;-.58,-7.25,;-.58,-5.71,;-1.92,-4.94,;-3.25,-5.71,;-3.25,-7.25,;-4.58,-8.02,;-4.58,-9.56,;-3.25,-10.33,;-3.25,-11.87,;-1.92,-3.4,;-1.92,-1.86,;-3.46,-3.4,;-.38,-3.4,;.39,-2.06,;1.93,-2.06,;2.41,-.6,;1.16,.3,;-.08,-.6,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453208
(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)C#CC1CCCC1 |(-.15,-1.29,;1.18,-2.06,;2.52,-1.29,;2.52,.25,;3.85,1.02,;5.19,.25,;5.19,-1.29,;3.85,-2.06,;3.85,-3.6,;2.52,-4.37,;1.18,-3.6,;-.15,-4.37,;-.15,-5.91,;1.18,-6.68,;2.52,-5.91,;3.85,-6.68,;5.19,-5.91,;5.19,-4.37,;6.52,-3.6,;-1.48,-6.68,;-2.25,-5.34,;-.71,-8.01,;-2.82,-7.45,;-4.15,-6.68,;-5.61,-7.15,;-6.52,-5.91,;-5.61,-4.66,;-4.15,-5.14,;3.85,2.56,;3.85,4.1,;3.85,5.64,;5.1,6.55,;4.62,8.01,;3.08,8.01,;2.61,6.55,)| Show InChI InChI=1S/C26H23N3O5S/c1-33-24-16-19(7-6-18-4-2-3-5-18)8-11-23(24)29-22-12-10-21(17-20(22)9-13-26(29)30)35(31,32)28-25-14-15-34-27-25/h8-18H,2-5H2,1H3,(H,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453214
(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)Show SMILES COc1cc(C#C[C@@H]2CCCC(F)(F)C2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:7.6,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;5.19,5.77,;5.19,7.31,;3.85,8.08,;2.52,7.31,;.98,7.31,;1.75,8.65,;2.52,5.77,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C27H22F3N3O5S/c1-37-24-14-18(5-4-17-3-2-11-27(29,30)16-17)21(28)15-23(24)33-22-8-7-20(13-19(22)6-9-26(33)34)39(35,36)32-25-10-12-38-31-25/h6-10,12-15,17H,2-3,11,16H2,1H3,(H,31,32)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453212
(1-(5-fluoro-2-methoxy-4-(((1R,2R)-2- (trifluoromet...)Show SMILES COc1cc(C#CC2(CC2)C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.26,;1.18,-2.03,;2.52,-1.26,;2.52,.28,;3.85,1.05,;3.85,2.59,;3.85,4.13,;3.85,5.67,;2.31,5.67,;3.08,7.01,;5.19,6.44,;6.52,5.67,;5.19,7.98,;6.52,7.21,;5.19,.28,;6.52,1.05,;5.19,-1.26,;3.85,-2.03,;3.85,-3.57,;2.52,-4.34,;1.18,-3.57,;-.15,-4.34,;-.15,-5.88,;1.18,-6.65,;2.52,-5.88,;3.85,-6.65,;5.19,-5.88,;5.19,-4.34,;6.52,-3.57,;-1.48,-6.65,;-2.25,-5.31,;-.71,-7.98,;-2.82,-7.42,;-4.15,-6.65,;-5.61,-7.12,;-6.52,-5.88,;-5.61,-4.63,;-4.15,-5.11,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-21-13-15(6-8-24(9-10-24)25(27,28)29)18(26)14-20(21)32-19-4-3-17(12-16(19)2-5-23(32)33)38(34,35)31-22-7-11-37-30-22/h2-5,7,11-14H,9-10H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217977
(US10729684, Example 9 | US9212182, 645)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-4,5.39,;-2.67,4.62,;-2.67,3.08,)| Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 8.95 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453215
