Found 2 hits Enz. Inhib. hit(s) with Target = 'C-C chemokine receptor type 2' and Ligand = 'BDBM50359117' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359117
(CHEMBL1922799)Show SMILES COc1ccc(cn1)C1CCC(CC1)NC(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(N)=O |(28.92,-24.66,;30.25,-23.9,;30.26,-22.36,;28.92,-21.58,;28.93,-20.04,;30.27,-19.28,;31.6,-20.05,;31.6,-21.58,;30.28,-17.74,;28.95,-16.96,;28.95,-15.43,;30.29,-14.67,;31.62,-15.43,;31.62,-16.97,;30.29,-13.13,;31.63,-12.36,;32.96,-13.14,;32.95,-14.68,;34.27,-15.45,;35.61,-14.69,;35.62,-13.15,;34.29,-12.37,;36.94,-15.47,;36.93,-17.01,;38.28,-14.71,;39.61,-15.49,;40.94,-14.73,;40.95,-13.2,;42.28,-12.43,;42.28,-10.89,;43.62,-13.21,;44.95,-12.45,;43.6,-14.75,;44.93,-15.53,;42.27,-15.51,;31.63,-10.82,;30.3,-10.05,;32.97,-10.06,)| Show InChI InChI=1S/C28H33F3N4O3/c1-38-24-8-5-20(16-33-24)18-3-6-21(7-4-18)34-27(28(32)37)19-10-12-35(13-11-19)25(36)9-2-17-14-22(29)26(31)23(30)15-17/h2,5,8-9,14-16,18-19,21,27,34H,3-4,6-7,10-13H2,1H3,(H2,32,37)/b9-2+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 635 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica NV
US Patent
| Assay Description
MCP-1 Receptor Binding Assay in THP-1 Cells Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va.,... |
US Patent US8921559 (2014)
BindingDB Entry DOI: 10.7270/Q270804M |
More data for this
Ligand-Target Pair | |
C-C chemokine receptor type 2
(Homo sapiens (Human)) | BDBM50359117
(CHEMBL1922799)Show SMILES COc1ccc(cn1)C1CCC(CC1)NC(C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)C(N)=O |(28.92,-24.66,;30.25,-23.9,;30.26,-22.36,;28.92,-21.58,;28.93,-20.04,;30.27,-19.28,;31.6,-20.05,;31.6,-21.58,;30.28,-17.74,;28.95,-16.96,;28.95,-15.43,;30.29,-14.67,;31.62,-15.43,;31.62,-16.97,;30.29,-13.13,;31.63,-12.36,;32.96,-13.14,;32.95,-14.68,;34.27,-15.45,;35.61,-14.69,;35.62,-13.15,;34.29,-12.37,;36.94,-15.47,;36.93,-17.01,;38.28,-14.71,;39.61,-15.49,;40.94,-14.73,;40.95,-13.2,;42.28,-12.43,;42.28,-10.89,;43.62,-13.21,;44.95,-12.45,;43.6,-14.75,;44.93,-15.53,;42.27,-15.51,;31.63,-10.82,;30.3,-10.05,;32.97,-10.06,)| Show InChI InChI=1S/C28H33F3N4O3/c1-38-24-8-5-20(16-33-24)18-3-6-21(7-4-18)34-27(28(32)37)19-10-12-35(13-11-19)25(36)9-2-17-14-22(29)26(31)23(30)15-17/h2,5,8-9,14-16,18-19,21,27,34H,3-4,6-7,10-13H2,1H3,(H2,32,37)/b9-2+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Antagonist activity at human CCR2 |
Bioorg Med Chem Lett 21: 7496-501 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.113
BindingDB Entry DOI: 10.7270/Q22J6C9M |
More data for this
Ligand-Target Pair | |
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