BindingDB PrimarySearch

Found 48 hits Enz. Inhib. hit(s) with Target = 'Free fatty acid receptor 1' and Ligand = 'BDBM50386790'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-TAK-875 from human recombinant full-length GPR40 expressed in human HEK293 cell membrane incubated for 2 hrs by solid scintillat...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)...				J Med Chem 59: 4849-58 (2016) Article DOI: 10.1021/acs.jmedchem.6b00202 BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO membrane...				ACS Med Chem Lett 1: 290-294 (2010) Article DOI: 10.1021/ml1000855 BindingDB Entry DOI: 10.7270/Q29G5NZJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from human GPR40 expressed in CHO cells a...				J Med Chem 55: 3960-74 (2012) Article DOI: 10.1021/jm300170m BindingDB Entry DOI: 10.7270/Q23779R6
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])-phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO cells aft...				J Med Chem 55: 3960-74 (2012) Article DOI: 10.1021/jm300170m BindingDB Entry DOI: 10.7270/Q23779R6
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl]propanoic acid from rat GPR40 expressed in CHO membranes ...				ACS Med Chem Lett 1: 290-294 (2010) Article DOI: 10.1021/ml1000855 BindingDB Entry DOI: 10.7270/Q29G5NZJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at FFA1 receptor (unknown origin) expressed in human 132N1 cells measured for 90 secs by Fura-2 AM dye based calcium mobilization as...				J Med Chem 59: 4849-58 (2016) Article DOI: 10.1021/acs.jmedchem.6b00202 BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	25.7	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization in presence of 0.05% BSA				J Med Chem 55: 6624-8 (2012) Article DOI: 10.1021/jm3002026 BindingDB Entry DOI: 10.7270/Q2P84D1H
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	21.9	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization				J Med Chem 55: 6624-8 (2012) Article DOI: 10.1021/jm3002026 BindingDB Entry DOI: 10.7270/Q2P84D1H
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in Flp-InTM T-RexTM HEK293 cells assessed as stimulation of calcium mobilization				J Med Chem 55: 6624-8 (2012) Article DOI: 10.1021/jm3002026 BindingDB Entry DOI: 10.7270/Q2P84D1H
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
Cadila Healthcare Ltd. Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in HEK293 cells measured after 18 to 20 hrs by beta-gal based luciferase reporter gene assay				ACS Med Chem Lett 7: 1134-1138 (2016) Article DOI: 10.1021/acsmedchemlett.6b00331 BindingDB Entry DOI: 10.7270/Q2K35WN3
Cadila Healthcare Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	14.1	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in human 1321N1 cells assessed as calcium mobilization by fluorescence spectrophotometry				J Med Chem 54: 6691-703 (2011) Article DOI: 10.1021/jm2005699 BindingDB Entry DOI: 10.7270/Q25T3MRW
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Rattus norvegicus)	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description Agonist activity at GPR40 in rat INS-1 cells assessed as glucose-stimulated insulin secretion				Bioorg Med Chem Lett 23: 2920-4 (2013) Article DOI: 10.1016/j.bmcl.2013.03.060 BindingDB Entry DOI: 10.7270/Q26M3878
Shanghai Hengrui Pharmaceutical Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a
Shanghai Hengrui Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description Agonist activity at human GPR40 transfected in CHO cells by calcium flux assay				Bioorg Med Chem Lett 23: 2920-4 (2013) Article DOI: 10.1016/j.bmcl.2013.03.060 BindingDB Entry DOI: 10.7270/Q26M3878
Shanghai Hengrui Pharmaceutical Co. Ltd Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as calcium influx by FLIPR assay in presence of 0.1 % BSA				ACS Med Chem Lett 1: 290-294 (2010) Article DOI: 10.1021/ml1000855 BindingDB Entry DOI: 10.7270/Q29G5NZJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Agonist activity at human GP40 receptor expressed in CHO cells assessed as increase in intracellular calcium level for 90 secs by FLIPR assay in the ...				J Med Chem 55: 3960-74 (2012) Article DOI: 10.1021/jm300170m BindingDB Entry DOI: 10.7270/Q23779R6
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Shanghai Institute of Materia Medica Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo 4-AM dye based assay				J Med Chem 60: 2697-2717 (2017) Article DOI: 10.1021/acs.jmedchem.6b01357 BindingDB Entry DOI: 10.7270/Q25141GQ
Shanghai Institute of Materia Medica Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFAR1 expressed in CHO cells assessed as increase in intracellular calcium level by Fluo 4-AM dye-based FLIPR assay				Bioorg Med Chem 25: 6647-6652 (2017) Article DOI: 10.1016/j.bmc.2017.10.040 BindingDB Entry DOI: 10.7270/Q2Z3226M
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Sungkyunkwan University Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay				ACS Med Chem Lett 8: 1336-1340 (2017) Article DOI: 10.1021/acsmedchemlett.7b00460 BindingDB Entry DOI: 10.7270/Q2WW7M7W
Sungkyunkwan University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium levels measured for 90 secs by Fluo 4-AM...				Bioorg Med Chem 26: 4560-4566 (2018) Article DOI: 10.1016/j.bmc.2018.07.050 BindingDB Entry DOI: 10.7270/Q2PZ5CG6
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a
Peking Union Medical College and Chinese Academy of Medical Sciences Curated by ChEMBL					Assay Description Transactivation of human GPR40 expressed in HEK293 cells after 24 hrs by Elk-Gal4 luciferase reporter assay				Bioorg Med Chem Lett 28: 3050-3056 (2018) Article DOI: 10.1016/j.bmcl.2018.07.048 BindingDB Entry DOI: 10.7270/Q2SQ9313
					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	32	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based FLIPR assay				Bioorg Med Chem 26: 703-711 (2018) Article DOI: 10.1016/j.bmc.2017.12.030 BindingDB Entry DOI: 10.7270/Q2SX6GWS
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
