Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Homo sapiens (Human)) | BDBM203873 (7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 44 | -41.8 | 162 | n/a | n/a | n/a | n/a | 7.4 | 24 |
Oncology Innovative Medicines Unit | Assay Description TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe.... | Nat Chem Biol 12: 931-936 (2016) Article DOI: 10.1038/nchembio.2174 BindingDB Entry DOI: 10.7270/Q2FN1513 | |||||||||||
More data for this Ligand-Target Pair |