Found 2 hits Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 3' and Ligand = 'BDBM102501' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102501
(US8536175, 2)Show SMILES CCN1CCN(CC1)c1cccc(NC(=O)c2ccc(-c3c(Cl)c(OC)cc(OC)c3Cl)c3nccnc23)c1 |(-10.01,4.67,;-8.47,4.67,;-7.7,3.33,;-6.16,3.33,;-5.39,2,;-6.16,.67,;-7.7,.67,;-8.47,2,;-5.39,-.67,;-6.16,-2,;-5.39,-3.33,;-3.85,-3.33,;-3.08,-2,;-1.54,-2,;-.77,-.67,;-1.54,.67,;.77,-.67,;1.54,.67,;3.08,.67,;3.85,-.67,;5.39,-.67,;6.16,-2,;5.39,-3.33,;7.7,-2,;8.47,-3.33,;10.01,-3.33,;8.47,-.67,;7.7,.67,;8.47,2,;7.7,3.33,;6.16,.67,;5.39,2,;3.08,-2,;3.85,-3.33,;3.08,-4.67,;1.54,-4.67,;.77,-3.33,;1.54,-2,;-3.85,-.67,)| Show InChI InChI=1S/C29H29Cl2N5O3/c1-4-35-12-14-36(15-13-35)19-7-5-6-18(16-19)34-29(37)21-9-8-20(27-28(21)33-11-10-32-27)24-25(30)22(38-2)17-23(39-3)26(24)31/h5-11,16-17H,4,12-15H2,1-3H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG
US Patent
| Assay Description
The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ... |
US Patent US8815901 (2014)
BindingDB Entry DOI: 10.7270/Q2XG9PT8 |
More data for this
Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM102501
(US8536175, 2)Show SMILES CCN1CCN(CC1)c1cccc(NC(=O)c2ccc(-c3c(Cl)c(OC)cc(OC)c3Cl)c3nccnc23)c1 |(-10.01,4.67,;-8.47,4.67,;-7.7,3.33,;-6.16,3.33,;-5.39,2,;-6.16,.67,;-7.7,.67,;-8.47,2,;-5.39,-.67,;-6.16,-2,;-5.39,-3.33,;-3.85,-3.33,;-3.08,-2,;-1.54,-2,;-.77,-.67,;-1.54,.67,;.77,-.67,;1.54,.67,;3.08,.67,;3.85,-.67,;5.39,-.67,;6.16,-2,;5.39,-3.33,;7.7,-2,;8.47,-3.33,;10.01,-3.33,;8.47,-.67,;7.7,.67,;8.47,2,;7.7,3.33,;6.16,.67,;5.39,2,;3.08,-2,;3.85,-3.33,;3.08,-4.67,;1.54,-4.67,;.77,-3.33,;1.54,-2,;-3.85,-.67,)| Show InChI InChI=1S/C29H29Cl2N5O3/c1-4-35-12-14-36(15-13-35)19-7-5-6-18(16-19)34-29(37)21-9-8-20(27-28(21)33-11-10-32-27)24-25(30)22(38-2)17-23(39-3)26(24)31/h5-11,16-17H,4,12-15H2,1-3H3,(H,34,37) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG
US Patent
| Assay Description
Protein kinase activity measured by the microfluidic caliper method. |
US Patent US8536175 (2013)
BindingDB Entry DOI: 10.7270/Q27D2SSH |
More data for this
Ligand-Target Pair | |
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