Found 10757 hits with Last Name = 'naduthambi' and Initial = 'd' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605286
(US11667652, Example 81)Show SMILES COC1CN(CCO[C@H]2\C=C\[C@H](OC)[C@@H]3CC[C@H]3CN3C[C@@]4(CCCc5cc(Cl)ccc45)COc4ccc(cc34)C(=O)N=[S@@](=O)(C[C@H]2C)NC(=O)c2cn(C)nc2OC)C1 |r,t:9| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449620
(US10703733, Example 233 | US10988451, Example 233)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)C#N)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H44ClN5O5S/c1-24-5-3-7-33(47-2)30-11-8-28(30)20-43-22-37(14-4-6-26-15-29(38)10-12-31(26)37)23-48-34-13-9-27(16-32(34)43)35(44)40-49(46,21-24)41-36(45)42-18-25(17-39)19-42/h3,7,9-10,12-13,15-16,24-25,28,30,33H,4-6,8,11,14,18-23H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t24-,28-,30+,33-,37-,49-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449620
(US10703733, Example 233 | US10988451, Example 233)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)C#N)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H44ClN5O5S/c1-24-5-3-7-33(47-2)30-11-8-28(30)20-43-22-37(14-4-6-26-15-29(38)10-12-31(26)37)23-48-34-13-9-27(16-32(34)43)35(44)40-49(46,21-24)41-36(45)42-18-25(17-39)19-42/h3,7,9-10,12-13,15-16,24-25,28,30,33H,4-6,8,11,14,18-23H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t24-,28-,30+,33-,37-,49-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449685
(US10703733, Example 298 | US11643400, Example 298)Show SMILES CO[C@H]1CC[C@H](O)[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O7S/c1-23-20-52(48,42-36(47)29-19-43(2)40-37(29)50-4)41-35(46)25-8-13-34-31(17-25)44(18-26-7-10-28(26)33(49-3)14-12-32(23)45)21-38(22-51-34)15-5-6-24-16-27(39)9-11-30(24)38/h8-9,11,13,16-17,19,23,26,28,32-33,45H,5-7,10,12,14-15,18,20-22H2,1-4H3,(H,41,42,46,47,48)/t23-,26+,28-,32+,33+,38+,52+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449686
(US10703733, Example 299 | US10988451, Example 298 ...)Show SMILES CO[C@H]1CC[C@H](OC)[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C39H50ClN5O7S/c1-24-21-53(48,43-37(47)30-20-44(2)41-38(30)51-5)42-36(46)26-9-13-35-32(18-26)45(19-27-8-11-29(27)34(50-4)15-14-33(24)49-3)22-39(23-52-35)16-6-7-25-17-28(40)10-12-31(25)39/h9-10,12-13,17-18,20,24,27,29,33-34H,6-8,11,14-16,19,21-23H2,1-5H3,(H,42,43,46,47,48)/t24-,27+,29-,33+,34+,39+,53+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM602144
(US11643400, Example 233)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)C#N)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@H](C)[C@H]1C)c3c2 |r,t:3| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449685
(US10703733, Example 298 | US11643400, Example 298)Show SMILES CO[C@H]1CC[C@H](O)[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O7S/c1-23-20-52(48,42-36(47)29-19-43(2)40-37(29)50-4)41-35(46)25-8-13-34-31(17-25)44(18-26-7-10-28(26)33(49-3)14-12-32(23)45)21-38(22-51-34)15-5-6-24-16-27(39)9-11-30(24)38/h8-9,11,13,16-17,19,23,26,28,32-33,45H,5-7,10,12,14-15,18,20-22H2,1-4H3,(H,41,42,46,47,48)/t23-,26+,28-,32+,33+,38+,52+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449659