(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)Show SMILES COc1cc(C#CC2(CCCC2)OCC(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-1.48,-1.29,;-.15,-2.06,;1.18,-1.29,;1.18,.25,;2.52,1.02,;2.52,2.56,;2.52,4.1,;2.52,5.64,;2.99,7.11,;1.75,8.01,;.5,7.11,;.98,5.64,;3.85,4.87,;5.19,5.64,;6.52,4.87,;7.85,5.64,;6.52,3.33,;7.85,4.1,;3.85,.25,;5.19,1.02,;3.85,-1.29,;2.52,-2.06,;2.52,-3.6,;1.18,-4.37,;-.15,-3.6,;-1.48,-4.37,;-1.48,-5.91,;-.15,-6.68,;1.18,-5.91,;2.52,-6.68,;3.85,-5.91,;3.85,-4.37,;5.19,-3.6,;-2.82,-6.68,;-3.59,-5.34,;-2.05,-8.01,;-4.15,-7.45,;-5.48,-6.68,;-6.95,-7.15,;-7.85,-5.91,;-6.95,-4.66,;-5.48,-5.14,)| Show InChI InChI=1S/C28H23F4N3O6S/c1-39-24-15-18(8-12-27(10-2-3-11-27)40-17-28(30,31)32)21(29)16-23(24)35-22-6-5-20(14-19(22)4-7-26(35)36)42(37,38)34-25-9-13-41-33-25/h4-7,9,13-16H,2-3,10-11,17H2,1H3,(H,33,34) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453213
(1-(5-fluoro-2-methoxy-4-((1- (trifluoromethyl)cycl...)Show SMILES COc1cc(C#CC2CCCC2)c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.29,;1.18,-2.06,;2.52,-1.29,;2.52,.25,;3.85,1.02,;3.85,2.56,;3.85,4.1,;3.85,5.64,;5.1,6.55,;4.62,8.01,;3.08,8.01,;2.61,6.55,;5.19,.25,;6.52,1.02,;5.19,-1.29,;3.85,-2.06,;3.85,-3.6,;2.52,-4.37,;1.18,-3.6,;-.15,-4.37,;-.15,-5.91,;1.18,-6.68,;2.52,-5.91,;3.85,-6.68,;5.19,-5.91,;5.19,-4.37,;6.52,-3.6,;-1.48,-6.68,;-2.25,-5.34,;-.71,-8.01,;-2.82,-7.45,;-4.15,-6.68,;-5.61,-7.15,;-6.52,-5.91,;-5.61,-4.66,;-4.15,-5.14,)| Show InChI InChI=1S/C26H22ClN3O5S/c1-34-24-15-18(7-6-17-4-2-3-5-17)21(27)16-23(24)30-22-10-9-20(14-19(22)8-11-26(30)31)36(32,33)29-25-12-13-35-28-25/h8-17H,2-5H2,1H3,(H,28,29) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 Cells stably transfected with either Nav 1.7 or Nav 1.5 were recorded in population patch-clamp mode with the IonWorks® Quattro automated ele... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217959
(US10729684, Example 10 | US9212182, 643)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.25,3.22,;-4.77,4.68,;-3.23,4.68,;-2.76,3.22,)| Show InChI InChI=1S/C26H22FN3O5S/c1-34-24-15-18(7-6-17-4-2-3-5-17)21(27)16-23(24)30-22-10-9-20(14-19(22)8-11-26(30)31)36(32,33)29-25-12-13-35-28-25/h8-17H,2-5H2,1H3,(H,28,29) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453213
(1-(5-fluoro-2-methoxy-4-((1- (trifluoromethyl)cycl...)Show SMILES COc1cc(C#CC2CCCC2)c(Cl)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.29,;1.18,-2.06,;2.52,-1.29,;2.52,.25,;3.85,1.02,;3.85,2.56,;3.85,4.1,;3.85,5.64,;5.1,6.55,;4.62,8.01,;3.08,8.01,;2.61,6.55,;5.19,.25,;6.52,1.02,;5.19,-1.29,;3.85,-2.06,;3.85,-3.6,;2.52,-4.37,;1.18,-3.6,;-.15,-4.37,;-.15,-5.91,;1.18,-6.68,;2.52,-5.91,;3.85,-6.68,;5.19,-5.91,;5.19,-4.37,;6.52,-3.6,;-1.48,-6.68,;-2.25,-5.34,;-.71,-8.01,;-2.82,-7.45,;-4.15,-6.68,;-5.61,-7.15,;-6.52,-5.91,;-5.61,-4.66,;-4.15,-5.14,)| Show InChI InChI=1S/C26H22ClN3O5S/c1-34-24-15-18(7-6-17-4-2-3-5-17)21(27)16-23(24)30-22-10-9-20(14-19(22)8-11-26(30)31)36(32,33)29-25-12-13-35-28-25/h8-17H,2-5H2,1H3,(H,28,29) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM217977
