| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM477576 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 290±n/a nM |
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| Citation |  Lain, S; Drummond, C; Leeuwen, IV; Haraldsson, M; Johansson, L; Sandberg, L; Yngve, U Tetrahydroindazoles and medical uses thereof US Patent US10889564 Publication Date 1/12/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM477576 |
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| n/a |
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| Name | BDBM477576 |
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| Synonyms: | N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,5,6,7-tetrahydrobenzo[c]isoxazole-3-carboxamide | US10889564, Example 5 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20F2N4O2 |
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| Mol. Mass. | 398.4059 |
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| SMILES | Fc1ccc(c(F)c1)-n1ncc2C(CCCc12)NC(=O)c1onc2CCCCc12 |
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| Structure | 
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