(US10703733, Example 272 | US10988451, Example 272 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(C2)CN(C)C(=O)O3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H48ClN5O7S/c1-25-6-4-8-33(50-3)30-12-9-28(30)18-44-20-38(15-5-7-26-16-29(40)11-13-31(26)38)24-51-34-14-10-27(17-32(34)44)35(46)41-53(49,19-25)42-36(47)45-22-39(23-45)21-43(2)37(48)52-39/h4,8,10-11,13-14,16-17,25,28,30,33H,5-7,9,12,15,18-24H2,1-3H3,(H,41,42,46,47,49)/b8-4+/t25-,28-,30+,33-,38-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449627
(US10703733, Example 240 | US10988451, Example 240)Show SMILES CO[C@H]1CCC[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O6S/c1-24-7-5-9-33(48-3)29-13-10-27(29)19-44-22-38(16-6-8-25-17-28(39)12-14-31(25)38)23-50-34-15-11-26(18-32(34)44)35(45)41-51(47,21-24)42-36(46)30-20-43(2)40-37(30)49-4/h11-12,14-15,17-18,20,24,27,29,33H,5-10,13,16,19,21-23H2,1-4H3,(H,41,42,45,46,47)/t24-,27-,29+,33-,38-,51-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449627
(US10703733, Example 240 | US10988451, Example 240)Show SMILES CO[C@H]1CCC[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r| Show InChI InChI=1S/C38H48ClN5O6S/c1-24-7-5-9-33(48-3)29-13-10-27(29)19-44-22-38(16-6-8-25-17-28(39)12-14-31(25)38)23-50-34-15-11-26(18-32(34)44)35(45)41-51(47,21-24)42-36(46)30-20-43(2)40-37(30)49-4/h11-12,14-15,17-18,20,24,27,29,33H,5-10,13,16,19,21-23H2,1-4H3,(H,41,42,45,46,47)/t24-,27-,29+,33-,38-,51-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449659
(US10703733, Example 272 | US10988451, Example 272 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(C2)CN(C)C(=O)O3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H48ClN5O7S/c1-25-6-4-8-33(50-3)30-12-9-28(30)18-44-20-38(15-5-7-26-16-29(40)11-13-31(26)38)24-51-34-14-10-27(17-32(34)44)35(46)41-53(49,19-25)42-36(47)45-22-39(23-45)21-43(2)37(48)52-39/h4,8,10-11,13-14,16-17,25,28,30,33H,5-7,9,12,15,18-24H2,1-3H3,(H,41,42,46,47,49)/b8-4+/t25-,28-,30+,33-,38-,53-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM602151
(US11643400, Example 240)Show SMILES CO[C@H]1CCC[C@H](C)C[S@@](=O)(NC(=O)C2CN(C)N=C2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,c:18| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449659
(US10703733, Example 272 | US10988451, Example 272 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(C2)CN(C)C(=O)O3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H48ClN5O7S/c1-25-6-4-8-33(50-3)30-12-9-28(30)18-44-20-38(15-5-7-26-16-29(40)11-13-31(26)38)24-51-34-14-10-27(17-32(34)44)35(46)41-53(49,19-25)42-36(47)45-22-39(23-45)21-43(2)37(48)52-39/h4,8,10-11,13-14,16-17,25,28,30,33H,5-7,9,12,15,18-24H2,1-3H3,(H,41,42,46,47,49)/b8-4+/t25-,28-,30+,33-,38-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449730
(US10703733, Example 343 | US10988451, Example 343 ...)Show SMILES C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1 |r| Show InChI InChI=1S/C38H45ClF3N3O6S/c1-6-9-23(3)24(4)52(49,44-36(48)38(40,41)42)43-35(47)27-12-16-34-32(19-27)45(20-28-11-14-30(28)33(7-2)51-25(5)46)21-37(22-50-34)17-8-10-26-18-29(39)13-15-31(26)37/h6-7,12-13,15-16,18-19,23-24,28,30,33H,1-2,8-11,14,17,20-22H2,3-5H3,(H,43,44,47,48,49)/t23-,24+,28-,30+,33-,37-,52-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449730
