Found 4 hits Enz. Inhib. hit(s) with Target = 'Catenin beta-1' and Ligand = 'BDBM50436058' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Catenin beta-1
(Homo sapiens (Human)) | BDBM50436058
![PNG](/data/jpeg/tenK5043/BindingDB_50436058.png) (CHEMBL254381 | PNU-74654 | US9738628, Compound PNU...)Show InChI InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Utah
Curated by ChEMBL
| Assay Description Inhibition of human wild-type beta-catenin (residues 138-686)/C-terminally fluorescein labeled human wild-type Tcf4 (residues 7-51) interaction after... |
J Med Chem 58: 4678-92 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00223 BindingDB Entry DOI: 10.7270/Q2G44S28 |
More data for this Ligand-Target Pair | |
Catenin beta-1
(Homo sapiens (Human)) | BDBM50436058
![PNG](/data/jpeg/tenK5043/BindingDB_50436058.png) (CHEMBL254381 | PNU-74654 | US9738628, Compound PNU...)Show InChI InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00228 BindingDB Entry DOI: 10.7270/Q2GQ72Q3 |
More data for this Ligand-Target Pair | |
Catenin beta-1
(Homo sapiens (Human)) | BDBM50436058
![PNG](/data/jpeg/tenK5043/BindingDB_50436058.png) (CHEMBL254381 | PNU-74654 | US9738628, Compound PNU...)Show InChI InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmc.2022.116920 BindingDB Entry DOI: 10.7270/Q2T157M8 |
More data for this Ligand-Target Pair | |
Catenin beta-1
(Homo sapiens (Human)) | BDBM50436058
![PNG](/data/jpeg/tenK5043/BindingDB_50436058.png) (CHEMBL254381 | PNU-74654 | US9738628, Compound PNU...)Show InChI InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a |
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
| Assay Description Inhibition of Tcf4 binding to beta-catenin (unknown origin) |
Bioorg Med Chem 21: 4020-6 (2013)
Article DOI: 10.1016/j.bmc.2013.02.050 BindingDB Entry DOI: 10.7270/Q2BP046Z |
More data for this Ligand-Target Pair | |