Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Excitatory amino acid transporter 1' and Ligand = 'BDBM50093753'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of [3H]-D-Asp uptake at human EAAT1 expressed in HEK293 cells measured after 3 mins by TopCount method				J Med Chem 59: 8771-8786 (2016) Article DOI: 10.1021/acs.jmedchem.6b01066 BindingDB Entry DOI: 10.7270/Q2Z03B4C
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Groningen Curated by ChEMBL					Assay Description Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method				J Med Chem 61: 7741-7753 (2018) Article DOI: 10.1021/acs.jmedchem.8b00700 BindingDB Entry DOI: 10.7270/Q2G44ST4
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Bioorganic Research Curated by ChEMBL					Assay Description Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1				Bioorg Med Chem Lett 10: 2407-10 (2001) Checked by Author BindingDB Entry DOI: 10.7270/Q2CR5TVN
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.37E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Bioorganic Research Curated by ChEMBL					Assay Description Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1				Bioorg Med Chem Lett 10: 2407-10 (2001) Checked by Author BindingDB Entry DOI: 10.7270/Q2CR5TVN
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.37E+5	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Bioorganic Research Curated by ChEMBL					Assay Description Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1				Bioorg Med Chem Lett 10: 2407-10 (2001) Checked by Author BindingDB Entry DOI: 10.7270/Q2CR5TVN
					More data for this Ligand-Target Pair
Excitatory amino acid transporter 1 (Homo sapiens (Human))	BDBM50093753 ((2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S...) Show SMILES N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)/t8-,9-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Bioorganic Research Curated by ChEMBL					Assay Description Concentration required for blocking [14C]glutamate uptake in COS-1 cells expressing human Excitatory amino acid transporter 1				Bioorg Med Chem Lett 10: 2407-10 (2001) Checked by Author BindingDB Entry DOI: 10.7270/Q2CR5TVN
					More data for this Ligand-Target Pair