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Found 1 hit Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member B1' and Ligand = 'BDBM50126783'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldo-keto reductase family 1 member B1


(Rattus norvegicus)		BDBM50126783
PNG
(CHEMBL283172 | Cyano-[5-fluoro-1-(4-methoxy-benzyl...)
Show SMILES COc1ccc(CN2C(=O)C(C(C#N)C(O)=O)c3cc(F)ccc23)cc1
Show InChI InChI=1S/C19H15FN2O4/c1-26-13-5-2-11(3-6-13)10-22-16-7-4-12(20)8-14(16)17(18(22)23)15(9-21)19(24)25/h2-8,15,17H,10H2,1H3,(H,24,25)
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n/an/a 110n/an/an/an/an/an/a



Università di Pisa

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against aldose reductase (ALR2) from rat lens extraction.

J Med Chem 46: 1419-28 (2003)


Article DOI: 10.1021/jm030762f
BindingDB Entry DOI: 10.7270/Q21G0KN9
More data for this
Ligand-Target Pair