Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Heme oxygenase 1 (Rattus norvegicus (rat)) | BDBM84804 (1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Catania Curated by ChEMBL | Assay Description Inhibition of Sprague-Dawley rat spleen microsome HO-1 preincubated for 10 mins followed by beta-NADPH addition and measured after 15 mins by gas chr... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111703 BindingDB Entry DOI: 10.7270/Q2WD441F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme oxygenase 1 (Rattus norvegicus (rat)) | BDBM84804 (1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00633 BindingDB Entry DOI: 10.7270/Q23F4TJN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme oxygenase 1 (Rattus norvegicus (rat)) | BDBM84804 (1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Queen's University Curated by ChEMBL | Assay Description Inhibition of Sprague-Dawley rat spleen microsome HO1 | Bioorg Med Chem 15: 3225-34 (2007) Article DOI: 10.1016/j.bmc.2007.02.034 BindingDB Entry DOI: 10.7270/Q2MG7QBV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Heme oxygenase 1 (Rattus norvegicus (rat)) | BDBM84804 (1-azolyl-4-phenyl-2-butanone, 6a | CHEMBL536514) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+6 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Queen's University | Assay Description Heme oxygenase activity in rat spleen and brain microsomal fractions was determined by the quantitation of CO formed from the degradation of methemal... | Chem Biol Drug Des 75: 68-90 (2010) Article DOI: 10.1111/j.1747-0285.2009.00909.x BindingDB Entry DOI: 10.7270/Q25B0101 | |||||||||||
More data for this Ligand-Target Pair |