(US10703733, Example 343 | US10988451, Example 343 ...)Show SMILES C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1 |r| Show InChI InChI=1S/C38H45ClF3N3O6S/c1-6-9-23(3)24(4)52(49,44-36(48)38(40,41)42)43-35(47)27-12-16-34-32(19-27)45(20-28-11-14-30(28)33(7-2)51-25(5)46)21-37(22-50-34)17-8-10-26-18-29(39)13-15-31(26)37/h6-7,12-13,15-16,18-19,23-24,28,30,33H,1-2,8-11,14,17,20-22H2,3-5H3,(H,43,44,47,48,49)/t23-,24+,28-,30+,33-,37-,52-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449730
(US10703733, Example 343 | US10988451, Example 343 ...)Show SMILES C[C@@H](CC=C)[C@@H](C)[S@@](=O)(NC(=O)C(F)(F)F)=NC(=O)c1ccc2OC[C@]3(CCCc4cc(Cl)ccc34)CN(C[C@@H]3CC[C@H]3[C@@H](OC(C)=O)C=C)c2c1 |r| Show InChI InChI=1S/C38H45ClF3N3O6S/c1-6-9-23(3)24(4)52(49,44-36(48)38(40,41)42)43-35(47)27-12-16-34-32(19-27)45(20-28-11-14-30(28)33(7-2)51-25(5)46)21-37(22-50-34)17-8-10-26-18-29(39)13-15-31(26)37/h6-7,12-13,15-16,18-19,23-24,28,30,33H,1-2,8-11,14,17,20-22H2,3-5H3,(H,43,44,47,48,49)/t23-,24+,28-,30+,33-,37-,52-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605237
(US11667652, Example 33)Show SMILES C[C@H]1C\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C1)Nc1nc(nc2nn(C)cc12)N1CCOCC1 |r,t:3| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM493822
(US10988451, Example 292)Show SMILES C[C@H]1C\C=C\[C@H](O)[C@@H]2CC[C@H]2CN2C[C@@]3(CCCc4cc(Cl)ccc34)COc3ccc(cc23)C(=O)N=[S@@](=O)(C1)NC(=O)N1CC(C1)OC(=O)N(C)C |r,t:3| Show InChI InChI=1S/C38H48ClN5O7S/c1-24-6-4-8-33(45)30-12-9-27(30)18-44-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-50-34-14-10-26(17-32(34)44)35(46)40-52(49,21-24)41-36(47)43-19-29(20-43)51-37(48)42(2)3/h4,8,10-11,13-14,16-17,24,27,29-30,33,45H,5-7,9,12,15,18-23H2,1-3H3,(H,40,41,46,47,49)/b8-4+/t24-,27-,30+,33-,38-,52-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449679
(US10703733, Example 292 | US11643400, Example 292)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)OC(=O)N(C)C)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H50ClN5O7S/c1-25-7-5-9-34(50-4)31-13-10-28(31)19-45-23-39(16-6-8-26-17-29(40)12-14-32(26)39)24-51-35-15-11-27(18-33(35)45)36(46)41-53(49,22-25)42-37(47)44-20-30(21-44)52-38(48)43(2)3/h5,9,11-12,14-15,17-18,25,28,30-31,34H,6-8,10,13,16,19-24H2,1-4H3,(H,41,42,46,47,49)/b9-5+/t25-,28-,31+,34-,39-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605397
(US11667652, Example 191)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2OC)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3n2 |r,t:3| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449679
(US10703733, Example 292 | US11643400, Example 292)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)OC(=O)N(C)C)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H50ClN5O7S/c1-25-7-5-9-34(50-4)31-13-10-28(31)19-45-23-39(16-6-8-26-17-29(40)12-14-32(26)39)24-51-35-15-11-27(18-33(35)45)36(46)41-53(49,22-25)42-37(47)44-20-30(21-44)52-38(48)43(2)3/h5,9,11-12,14-15,17-18,25,28,30-31,34H,6-8,10,13,16,19-24H2,1-4H3,(H,41,42,46,47,49)/b9-5+/t25-,28-,31+,34-,39-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449559
