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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit' and Ligand = 'BDBM392385'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM392385
PNG
(N-[1-(benzenesulfonyl)-2-[1- (morpholine-4-carbony...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3n(c(cc3c2)C2=CCN(CC2)C(=O)N2CCOCC2)S(=O)(=O)c2ccccc2)c1C |t:19|
Show InChI InChI=1S/C29H31N7O5S/c1-19-20(2)32-33-26(19)28(37)31-23-16-22-17-25(21-8-10-34(11-9-21)29(38)35-12-14-41-15-13-35)36(27(22)30-18-23)42(39,40)24-6-4-3-5-7-24/h3-8,16-18H,9-15H2,1-2H3,(H,31,37)(H,32,33)
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<1.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research



Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...

J Med Chem 52: 1799-802 (2009)


BindingDB Entry DOI: 10.7270/Q2HH6NDZ
More data for this
Ligand-Target Pair