Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Sodium channel protein type 9 subunit alpha | ||
Ligand | BDBM453206 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Nav 1.7 or Nav 1.5 IWQ In Vitro Assay | ||
IC50 | 3.30±n/a nM | ||
Citation | Weiss, M; Dineen, T; Vaida, KR Alkynyl dihydroquinoline sulfonamide compounds US Patent US10729684 Publication Date 8/4/2020 | ||
More Info.: | Get all data from this article, Assay Method | ||
Sodium channel protein type 9 subunit alpha | |||
Name: | Sodium channel protein type 9 subunit alpha | ||
Synonyms: | NENA | Neuroendocrine sodium channel | Peripheral sodium channel 1 | SCN9A | SCN9A_HUMAN | Sodium channel protein type IX alpha subunit | Voltage-gated sodium channel subunit Nav1.7 | Voltage-gated sodium channel subunit alpha Nav1.7 | hNE-Na | ||
Type: | Protein | ||
Mol. Mass.: | 226375.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15858 | ||
Residue: | 1988 | ||
Sequence: |
| ||
BDBM453206 | |||
n/a | |||
Name | BDBM453206 | ||
Synonyms: | 1-(4-((4,4-difluorocyclohexyl)ethynyl)-5-fluoro-2- methoxyphenyl)-N-3-isoxazolyl-2-oxo-1,2-dihydro-6- quinolinesulfonamide | US10729684, Example 1 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H22F3N3O5S | ||
Mol. Mass. | 557.541 | ||
SMILES | COc1cc(C#CC2CCC(F)(F)CC2)c(F)cc1-n1c2ccc(cc2ccc1=O)S(=O)(=O)Nc1ccon1 |(-.15,-2.31,;1.18,-3.08,;2.52,-2.31,;2.52,-.77,;3.85,,;3.85,1.54,;3.85,3.08,;3.85,4.62,;5.19,5.39,;5.19,6.93,;3.85,7.7,;4.62,9.03,;3.08,9.03,;2.52,6.93,;2.52,5.39,;5.19,-.77,;6.52,,;5.19,-2.31,;3.85,-3.08,;3.85,-4.62,;2.52,-5.39,;1.18,-4.62,;-.15,-5.39,;-.15,-6.93,;1.18,-7.7,;2.52,-6.93,;3.85,-7.7,;5.19,-6.93,;5.19,-5.39,;6.52,-4.62,;-1.48,-7.7,;-2.25,-6.37,;-.71,-9.03,;-2.82,-8.47,;-4.15,-7.7,;-5.61,-8.18,;-6.52,-6.93,;-5.61,-5.68,;-4.15,-6.16,)| | ||
Structure |