(US10729684, Example 9 | US9212182, 645)Show SMILES COc1cc(C#CC2CCCC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1cccnn1 |(6.67,-5.39,;5.33,-4.62,;4,-5.39,;4,-6.93,;2.67,-7.7,;2.67,-9.24,;2.67,-10.78,;2.67,-12.32,;3.91,-13.23,;3.44,-14.69,;1.9,-14.69,;1.42,-13.23,;1.33,-6.93,;,-7.7,;1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;;1.33,-.77,;2.67,,;4,-.77,;4,-2.31,;5.33,-3.08,;-2.67,,;-3.44,-1.33,;-1.9,1.33,;-4,.77,;-4,2.31,;-5.33,3.08,;-5.33,4.62,;-4,5.39,;-2.67,4.62,;-2.67,3.08,)| Show InChI InChI=1S/C27H23FN4O4S/c1-36-25-16-19(9-8-18-5-2-3-6-18)22(28)17-24(25)32-23-12-11-21(15-20(23)10-13-27(32)33)37(34,35)31-26-7-4-14-29-30-26/h4,7,10-18H,2-3,5-6H2,1H3,(H,30,31) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453207
(1-(5-fluoro-2-methoxy-4-(4,4,4-trifluoro-3,3- dime...)Show SMILES COc1cc(C#CC(C)(C)C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.26,;1.18,-2.03,;2.52,-1.26,;2.52,.28,;3.85,1.05,;3.85,2.59,;3.85,4.13,;3.85,5.67,;3.08,7.01,;2.31,5.67,;5.19,6.44,;6.52,5.67,;5.19,7.98,;6.52,7.21,;5.19,.28,;6.52,1.05,;5.19,-1.26,;3.85,-2.03,;3.85,-3.57,;2.52,-4.34,;1.18,-3.57,;-.15,-4.34,;-.15,-5.88,;1.18,-6.65,;2.52,-5.88,;3.85,-6.65,;5.19,-5.88,;5.19,-4.34,;6.52,-3.57,;-1.48,-6.65,;-2.25,-5.31,;-.71,-7.98,;-2.82,-7.42,;-4.15,-6.65,;-5.61,-7.12,;-6.52,-5.88,;-5.61,-4.63,;-4.15,-5.11,)| Show InChI InChI=1S/C25H19F4N3O5S/c1-24(2,25(27,28)29)10-8-15-13-21(36-3)20(14-18(15)26)32-19-6-5-17(12-16(19)4-7-23(32)33)38(34,35)31-22-9-11-37-30-22/h4-7,9,11-14H,1-3H3,(H,30,31) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453215
(1-(4-(((1R)-3,3-difluorocyclohexyl)ethynyl)-5-fluo...)Show SMILES COc1cc(C#CC2(CCCC2)OCC(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-1.48,-1.29,;-.15,-2.06,;1.18,-1.29,;1.18,.25,;2.52,1.02,;2.52,2.56,;2.52,4.1,;2.52,5.64,;2.99,7.11,;1.75,8.01,;.5,7.11,;.98,5.64,;3.85,4.87,;5.19,5.64,;6.52,4.87,;7.85,5.64,;6.52,3.33,;7.85,4.1,;3.85,.25,;5.19,1.02,;3.85,-1.29,;2.52,-2.06,;2.52,-3.6,;1.18,-4.37,;-.15,-3.6,;-1.48,-4.37,;-1.48,-5.91,;-.15,-6.68,;1.18,-5.91,;2.52,-6.68,;3.85,-5.91,;3.85,-4.37,;5.19,-3.6,;-2.82,-6.68,;-3.59,-5.34,;-2.05,-8.01,;-4.15,-7.45,;-5.48,-6.68,;-6.95,-7.15,;-7.85,-5.91,;-6.95,-4.66,;-5.48,-5.14,)| Show InChI InChI=1S/C28H23F4N3O6S/c1-39-24-15-18(8-12-27(10-2-3-11-27)40-17-28(30,31)32)21(29)16-23(24)35-22-6-5-20(14-19(22)4-7-26(35)36)42(37,38)34-25-9-13-41-33-25/h4-7,9,13-16H,2-3,10-11,17H2,1H3,(H,33,34) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453206
