| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
|---|
| Ligand | BDBM50126783 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_31933 (CHEMBL642975) |
|---|
| IC50 | 110±n/a nM |
|---|
| Citation |  Da Settimo, F; Primofiore, G; Da Settimo, A; La Motta, C; Simorini, F; Novellino, E; Greco, G; Lavecchia, A; Boldrini, E Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives. J Med Chem46:1419-28 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldo-keto reductase family 1 member B1 |
|---|
| Name: | Aldo-keto reductase family 1 member B1 |
|---|
| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 35797.87 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1512484 |
|---|
| Residue: | 316 |
|---|
| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
|
|
|
|---|
| BDBM50126783 |
|---|
| n/a |
|---|
| Name | BDBM50126783 |
|---|
| Synonyms: | CHEMBL283172 | Cyano-[5-fluoro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-acetic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15FN2O4 |
|---|
| Mol. Mass. | 354.3318 |
|---|
| SMILES | COc1ccc(CN2C(=O)C(C(C#N)C(O)=O)c3cc(F)ccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
