| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Ligand | BDBM449659 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Binding AlphaLISA Assay |
|---|
| IC50 | 0.018±n/a nM |
|---|
| Citation |  Chu, H; Guerrero, JA; Hurtley, AE; Hwang, TH; Jiang, L; Kato, D; Kobayashi, T; Knox, JE; Lazerwith, SE; Li, X; Lin, DW; Medley, JW; Mitchell, ML; Naduthambi, D; Newby, Z; Squires, NH; Tsui, VH; Venkataramani, C; Watkins, WJ; Yang, H MCL-1 inhibitors US Patent US10703733 Publication Date 7/7/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Name: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Synonyms: | Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]/Bcl-2-like protein 11 [51-76] | Mcl-1 and BIM | Mcl-1/BIM |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] |
|---|
| Synonyms: | BCL2L3 | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1 | MCL1_HUMAN | Myeloid cell leukemia 1 (Mcl-1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 17896.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q07820[171-327] |
|---|
| Residue: | 157 |
|---|
| Sequence: | EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQG
MLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
|
|
|
|---|
| Component 2 |
| Name: | Bcl-2-like protein 11 [51-76] |
|---|
| Synonyms: | B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (51-76) | Bcl-2-like protein 11 (BIM) (51-76) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 2530.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O43521[51-76] |
|---|
| Residue: | 26 |
|---|
| Sequence: | EGDSCPHGSP QGPLAPPASP GPFATR
|
|
|
|---|
| BDBM449659 |
|---|
| n/a |
|---|
| Name | BDBM449659 |
|---|
| Synonyms: | US10703733, Example 272 | US10988451, Example 272 | US11643400, Example 272 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H48ClN5O7S |
|---|
| Mol. Mass. | 766.346 |
|---|
| SMILES | CO[C@H]1\C=C\C[C@H](C)C[S@@](=O)(NC(=O)N2CC3(C2)CN(C)C(=O)O3)=NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2 |r,t:3| |
|---|
| Structure | 
|
|---|
Search and Browse