(1-(4-((4,4-difluorocyclohexyl)ethynyl)-5-fluoro-2-...)Show SMILES COc1cc(C#CC2CCC(F)(F)CC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-2.31,;1.18,-3.08,;2.52,-2.31,;2.52,-.77,;3.85,,;3.85,1.54,;3.85,3.08,;3.85,4.62,;5.19,5.39,;5.19,6.93,;3.85,7.7,;4.62,9.03,;3.08,9.03,;2.52,6.93,;2.52,5.39,;5.19,-.77,;6.52,,;5.19,-2.31,;3.85,-3.08,;3.85,-4.62,;2.52,-5.39,;1.18,-4.62,;-.15,-5.39,;-.15,-6.93,;1.18,-7.7,;2.52,-6.93,;3.85,-7.7,;5.19,-6.93,;5.19,-5.39,;6.52,-4.62,;-1.48,-7.7,;-2.25,-6.37,;-.71,-9.03,;-2.82,-8.47,;-4.15,-7.7,;-5.61,-8.18,;-6.52,-6.93,;-5.61,-5.68,;-4.15,-6.16,)| Show InChI InChI=1S/C27H22F3N3O5S/c1-37-24-15-18(3-2-17-8-11-27(29,30)12-9-17)21(28)16-23(24)33-22-6-5-20(14-19(22)4-7-26(33)34)39(35,36)32-25-10-13-38-31-25/h4-7,10,13-17H,8-9,11-12H2,1H3,(H,31,32) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453208
(1-(4-(cyclopentylethynyl)-2-methoxyphenyl)-N-3- is...)Show SMILES COc1cc(ccc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1)C#CC1CCCC1 |(-.15,-1.29,;1.18,-2.06,;2.52,-1.29,;2.52,.25,;3.85,1.02,;5.19,.25,;5.19,-1.29,;3.85,-2.06,;3.85,-3.6,;2.52,-4.37,;1.18,-3.6,;-.15,-4.37,;-.15,-5.91,;1.18,-6.68,;2.52,-5.91,;3.85,-6.68,;5.19,-5.91,;5.19,-4.37,;6.52,-3.6,;-1.48,-6.68,;-2.25,-5.34,;-.71,-8.01,;-2.82,-7.45,;-4.15,-6.68,;-5.61,-7.15,;-6.52,-5.91,;-5.61,-4.66,;-4.15,-5.14,;3.85,2.56,;3.85,4.1,;3.85,5.64,;5.1,6.55,;4.62,8.01,;3.08,8.01,;2.61,6.55,)| Show InChI InChI=1S/C26H23N3O5S/c1-33-24-16-19(7-6-18-4-2-3-5-18)8-11-23(24)29-22-12-10-21(17-20(22)9-13-26(29)30)35(31,32)28-25-14-15-34-27-25/h8-18H,2-5H2,1H3,(H,27,28) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453209
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2-(trifluorometh...)Show SMILES COc1cc(C#CC2CC2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-1.92,-14.18,;-1.92,-12.64,;-.58,-11.87,;.75,-12.64,;2.09,-11.87,;3.42,-12.64,;4.75,-13.41,;6.09,-14.18,;6.86,-15.51,;5.32,-15.58,;4.01,-16.4,;2.71,-17.21,;3.2,-15.09,;4.83,-17.7,;2.09,-10.33,;3.42,-9.56,;.75,-9.56,;-.58,-10.33,;-1.92,-9.56,;-1.92,-8.02,;-.58,-7.25,;-.58,-5.71,;-1.92,-4.94,;-3.25,-5.71,;-3.25,-7.25,;-4.58,-8.02,;-4.58,-9.56,;-3.25,-10.33,;-3.25,-11.87,;-1.92,-3.4,;-1.92,-1.86,;-3.46,-3.4,;-.38,-3.4,;.39,-2.06,;1.93,-2.06,;2.41,-.6,;1.16,.3,;-.08,-.6,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31) | PDB
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AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453212