(US10703733, Example 172 | US10988451, Example 172 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,30.31,15.14,17.17,wD:2.1,47.49,44.47,6.6,9.10,17.18,t:3,(-.39,6.42,;1.1,6.03,;1.5,4.54,;.41,3.45,;-1.08,3.85,;-2.17,2.76,;-1.77,1.27,;-.28,1.67,;-2.86,.18,;-2.46,-1.3,;-2.06,-2.79,;-3.79,-2.07,;-5.13,-1.3,;-5.13,.24,;-6.46,-2.07,;-7.8,-1.3,;-9.28,-1.7,;-9.68,-.22,;-11.17,-.61,;-10.45,1.12,;-8.19,.18,;-.97,-1.7,;.12,-.61,;-.28,.87,;1.6,-1.01,;2,-2.5,;3.49,-2.9,;4.4,-1.88,;5.64,-2.89,;7.12,-2.6,;7.84,-1.24,;8.55,.13,;10.09,.2,;10.92,-1.1,;10.21,-2.46,;11.04,-3.76,;10.34,-5.13,;11.17,-6.42,;8.8,-5.2,;7.97,-3.9,;8.68,-2.54,;7.12,.17,;5.64,.57,;5.14,2.2,;3.53,2.62,;2.18,1.83,;1.78,3.32,;3.13,4.1,;4.22,-.4,;2.69,.08,)| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-6-4-8-33(48-3)30-12-9-27(30)20-43-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-49-34-14-10-26(17-32(34)43)35(44)41-50(47,21-24)42-36(45)40-29-18-37(2,46)19-29/h4,8,10-11,13-14,16-17,24,27,29-30,33,46H,5-7,9,12,15,18-23H2,1-3H3,(H2,40,41,42,44,45,47)/b8-4+/t24-,27-,29-,30+,33-,37-,38-,50-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449559
(US10703733, Example 172 | US10988451, Example 172 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,30.31,15.14,17.17,wD:2.1,47.49,44.47,6.6,9.10,17.18,t:3,(-.39,6.42,;1.1,6.03,;1.5,4.54,;.41,3.45,;-1.08,3.85,;-2.17,2.76,;-1.77,1.27,;-.28,1.67,;-2.86,.18,;-2.46,-1.3,;-2.06,-2.79,;-3.79,-2.07,;-5.13,-1.3,;-5.13,.24,;-6.46,-2.07,;-7.8,-1.3,;-9.28,-1.7,;-9.68,-.22,;-11.17,-.61,;-10.45,1.12,;-8.19,.18,;-.97,-1.7,;.12,-.61,;-.28,.87,;1.6,-1.01,;2,-2.5,;3.49,-2.9,;4.4,-1.88,;5.64,-2.89,;7.12,-2.6,;7.84,-1.24,;8.55,.13,;10.09,.2,;10.92,-1.1,;10.21,-2.46,;11.04,-3.76,;10.34,-5.13,;11.17,-6.42,;8.8,-5.2,;7.97,-3.9,;8.68,-2.54,;7.12,.17,;5.64,.57,;5.14,2.2,;3.53,2.62,;2.18,1.83,;1.78,3.32,;3.13,4.1,;4.22,-.4,;2.69,.08,)| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-6-4-8-33(48-3)30-12-9-27(30)20-43-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-49-34-14-10-26(17-32(34)43)35(44)41-50(47,21-24)42-36(45)40-29-18-37(2,46)19-29/h4,8,10-11,13-14,16-17,24,27,29-30,33,46H,5-7,9,12,15,18-23H2,1-3H3,(H2,40,41,42,44,45,47)/b8-4+/t24-,27-,29-,30+,33-,37-,38-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449559
(US10703733, Example 172 | US10988451, Example 172 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@](C)(O)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,wU:9.8,30.31,15.14,17.17,wD:2.1,47.49,44.47,6.6,9.10,17.18,t:3,(-.39,6.42,;1.1,6.03,;1.5,4.54,;.41,3.45,;-1.08,3.85,;-2.17,2.76,;-1.77,1.27,;-.28,1.67,;-2.86,.18,;-2.46,-1.3,;-2.06,-2.79,;-3.79,-2.07,;-5.13,-1.3,;-5.13,.24,;-6.46,-2.07,;-7.8,-1.3,;-9.28,-1.7,;-9.68,-.22,;-11.17,-.61,;-10.45,1.12,;-8.19,.18,;-.97,-1.7,;.12,-.61,;-.28,.87,;1.6,-1.01,;2,-2.5,;3.49,-2.9,;4.4,-1.88,;5.64,-2.89,;7.12,-2.6,;7.84,-1.24,;8.55,.13,;10.09,.2,;10.92,-1.1,;10.21,-2.46,;11.04,-3.76,;10.34,-5.13,;11.17,-6.42,;8.8,-5.2,;7.97,-3.9,;8.68,-2.54,;7.12,.17,;5.64,.57,;5.14,2.2,;3.53,2.62,;2.18,1.83,;1.78,3.32,;3.13,4.1,;4.22,-.4,;2.69,.08,)| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-6-4-8-33(48-3)30-12-9-27(30)20-43-22-38(15-5-7-25-16-28(39)11-13-31(25)38)23-49-34-14-10-26(17-32(34)43)35(44)41-50(47,21-24)42-36(45)40-29-18-37(2,46)19-29/h4,8,10-11,13-14,16-17,24,27,29-30,33,46H,5-7,9,12,15,18-23H2,1-3H3,(H2,40,41,42,44,45,47)/b8-4+/t24-,27-,29-,30+,33-,37-,38-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0220 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449749
