Compile Data Set for Download or QSAR

Found 457 hits Enz. Inhib. hit(s) with all data for entry = 9854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449686 (US10703733, Example 299 | US10988451, Example 298 ...) Show SMILES CO[C@H]1CC[C@H](OC)[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C39H50ClN5O7S/c1-24-21-53(48,43-37(47)30-20-44(2)41-38(30)51-5)42-36(46)26-9-13-35-32(18-26)45(19-27-8-11-29(27)34(50-4)15-14-33(24)49-3)22-39(23-52-35)16-6-7-25-17-28(40)10-12-31(25)39/h9-10,12-13,17-18,20,24,27,29,33-34H,6-8,11,14-16,19,21-23H2,1-5H3,(H,42,43,46,47,48)/t24-,27+,29-,33+,34+,39+,53+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449620 (US10703733, Example 233 | US10988451, Example 233) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)C#N)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H44ClN5O5S/c1-24-5-3-7-33(47-2)30-11-8-28(30)20-43-22-37(14-4-6-26-15-29(38)10-12-31(26)37)23-48-34-13-9-27(16-32(34)43)35(44)40-49(46,21-24)41-36(45)42-18-25(17-39)19-42/h3,7,9-10,12-13,15-16,24-25,28,30,33H,4-6,8,11,14,18-23H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t24-,28-,30+,33-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449627 (US10703733, Example 240 | US10988451, Example 240) Show SMILES CO[C@H]1CCC[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O6S/c1-24-7-5-9-33(48-3)29-13-10-27(29)19-44-22-38(16-6-8-25-17-28(39)12-14-31(25)38)23-50-34-15-11-26(18-32(34)44)35(45)41-51(47,21-24)42-36(46)30-20-43(2)40-37(30)49-4/h11-12,14-15,17-18,20,24,27,29,33H,5-10,13,16,19,21-23H2,1-4H3,(H,41,42,45,46,47)/t24-,27-,29+,33-,38-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0180	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449659 (US10703733, Example 272 | US10988451, Example 272 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(C2)CN(C)C(=O)O3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H48ClN5O7S/c1-25-6-4-8-33(50-3)30-12-9-28(30)18-44-20-38(15-5-7-26-16-29(40)11-13-31(26)38)24-51-34-14-10-27(17-32(34)44)35(46)41-53(49,19-25)42-36(47)45-22-39(23-45)21-43(2)37(48)52-39/h4,8,10-11,13-14,16-17,25,28,30,33H,5-7,9,12,15,18-24H2,1-3H3,(H,41,42,46,47,49)/b8-4+/t25-,28-,30+,33-,38-,53-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0180	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449730 (US10703733, Example 343 | US10988451, Example 343 ...) Show SMILES C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1 |r| Show InChI InChI=1S/C38H45ClF3N3O6S/c1-6-9-23(3)24(4)52(49,44-36(48)38(40,41)42)43-35(47)27-12-16-34-32(19-27)45(20-28-11-14-30(28)33(7-2)51-25(5)46)21-37(22-50-34)17-8-10-26-18-29(39)13-15-31(26)37/h6-7,12-13,15-16,18-19,23-24,28,30,33H,1-2,8-11,14,17,20-22H2,3-5H3,(H,43,44,47,48,49)/t23-,24+,28-,30+,33-,37-,52-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0190	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM493822 (US10988451, Example 292) Show SMILES C[C@H]1C\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C1)NC(=O)N1CC(C1)OC(=O)N(C)C |r,t:3| Show InChI InChI=1S/C38H48ClN5O7S/c1-24-6-4-8-33(45)30-12-9-27(30)18-44-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-50-34-14-10-26(17-32(34)44)35(46)40-52(49,21-24)41-36(47)43-19-29(20-43)51-37(48)42(2)3/h4,8,10-11,13-14,16-17,24,27,29-30,33,45H,5-7,9,12,15,18-23H2,1-3H3,(H,40,41,46,47,49)/b8-4+/t24-,27-,30+,33-,38-,52-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449559 (US10703733, Example 172 | US10988451, Example 172 