| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Ligand | BDBM449730 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaLISA Assay |
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| IC50 | 0.019±n/a nM |
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| Citation |  Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H MCL-1 inhibitors US Patent US10988451 Publication Date 4/27/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
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| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 17896.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820[171-327] |
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| Residue: | 157 |
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| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
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| BDBM449730 |
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| n/a |
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| Name | BDBM449730 |
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| Synonyms: | US10703733, Example 343 | US10988451, Example 343 | US11643400, Example 343 | US11667652, Example 34 |
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| Type | Small organic molecule |
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| Emp. Form. | C38H45ClF3N3O6S |
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| Mol. Mass. | 764.294 |
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| SMILES | C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1 |r| |
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| Structure | 
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