Found 2 hits Enz. Inhib. hit(s) with Target = 'Diacylglycerol O-acyltransferase 1' and Ligand = 'BDBM50003857' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50003857
![PNG](/data/jpeg/tenK5000/BindingDB_50003857.png) (CHEMBL3235314)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CCC(O)=O)CC1 |r,wU:19.21,wD:22.25,c:12,(25.63,-58.39,;24.09,-58.39,;24.86,-59.72,;22.76,-59.17,;21.42,-58.4,;20.09,-59.18,;18.75,-58.41,;18.76,-56.86,;20.09,-56.09,;20.08,-54.55,;21.42,-56.86,;22.75,-56.08,;24.08,-56.84,;25.41,-56.06,;26.75,-56.83,;28.07,-56.06,;28.07,-54.51,;26.72,-53.75,;25.4,-54.53,;29.39,-53.73,;29.37,-52.2,;30.71,-51.42,;32.05,-52.18,;33.38,-51.41,;34.71,-52.17,;34.72,-53.71,;33.39,-54.49,;36.06,-54.48,;32.05,-53.72,;30.73,-54.5,)| Show InChI InChI=1S/C23H28N4O3/c1-23(2)20(27-19-21(24)25-13-26-22(19)30-23)17-10-8-16(9-11-17)15-6-3-14(4-7-15)5-12-18(28)29/h8-11,13-15H,3-7,12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human liver flag-tagged DGAT1 expressed in baculovirus infected insect cells after 2 hrs by SPA |
J Med Chem 57: 3464-83 (2014)
Article DOI: 10.1021/jm500135c BindingDB Entry DOI: 10.7270/Q23X886W |
More data for this Ligand-Target Pair | |
Diacylglycerol O-acyltransferase 1
(Homo sapiens (Human)) | BDBM50003857
![PNG](/data/jpeg/tenK5000/BindingDB_50003857.png) (CHEMBL3235314)Show SMILES CC1(C)Oc2ncnc(N)c2N=C1c1ccc(cc1)[C@H]1CC[C@H](CCC(O)=O)CC1 |r,wU:19.21,wD:22.25,c:12,(25.63,-58.39,;24.09,-58.39,;24.86,-59.72,;22.76,-59.17,;21.42,-58.4,;20.09,-59.18,;18.75,-58.41,;18.76,-56.86,;20.09,-56.09,;20.08,-54.55,;21.42,-56.86,;22.75,-56.08,;24.08,-56.84,;25.41,-56.06,;26.75,-56.83,;28.07,-56.06,;28.07,-54.51,;26.72,-53.75,;25.4,-54.53,;29.39,-53.73,;29.37,-52.2,;30.71,-51.42,;32.05,-52.18,;33.38,-51.41,;34.71,-52.17,;34.72,-53.71,;33.39,-54.49,;36.06,-54.48,;32.05,-53.72,;30.73,-54.5,)| Show InChI InChI=1S/C23H28N4O3/c1-23(2)20(27-19-21(24)25-13-26-22(19)30-23)17-10-8-16(9-11-17)15-6-3-14(4-7-15)5-12-18(28)29/h8-11,13-15H,3-7,12H2,1-2H3,(H,28,29)(H2,24,25,26)/t14-,15- | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of DGAT1 (unknown origin) by cell-based assay |
J Med Chem 57: 3464-83 (2014)
Article DOI: 10.1021/jm500135c BindingDB Entry DOI: 10.7270/Q23X886W |
More data for this Ligand-Target Pair | |