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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit' and Ligand = 'BDBM392497'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM392497
PNG
(N-[2-(2,2-difluoro-1,3- benzodioxol-4-yl)-1H- pyrr...)
Show SMILES Cc1n[nH]c(C(=O)Nc2cnc3[nH]c(cc3c2)-c2cccc3OC(F)(F)Oc23)c1C
Show InChI InChI=1S/C20H15F2N5O3/c1-9-10(2)26-27-16(9)19(28)24-12-6-11-7-14(25-18(11)23-8-12)13-4-3-5-15-17(13)30-20(21,22)29-15/h3-8H,1-2H3,(H,23,25)(H,24,28)(H,26,27)
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<1.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research



Assay Description
The c-kit mutant D816V (or kinase domain thereof) is an active kinase in AlphaScreen. IC50 values are determined with respect to inhibition of c-Kit ...

J Med Chem 52: 1799-802 (2009)


BindingDB Entry DOI: 10.7270/Q2HH6NDZ
More data for this
Ligand-Target Pair