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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50457831'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50457831
PNG
(CHEMBL4207464)
Show SMILES Cn1cnc(c1)-c1ccc(OC2CCN(CC2)C(=O)Cc2ccc(OC(F)(F)F)c(F)c2)c(c1)C(N)=O
Show InChI InChI=1S/C25H24F4N4O4/c1-32-13-20(31-14-32)16-3-5-21(18(12-16)24(30)35)36-17-6-8-33(9-7-17)23(34)11-15-2-4-22(19(26)10-15)37-25(27,28)29/h2-5,10,12-14,17H,6-9,11H2,1H3,(H2,30,35)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...

J Med Chem 61: 6779-6800 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00633
BindingDB Entry DOI: 10.7270/Q2K64MPW
More data for this
Ligand-Target Pair