BDBM477576 N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide::US10889564, Example 5

SMILES: Fc1ccc(c(F)c1)-n1ncc2C(CCCc12)NC(=O)c1onc2CCCCc12

InChI Key: InChIKey=MYADYGPLMDTBMB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 477576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM477576 (N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-in...) Show SMILES Fc1ccc(c(F)c1)-n1ncc2C(CCCc12)NC(=O)c1onc2CCCCc12 Show InChI InChI=1S/C21H20F2N4O2/c22-12-8-9-19(15(23)10-12)27-18-7-3-6-16(14(18)11-24-27)25-21(28)20-13-4-1-2-5-17(13)26-29-20/h8-11,16H,1-7H2,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Genase Therapeutics B.V. US Patent					Assay Description Assay A: DHODH enzyme assays were performed with 6 nM recombinant human DHODH (purified essentially as described by Walse et. al., Biochemistry, 47, ...				US Patent US10889564 (2021)
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