(US10703733, Example 362 | US10988451, Example 362 ...)Show SMILES COC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)18-42-22-37(15-5-7-25-16-28(38)11-13-31(25)37)23-48-34-14-10-26(17-32(34)42)35(43)39-49(45,21-24)40-36(44)41-19-29(20-41)46-2/h4,8,10-11,13-14,16-17,24,27,29-30,33H,5-7,9,12,15,18-23H2,1-3H3,(H,39,40,43,44,45)/b8-4+/t24-,27-,30+,33-,37-,49-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449749
(US10703733, Example 362 | US10988451, Example 362 ...)Show SMILES COC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)18-42-22-37(15-5-7-25-16-28(38)11-13-31(25)37)23-48-34-14-10-26(17-32(34)42)35(43)39-49(45,21-24)40-36(44)41-19-29(20-41)46-2/h4,8,10-11,13-14,16-17,24,27,29-30,33H,5-7,9,12,15,18-23H2,1-3H3,(H,39,40,43,44,45)/b8-4+/t24-,27-,30+,33-,37-,49-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449698
(US10703733, Example 311 | US10988451, Example 311 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H45ClF2N4O5S/c1-22-5-3-7-32(48-2)27-11-8-25(27)18-44-20-37(14-4-6-23-15-26(38)10-12-29(23)37)21-49-33-13-9-24(16-31(33)44)35(45)42-50(47,19-22)43-36(46)41-30-17-28(30)34(39)40/h3,7,9-10,12-13,15-16,22,25,27-28,30,32,34H,4-6,8,11,14,17-21H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t22-,25-,27+,28-,30-,32-,37-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449749
(US10703733, Example 362 | US10988451, Example 362 ...)Show SMILES COC1CN(C1)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:45| Show InChI InChI=1S/C37H47ClN4O6S/c1-24-6-4-8-33(47-3)30-12-9-27(30)18-42-22-37(15-5-7-25-16-28(38)11-13-31(25)37)23-48-34-14-10-26(17-32(34)42)35(43)39-49(45,21-24)40-36(44)41-19-29(20-41)46-2/h4,8,10-11,13-14,16-17,24,27,29-30,33H,5-7,9,12,15,18-23H2,1-3H3,(H,39,40,43,44,45)/b8-4+/t24-,27-,30+,33-,37-,49-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449698
(US10703733, Example 311 | US10988451, Example 311 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H45ClF2N4O5S/c1-22-5-3-7-32(48-2)27-11-8-25(27)18-44-20-37(14-4-6-23-15-26(38)10-12-29(23)37)21-49-33-13-9-24(16-31(33)44)35(45)42-50(47,19-22)43-36(46)41-30-17-28(30)34(39)40/h3,7,9-10,12-13,15-16,22,25,27-28,30,32,34H,4-6,8,11,14,17-21H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t22-,25-,27+,28-,30-,32-,37-,50-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449698
(US10703733, Example 311 | US10988451, Example 311 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2C[C@@H]2C(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C37H45ClF2N4O5S/c1-22-5-3-7-32(48-2)27-11-8-25(27)18-44-20-37(14-4-6-23-15-26(38)10-12-29(23)37)21-49-33-13-9-24(16-31(33)44)35(45)42-50(47,19-22)43-36(46)41-30-17-28(30)34(39)40/h3,7,9-10,12-13,15-16,22,25,27-28,30,32,34H,4-6,8,11,14,17-21H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t22-,25-,27+,28-,30-,32-,37-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449548
