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Found 1 hit Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4' and Ligand = 'BDBM320288'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))		BDBM320288
PNG
(US10174024, Example 5 | tert-Butyl 4-[3-(dimethyl-...)
Show SMILES Cc1nnn(C)c1-c1cnc2c(c1)n([C@@H](C1CCOCC1)c1ccccc1)c1ccc(cc21)C1CCN(CC1)C(=O)OC(C)(C)C |r|
Show InChI InChI=1S/C37H44N6O3/c1-24-34(41(5)40-39-24)29-22-32-33(38-23-29)30-21-28(25-13-17-42(18-14-25)36(44)46-37(2,3)4)11-12-31(30)43(32)35(26-9-7-6-8-10-26)27-15-19-45-20-16-27/h6-12,21-23,25,27,35H,13-20H2,1-5H3/t35-/m1/s1
PDB

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US Patent
n/an/a<5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...

US Patent US10174024 (2019)


BindingDB Entry DOI: 10.7270/Q2319XZ1
More data for this
Ligand-Target Pair