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,30.31,15.14,17.17,wD:2.1,47.49,44.47,6.6,9.10,17.18,t:3,(-.39,6.42,;1.1,6.03,;1.5,4.54,;.41,3.45,;-1.08,3.85,;-2.17,2.76,;-1.77,1.27,;-.28,1.67,;-2.86,.18,;-2.46,-1.3,;-2.06,-2.79,;-3.79,-2.07,;-5.13,-1.3,;-5.13,.24,;-6.46,-2.07,;-7.8,-1.3,;-9.28,-1.7,;-9.68,-.22,;-11.17,-.61,;-10.45,1.12,;-8.19,.18,;-.97,-1.7,;.12,-.61,;-.28,.87,;1.6,-1.01,;2,-2.5,;3.49,-2.9,;4.4,-1.88,;5.64,-2.89,;7.12,-2.6,;7.84,-1.24,;8.55,.13,;10.09,.2,;10.92,-1.1,;10.21,-2.46,;11.04,-3.76,;10.34,-5.13,;11.17,-6.42,;8.8,-5.2,;7.97,-3.9,;8.68,-2.54,;7.12,.17,;5.64,.57,;5.14,2.2,;3.53,2.62,;2.18,1.83,;1.78,3.32,;3.13,4.1,;4.22,-.4,;2.69,.08,)| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-6-4-8-33(48-3)30-12-9-27(30)20-43-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-49-34-14-10-26(17-32(34)43)35(44)41-50(47,21-24)42-36(45)40-29-18-37(2,46)19-29/h4,8,10-11,13-14,16-17,24,27,29-30,33,46H,5-7,9,12,15,18-23H2,1-3H3,(H2,40,41,42,44,45,47)/b8-4+/t24-,27-,29-,30+,33-,37-,38-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0220	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449749 (US10703733, Example 362 | US10988451, Example 362 ...) Show SMILES COC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)18-42-22-37(15-5-7-25-16-28(38)11-13-31(25)37)23-48-34-14-10-26(17-32(34)42)35(43)39-49(45,21-24)40-36(44)41-19-29(20-41)46-2/h4,8,10-11,13-14,16-17,24,27,29-30,33H,5-7,9,12,15,18-23H2,1-3H3,(H,39,40,43,44,45)/b8-4+/t24-,27-,30+,33-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449698 (US10703733, Example 311 | US10988451, Example 311 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H45ClF2N4O5S/c1-22-5-3-7-32(48-2)27-11-8-25(27)18-44-20-37(14-4-6-23-15-26(38)10-12-29(23)37)21-49-33-13-9-24(16-31(33)44)35(45)42-50(47,19-22)43-36(46)41-30-17-28(30)34(39)40/h3,7,9-10,12-13,15-16,22,25,27-28,30,32,34H,4-6,8,11,14,17-21H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t22-,25-,27+,28-,30-,32-,37-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449548 (US10703733, Example 161 | US10988451, Example 161 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2CC2(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C36H43ClF2N4O5S/c1-22-5-3-7-30(47-2)27-11-8-25(27)18-43-20-35(14-4-6-23-15-26(37)10-12-28(23)35)21-48-31-13-9-24(16-29(31)43)33(44)41-49(46,19-22)42-34(45)40-32-17-36(32,38)39/h3,7,9-10,12-13,15-16,22,25,27,30,32H,4-6,8,11,14,17-21H2,1-2H3,(H2,40,41,42,44,45,46)/b7-3+/t22-,25-,27+,30-,32-,35-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449687 (US10703733, Example 300 | US10988451, Example 300 ...) Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC(=O)CCN4CCOCC4)\C=C\C[C@H](C)C1)c3c2 |r,t:57| Show InChI InChI=1S/C44H55ClN6O8S/c1-29-6-4-8-38(59-40(52)15-17-50-18-20-57-21-19-50)34-12-9-32(34)24-51-27-44(16-5-7-30-22-33(45)11-13-36(30)44)28-58-39-14-10-31(23-37(39)51)41(53)47-60(55,26-29)48-42(54)35-25-49(2)46-43(35)56-3/h4,8,10-11,13-14,22-23,25,29,32,34,38H,5-7,9,12,15-21,24,26-28H2,1-3H3,(H,47,48,53,54,55)/b8-4+/t29-,32-,34+,38-,44-,60-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0260	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449736 (US10703733, Example 349 | US10988451, Example 349 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C40H52ClN5O6S/c1-27-5-3-7-36(50-2)33-11-8-30(33)21-46-25-40(14-4-6-28-19-31(41)10-12-34(28)40)26-52-37-13-9-29(20-35(37)46)38(47)42-53(49,24-27)43-39(48)45-22-32(23-45)44-15-17-51-18-16-44/h3,7,9-10,12-13,19-20,27,30,32-33,36H,4-6,8,11,14-18,21-26H2,1-2H3,(H,42,43,47,48,49)/b7-3+/t27-,30-,33+,36-,40-,53-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0260	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449617 (US10703733, Example 230 | US10988451, Example 230) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(CCO3)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C38H47ClN4O6S/c1-25-5-3-7-33(47-2)30-11-8-28(30)19-42-21-37(14-4-6-26-17-29(39)10-12-31(26)37)24-48-34-13-9-27(18-32(34)42)35(44)40-50(46,20-25)41-36(45)43-22-38(23-43)15-16-49-38/h3,7,9-10,12-13,17-18,25,28,30,33H,4-6,8,11,14-16,19-24H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t25-,28-,30+,33-,37-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0270	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449670 (US10703733, Example 283 | US10988451, Example 283 ...) Show SMILES CO[C@H]1\C=C\[C@H](OC)[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H48ClN5O7S/c1-24-21-53(48,43-37(47)30-20-44(2)41-38(30)51-5)42-36(46)26-9-13-35-32(18-26)45(19-27-8-11-29(27)34(50-4)15-14-33(24)49-3)22-39(23-52-35)16-6-7-25-17-28(40)10-12-31(25)39/h9-10,12-15,17-18,20,24,27,29,33-34H,6-8,11,16,19,21-23H2,1-5H3,(H,42,43,46,47,48)/b15-14+/t24-,27+,29-,33+,34+,39+,53+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449674 (US10703733, Example 287 | US10988451, Example 287 ...) Show SMILES COC1CCN(CC1)C1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:52| Show InChI InChI=1S/C42H56ClN5O6S/c1-28-6-4-8-38(53-3)35-12-9-31(35)22-48-26-42(17-5-7-29-20-32(43)11-13-36(29)42)27-54-39-14-10-30(21-37(39)48)40(49)44-55(51,25-28)45-41(50)47-23-33(24-47)46-18-15-34(52-2)16-19-46/h4,8,10-11,13-14,20-21,28,31,33-35,38H,5-7,9,12,15-19,22-27H2,1-3H3,(H,44,45,49,50,51)/b8-4+/t28-,31-,35+,38-,42-,55-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449729 (US10703733, Example 342 | US10988451, Example 342 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@@H]2CC22CCOC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H49ClN4O6S/c1-25-5-3-7-33(48-2)30-11-8-28(30)20-44-22-39(14-4-6-26-17-29(40)10-12-31(26)39)24-50-34-13-9-27(18-32(34)44)36(45)42-51(47,21-25)43-37(46)41-35-19-38(35)15-16-49-23-38/h3,7,9-10,12-13,17-18,25,28,30,33,35H,4-6,8,11,14-16,19-24H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t25-,28-,30+,33-,35+,38?,39-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449696 (US10703733, Example 309 | US10988451, Example 309 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc(CN3CCN(CC3)C3COC3)n(C)c2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C46H59ClN6O6S/c1-31-6-4-8-42(57-3)39-12-9-34(39)24-53-29-46(15-5-7-32-20-36(47)11-13-40(32)46)30-59-43-14-10-33(22-41(43)53)44(54)48-60(56,28-31)49-45(55)35-21-37(50(2)23-35)25-51-16-18-52(19-17-51)38-26-58-27-38/h4,8,10-11,13-14,20-23,31,34,38-39,42H,5-7,9,12,15-19,24-30H2,1-3H3,(H,48,49,54,55,56)/b8-4+/t31-,34-,39+,42-,46-,60-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449637 (US10703733, Example 250 | US10988451, Example 250) Show SMILES CO[C@H]1CN([C@@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-7-5-9-33(47-3)30-13-10-28(30)19-42-22-38(16-6-8-26-17-29(39)12-14-31(26)38)23-49-34-15-11-27(18-32(34)42)36(44)40-50(46,21-24)41-37(45)43-20-35(48-4)25(43)2/h5,9,11-12,14-15,17-18,24-25,28,30,33,35H,6-8,10,13,16,19-23H2,1-4H3,(H,40,41,44,45,46)/b9-5+/t24-,25+,28-,30+,33-,35-,38-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0290	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449717 (US10703733, Example 330 | US10988451, Example 330 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CCC(CC2)OC(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H49ClF2N4O6S/c1-25-5-3-7-34(50-2)31-11-8-28(31)21-46-23-39(16-4-6-26-19-29(40)10-12-32(26)39)24-51-35-13-9-27(20-33(35)46)36(47)43-53(49,22-25)44-38(48)45-17-14-30(15-18-45)52-37(41)42/h3,7,9-10,12-13,19-20,25,28,30-31,34,37H,4-6,8,11,14-18,21-24H2,1-2H3,(H,43,44,47,48,49)/b7-3+/t25-,28-,31+,34-,39-,53-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449577 (US10703733, Example 190 | US10703733, Example 194 ...) Show SMILES COC1CCCn2cc(cc2C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:52| Show InChI