East China Normal University Curated by ChEMBL					Assay Description Agonist activity at recombinant human GPR40 expressed in HEK293 cells assessed as increase in intracellular calcium flux measured for 120 secs by cal...				Eur J Med Chem 158: 123-133 (2018) Article DOI: 10.1016/j.ejmech.2018.08.075 BindingDB Entry DOI: 10.7270/Q2W66PF4
East China Normal University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in human HEK293 cells assessed as increase in intracellular calcium flux after 10 mins by fluorescence assa...				Bioorg Med Chem 26: 5780-5791 (2018) Article DOI: 10.1016/j.bmc.2018.10.019 BindingDB Entry DOI: 10.7270/Q2319ZKH
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at FFA1 (unknown origin)				Eur J Med Chem 159: 267-276 (2018) Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ flux after 1 hr by Fluo4-AM dye based FLIPR assay				Eur J Med Chem 159: 267-276 (2018) Article DOI: 10.1016/j.ejmech.2018.09.071 BindingDB Entry DOI: 10.7270/Q27D2XTM
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	31	n/a	n/a	n/a	n/a
Janssen Research & Development Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in HEK293 cells assessed as induction of intracellular calcium mobilization by Fluo-8 dye based FLIPR assay				ACS Med Chem Lett 10: 16-21 (2019) Article DOI: 10.1021/acsmedchemlett.8b00444 BindingDB Entry DOI: 10.7270/Q2X63RBS
Janssen Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at FFA1 receptor (unknown origin) stably expressed in CHO cells assessed as increase in calcium flux by Fluo4-AM based FLIPR assay				Eur J Med Chem 179: 608-622 (2019) Article DOI: 10.1016/j.ejmech.2019.06.087 BindingDB Entry DOI: 10.7270/Q23B63GS
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
East China Normal University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in HEK293 cells assessed as increase in intracellular Ca2+ flux by Fluo-4 dye based assay				Bioorg Med Chem Lett 29: 848-852 (2019) Article DOI: 10.1016/j.bmcl.2019.01.014 BindingDB Entry DOI: 10.7270/Q21J9F8T
East China Normal University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Guangdong Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in CHO cells by Fluo 4-AM dye based FLIPR assay				Eur J Med Chem 164: 352-365 (2019) Article DOI: 10.1016/j.ejmech.2018.12.069 BindingDB Entry DOI: 10.7270/Q2V1289T
Guangdong Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at GPR40 (unknown origin)				Bioorg Med Chem 28: (2020) Article DOI: 10.1016/j.bmc.2020.115574 BindingDB Entry DOI: 10.7270/Q2CR5XXS
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in intracellular calcium level measu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human recombinant full-length Prolink-tagged GPR40 fused with EA-tagged beta-arrestin expressed in human HEK293 cells assessed as...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Mus musculus)	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.60	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at Prolink-tagged mouse GPR40 fused with EA-tagged beta-arrestin expressed in human U2OS cells assessed as induction of beta-arresti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	0.350	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human recombinant full length GPR40 overexpressed in human HEK293 cells assessed as increase in inositol phosphate accumulation i...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]-(S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)biphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid from human...				Citation and Details Article DOI: 10.1021/acs.jmedchem.6b00892 BindingDB Entry DOI: 10.7270/Q2GH9NPC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00843 BindingDB Entry DOI: 10.7270/Q2R2152G
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00843 BindingDB Entry DOI: 10.7270/Q2R2152G
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	53	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmcl.2021.127969 BindingDB Entry DOI: 10.7270/Q2SJ1QKZ
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.114061 BindingDB Entry DOI: 10.7270/Q2CR5ZFX
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	9.30	n/a	n/a	n/a	n/a
University of Southern Denmark Curated by ChEMBL					Assay Description Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins...				J Med Chem 59: 4849-58 (2016) Article DOI: 10.1021/acs.jmedchem.6b00202 BindingDB Entry DOI: 10.7270/Q24T6M9W
University of Southern Denmark Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human GPR40 expressed in CHO cells by FLIPR calcium flux assay				Eur J Med Chem 116: 46-58 (2016) Article DOI: 10.1016/j.ejmech.2016.03.054 BindingDB Entry DOI: 10.7270/Q2FJ2JN2
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as intracellular Ca2+ level measured for 90 secs by Fluo-4 AM-based FLIPR assay				Bioorg Med Chem 24: 1981-7 (2016) Article DOI: 10.1016/j.bmc.2016.03.014 BindingDB Entry DOI: 10.7270/Q2RF5WW7
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 receptor expressed in CHO cells assessed as increase in intracellular calcium flux by FLIPR assay				Bioorg Med Chem 23: 7158-64 (2015) Article DOI: 10.1016/j.bmc.2015.10.011 BindingDB Entry DOI: 10.7270/Q2WW7KH2
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB	n/a	n/a	n/a	n/a	37.1	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as increase in intracellular Ca2+ concentration by Fluo-4 AM based fluorescence assay				Bioorg Med Chem 23: 132-40 (2014) Article DOI: 10.1016/j.bmc.2014.11.016 BindingDB Entry DOI: 10.7270/Q2DR2X4N
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Free fatty acid receptor 1 (Homo sapiens (Human))	BDBM50386790 (CHEMBL1829174 \| CHEMBL2047159 \| TAK-875 \| US119052...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at human FFA1 expressed in CHO cells assessed as induction of receptor activation by measuring Ca2+influx incubated for by FLIPR met...				Bioorg Med Chem 23: 6666-72 (2015) Article DOI: 10.1016/j.bmc.2015.09.010 BindingDB Entry DOI: 10.7270/Q2RX9DVB
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)