Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Bromodomain-containing protein 4 [368-440]' and Ligand = 'BDBM249279'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM249279 (US10017501, Compound 1020-28 | US9458145, 1020-28) Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences Inc US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human))	BDBM249279 (US10017501, Compound 1020-28 | US9458145, 1020-28) Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	7.5	25
Gilead Sciences, Inc. US Patent					Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...				US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53
					More data for this Ligand-Target Pair