InChI=1S/C43H53ClN4O6S/c1-28-7-4-10-39(53-3)36-14-11-31(36)23-48-26-43(17-5-8-29-19-33(44)13-15-37(29)43)27-54-40-16-12-30(21-38(40)48)41(49)45-55(51,25-28)46-42(50)32-20-34-22-35(52-2)9-6-18-47(34)24-32/h4,10,12-13,15-16,19-21,24,28,31,35-36,39H,5-9,11,14,17-18,22-23,25-27H2,1-3H3,(H,45,46,49,50,51)/b10-4+/t28-,31-,35?,36+,39-,43-,55-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM493759 (US10988451, Example 229 | US11643400, Example 229) Show SMILES C[C@H]1C\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@](=O)(NC(=O)c2cc3CO[C@@H](CN4CCN5CCOC[C@H]5C4)Cn3c2)[C@@H]1C |r,t:3| Show InChI InChI=1S/C48H61ClN6O7S/c1-31-5-3-7-44(56)41-11-8-35(41)22-55-29-48(14-4-6-33-19-37(49)10-12-42(33)48)30-62-45-13-9-34(21-43(45)55)46(57)50-63(59,32(31)2)51-47(58)36-20-38-28-61-40(26-54(38)23-36)25-52-15-16-53-17-18-60-27-39(53)24-52/h3,7,9-10,12-13,19-21,23,31-32,35,39-41,44,56H,4-6,8,11,14-18,22,24-30H2,1-2H3,(H,50,51,57,58,59)/b7-3+/t31-,32+,35-,39+,40-,41+,44-,48-,63-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449654 (US10703733, Example 267 | US10988451, Example 267 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(CO)(C2)OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C38H49ClN4O7S/c1-25-6-4-8-33(48-2)30-12-9-28(30)18-42-20-37(15-5-7-26-16-29(39)11-13-31(26)37)24-50-34-14-10-27(17-32(34)42)35(45)40-51(47,19-25)41-36(46)43-21-38(22-43,23-44)49-3/h4,8,10-11,13-14,16-17,25,28,30,33,44H,5-7,9,12,15,18-24H2,1-3H3,(H,40,41,45,46,47)/b8-4+/t25-,28-,30+,33-,37-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449677 (US10703733, Example 290 | US10988451, Example 290 ...) Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](O)CCC[C@H](C)[C@H]1C)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O6S/c1-23-7-5-9-33(45)29-13-10-27(29)19-44-21-38(16-6-8-25-17-28(39)12-14-31(25)38)22-50-34-15-11-26(18-32(34)44)35(46)41-51(48,24(23)2)42-36(47)30-20-43(3)40-37(30)49-4/h11-12,14-15,17-18,20,23-24,27,29,33,45H,5-10,13,16,19,21-22H2,1-4H3,(H,41,42,46,47,48)/t23-,24+,27-,29+,33-,38-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449727 (US10703733, Example 340 | US10988451, Example 340 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)NC23CC(C)(C2)OC3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,wD:9.10,6.6,48.51,45.49,31.43,2.1,t:3,(1.2,6.9,;2.54,6.13,;2.54,4.59,;1.24,3.82,;-.09,4.59,;-1.38,3.82,;-1.38,2.28,;.1,2.68,;-2.68,1.51,;-2.68,-.03,;-3.76,-1.12,;-4.01,.74,;-5.34,-.03,;-5.34,-1.57,;-6.68,.74,;-8.01,-.03,;-8.17,-1.56,;-9.68,-1.88,;-10.3,-3.29,;-9.46,-.36,;-10.45,-.55,;-9.42,.6,;-1.34,-.8,;-.01,-.03,;-.01,1.51,;1.33,-.8,;1.33,-2.34,;2.66,-3.11,;3.99,-2.34,;5.2,-3.3,;6.7,-2.96,;7.37,-1.57,;8.14,-.23,;9.68,-.23,;10.45,-1.57,;9.68,-2.9,;10.45,-4.24,;9.68,-5.57,;10.45,-6.9,;8.14,-5.57,;7.37,-4.24,;8.14,-2.9,;6.7,-.18,;5.2,.16,;5.2,1.51,;3.87,2.28,;2.54,1.51,;2.54,3.05,;3.87,3.82,;3.99,-.8,;2.66,-.03,)| Show InChI InChI=1S/C39H49ClN4O6S/c1-25-6-4-8-33(48-3)30-12-9-28(30)18-44-22-38(15-5-7-26-16-29(40)11-13-31(26)38)23-49-34-14-10-27(17-32(34)44)35(45)42-51(47,19-25)43-36(46)41-39-20-37(2,21-39)50-24-39/h4,8,10-11,13-14,16-17,25,28,30,33H,5-7,9,12,15,18-24H2,1-3H3,(H2,41,42,43,45,46,47)/b8-4+/t25-,28-,30+,33-,37?,38-,39?,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449733 (US10703733, Example 346 | US10988451, Example 346 ...) Show SMILES COCC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-25-6-4-8-34(48-3)31-12-9-29(31)20-43-23-38(15-5-7-27-16-30(39)11-13-32(27)38)24-49-35-14-10-28(17-33(35)43)36(44)40-50(46,22-25)41-37(45)42-18-26(19-42)21-47-2/h4,8,10-11,13-14,16-17,25-26,29,31,34H,5-7,9,12,15,18-24H2,1-3H3,(H,40,41,44,45,46)/b8-4+/t25-,29-,31+,34-,38-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449547 (US10703733, Example 160 | US10703733, Example 195 ...) Show SMILES CO[C@H]1C[C@@H]1NC(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-23-6-4-8-32(46-2)28-12-9-26(28)19-42-21-37(15-5-7-24-16-27(38)11-13-29(24)37)22-48-33-14-10-25(17-31(33)42)35(43)40-49(45,20-23)41-36(44)39-30-18-34(30)47-3/h4,8,10-11,13-14,16-17,23,26,28,30,32,34H,5-7,9,12,15,18-22H2,1-3H3,(H2,39,40,41,43,44,45)/b8-4+/t23-,26-,28+,30-,32-,34-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449695 (US10703733, Example 308 | US10988451, Example 308 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc(CN3CCOCC3)n(C)c2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C43H54ClN5O6S/c1-29-6-4-8-39(53-3)36-12-9-32(36)24-49-27-43(15-5-7-30-20-34(44)11-13-37(30)43)28-55-40-14-10-31(22-38(40)49)41(50)45-56(52,26-29)46-42(51)33-21-35(47(2)23-33)25-48-16-18-54-19-17-48/h4,8,10-11,13-14,20-23,29,32,36,39H,5-7,9,12,15-19,24-28H2,1-3H3,(H,45,46,50,51,52)/b8-4+/t29-,32-,36+,39-,43-,56-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449757 (US10703733, Example 376 | US10988451, Example 376 ...) Show SMILES COCCOCCO[C@H]1\C=C\[C@H](OC)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C[C@H]1C)NC(=O)c1cn(C)nc1OC |r,t:9| Show InChI InChI=1S/C43H56ClN5O9S/c1-28-25-59(52,47-41(51)34-24-48(2)45-42(34)55-5)46-40(50)30-9-13-39-36(22-30)49(26-43(27-58-39)16-6-7-29-21-32(44)10-12-35(29)43)23-31-8-11-33(31)38(54-4)15-14-37(28)57-20-19-56-18-17-53-3/h9-10,12-15,21-22,24,28,31,33,37-38H,6-8,11,16-20,23,25-27H2,1-5H3,(H,46,47,50,51,52)/b15-14+/t28-,31+,33-,37+,38+,43+,59+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0310	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449631 (US10703733, Example 244 | US10988451, Example 244) Show SMILES COC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@H](CCC[C@H](C)C1)OC)c3c2 |r| Show InChI InChI=1S/C37H49ClN4O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)18-42-22-37(15-5-7-25-16-28(38)11-13-31(25)37)23-48-34-14-10-26(17-32(34)42)35(43)39-49(45,21-24)40-36(44)41-19-29(20-41)46-2/h10-11,13-14,16-17,24,27,29-30,33H,4-9,12,15,18-23H2,1-3H3,(H,39,40,43,44,45)/t24-,27-,30+,33-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449728 (US10703733, Example 341 | US10988451, Example 341 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2CC22CCOC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H49ClN4O6S/c1-25-5-3-7-33(48-2)30-11-8-28(30)20-44-22-39(14-4-6-26-17-29(40)10-12-31(26)39)24-50-34-13-9-27(18-32(34)44)36(45)42-51(47,21-25)43-37(46)41-35-19-38(35)15-16-49-23-38/h3,7,9-10,12-13,17-18,25,28,30,33,35H,4-6,8,11,14-16,19-24H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t25-,28-,30+,33-,35-,38?,39-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449625 (US10703733, Example 238 | US10988451, Example 238) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc(CN3CCN4CCOC[C@@H]4C3)n(C)c2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C46H59ClN6O6S/c1-31-6-4-8-42(57-3)39-12-9-34(39)24-53-29-46(15-5-7-32-20-36(47)11-13-40(32)46)30-59-43-14-10-33(22-41(43)53)44(54)48-60(56,28-31)49-45(55)35-21-37(50(2)23-35)25-51-16-17-52-18-19-58-27-38(52)26-51/h4,8,10-11,13-14,20-23,31,34,38-39,42H,5-7,9,12,15-19,24-30H2,1-3H3,(H,48,49,54,55,56)/b8-4+/t31-,34-,38-,39+,42-,46-,60-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449558 (US10703733, Example 171 | US10988451, Example 171 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2CO)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H47ClN4O6S/c1-23-5-3-7-33(47-2)29-11-8-26(29)18-42-21-37(14-4-6-24-15-28(38)10-12-30(24)37)22-48-34-13-9-25(17-32(34)42)35(44)40-49(46,20-23)41-36(45)39-31-16-27(31)19-43/h3,7,9-10,12-13,15,17,23,26-27,29,31,33,43H,4-6,8,11,14,16,18-22H2,1-2H3,(H2,39,40,41,44,45,46)/b7-3+/t23-,26-,27+,29+,31-,33-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM493719 (US10988451, Example 189) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)C2C[C@H](CO)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,wD:29.40,2.1,6.6,46.48,43.46,9.10,16.16,t:3,(1.06,6.92,;2.39,6.14,;2.39,4.6,;1.05,3.84,;-.28,4.61,;-1.62,3.84,;-1.62,2.3,;-.13,2.7,;-2.96,1.54,;-2.96,-0,;-4.05,-1.09,;-4.3,.77,;-5.63,-0,;-5.63,-1.54,;-6.96,.77,;-8.43,.29,;-9.1,1.85,;-10.46,2.56,;-11.76,1.73,;-7.59,2.17,;-1.63,-.78,;-.3,-.01,;-.29,1.53,;1.04,-.78,;1.03,-2.32,;2.36,-3.1,;3.7,-2.33,;4.9,-3.3,;6.4,-2.96,;7.08,-1.57,;7.85,-.24,;9.39,-.24,;10.16,-1.58,;9.38,-2.91,;10.15,-4.25,;9.37,-5.58,;10.14,-6.92,;7.83,-5.57,;7.07,-4.24,;7.84,-2.91,;6.41,-.18,;4.93,.22,;5.04,1.51,;3.71,2.29,;2.38,1.52,;2.38,3.06,;3.72,3.83,;3.7,-.79,;2.37,-.02,)| Show InChI InChI=1S/C38H48ClN3O6S/c1-24-5-3-7-34(47-2)31-11-8-28(31)19-42-22-38(14-4-6-26-17-30(39)10-12-32(26)38)23-48-35-13-9-27(18-33(35)42)36(44)40-49(46,21-24)41-37(45)29-15-25(16-29)20-43/h3,7,9-10,12-13,17-18,24-25,28-29,31,34,43H,4-6,8,11,14-16,19-23H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t24-,25-,28-,29?,31+,34-,38-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM493827 (US10988451, Example 297 | US11643400, Example 297) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCN3CCOCC3C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C43H57ClN6O6S/c1-29-5-3-7-39(54-2)36-11-8-32(36)21-50-27-43(14-4-6-30-19-33(44)10-12-37(30)43)28-56-40-13-9-31(20-38(40)50)41(51)45-57(53,26-29)46-42(52)49-22-34(23-49)48-16-15-47-17-18-55-25-35(47)24-48/h3,7,9-10,12-13,19-20,29,32,34-36,39H,4-6,8,11,14-18,21-28H2,1-2H3,(H,45,46,51,52,53)/b7-3+/t29-,32-,35?,36+,39-,43-,57-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0330	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449704 (US10703733, Example 317 | US10988451, Example 317 ...) Show SMILES CO[C@@H]1C[C@@H]1NC(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-23-6-4-8-32(46-2)28-12-9-26(28)19-42-21-37(15-5-7-24-16-27(38)11-13-29(24)37)22-48-33-14-10-25(17-31(33)42)35(43)40-49(45,20-23)41-36(44)39-30-18-34(30)47-3/h4,8,10-11,13-14,16-17,23,26,28,30,32,34H,5-7,9,12,15,18-22H2,1-3H3,(H2,39,40,41,43,44,45)/b8-4+/t23-,26-,28+,30-,32-,34+,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449801 (US10703733, Example 422 | US10988451, Example 422) Show SMILES CCn1ncc(n1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C37H45ClN6O5S/c1-4-44-39-19-31(40-44)36(46)42-50(47)21-24(2)7-5-9-33(48-3)29-13-10-27(29)20-43-22-37(16-6-8-25-17-28(38)12-14-30(25)37)23-49-34-15-11-26(18-32(34)43)35(45)41-50/h5,9,11-12,14-15,17-19,24,27,29,33H,4,6-8,10,13,16,20-23H2,1-3H3,(H,41,42,45,46,47)/b9-5+/t24-,27-,29+,33-,37-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449552 (US10703733, Example 165 | US10988451, Example 165 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)[C@H]2C[C@@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,29.30,14.13,16.17,wD:2.1,46.48,43.46,6.6,9.10,16.16,t:3,(-.95,6.42,;.53,6.03,;.93,4.54,;-.16,3.45,;-1.64,3.85,;-2.73,2.76,;-2.33,1.27,;-.85,1.67,;-3.42,.18,;-3.02,-1.3,;-2.63,-2.79,;-4.51,-.91,;-5.85,-1.68,;-5.85,-3.22,;-7.18,-.91,;-8.67,-1.3,;-9.07,.18,;-10.61,.18,;-9.46,1.67,;-7.58,.58,;-1.54,-1.7,;-.45,-.61,;-.85,.87,;1.04,-1.01,;1.44,-2.5,;2.93,-2.9,;3.83,-1.88,;5.07,-2.89,;6.56,-2.6,;7.28,-1.24,;7.99,.13,;9.53,.2,;10.36,-1.1,;9.65,-2.46,;10.48,-3.76,;9.77,-5.13,;10.61,-6.42,;8.24,-5.2,;7.4,-3.9,;8.11,-2.54,;6.56,.17,;5.07,.57,;4.58,2.2,;2.96,2.62,;1.87,1.53,;1.48,3.01,;2.56,4.1,;3.66,-.4,;2.13,.08,)| Show InChI