Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477604 ((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477601 (N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477599 (N-[1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477616 ((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477618 ((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477586 (N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477584 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477600 (N-[1-(3-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477583 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477622 (Propan-2-yl-3-[(4R)-4-(4,5,6,7-tetrahydro-1,2-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477595 (4-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477619 ((R)—N-(1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477598 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477609 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477602 (Ethyl 3-[4-(4,5,6,7-tetrahydro-1,2-benzoxazole-3-a...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477606 (4-chloro-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477579 (N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477621 (N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477592 (N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477614 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477607 (4-bromo-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477612 ((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477617 (4-fluoro-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477594 (5-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477611 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477603 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477596 (3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477597 (N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477620 (N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477587 (N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477589 (3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477574 ((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 166 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477623 (US10889564, Example 53) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477576 (N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477590 (N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 355 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477613 (4-methyl-N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 441 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477588 (3-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 459 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477585 (N-[(4R*)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 735 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477591 (2-hydroxy-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetra...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 881 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477575 (N-[1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477610 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477608 ((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477572 (N-(1-(2-Fluorophenyl)-4,5,6,7-tetrahydro-1H-indazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 2.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM62235 (MLS-0412040.0001 | N-[1-(2,4-difluorophenyl)-4,5,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477605 (N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.67E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477615 (6-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay B: Example compounds as described herein were dispensed with an acoustic liquid handler, Echo 550 (Labcyte) to a maximum volume of 50 nl per we... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477577 (N-[1-(3,4-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477573 ((S)—N-(1-(2-Fluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 6.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477582 (N-[1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-in...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human)) | BDBM477580 (Methyl 6-({[1-(3,5-difluorophenyl)-4,5,6,7-tetrahy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genase Therapeutics B.V. US Patent | Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ... | US Patent US10889564 (2021) BindingDB Entry DOI: 10.7270/Q2N019MP | |||||||||||
More data for this Ligand-Target Pair |
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