(1-(5-fluoro-2-methoxy-4-(((1R,2R)-2- (trifluoromet...)Show SMILES COc1cc(C#CC2(CC2)C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-1.26,;1.18,-2.03,;2.52,-1.26,;2.52,.28,;3.85,1.05,;3.85,2.59,;3.85,4.13,;3.85,5.67,;2.31,5.67,;3.08,7.01,;5.19,6.44,;6.52,5.67,;5.19,7.98,;6.52,7.21,;5.19,.28,;6.52,1.05,;5.19,-1.26,;3.85,-2.03,;3.85,-3.57,;2.52,-4.34,;1.18,-3.57,;-.15,-4.34,;-.15,-5.88,;1.18,-6.65,;2.52,-5.88,;3.85,-6.65,;5.19,-5.88,;5.19,-4.34,;6.52,-3.57,;-1.48,-6.65,;-2.25,-5.31,;-.71,-7.98,;-2.82,-7.42,;-4.15,-6.65,;-5.61,-7.12,;-6.52,-5.88,;-5.61,-4.63,;-4.15,-5.11,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-21-13-15(6-8-24(9-10-24)25(27,28)29)18(26)14-20(21)32-19-4-3-17(12-16(19)2-5-23(32)33)38(34,35)31-22-7-11-37-30-22/h2-5,7,11-14H,9-10H2,1H3,(H,30,31) | PDB
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453214
(1-(5-chloro-4-(cyclopentylethynyl)-2- methoxypheny...)Show SMILES COc1cc(C#C[C@@H]2CCCC(F)(F)C2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:7.6,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;5.19,5.77,;5.19,7.31,;3.85,8.08,;2.52,7.31,;.98,7.31,;1.75,8.65,;2.52,5.77,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C27H22F3N3O5S/c1-37-24-14-18(5-4-17-3-2-11-27(29,30)16-17)21(28)15-23(24)33-22-8-7-20(13-19(22)6-9-26(33)34)39(35,36)32-25-10-12-38-31-25/h6-10,12-15,17H,2-3,11,16H2,1H3,(H,31,32)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 66.7 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453211
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)Show SMILES COc1cc(C#C[C@@H]2C[C@@H]2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:7.6,9.10,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;4.62,6.34,;3.08,6.34,;1.75,7.11,;.41,6.34,;1.75,8.65,;.41,7.88,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31)/t14-,18+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 139 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 9 subunit alpha
(Homo sapiens (Human)) | BDBM453210
(1-(5-fluoro-2-methoxy-4-(((1R,2S)-2- (trifluoromet...)Show SMILES COc1cc(C#C[C@H]2C[C@@H]2C(F)(F)F)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |r,wU:9.10,wD:7.6,(-.15,-1.93,;1.18,-2.7,;2.52,-1.93,;2.52,-.39,;3.85,.38,;3.85,1.92,;3.85,3.46,;3.85,5,;4.62,6.34,;3.08,6.34,;1.75,7.11,;.41,6.34,;1.75,8.65,;.41,7.88,;5.19,-.39,;6.52,.38,;5.19,-1.93,;3.85,-2.7,;3.85,-4.24,;2.52,-5.01,;1.18,-4.24,;-.15,-5.01,;-.15,-6.55,;1.18,-7.32,;2.52,-6.55,;3.85,-7.32,;5.19,-6.55,;5.19,-5.01,;6.52,-4.24,;-1.48,-7.32,;-2.25,-5.98,;-.71,-8.65,;-2.82,-8.09,;-4.15,-7.32,;-5.61,-7.79,;-6.52,-6.55,;-5.61,-5.3,;-4.15,-5.78,)| Show InChI InChI=1S/C25H17F4N3O5S/c1-36-22-12-15(3-2-14-11-18(14)25(27,28)29)19(26)13-21(22)32-20-6-5-17(10-16(20)4-7-24(32)33)38(34,35)31-23-8-9-37-30-23/h4-10,12-14,18H,11H2,1H3,(H,30,31)/t14-,18-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy... |
US Patent US10729684 (2020)
BindingDB Entry DOI: 10.7270/Q27S7RVP |
More data for this
Ligand-Target Pair | |
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