Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin Curated by ChEMBL | Assay Description Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s... | Bioorg Med Chem 25: 2609-2616 (2017) Article DOI: 10.1016/j.bmc.2017.03.018 BindingDB Entry DOI: 10.7270/Q2833VFF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 354 | n/a | n/a | n/a | n/a | n/a | n/a |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent | Assay Description The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra... | US Patent US10981896 (2021) BindingDB Entry DOI: 10.7270/Q24X5BWV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 354 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin Curated by ChEMBL | Assay Description Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s... | Bioorg Med Chem 25: 2609-2616 (2017) Article DOI: 10.1016/j.bmc.2017.03.018 BindingDB Entry DOI: 10.7270/Q2833VFF | |||||||||||
More data for this Ligand-Target Pair |