(US10703733, Example 161 | US10988451, Example 161 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2CC2(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C36H43ClF2N4O5S/c1-22-5-3-7-30(47-2)27-11-8-25(27)18-43-20-35(14-4-6-23-15-26(37)10-12-28(23)35)21-48-31-13-9-24(16-29(31)43)33(44)41-49(46,19-22)42-34(45)40-32-17-36(32,38)39/h3,7,9-10,12-13,15-16,22,25,27,30,32H,4-6,8,11,14,17-21H2,1-2H3,(H2,40,41,42,44,45,46)/b7-3+/t22-,25-,27+,30-,32-,35-,49-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449548
(US10703733, Example 161 | US10988451, Example 161 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2CC2(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C36H43ClF2N4O5S/c1-22-5-3-7-30(47-2)27-11-8-25(27)18-43-20-35(14-4-6-23-15-26(37)10-12-28(23)35)21-48-31-13-9-24(16-29(31)43)33(44)41-49(46,19-22)42-34(45)40-32-17-36(32,38)39/h3,7,9-10,12-13,15-16,22,25,27,30,32H,4-6,8,11,14,17-21H2,1-2H3,(H2,40,41,42,44,45,46)/b7-3+/t22-,25-,27+,30-,32-,35-,49-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449548
(US10703733, Example 161 | US10988451, Example 161 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@H]2CC2(F)F)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C36H43ClF2N4O5S/c1-22-5-3-7-30(47-2)27-11-8-25(27)18-43-20-35(14-4-6-23-15-26(37)10-12-28(23)35)21-48-31-13-9-24(16-29(31)43)33(44)41-49(46,19-22)42-34(45)40-32-17-36(32,38)39/h3,7,9-10,12-13,15-16,22,25,27,30,32H,4-6,8,11,14,17-21H2,1-2H3,(H2,40,41,42,44,45,46)/b7-3+/t22-,25-,27+,30-,32-,35-,49-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449687
(US10703733, Example 300 | US10988451, Example 300 ...)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC(=O)CCN4CCOCC4)\C=C\C[C@H](C)C1)c3c2 |r,t:57| Show InChI InChI=1S/C44H55ClN6O8S/c1-29-6-4-8-38(59-40(52)15-17-50-18-20-57-21-19-50)34-12-9-32(34)24-51-27-44(16-5-7-30-22-33(45)11-13-36(30)44)28-58-39-14-10-31(23-37(39)51)41(53)47-60(55,26-29)48-42(54)35-25-49(2)46-43(35)56-3/h4,8,10-11,13-14,22-23,25,29,32,34,38H,5-7,9,12,15-21,24,26-28H2,1-3H3,(H,47,48,53,54,55)/b8-4+/t29-,32-,34+,38-,44-,60-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605307
(US11667652, Example 102 | US11667652, Example 111)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@](O)(CC(=O)N4CCN5CCOCC5C4)\C=C\C[C@H](C)C1)c3c2 |r,t:61| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605306
(US11667652, Example 101)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@](O)(CC(=O)N4CCN(C)CC4)\C=C\C[C@H](C)C1)c3c2 |r,t:57| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449736
(US10703733, Example 349 | US10988451, Example 349 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C40H52ClN5O6S/c1-27-5-3-7-36(50-2)33-11-8-30(33)21-46-25-40(14-4-6-28-19-31(41)10-12-34(28)40)26-52-37-13-9-29(20-35(37)46)38(47)42-53(49,24-27)43-39(48)45-22-32(23-45)44-15-17-51-18-16-44/h3,7,9-10,12-13,19-20,27,30,32-33,36H,4-6,8,11,14-18,21-26H2,1-2H3,(H,42,43,47,48,49)/b7-3+/t27-,30-,33+,36-,40-,53-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449736
(US10703733, Example 349 | US10988451, Example 349 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C40H52ClN5O6S/c1-27-5-3-7-36(50-2)33-11-8-30(33)21-46-25-40(14-4-6-28-19-31(41)10-12-34(28)40)26-52-37-13-9-29(20-35(37)46)38(47)42-53(49,24-27)43-39(48)45-22-32(23-45)44-15-17-51-18-16-44/h3,7,9-10,12-13,19-20,27,30,32-33,36H,4-6,8,11,14-18,21-26H2,1-2H3,(H,42,43,47,48,49)/b7-3+/t27-,30-,33+,36-,40-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449687