InChI=1S/C38H48ClN3O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)20-42-22-38(15-5-7-25-16-29(39)11-13-31(25)38)23-48-34-14-10-26(17-32(34)42)35(43)40-49(46,21-24)41-36(44)28-18-37(2,45)19-28/h4,8,10-11,13-14,16-17,24,27-28,30,33,45H,5-7,9,12,15,18-23H2,1-3H3,(H,40,41,43,44,46)/b8-4+/t24-,27-,28-,30+,33-,37+,38-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449622 (US10703733, Example 235 | US10988451, Example 235) Show SMILES CCOC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-4-48-30-20-42(21-30)37(45)41-50(46)22-25(2)7-5-9-34(47-3)31-13-10-28(31)19-43-23-38(16-6-8-26-17-29(39)12-14-32(26)38)24-49-35-15-11-27(18-33(35)43)36(44)40-50/h5,9,11-12,14-15,17-18,25,28,30-31,34H,4,6-8,10,13,16,19-24H2,1-3H3,(H,40,41,44,45,46)/b9-5+/t25-,28-,31+,34-,38-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449738 (US10703733, Example 351 | US10988451, Example 351 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H45ClF2N4O5S/c1-23-5-3-7-32(48-2)29-11-8-26(29)17-44-21-37(14-4-6-24-15-28(38)10-12-30(24)37)22-49-33-13-9-25(16-31(33)44)35(45)41-50(47,20-23)42-36(46)43-18-27(19-43)34(39)40/h3,7,9-10,12-13,15-16,23,26-27,29,32,34H,4-6,8,11,14,17-22H2,1-2H3,(H,41,42,45,46,47)/b7-3+/t23-,26-,29+,32-,37-,50-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449707 (US10703733, Example 320 | US10988451, Example 320) Show SMILES COC1CCN(CC1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:47| Show InChI InChI=1S/C39H51ClN4O6S/c1-26-6-4-8-35(49-3)32-12-9-29(32)22-44-24-39(17-5-7-27-20-30(40)11-13-33(27)39)25-50-36-14-10-28(21-34(36)44)37(45)41-51(47,23-26)42-38(46)43-18-15-31(48-2)16-19-43/h4,8,10-11,13-14,20-21,26,29,31-32,35H,5-7,9,12,15-19,22-25H2,1-3H3,(H,41,42,45,46,47)/b8-4+/t26-,29-,32+,35-,39-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449547 (US10703733, Example 160 | US10703733, Example 195 ...) Show SMILES CO[C@H]1C[C@@H]1NC(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-23-6-4-8-32(46-2)28-12-9-26(28)19-42-21-37(15-5-7-24-16-27(38)11-13-29(24)37)22-48-33-14-10-25(17-31(33)42)35(43)40-49(45,20-23)41-36(44)39-30-18-34(30)47-3/h4,8,10-11,13-14,16-17,23,26,28,30,32,34H,5-7,9,12,15,18-22H2,1-3H3,(H2,39,40,41,43,44,45)/b8-4+/t23-,26-,28+,30-,32-,34-,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0360	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449538 (US10703733, Example 151 | US10988451, Example 151 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cnn(c2)C2CC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H46ClN5O5S/c1-25-5-3-7-35(49-2)32-13-8-28(32)20-44-23-39(16-4-6-26-17-30(40)10-14-33(26)39)24-50-36-15-9-27(18-34(36)44)37(46)42-51(48,22-25)43-38(47)29-19-41-45(21-29)31-11-12-31/h3,7,9-10,14-15,17-19,21,25,28,31-32,35H,4-6,8,11-13,16,20,22-24H2,1-2H3,(H,42,43,46,47,48)/b7-3+/t25-,28-,32+,35-,39-,51-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0360	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449638 (US10703733, Example 251 | US10988451, Example 251 ...) Show SMILES COCCOC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:48| Show InChI InChI=1S/C39H51ClN4O7S/c1-26-6-4-8-35(49-3)32-12-9-29(32)20-44-24-39(15-5-7-27-18-30(40)11-13-33(27)39)25-51-36-14-10-28(19-34(36)44)37(45)41-52(47,23-26)42-38(46)43-21-31(22-43)50-17-16-48-2/h4,8,10-11,13-14,18-19,26,29,31-32,35H,5-7,9,12,15-17,20-25H2,1-3H3,(H,41,42,45,46,47)/b8-4+/t26-,29-,32+,35-,39-,52-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449532 (US10703733, Example 145 | US10988451, Example 145 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc3CCCC(=O)n3c2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C41H47ClN4O6S/c1-26-6-3-9-36(51-2)33-14-11-29(33)21-45-24-41(17-5-7-27-18-31(42)13-15-34(27)41)25-52-37-16-12-28(20-35(37)45)39(48)43-53(50,23-26)44-40(49)30-19-32-8-4-10-38(47)46(32)22-30/h3,9,12-13,15-16,18-20,22,26,29,33,36H,4-8,10-11,14,17,21,23-25H2,1-2H3,(H,43,44,48,49,50)/b9-3+/t26-,29-,33+,36-,41-,53-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449803 (US10703733, Example 424 | US10988451, Example 424 ...) Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc3COCCn3n2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H46ClN5O6S/c1-25-5-3-7-35(49-2)31-11-8-28(31)20-44-23-39(14-4-6-26-17-29(40)10-12-32(26)39)24-51-36-13-9-27(18-34(36)44)37(46)42-52(48,22-25)43-38(47)33-19-30-21-50-16-15-45(30)41-33/h3,7,9-10,12-13,17-19,25,28,31,35H,4-6,8,11,14-16,20-24H2,1-2H3,(H,42,43,46,47,48)/b7-3+/t25-,28-,31+,35-,39-,52-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449708 (US10703733, Example 321 | US10988451, Example 321 ...) Show SMILES C[C@H]1C\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C1)NC(=O)N[C@H]1C[C@@H]1C(F)F |r,t:3| Show InChI InChI=1S/C36H43ClF2N4O5S/c1-21-4-2-6-31(44)26-10-7-24(26)17-43-19-36(13-3-5-22-14-25(37)9-11-28(22)36)20-48-32-12-8-23(15-30(32)43)34(45)41-49(47,18-21)42-35(46)40-29-16-27(29)33(38)39/h2,6,8-9,11-12,14-15,21,24,26-27,29,31,33,44H,3-5,7,10,13,16-20H2,1H3,(H2,40,41,42,45,46,47)/b6-2+/t21-,24-,26+,27-,29-,31-,36-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449732 (US10703733, Example 345 | US10988451, Example 345 ...) Show SMILES COC[C@@H]1Cn2cc(cc2CO1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](O)\C=C\C[C@H](C)[C@H]1C)c3c2 |r,t:51| Show InChI InChI=1S/C42H51ClN4O7S/c1-26-6-4-8-38(48)35-12-9-30(35)19-47-24-42(15-5-7-28-16-32(43)11-13-36(28)42)25-54-39-14-10-29(18-37(39)47)40(49)44-55(51,27(26)2)45-41(50)31-17-33-22-53-34(23-52-3)21-46(33)20-31/h4,8,10-11,13-14,16-18,20,26-27,30,34-35,38,48H,5-7,9,12,15,19,21-25H2,1-3H3,(H,44,45,49,50,51)/b8-4+/t26-,27+,30-,34-,35+,38-,42-,55-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM493783 (US10988451, Example 253) Show SMILES CO[C@@H]1CN([C@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\CCC1)c3c2 |r,t:46| Show InChI InChI=1S/C37H47ClN4O6S/c1-24-34(47-3)21-42(24)36(44)40-49(45)17-6-4-5-9-32(46-2)29-13-10-27(29)20-41-22-37(16-7-8-25-18-28(38)12-14-30(25)37)23-48-33-15-11-26(19-31(33)41)35(43)39-49/h5,9,11-12,14-15,18-19,24,27,29,32,34H,4,6-8,10,13,16-17,20-23H2,1-3H3,(H,39,40,43,44,45)/b9-5+/t24-,27-,29+,32-,34+,37-,49-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449673 (US10703733, Example 286 | US10988451, Example 286 ...) Show SMILES COC1CN(C1)C1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:50| Show InChI InChI=1S/C40H52ClN5O6S/c1-26-6-4-8-36(51-3)33-12-9-29(33)18-46-24-40(15-5-7-27-16-30(41)11-13-34(27)40)25-52-37-14-10-28(17-35(37)46)38(47)42-53(49,23-26)43-39(48)45-19-31(20-45)44-21-32(22-44)50-2/h4,8,10-11,13-14,16-17,26,29,31-33,36H,5-7,9,12,15,18-25H2,1-3H3,(H,42,43,47,48,49)/b8-4+/t26-,29-,33+,36-,40-,53-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0370	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human))	BDBM449519 (US10703733, Example 132 | US10988451, Example 132 ...) Show SMILES COCCNC(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:43| Show InChI InChI=1S/C36H47ClN4O6S/c1-24-6-4-8-32(46-3)29-12-9-27(29)20-41-22-36(15-5-7-25-18-28(37)11-13-30(25)36)23-47-33-14-10-26(19-31(33)41)34(42)39-48(44,21-24)40-35(43)38-16-17-45-2/h4,8,10-11,13-14,18-19,24,27,29,32H,5-7,9,12,15-17,20-23H2,1-3H3,(H2,38,39,40,42,43,44)/b8-4+/t24-,27-,29+,32-,36-,48-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0380	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17...				US Patent US10988451 (2021) BindingDB Entry DOI: 10.7270/Q2M048KN
					More data for this Ligand-Target Pair

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