(US10703733, Example 300 | US10988451, Example 300 ...)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC(=O)CCN4CCOCC4)\C=C\C[C@H](C)C1)c3c2 |r,t:57| Show InChI InChI=1S/C44H55ClN6O8S/c1-29-6-4-8-38(59-40(52)15-17-50-18-20-57-21-19-50)34-12-9-32(34)24-51-27-44(16-5-7-30-22-33(45)11-13-36(30)44)28-58-39-14-10-31(23-37(39)51)41(53)47-60(55,26-29)48-42(54)35-25-49(2)46-43(35)56-3/h4,8,10-11,13-14,22-23,25,29,32,34,38H,5-7,9,12,15-21,24,26-28H2,1-3H3,(H,47,48,53,54,55)/b8-4+/t29-,32-,34+,38-,44-,60-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605229
(US11667652, Example 24)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cn(C)nc2N2CCN(CC2)C2COC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449687
(US10703733, Example 300 | US10988451, Example 300 ...)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC(=O)CCN4CCOCC4)\C=C\C[C@H](C)C1)c3c2 |r,t:57| Show InChI InChI=1S/C44H55ClN6O8S/c1-29-6-4-8-38(59-40(52)15-17-50-18-20-57-21-19-50)34-12-9-32(34)24-51-27-44(16-5-7-30-22-33(45)11-13-36(30)44)28-58-39-14-10-31(23-37(39)51)41(53)47-60(55,26-29)48-42(54)35-25-49(2)46-43(35)56-3/h4,8,10-11,13-14,22-23,25,29,32,34,38H,5-7,9,12,15-21,24,26-28H2,1-3H3,(H,47,48,53,54,55)/b8-4+/t29-,32-,34+,38-,44-,60-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449736
(US10703733, Example 349 | US10988451, Example 349 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC(C2)N2CCOCC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C40H52ClN5O6S/c1-27-5-3-7-36(50-2)33-11-8-30(33)21-46-25-40(14-4-6-28-19-31(41)10-12-34(28)40)26-52-37-13-9-29(20-35(37)46)38(47)42-53(49,24-27)43-39(48)45-22-32(23-45)44-15-17-51-18-16-44/h3,7,9-10,12-13,19-20,27,30,32-33,36H,4-6,8,11,14-18,21-26H2,1-2H3,(H,42,43,47,48,49)/b7-3+/t27-,30-,33+,36-,40-,53-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM602141
(US11643400, Example 230)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(CCO3)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@H](C)[C@H]1C)c3c2 |r,t:3| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q24B357N |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449617
(US10703733, Example 230 | US10988451, Example 230)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(CCO3)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C38H47ClN4O6S/c1-25-5-3-7-33(47-2)30-11-8-28(30)19-42-21-37(14-4-6-26-17-29(39)10-12-31(26)37)24-48-34-13-9-27(18-32(34)42)35(44)40-50(46,20-25)41-36(45)43-22-38(23-43)15-16-49-38/h3,7,9-10,12-13,17-18,25,28,30,33H,4-6,8,11,14-16,19-24H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t25-,28-,30+,33-,37-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449617
(US10703733, Example 230 | US10988451, Example 230)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(CCO3)C2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C38H47ClN4O6S/c1-25-5-3-7-33(47-2)30-11-8-28(30)19-42-21-37(14-4-6-26-17-29(39)10-12-31(26)37)24-48-34-13-9-27(18-32(34)42)35(44)40-50(46,20-25)41-36(45)43-22-38(23-43)15-16-49-38/h3,7,9-10,12-13,17-18,25,28,30,33H,4-6,8,11,14-16,19-24H2,1-2H3,(H,40,41,44,45,46)/b7-3+/t25-,28-,30+,33-,37-,50-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6× His-Mcl-1 (17... |
US Patent US10988451 (2021)
BindingDB Entry DOI: 10.7270/Q2M048KN |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605358
(US11667652, Example 152)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@H]4O[C@H](CCN(C)C)C[C@@H]4CC[C@H](C)C1)c3c2 |r| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM605315
(US11667652, Example 109)Show SMILES COc1nn(C)cc1C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@](O)(\C=C\C[C@H](C)C1)C#CCN(C)C)c3c2 |r,t:46| | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| | n/a | n/a | 0.0280 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2BK1H96 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449637
(US10703733, Example 250 | US10988451, Example 250)Show SMILES CO[C@H]1CN([C@@H]1C)C(=O)N[S@@]1(=O)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@@H](OC)\C=C\C[C@H](C)C1)c3c2 |r,t:46| Show InChI InChI=1S/C38H49ClN4O6S/c1-24-7-5-9-33(47-3)30-13-10-28(30)19-42-22-38(16-6-8-26-17-29(39)12-14-31(26)38)23-49-34-15-11-27(18-32(34)42)36(44)40-50(46,21-24)41-37(45)43-20-35(48-4)25(43)2/h5,9,11-12,14-15,17-18,24-25,28,30,33,35H,6-8,10,13,16,19-23H2,1-4H3,(H,40,41,44,45,46)/b9-5+/t24-,25+,28-,30+,33-,35-,38-,50-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0290 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449696
(US10703733, Example 309 | US10988451, Example 309 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)c2cc(CN3CCN(CC3)C3COC3)n(C)c2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C46H59ClN6O6S/c1-31-6-4-8-42(57-3)39-12-9-34(39)24-53-29-46(15-5-7-32-20-36(47)11-13-40(32)46)30-59-43-14-10-33(22-41(43)53)44(54)48-60(56,28-31)49-45(55)35-21-37(50(2)23-35)25-51-16-18-52(19-17-51)38-26-58-27-38/h4,8,10-11,13-14,20-23,31,34,38-39,42H,5-7,9,12,15-19,24-30H2,1-3H3,(H,48,49,54,55,56)/b8-4+/t31-,34-,39+,42-,46-,60-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0290 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
(Homo sapiens (Human)) | BDBM449729
(US10703733, Example 342 | US10988451, Example 342 ...)Show SMILES CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N[C@@H]2CC22CCOC2)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| Show InChI InChI=1S/C39H49ClN4O6S/c1-25-5-3-7-33(48-2)30-11-8-28(30)20-44-22-39(14-4-6-26-17-29(40)10-12-31(26)39)24-50-34-13-9-27(18-32(34)44)36(45)42-51(47,21-25)43-37(46)41-35-19-38(35)15-16-49-23-38/h3,7,9-10,12-13,17-18,25,28,30,33,35H,4-6,8,11,14-16,19-24H2,1-2H3,(H2,41,42,43,45,46,47)/b7-3+/t25-,28-,30+,33-,35+,38?,39-,51-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 0.0290 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences, Inc.
US Patent
| Assay Description
The AlphaLISA assay was performed in a 384-well Proxiplate in a total volume of 40 μL. The reaction mixture contained 0.0625 nM 6×His-Mcl-1 (171... |
US Patent US10703733 (2020)
BindingDB Entry DOI: 10.7270/Q2XK8JK4 |
More data for this
Ligand-Target Pair | |
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